"Fosinopril": malangizo ntchito. "Fosinopril": zikuonetsa ntchito kwenikweni Anzawo

"Fosinopril" ndi woletsa wa angiotensin akatembenuka enzyme. mankhwala ali hypotensive kanthu, angagwiritsidwe ntchito kuthamanga kwa magazi, yekhayekha mu mankhwala zovuta. Komanso, medicament ochitachita natriuretic, vasodilating ndi kanthu cardioprotective, amagwiritsidwanso ntchito limodzi ndi mankhwala ena pa chithandizo cha matenda a mtima.

Pharmacological katundu "fosinopril"

Kukonzekera "Fosinopril" thupi zimatengera mtundu wa metabolite ochita ogwetsa zimakhudzanso angiotensin akatembenuka enzyme. Mankhwala kuchepetsa mlingo wa mapangidwe angiotensin 2, normalizes kuthamanga zokhudza zonse magazi, ubwino ziwiya magazi.

Angiotensin akatembenuka ntchito enzyme ntchito 10, 20 ndi 40 mg wa mankhwala ndi zayamba yafupika pafupifupi maola 7 (palibe mofulumira kuposa maola 2, koma pasanafike 12 maola pambuyo kumwa mankhwala a). Pa tsiku yafupika ndi 7-15%.

"Fosinopril" Mapale kulola kuti achotse m'mnyewa wamtima hypertrophy ndi dilation wa ventricle kumanzere, mu kukhalapo kwa zinthu zimenezi zimathandiza kuti Kupha kwawo. Mankhwala kumabwezera mmbuyo mapangidwe aldosterone yomwe ikuchitika mu zopangitsa kwa adrenal, kumaonjezera ntchito dongosolo kallikrein-kinin, ziziyenda okhutira bradykinin mu zimakhala ndi magazi. mankhwala chifukwa zochokera ntchito "fosinopril" ukuwonjezeka liberatiou zinthu zomwe kusintha kusowa magazi kwa impso, ndi natriuretic, kanthu vasorelaxant. The medicament kumachepetsa kupanga arginine vasopressin ndi endothelin-1, amene kanthu vasoconstrictor.

Ndi kuchepetsa zoipazi (diastolic, systolic) sindikufuna kukhala ndi postural orthostatic tachycardia anachita sasintha Bcc. Palibe kusintha pa ntchito reflex wa myocardium, aimpso ndi oziziritsa magazi. Palibe kuphwanya kotunga magazi kwa khungu, ziwalo, chigoba minofu minofu.

Monga malangizo Buku, "Fosinopril" ntchito mlingo umodzi, ali ndi kanthu hypotensive amene kwambiri kutchulidwa pambuyo maola pafupifupi asanu. Zotsatira chifukwa ali anapitiriza patsiku, amene amalola kukhala zabwinobwino magawo magazi. Kusonyeza pazipita zotheka tingati chofunika zapita masabata ochepa.

Pa mankhwala "fosinopril" oopsa kusintha ayankhe thupi kuchepa mofulumira kuthamanga zokhudza zonse magazi. Zimagwira mankhwala ndi thiazides ndi "Fosinopril" njira amapezeka kwambiri kutchulidwa antihypertensive ntchito. Ngati ndi kotheka, adzafafaniza "fosinopril" sanali kukhala matendawa, si ngakhale choncho pamene Kulipira wapangidwa kwambiri. Kukonzekera bwino wodwalayo mwakhama loyenda mawonekedwe aakulu mtima kulephera, komanso ayankhe thupi nkhawa thupi.

Ponena za chionetsero cha katundu mutagenic ndi genotoxic mu nthawi ya mankhwala "Fosinopril" mankhwala kalozera amasonyeza ajombera. Komabe, ntchito Mlingo cytotoxic kumabweretsa zina matenda kugwirizana ndi aberrations chromosomal. Studies inkachitikira mbewa ndi makoswe anasonyeza kuti mlingo tsiku osati choposa 400 mg / kg sayambitsa zizindikiro za carcinogenicity. Chifukwa mlingo waukulu ku makoswe wamwamuna kubisa lipomas nthawi zambiri. Daily Mlingo wa mankhwala mpaka 60 mg / kg pa makoswe sanazichite matenda kugwirizana ndi kukhazikitsa ntchito ubereki. Pamene kutumikiridwa medicament makoswe pakati (tsiku kumwa mankhwala mpaka 400 mg / kg pa tsiku) ndi akalulu (tsiku mlingo 40 mg / kg) zinachitika kuledzera, mankhwala kusokoneza Inde mimba.

Suction amatanthauza "Fosinopril" wogwiritsa Phunziro pankhaniyi yodziwika monga pang'onopang'ono chifukwa kuchepekela zakudya zambiri. Chifukwa cha m'nthawi ya chiphaso kagayidwe bioavailability pang'ono (36%). "Fosinopril" hydrolyzed, ndondomeko izi zimachitika mu magazi, chiwindi ndi chipolopolo m'mimba chifukwa kukhazikitsa fozinoprilat kupangidwa, chomwe ndi metabolite yogwira. Mlingo pazipita mankhwala mu thupi pa maola pafupifupi atatu pambuyo tanthauzo lake. Theka-kuukitsidwa maola 12-15. Kulankhulana ndi madzi ndi pafupifupi - mpaka 98%, voliyumu ya yogawa ndi yaing'ono.

Mankhwala popanda kuphwanya malire placental ndi magazi ubongo zotchinga nthawi ya mankhwala alipo mu mkaka wa m'mawere. Mu matenda enaake (mowa, biliary) utachepa chilolezo, hydrolysis atuluka pang'onopang'ono. Mu insufficiency aimpso amapezeka kusokonezeka diatsidnyh yogwira metabolites excretion, mankhwala akhoza kudziunjikira mu thupi. Ntchito dialysis kuchotsa mankhwala kuchokera chamoyo "Fosinopril" malangizo Buku kusonyezedwa monga chinthu zomwe si kubala mukufuna.

Zikuonetsa "Fosinopril" kukonzekera

"Fosinopril" analamula kuti matenda a mtima ndi matenda oopsa. Mbali yoyamba, mankhwala ndi maziko mankhwala zina, mu zovuta chachiwiri ntchito mankhwala ndi monotherapy.

Mankhwalawa "Fosinopril"

Childs, mapiritsi akumwa nthawi imodzi kapena ziwiri tsiku nthawi yomweyo. Mankhwalawa matenda oopsa tikulimbikitsidwa choyamba 10 mg wa mankhwala, ndipo kenako - 20-40 mg. Mankhwalawa amaphatikizidwa, kupatula pamene "fosinopril" ntchito diuretic, kutenga 10 mg wa mankhwala. Pankhaniyi, mosalekeza kuwunika magazi, pazipita zotheka mlingo wa mankhwala ndi 80 mg pa tsiku. Ngati mankhwala, mlingo wina sakhala pawiri anali analilumpha. Mlingo Chithandizo pogwiritsa ntchito zida analimbikitsa ndi dokotala sangathe kutenga zazikulu ang'onoang'ono kuchuluka kwa mankhwala ndi kuonjezera pafupipafupi ake a ntchito, kapena tikhoza kuchita Kulipira "fosinopril" popanda kufunsa dokotala.

Tisanayambe mankhwala "Fosinopril" Buku tikulimbikitsidwa kuti muyese mlingo wa kuwonjezeka magazi. Poika chithandizo amaganizira osiyana matenda, dokotala nthawi zonse tiyenera kuyan'ana mmene wodwalayo.

Kuti tichepetse kutenga chitukuko cha matenda oopsa sekondale, mlingo yaing'ono tikulimbikitsidwa pa nthawi yogona. chithandizo Antihypertensive kuletsa masiku asanu isanafike mwambo wa mankhwala, "fosinopril". Ngati inu kale anachita mankhwala diuretic ndi kuchepetsa chiopsezo symptomatic hypotension, kukonza madzimadzi ndi electrolyte bwino, diuretic kuchepetsa mlingo, zina, siyani kumwa mankhwala kwathunthu (masiku 4-7 asanayambe mlingo woyamba "fosinopril").

Pambuyo m'mnyewa wamtima infarction mankhwala amatanthauza "Fosinopril" malangizo ntchito limakupatsani kuyamba patapita masiku atatu. Pa mankhwala amafuna muyeso zonse za magazi ndipo cheke Pantchito za magazi zotumphukira (kufufuzidwa isanapite mankhwala amazilamulira mkati 3-6 miyezi ya mankhwala mu yachinsinsi tsogolo imagwiridwa pachaka, pafupipafupi polojekiti kungakhale kofunika pamene mkulu Mwina wa zosayembekezereka ya neutropenia). Komanso, m'pofunika kuchepetsa thupi, fufuzani udindo wa impso ndi milingo creatinine, potaziyamu mu zikuchokera kwa plasma mapuloteni, magazi urea asafe. Pa mankhwala muyenera kutsatira zakudya.

Odwala amene zilonda matenda oopsa ali ndi khalidwe mankhwala mlingo pang'onopang'ono kuchuluka (usiku uliwonse), kuganizira kusintha magazi, pamene zotsatira adzakhala maximized.

Contraindications kulandira "Fosinopril" mankhwala

Pamene kugawa mapiritsi "Fosinopril" zikuonetsa ntchito amaonedwa imodzi ndi contraindications. mankhwala si ntchito ngati hypersensitivity kwa zigawo zake ndi mankhwala ena ofanana. Mankhwala si Kwalamulidwa kwa odwala zaka zosakwana 18 zakubadwa ndipo amayi oyembekezera, kuyamwitsa mwana mkaka akazi. Contraindication ali kwambiri loyenda kulephera aimpso. Contraindications monga angioedema (idiopathic, kumtundu) monga pa nthawi ya poika mankhwala, komanso anthu amene ali ndi mbiri anasonyeza hyperkalemia, hypotension.

pregnancy

Miyala "Fosinopril" malangizo Buku imaletsa ntchito woyembekezera, chifukwa mankhwala a mtundu uwu kungayambitse matenda kakulidwe ndi imfa yoopsa.

Ngati mimba ndi nthawi kukhazikitsa mankhwala amafuna chiyembekezo chakuti mofulumira mankhwala. Zikatero, kuphunzira ultrasound kudziwa kuvulaza mwana wosabadwayo.

akhanda A amene mayi woyesedwa pa mimba "fosinopril" mungazipeze hyperkalemia, hypotension, oliguria. Ngati anayamba oliguria, ndikofunika kupereka thandizo kwa perfusion aimpso ndi magazi kufufuzidwa zonse. Ngati ntchito impso ndi kuti matenda a kuthamanga magazi mogzhet kuchitidwa kuika kapena dialysis.

Zofooka kugwiritsa ntchito "Fosinopril" kukonzekera

Pa nkomwe wotuluka matenda autoimmune ayenera kuganizira chiŵerengero cha ubwino ndi kuopsa angathe mankhwala amatanthauza "Fosinopril". Malangizo ntchito, mayankho kusonyeza kuti muyenera kuganizira kuopsa ndi ubwino milandu zotsatirazi:

• inatsekeratu mtsempha wamagazi matenda;
• pamaso pa mtima kuziika impso;
• gout;
• shuga;
• mbiri angioedema;
• mitundu aakulu matenda obstructive m'mapapo;
• hyperkalemia ndi index kuposa 5.5 mmol / l;
• desensitization;
• matenda enaake;
• obstructive kusintha, limodzi ndi mkhutu outflow magazi kuchokera pansi pa mtima (kung'ambika stenosis, mitral);
• aakulu kulephera mtima;
• chakudya, kupereka wambiri zochepa za zomwe zili mchere kapena a osachepera kuchuluka kwa sodium wochuluka chakudya ankadya;
• hyponatremia;
• leukopenia, thrombocytopenia;
• ena njira (dialysis, ochititsa dzanzi) kugwira ntchito;
• atherosclerosis, kumene kumakhudza nthambi m'munsi;
• madzi m'thupi;
• aimpso kulephera creatinine pamwamba 300 pmol / L;
• ukalamba;
• chiwindi;
• mavuto ndi ubongo ndi inatsekeratu magazi;
• stenosis;
• zinthu zimene kucheperachepera Bcc.

Zotsatira zake zoyipa ku "Fosinopril" mankhwala

Kupezeka kwa medicament "Fosinopril" ndemanga ndi kalozera kusonyeza mosavuta kukhala zotsatira zina zoyipa. Angagwe matenda a dongosolo hematopoiesis ndi dongosolo mtima. kusintha zotheka ya ubongo, m'mimba dongosolo, kukula kwa mphamvu ntchito. Odwala ena anali kusintha mu magawo zasayansi ndi zochitika chowawa, mawonetseredwe a khungu anakhudzidwa, minofu ndi mafupa dongosolo. Kumachitika zipolowe mu dongosolo kupuma ndi urogenital. Mwa zochita zina chokhwima thupi - hyperhidrosis, kuwonda, kusanza, malungo, angioneurotic edema, chitukuko thupi njira matenda kapena njira yotupa mu mwanabele, lymphadenopathy, akuchuluka wa gout. mavuto iliyonse imene mankhwala ayenera kunenedwa dokotala. pachiopsezo chachikulu chotenga zochitika chowawa kugwirizana ndi kumwa mankhwala osokoneza bongo.

Ambiri osokoneza "Fosinopril" mankhwala

Mu mankhwala, "Fosinopril" mayankho amasonyeza kuti kuli Mwina cha mankhwala osokoneza bongo chifukwa cha choposa mlingo. Ambiri osokoneza limodzi ndi mawonetseredwe wokonda hypotension, aimpso kulephera, stupor, mantha, bradycardia, chosokoneza wa madzi ndi electrolyte bwino.

Ndisonyezeni kuchepetsa mlingo kapena kuwonongedwa kwa medicament kutsukidwa m'mimba ndi wodwalayo kumwa sorbent. Nkofunikira kuti anthu kutenga malo yopingasa, ndikofunika kukhazikitsa miyezo umalimbana kuwonjezeka Bcc. Komanso amafuna mankhwala symptomatic. Hemodialysis Pankhaniyi sapereka zotsatira ankafuna.

mogwirizana mankhwala "Fosinopril" kukonzekera

Mwina zosayembekezereka wa hyperkalemia apamwamba ntchito mankhwala osokoneza bongo ndipo wapangidwa ndi mmalo potaziyamu mchere, cyclosporine, supplementation ndi potassium potaziyamu-yosalekerera okodzetsa.

Zotsatira za mankhwala zimakhala anafotokoza bwino kugwiritsa ntchito njira ina, ali ndi zotsatira hypotensive, ndi mowa. A zotsatira ofooka kuposa kuyembekezera alipo chifukwa cha ntchito zinthu yambitsa ndi renin-angiotensin-aldosterone dongosolo, esitirojeni, NSAIDS ndi sympathomimetics. Zikatero m'pofunika akana kulandira ndalama izi kapena m'malo "Fosinopril". Analogs amasankhidwa ndi dokotala nawo. Pa kuthekera kaphatikizidwe mankhwala ndi mankhwala ena akhoza kuwapeza katswiri.

Analogs, "Fosinopril" ofanana mankhwala

"Fosinopril" ali ofanana ndi analogues. Pakuti ofanana matanthauzo a "Fosinopril-Teva", "Monopril." Ku gulu la mankhwala opangidwa "Fosinopril-OBL», «Fozikard". Wa ofanana matanthauzo mukhoza kusankha "Fozinal", "Fozinotek".

Pamene mankhwala sumapereka amatanthauza "Fosinopril" malangizo ntchito, ofanana matanthauzo kapena analogs yoikidwiratu katswiri mankhwala. Analogs "Berliprilom ',' Renitec '" ramipril "," Moeksom "," lisinopril ". Mumadziwika analogs komanso mwini "Prestarium", "Enap" ndi "enalapril". Wa analogues awerenge "Tritatse", "Akkupro", "captopril". Zotheka matenda pogwiritsa ntchito "hayala" kapena "Prenessa".

Ngati loletsa kugwiritsa ntchito mankhwala "Fosinopril" malangizo ntchito, analogs kapena ofanana matanthauzo kusankha wasankha katswiri.

Reviews kukonzekera "Fosinopril"

Nkofunika kusankha bwino mankhwala wodwala odana hypertensive, kutenga nkhani za peculiarities wa thupi lake. Ngati "Fosinopril" mankhwala munthu oyenera anzawo yafupika bwino, ndi mavuto sanalembedwepo. Monga mauniko, pali olimba a magazi, bwino thanzi akukhudzidwira. Ngati zosiyanasiyana chokhwima kwa thupi ndipo anati, ali ofatsa, makamaka kulawa bata ankatenthetsa, chifuwa.

Kuthamanga magazi kungayambitse mavuto aakulu kugwirizana ndi kuwonongeka kwa ziwalo zofunika kwambiri, kotero muyenera nthawi kuti mankhwala zofunika ndi kuwerenga za mankhwala "Fosinopril" analogues, kuti timudziwe bwino mfundo zina zothandiza.