"Imipenem + Cilastatin": kufotokoza, mavoti wosuta ndi ndemanga

Ena opatsirana matenda kugonjetsedwa si yapafupi. Iwo sangakhoze kwambiri yekha kusokoneza thanzi, koma ngakhale kulenga owononga moyo wa wodwalayo. Zikatero, iwo ayenera kugwiritsidwa ntchito ndi khalidwe aatali ndi mankhwala amphamvu kwambiri mwakuti angathe kugonjetsa matenda oopsa ndipo mwakale. Pofuna zosiyanasiyana matenda opatsirana kawirikawiri amatanthauza "Imipenem + Cilastatin". Malinga ndi mayankho a odwala ndi madokotala, ndi amazipanga ogwira. Musanayambe kusankha kuyamba chithandizo cha ndalama, m'pofunika kupeza mfundo zambiri za mankhwala "Imipenem + Cilastatin": dzina malonda mankhwala, makamaka kanthu ndi njira tanthauzo lake. Ndani ayenera kugwiritsa ntchito mankhwala funso? ndi contraindications chiyani? Kodi mankhwalawo angathe ndimayembekezera? Zonsezi mukhoza kuphunzira ndi kuwerenga nkhaniyi.

kapangidwe

Kukonza "+ Imipenem Cilastatin" ndi kuwapatsa cilastatin kuphatikiza (chomwe ndi woletsa wa enzyme aimpso digidropeptidazy) ndi mchere ndi sodium wa imipenem (mankhwala). Chimodzi kukonzekera vial zambiri lili mamiligalamu mazana asanu zinthu zonse.

Fomu kumasulidwa

Ankaona mankhwala "+ Imipenem Cilastatin" ndi alembedwe ufa jakisoni (kwa makonzedwe mtsempha) mu mbale zamitundu yosiyanasiyana, ndicho makumi asanu ndi zana ndi makumi awiri Botolo. ufa ayenera kusungunuka njira (buffered) ndi carbonate ndi sodium wa hydrogen.

Ngati kumene mankhwala Kwalamulidwa kwa makonzedwe mu mnofu ayenera kupeza mbale uliwonse uli 0.5 kapena 0,75 gram wa imipenem ndi cilastatin (malingana ndi mlingo, umene kutumikiridwa kwa wodwala ndi dokotala kupezeka).

zikuonetsa

The medicament "Imipenem + Cilastatin" zotchulidwa ntchito ndi odwala pamaso matenda opatsirana ndi yotupa kuti akhala chifukwa cha aliyense tcheru zochita za zinthu zofunika kuphunzira tizilombo mankhwala, monga onse polymicrobial osokonezeka aerobic-anaerobic matenda (kuphatikizapo matenda matenda a njira ya mkodzo kapepala ndipo m'munsi kupuma thirakiti, sepsis, matenda zimfundo ndi mafupa; peritonitis, matenda kwapakati pa-m'mimba, kutupa, etc. zomwe zimachitika ziwalo m'chiuno ,. matenda osiyanasiyana opatsirana a khungu ndipo zimakhala zofewa, komanso endocarditis Komanso, mankhwala ndi bwino ntchito kupewa mavuto pambuyo opaleshoni.

zotsatira pharmacological

Efficacy wa mankhwala "+ Imipenem Cilastatin" zowongolera bwino Kuphatikiza zigawo ziwiri yogwira. Choyamba, imipenem likuimira inayake beta-lactam maantibayotiki omwe amapha mabakiteriya mwachangu (potero kupereka zotsatira bactericidal). Nkhanizi ali sipekitiramu mokwanira waukulu ntchito. Izi zikutanthauza kuti tizilombo toyambitsa matenda ambiri amazindikira zotsatira zake. The chigawo chachiwiri, cilastatin ndi sodium ali kugwira ntchito pa enzyme amene linawola imipenem mu impso wodwalayo, kumabwezera mmbuyo ntchito yake, zomwe zimalimbikitsa kuwonjezeka okwanira mu ndende ya mankhwala pamwamba mu mawonekedwe unmodified mu mtima. Choncho, mphamvu yaikulu ya mankhwala "Imipenem + Cilastatin" zikuchulukireni.

ntchito

Kuti tikwaniritse zotsatira kwambiri, ndipo pofuna kupewa zovuta zilizonse chowawa mankhwala n'kofunika amatsatira malangizo pa kagwiritsidwe ntchito ka mankhwala. The medicament "Imipenem ndi Cilastatin Dzhodas" chikuyendetsedwera kuti wodwala m'nsinga (kukapanda kuleka).

Ngakhale kuti chitsogozo amapereka mlingo pafupifupi mankhwala, musanayambe chithandizo, n'kofunika kusintha chiwembu cha mankhwala mwachindunji dokotala amene angathe bwino kwabasi mlingo woyenera polingalira mbiri wodwalayo ndi mbali yake yeniyeni.

Mlingo imene muli medicament "+ Imipenem Cilastatin" malangizo thunthu ankaona anafuna kuti anthu odwala amene kulemera kuposa makumi kilogalamu. Anthu odwala amene thupi ndi zochepa, ayenera kuchepetsedwa mogwirizana ndi mlingo ntchito mankhwala (nkofunika kuti ndondomeko imeneyi wotsogozedwa ndi munthu oyenera).

Kwa odwala wamkulu ndi tsiku pafupifupi mlingo wa mankhwala "Imipenem ndi Cilastatin Dzhodas" ndi chimodzi - magalamu awiri, anapereka magawano ake patatu - anayi utsogoleli. Pa nthawi yomweyo, mlingo pazipita zomwe zili zovomerezeka kwa makonzedwe kwa tsiku limodzi ndi magalamu anayi ndi asanu kapena mamiligalamu pa kilogalamu ya kulemera kwa thupi (kusankha ayenera kugwera pa ang'onoang'ono wa Mlingo awiri kololeka).

Komanso, mlingo zimasiyanasiyana malinga ndi kukula kwa matendawa. Choncho, nkhani ya munthu wodwala mwamphamvu wofatsa wa matenda, kugwira ntchito mlingo adzakhala mamiligalamu mazana awiri ndi makumi asanu (mobwerezabwereza jakisoni akhale kanayi pa tsiku). Ngati digiri avareji mwamphamvu, kuchuluka kwa chiphunzitso cha utsogoleli wosakwatiwa ayenera kukhala mazana asanu mamiligalamu. Lowetsani njira ayenera katatu pa tsiku. Ngati matenda aakulu, ndiye mlingo wa mankhwala ayenera kugwiritsidwa ntchito kanayi pa tsiku. Pamene alili ndi yaikulu kwambiri moti pali loopsa kwambiri m'moyo wake, ayenera kuperekedwa pa galamu imodzi atatu - kanayi pa tsiku. mankhwala ayenera kuperekedwa pang'onopang'ono (magalamu pa ola limodzi, mazana awiri mphambu makumi asanu - faifi handiredi mamiligalamu - kwa makumi awiri - mphindi makumi atatu).

Ngati mankhwala ntchito kupewa matenda postoperative n'kofunika kuti atchule galamu imodzi pa ochititsa dzanzi ndi mlingo chomwecho, maola atatu pambuyo.

Ngati pa ntchito munali kuwopsyeza kwa mtundu uliwonse wa matenda (makamaka ntchito mu rectum ndi m'matumbo), "Imipenem + Cilastatin" malangizo ntchito akuonetsa kuti alowe mamiligalamu mazana asanu, asanu ndi atatu maola khumi ndi zisanu ndi chimodzi pambuyo mankhwala ochititsa dzanzi.

Kuti akonze njira ntchito mu mbale n'kofunika kuwonjezera ufa zinthu Botolo mazana a zosungunulira apadera, womwenso peresenti zisanu kapena chakhumi amadzimadzi dextrose, 0,9% sodium kolorayidi njira. Izi njira imipenem mankhwala ndende sayenera upambana mamiligalamu asanu pa milliliter.

Ziyenera kukhala kugwiritsa ntchito mankhwala molumikizana ndi mankhwala ena antibacterial, komanso mchere asidi lactic.

thunthu si yogwirizana ndi zina mankhwala beta-lactam (monga cephalosporin, penicillin ndi monobactam). ntchito zawo munthawi yomweyo zingachititse kuti zochita mtanda matupi awo sagwirizana.

Mogwirizana ndi ganciclovir zina amakwiya zopweteka zowombetsa mkota.

Various zinthu ndigwire katulutsidwe tubular, kuwonjezera ndende ya imipenem mu madzi a m'magazi, ndiponso nthawi theka moyo. Choncho, ngati mankhwala amafuna adzathandiza anthu wothandizila mu mlingo waukulu si koyenera kugwiritsira ntchito magulu awa zinthu imodzi.

Iwo analetsedwa kugwiritsa ntchito mankhwala funso mu nthawi ya gestation mwana, komanso nthawi yoyamwitsa.

mankhwala sayenera kugwiritsidwa ntchito pofuna kuthana ndi matenda oumitsa khosi.

Mkodzo pa mankhwala akhoza pang'ono akuda mu utoto kulocha.

Mlingo mtundu wa mankhwala (kwa mtsempha ndi makonzedwe mu mnofu) kuti ntchito pongofuna cholinga chimenecho. Iwo sali mosinthana. Asanayambe mankhwala chithandizo kwa kuziona kuti n'zofunika kuchititsa yofufuza pa mutu wa thupi lawo siligwirizana kapena hypersensitivity munthu opha tizilombo beta-lactam.

Ngati wodwala kale anali ndi matenda ena pa mundawo m'mimba, monga matenda a m'matumbo, kuti pamene ntchito mankhwala pansi review, pali kuthekera kwa enterocolitis pseudomembranous.

Kuti bwinobwino kupeŵa kuchita chilichonse wokhotakhota mu chapakati mantha dongosolo anthu odwala amene anali choipa chilichonse kwa ubongo kapena khunyu zowawa pansiyi analimbikitsa mankhwala mankhwala Mkhalidwe wothandizila antiepileptic.

Ziyenera adzanyamula kukumbukira kuti odwala achikulire ayenera kukhala obwera ndi ukalamba aimpso kukanika, amene kungafune kuchepetsa mlingo.

Nkofunika kukumbukira kuti odwala achikulire ayenera kugwiritsa ntchito mankhwala mosamala. Monga ulamuliro, amasonyeza zizindikiro zosiyanasiyana matenda obwera ndi ukalamba mu ntchito kwa impso. Pankhaniyi, ngati n'koyenera, kugwiritsa ntchito mankhwala "Imipenem + Cilastatin" malangizo Buku akuonetsa kuti kukaonana ndi dokotala anu kuchepetsa mankhwala mlingo ntchito.

Pali ena zinthu zapadera za ntchito mankhwala kwa ana. Ngati thupi lawo kuposa makumi kilogalamu, ndondomeko yomweyo ungagwiritsidwe kwa iwo monga akuluakulu. Ngati mwana ali wamkulu kuposa miyezi itatu, ndipo ake kulemera ndi zosakwana makumi anayi pogwiritsa, pazipita tsiku mlingo umenewu mtima adzakhala magalamu awiri. Iwo ayenera kuperekedwa mamiligalamu khumi pa kilogalamu kanayi pa tsiku.

Palibe kugwiritsa ntchito mankhwala "Imipenem + Cilastatin" ana amene sanafike apabe miyezi itatu, ndi ana amene akusokoneza uziyenda yachibadwa a impso, amene tingasonyezere mlingo wa ndende seramu creatinine kuposa mamiligalamu awiri pa desilita iliyonse.

contraindications

Pali ena mokoma kuti muyenera kuganizira ntchito "+ Cilastatin Imepenem". Malangizo akuonetsa mosamala contraindications kuti mankhwala. Ndipo mwa iwo ndi izi:

• nthawi gestation wa mwanayo;
• Kuyamwitsa;
• Ana osakwana zaka miyezi itatu;
• Ana amene akumva zowawa chakhungu aimpso kugwira ntchito kugwirizana ndi woipa mkulu wa creatinine seramu;
• tilinazo munthu kwa munthu zigawo zikuluzikulu za mankhwala mukukambirana, komanso zina mankhwala beta-lactam ndi carbapenems.

Nkofunika kukumbukira kuti odwala okalamba ndiponso amene akudwala kapena nthawi anadwala matenda a chapakati mantha dongosolo kapena matenda pa mundawo m'mimba ayenera kutenga mankhwala mosamala kuyang'aniridwa zonse dokotala. Kuti akhoza mwaluso perekani mlingo molondola za mankhwala "Imipenem + Cilastatin". Contraindications tifunika kuphunzira musanayambe chithandizo.

zotsatira zoyipazi

Nkofunika kudziwa chinthu chimodzi zambiri za chida "Imipenem + Cilastatin". Chilinganizo kukonzekera ndi odwala ena kupeza zochita mbali mu kachitidwe zosiyanasiyana za thupi. Ena mwa iwo: thrombophlebitis, chosokoneza kulawa, candidiasis, oliguria, myoclonus, kuyerekezera zinthu m'maganizo, paresthesia, chisokonezo, pachimake kulephera aimpso matenda okhudza ubongo, khunyu, polyuria, anuria, kutsekula m'mimba, matenda a chiwindi, kunyansidwa ndi kusanza, leukopenia, pseudomembranous enterocolitis, lymphocytosis, hyperbilirubinemia, eosinophilia, pruritus, leukopenia, zotupa pa khungu thrombocytosis, hypercreatininemia, monocytosis, urticaria, basophils, chenichenicho mwachindunji Coombs mayeso.

Palibe mfundo yeniyeni mmene kuthana ndi ambiri osokoneza mankhwala pansi kulingalira. Komabe amadziwika kuti izi yogwira zosakaniza bwinobwino kukumana hemodialysis. Komabe, akadali osadziwika bwino momwe ndondomeko izi mu nkhani ya mankhwala osokoneza bongo. Choncho n'kofunika kusunga malangizo onse, omwe limapangidwa njira kutsatira "+ Imipenem Cilastatin" kufotokoza lokonzekera.

zinthu yosungirako

Pofuna kuti ntchito mankhwala kuti azigwira, n'kofunika kuganizira mfundo ina yofunika. Ndicho, momwe kusunga mankhwala "Imipenem + Cilastatin". Kufotokozera za mankhwala ndizo nsonga zotsatirazi.

ufa ayenera munali mu chipinda chimene firiji lili. ayenera kugwiritsidwa ntchito yokonzekera ntchito njira palibe pasanafike ola limodzi pambuyo yonama. sodium kolorayidi njira firiji zikhoza kusungidwa kwa maola oposa khumi ndi mu firiji - osapitirira forte-eyiti. njira shuga akhoza kusungidwa kwa zosaposa anayi ndi makumi awiri mphambu anai maola, motero.

analogs

Pali mankhwala amene ali m'gulu la zikutanthauza analogues "Imipenem + Cilastatin". Mmalo ankaona mankhwala - "Inemplyus", "Miksatsil", "Lastin", "Sinerpen", "Tiaktam", "Piminov", "Supranem" ndi "Tienam". Monga ulamuliro, onse mankhwala awa ali yemweyo yogwira pophika monga mankhwala ankaona. Waukulu yogwira zosakaniza mankhwala awa - imipenem, cilastatin (dzina malonda ndi zomwe zimasonyeza mankhwala awa). Choncho, mankhwala awa ali kwakukulukulu lofanana ndi contraindications ndi mavuto ndi zotsatira pharmacological. Komabe, tiyenera kukumbukira kuti mlingo ayenera kusankha dokotala amene adzatha tikambirane zina zabwino zonse. Mankhwala "Imipenem + Cilastatin" analogues mankhwala sayenera kugwiritsidwa ntchito ndi odwala popanda chilolezo, popanda dokotala amachitira ndi ulamuliro wake nthawi zonse. Kuphatikizapo malangizo ake ndi ofunika ndi kusankha kufanizira yoyenera.

generalization

Khalani akutsimikiza kuti mphamvu ya mankhwala "+ Imipenem Cilastatin". Reviews mwasonyeza bwino chithandizo zakambidwa. Komabe, madokotala ndi odwala kuti lolunjika pa zinthu zofunika molondola kutsatira malangizo opezeka m'mabuku a malangizo anapereka dokotala nawo. Only njira ya mankhwala phindu kwa thupi la wodwalayo.

Tisanyalanyaze contraindications, pamaso amene salola kuyamba chithandizo ankaona mankhwala. Apo ayi, ntchito yake osati kungopereka zabwino, komanso kuwononga kwambiri thanzi la wodwalayo. Komanso, ntchito pachithunzichi wa mankhwala ankaona akhoza kuyambitsa zotsatira zoyipa, ena amene akhoza kwambiri kuvutika alili. Nkofunika kuti mankhwala zinachitika kuyang'aniridwa ndi dokotala woyenera, amene osati bwino ndi peculiarities wa ntchito mankhwala, komanso kuti katswiri luso zofunika ndi chidziwitso kupirira mavuto emergent kovuta. thanzi lanu akhale m'manja mwa akatswiri woona.

Musanayambe kusankha kuyamba chithandizo ankaona mankhwala, ndikofunika mwawerenga mosamala mfundo zonse za izo, zomwe amasonyeza makhalidwe a zotsatira zake pa thupi. Zonse muyenera kudziwa za lingathe zochita zoipa, pakutchulidwa amene akhoza kupulumutsa kwambiri za mavuto kwa wodwalayo ndiponso mavuto a dokotala wake.

Ndi kusankha chithandizo n'kofunika kuchitira moyenera. Sankhani malonda wapamwamba kwambiri!