"Osterepar": malangizo Buku, ndemanga, Mlengi analogues

Kuchepetsa mlingo wa mchere mu minofu fupa chifukwa cha kuchuluka yaikulu kuwonongeka kwa fupa ndi articular zida mu anthu a misinkhu yosiyanasiyana. Nthawi zambiri, mafupa amachepetsa chifukwa kuchuluka wovulala fupa - otchedwa fupa resorption. The normalization njira thupi pakati pa chiwonongeko ndi chilengedwe cha fupa - cholinga chachikulu cha mankhwala a matenda a mtundu umenewu. Mmodzi wa mankhwala ntchito mankhwala kufooka kwa mafupa, ndi "Osterepar". Tiyeni tiwone chimene akunena za "Osterepar" kukonzekera malangizo ntchito, madokotala weniweni ndi odwala.

pharmacological mapangidwe

Thunthu yogwira ntchito yokonza "Osterepar" ndi alendronic asidi, amene akuimira mu mawonekedwe a mchere ndi sodium - sodium wochuluka alendronate. Limagwirira cha zochita za mankhwala si bwino ankafufuza Koma amadziwika kuti endpoint kukhudzana alendronate ndi sodium n'choti bwino HIV pakati pa chiwonongeko ndi kubwezeretsa minofu fupa. Gawo la ndondomeko izi anazindikira mwa inhibiting osteoclasts - apadera maselo fupa udindo uwonongedwe.

Komanso amadziwika kuti kuchepetsa madzi a m'magazi kashiamu amachititsa kudzikundikira ake mu minofu fupa tikadwala mankhwala "Osterepar". Malangizo ntchito limati kumalimbitsa dongosolo fupa ndi kuchepetsa chiopsezo fractures.

Makhalidwe pharmacokinetic wa

Ngakhale kuti alendronate ndi sodium mosavuta sungunuka m'madzi ndi njira amadzimadzi, mankhwala mayamwidwe ku lumen wa matumbo si wabwino - mayamwidwe kokha pafupifupi 25%. Amadziwika kuti "Osterepar" chimango wabwino kwa mapulotini plasma (mlingo kumangako ndi 70-75%) sali zimapukusidwa mu thupi.

Zikuonetsa "Osterepar" kukonzekera

Malangizo ntchito limanena kuti mankhwala akusonyeza kuti deforming matenda fupa lomwe limatchedwa kufooka kwa mafupa (kuphatikizapo postmenopausal kufooka kwa mafupa mu akazi). Alendronate ndi sodium bwino ntchito mankhwala okwera plasma kashiamu mlingo odwala ndi njira yoopsa.

contraindications

Official mankhwala "Osterepar" Buku lili mndandanda wonse wa contraindications kuti mankhwala anafuna. Kotero, "Osterepar" ali contraindicated ntchito ana, chomaliza mankhwala ndi dzuwa la chitetezo cha ntchito yake si bwino.

Alendronate ndi sodium si anasonyeza pa mapangidwe mkaka wa m'mawere, kudyetsa ndi kumapitiriza mimba. Komanso, mankhwala ali contraindicated mu yafupika plasma milingo kashiamu rickets akusowa ndi vitamini D. CHENJEZO medicament ayenera kugwiritsidwa ntchito odwala popanda aimpso ntchito excretory.

zotsatira zoyipazi

Pamaso oyamba mu ntchito yachipatala wa alendronate ndi sodium anali awiri akhungu, placebo womwe kuphunzira. Malinga ndi zotsatira za maphunziro awa pafupipafupi zochita mbali mwa anthu kutenga alendronate sodium, anali pang'ono poyerekeza pafupipafupi zosiyanasiyana chokhwima odwala mankhwala placebo.

Mwa zochita chowawa chifukwa cha mankhwala "Osterepar" odwala taonera matenda a thirakiti m'mimba (dyspepsia, kupweteka m'mimba, matenda a mpando ndi chizolowezi kudzimbidwa) ndi dongosolo chapakati mantha (mutu). Pali zotsatira zina zimapezeka ndi kugwiritsa ntchito "Osterepar" mankhwala. Malangizo ntchito limasonyeza zochita chosowa kwambiri matupi awo sagwirizana monga zotupa kapena kuyabwa.

Kusamala

Kutenga "Osterepar" mapiritsi ayenera kumwa wamba madzi akumwa monga zakumwa zina (madzi mchere, mkaka, madzi zipatso) zingakhudze bioavailability ndipo m'mbuyo mayamwidwe ake. Popeza alendronate ndi sodium kungakhale kopweteka mbali chapamwamba pa mundawo m'mimba, phale ayenera kumwedwa ndi madzi ambiri (chikho zonse). Mu malo yopingasa, pali chiopsezo kukhala zotupa esophageal pa phwando "Osterepar" mankhwala kuchuluka. Malangizo ntchito analemba kuti Sikuti osachepera theka la ola kukagona pambuyo kutenga mankhwala, komanso kumwa mankhwala pamaso bedi.

CHENJEZO mankhwala Kwalamulidwa kwa odwala ndi matenda mano, kuphatikizapo chotupa chiyambi. Pamene kugawa "Osterepara" tikulimbikitsidwa kuti mwanjira mano Kupenda zonse azichita ziŵalo wathunthu wa M'mimbamo m'kamwa. pochotsedwa mano ayenera kuzipewa pa phwando.

Pamene yaitali mankhwala (zaka zoposa chimodzi ndi theka) mankhwala ku gulu la bisphosphonates, zikhoza m'chiuno fractures mu gawo proximal. Mu chochitika cha wovulala wodwala tikulimbikitsidwa kuti atumize mosamala yachiwiri femur kuti kuchepetsa mosavuta kukonzanso wovulala. Komanso, "Oseoreparom" mankhwala ndi anaima mpaka ngozi phindu ziyenera a chithandizo.

mwapadera ayenera kukhala poika "Osterepara" odwala kutenga glucocorticoids. Mankhwalawa amatha kuchepetsa mayamwidwe ndipo motero, kashiamu ndi vitamini D wambiri m'thupi. Odwala awa, hypocalcemia kuvala asymptomatic n'kumasonyeza kwambiri pamaso pa kutengera za kumtundu. Pofuna kuteteza vuto ili yake matenda hypocalcemia analimbikitsa kuonetsetsa kashiamu chokwanira ndi vitamini D. phwando

Mankhwala si Kwalamulidwa kwa odwala matenda ochepa chabe osiyana anachititsa kugwirizana ndi tsankho lactose.

Mankhwala alibe mphamvu pa mlingo anachita ndi luso ntchito makina. Komabe, tiyenera kukumbukira kuti pali mavuto ndi zochita chowawa pambuyo kutenga "Osterepara" zingakhudze pasukuluyi.

Mwanjira mankhwala

"Osterepar" osavomerezeka ntchito limodzi ndi aspirin kuyambira ndi aspirin kumawonjezera mavuto a alendronate ndi sodium (makamaka zotsatira thirakiti matumbo). Komabe, "Osterepar" bwino analekerera odwala kulandira chithandizo lina sanali steroidal mankhwala odana ndi yotupa. Ngakhale izi, m'modzi ayenera kupeŵa ntchito ophatikizana a mankhwala monga mankhwala odana ndi yotupa nonsteroidal okha angathe kuyambitsa zotsatira kwambiri mbali.

Cholinga cha alendronic asidi akazi kulandira estrogens limodzi nanu progesterone ndi anapereka kuwonjezeka kwambiri kutchulidwa mu mafupa ndi kuchepa kwambiri mlingo wa fupa resorption.

Thiazide diuretic mankhwala osakaniza ndi asidi mzere lakuti alendronic akutitsogolera kuti kuchepa kwa imfa kashiamu ndi amachepetsa zotsatira za "Osterepara".

Poyizoni ndi mankhwala ambiri osokoneza bongo

Ngati chiphe alendronate anati kuchokera matumbo matenda, anawonetseredwa mu mawonekedwe a kusanza, kutentha, esophagitis ndi ulceration mu matumbo lumen. Pa mbali ya dongosolo chigoba ndi dongosolo la mwazi zikhoza hypocalcemia ndi hypophosphatemia.

Chithandizo cha poyizoni ndipo ambiri osokoneza walangizidwa mankhwala kumanga mu lumen wa matumbo ndi inactivation ake. Mukhoza kugwiritsa ntchito mkaka, Mankhwalawa ayenera kumwedwa, calcium ofotokoza binders. Self-kupangira kusanza sayenera kukhala, chifukwa mankhwala zingachititse mkwiyo ndipo amayaka la kholingo. Pakuti lavage chapamimba m'pofunika ntchito kafukufuku. Symptomatic mankhwala ndi umalimbana ofunika mlingo kashiamu mu madzi a m'magazi.

Reviews madokotala ndi odwala

Pa tsiku lokonzekera "Osterepar" mayankho zosiyanasiyana, koma makamaka positive. Ndi odwala kumwa mankhwala, mkwiyo chifukwa cha zimakhudzanso irritant mankhwala pa mucosa pa mundawo matumbo. Amazionera madokotala, mankhwala "Osterepar" analogs wa mankhwala okhala ndi sodium alendronate mogwira mtima kuchitira kufooka kwa mafupa a Genesis zosiyanasiyana komanso matenda a dongosolo minofu ndi mafupa.

Analogs medicament

Mu msika mankhwala ukufanizidwa ndi nambala okwanira analogs wa mankhwala okhala ndi sodium alendronate monga pophika yogwira. "Alendronate" "asidi Alendronic", "Alental", "Strongos" Tevanat ". awa ndi mankhwala ambiri zonse - analogues wa mankhwala "Osterepar".

Malangizo ntchito analogues wa mankhwala silimanena Komabe, ngati pali gawo asidi alendronic - mankhwala angagwiritsidwe ntchito mwapadera zochizira kufooka kwa mafupa.

Pomaliza

Kufooka kwa mafupa - matenda sioneka, ndi mankhwala ake ndi ovuta ndiponso yaitali. Mungayankhule bwanji zokhudza mankhwala "malangizo Osterepar 'ntchito, Mlengi, odwala ndi madokotala, kugwiritsa ntchito njira za zotsatira opindulitsa pa dongosolo chigoba normalizing kashiamu ndi phosphorous kagayidwe ndi kucheperachepera fupa resorption.

Mnthawi utsogoleli wa mankhwala, chifukwa zotsatira pazipita, muyenera kutsatira malamulo ochepa osavuta amene akufotokozedwa malangizo ntchito, ndiponso kulankhulana zonse ndi dokotala kupewa zotsatira osafunika mankhwala. Pa mankhwala, musanyalanyaze poika akatswiri, ngati iwo ali ofunika kwambiri kwa chithandizo bwino ndi kuchira othamanga.