Lozap Plus - Malangizo Ntchito

Medicine "Lozap kuphatikiza" umaperekedwa monga miyala filimu TACHIMATA, kuwala chikasu kapena wotumbululuka mu mtundu. miyala ndi mawonekedwe oblong n'kuduladula chiopsezo mbali imodzi.

kapangidwe

Yogwira zosakaniza:

• hydrochlorothiazide - 12,5 mg wa (1 tsamba.)
• losartan - 50 mg (Table 1).

Excipients:

• macrogol 6000;
• microcrystalline mapadi;
• mannitol;
• krosparmelloza ndi sodium;
• mankhwala enaake a stearate;
• povidone;
• Valium;
• talc;
• utoto;
• simethicone emulsion.

zotsatira pharmacological

Losartan - ndi angiotensin 2 cholandilira antagonist kuti si ziletsa kinase 2. Kukonzekera kumachepetsa OPSS, kuthamanga kwa magazi, milingo magazi a aldosterone ndi Epinephrine. Komanso, mankhwala ali bwino diuretic zotsatira ndipo kumachepetsa afterload.

Losartan angalepheretse chitukuko cha kudwala monga hypertrophy m'mnyewa wamtima, komanso kusintha mtendere wa odwala amene mankhwala kulephera mtima.

Hydrochlorothiazide wa okodzetsa thiazide. Iwo amachepetsa reabsorption ya soda ndi kumawonjezera linanena bungwe la potassium mankwala ndi wa hydrogen mu mkodzo.

pazipita antihypertensive zotsatira zake akhoza kufika masabata 3.

umboni

• oopsa wodwalayo;
• kuchepetsa chiopsezo cha CVD odwala ndi zapamwamba kumanzere hypertrophy yamitsempha yamagazi ndi oopsa

zotsatira zoyipazi

Zotsatira zake zoyipa kuphatikiza Lozap anafotokoza malangizo pamaziko a mavuto a zosakaniza yake yaikulu yogwira - losartan ndi hydrochlorothiazide.

Zotsatira zoyipa zimene zimakhudza chapakati mantha dongosolo

• chizungulire (kumachitika kawirikawiri zokwanira).

Mankhwalawo kuti tifulumizane thupi lawo siligwirizana cha thupi:

• angioedema;
• laryngeal edema (ndi mbali zina za kapepala chapamwamba kupuma);
• ming'oma;
• vasculitis;
• matenda Henoch a.

Zotsatira zoyipa zokhudza mtima (dongosolo mtima):

• oopsa.

Zotsatira zoyipa zimene zimakhudza thirakiti m'mimba (chiopsezo zosakwana 1%):

• chiwindi;
• m'mimba;
• kuwonjezera transaminases chiwindi.

Zotsatira zoyipa zimene zimakhudza dongosolo kupuma:

• kutsokomola.

Zotsatira zoyipa zimene zimakhudza madzi electrolyte bwino (chiopsezo zosakwana 1%):

• hyperkalemia.

contraindications

• oopsa;
• anuria;
• hypovolemia;
• kukanika a impso ndi chiwindi;
• zaka 18;
• kudziwa zigawo zikuluzikulu;
• mimba;
• mkaka wa m'mawere.

Ngati mimba wodwala chinachitika ndi maziko a mowa mankhwala, tiyenera yomweyo zimafika. chakuti Lozap kuphatikiza mwachindunji bwanji renin-angiotensin dongosolo, tingayambe imfa yoopsa mu trimesters awiri otsiriza wa mimba.

Miyala "Lozap kuphatikiza" kutenga munthu wodwala pakati akadali osavomerezeka chifukwa mankhwala zingachititse matenda a chikasu ndiyo mwa ana akhanda, ndi thrombocytopenia amayi. Therapy imachitika ntchito okodzetsa, mu nkhani iyi si kuthandiza kupewa kawopsedwe.

ambiri osokoneza

Zizindikiro cha mankhwala osokoneza bongo:

• kutsitsa magazi;
• bradycardia;
• tachycardia;
• madzi m'thupi (chifukwa kuchuluka mkodzo linanena bungwe).

mankhwala ambiri osokoneza bongo chithandizo ayenera kuyamba ndi chapamimba lavage mu chochitika kuti wodwalayo watenga Lozap kuphatikiza posachedwapa. Ndiye mtima n'kofunika symptomatic mankhwala, ndipo nthawi zina - malangizo madzimadzi ndi electrolyte chisokonezo. Hemodialysis sangathe kuchotsa monga losartan ndi metabolites ake.

Mwanjira mankhwala

Losap kuphatikiza potentiates zimene ena mankhwala antihypertensive pa nkhani ya ntchito zawo kuphatikiza. Mankhwala akhoza kuyambitsa ndi potentiation wa orthostatic hypotension, ngati pamene ntchito pamodzi ndi barbiturates.