"Hydrea": malangizo Buku, ndemanga, photos, analogues

Mankhwala "Hydrea" uli anticancer mankhwala. Mankhwala kumakhudza cytostatic, limagwirira wa ozikidwa pa chopinga wa DNA kaphatikizidwe, ndi zotsatira pa RNA ndi kaphatikizidwe mapuloteni akusowa.

Mu mawonekedwe chimene chopangidwa mankhwala, zomwe tichipeza?

medicament The amachoka mu mawonekedwe a makapisozi chinaperekedwa potsatira hydroxycarbamide, ndilo 500 mg aliyense kapisozi. Mankhwala akupezeka mu nsupa galasi (100 makapisozi), kapena chithuza paketi (10 makapisozi). A zigawo zikuluzikulu wothandiza ntchito mankhwala enaake a stearate ndi citric acid. Komanso, zikuchokera ndi wodzilemekeza ndi mankwala ndi sodium wa hydrogen dihydrate ndi lactose monohydrate.

Zinthu zomwe zimapanga chigoba cha makapisozi "Hydrea" malangizo ndi titaniyamu dioxide, utoto ndi gelatin. lolembedwa ndi aumbike mwa inki amene analandira chifukwa pawiri la propylene glycol, shellac, mowa (isopropyl, methylated mafakitale ndi N-butyl), ndi madzi oyera ndi chitsulo okusayidi wakuda.

pharmacodynamics

The mankhwala ndi antimetabolite, zotsatira zake akuwonetseredwa mu gawo selo mkombero S. "Hydrea" amalola kuti asiye chitukuko cha maselo interphase G1-S, chimene chiri chofunika kwambiri pamene imodzi ndi phwando medicament anatenga radiotherapy, monga gawo G1 maselo chotupa amazindikira walitsa. lokonzekera timapitiriza kanthu anagwira ribonukleoziddifosfatreduktazoy (RNA reductase woletsa). Pogwiritsa ntchito imathetsa ake DNA kaphatikizidwe, koma osati akusokoneza mapuloteni ndi RNA mapangidwe.

Pharmacokinetics

Mayamwidwe mankhwala kapepala kakuti m'mimba "Hydrea" malangizo Buku limafotokoza mmene kudya popanda kutengera kudya chakudya ndi kumabweretsa kukwaniritsa mlingo pazipita mankhwala yogwira m'thupi maola awiri pambuyo kumwa njira eni. The medicament umadutsa chotchinga magazi mu ubongo, yodziwika ndi kugawa mofulumira pano mu ascites ndi madzi cerebrospinal. The mankhwala ndi atasunga erythrocytes ndi leukocytes pang'ono excreted maola atatu kapena anayi. Tsankho kagayidwe mu chiwindi. Kwambiri mankhwala ndi excreted ndi impso mu mawonekedwe a hydroxyurea, ndi nthawi labwino la ndondomeko izi maola khumi. Sizisintha ena chikuoneka, pang'ono atachotsedwa thupi mu mkodzo. Via kupuma thirakiti mankhwala excreted ngati mpweya. Atalandira "Hydrea" malangizo akulengeza kuwonongedwa kwake kwathunthu mu tsiku. Popeza Mbali yaikulu ya mankhwala umadutsa impso, odwala amene ali ndi kudwala ziwalo, kuchepetsa mlingo wa mankhwala.

umboni

"Hydrea" malangizo ntchito limakupatsani perekani m'mikhalidwe yoteroyo wa chamoyo:

• khansa;
• myelogenous khansa;
• khansa, kupanga izi zimakhudza chiberekero, m'mapapo, prostate, m'matumbo, kapena thumba losunga mazira (mankhwala ayenera pamodzi);
• osteomyelofibrosis;
• erythremia;
• pamaso pa chikhalidwe zilonda za zotupa mu khosi ndi mutu, nokha ndi khansa izi zimakhudza milomo (pali chithandizo bwino);
• N'kofunika thrombocythemia;
• horionepitelioma chiberekero;
• pachimake lymphoblastic khansa otaya;
• thrombocytosis monga vuto la matenda myeloproliferative;
• matenda Hodgkin ndi;
• zosayembekezereka wa metastasis khansa, zosokoneza mammary England ndi m'mimba.

contraindications

Pali milandu imene chithandizo ndi zosavomerezeka amatanthauza "Hydrea". Mankhwala malangizo limaletsa anaika mu Zikatero:

• Mkulu kudziwa makapisozi a;
• thrombocytopenia ndi leukopenia pa mitengo ya zosakwana 100,000 ndi 2500 / ml motero;
• pregnancy, kuyamwitsa mkaka wa m'mawere.

Ngakhale milandu awa ndi mankhwala si contraindicated, pamene anaikidwa ndipo ntchito amafuna kusamalidwa:

• shuga-galactose malabsorption;
• lactose tsankho;
• kusowa lactase;
• Lolemera umayenda magazi m'thupi;
• kulephera impso ndi chiwindi.

Ngati wodwala wachita kale pansi Morning mankhwala poizoni chiopsezo cheza pachimake erythema ndi chitukuko cha myelosuppression Choncho, mu nkhani iyi, nayenso, ayenera mokoma ntchito mankhwalawo.

Pa mankhwala ayenera kulera odalirika, ngati koma mimba, wodwalayo ayenera kudziwa chiopsezo umene ulipo kwa mwana wosabadwayo. Chifukwa malowedwe a mankhwala mu mkaka wa m'mawere wa amayi amene kuyamwitsa, m'pofunika kuti asiye mtundu wa kudya. Ngati mankhwala zakonzedwa kuti muletse, katswiri ayenera kuganizira mfundo zosiyanasiyana asanafike adzalola mtima kukana chithandizo zochokera phwando makapisozi "Hydrea".

chithandizo

Pa mankhwala a medicament "Hydrea" malangizo Buku amalimbikitsa ntchito mlingo wosiyana wa wothandizila mu maiko osiyana, anapatsidwa makhalidwe a wodwalayo.

Ngati wodwala zovuta akudya kapisozi, imaonetsa kuti kutsegula kwa mankhwala kupasuka mu madzi. Zikatero, wothandizila ayenera kumwa nthawi yomweyo. Ziyenera adzanyamula kukumbukira kuti si zigawo zikuluzikulu zonse za makapisozi a kupasuka mu madzi, otsala pamwamba pake. Odwala amene akukuchitirani "Hydrea", m'pofunika kumamwa kowirikiza madzi.

Myelogenous khansa (mawonekedwe aakulu)

Chithandizo imagwiridwa mosalekeza. Pakuti aliyense kilogalamu ya kulemera kwa thupi atenga 20-30 mg wa mankhwala. Izi mlingo tsiku, mankhwala chimadyedwa kamodzi tsiku lililonse. Mwayi kuwunika mphamvu ya mankhwala wakhala pa miyezi 1.5 kukhazikitsa. Ngati zotsatira zabwino zasonyezedwa, mankhwala akhoza kukhala motalika kokwanira (osowa Hud), pa kugwa kuchuluka kwa maselo othandiza magazi kuundana ndi leukocytes pansipa ponseponse yake ndinayima. Ngati atapita masiku atatu (osati kale) magazi zinayambanso kuyenda bwino, mungathe kuyambiranso mankhwala ndi "Hydrea". Malangizo ntchito limasonyeza kuti mwayi wotero amabwera msanga.

erythremia

Mlingo anafuna utsogoleli tsiku la 15-20 mg. Monga momwe zinalili m'mbuyomu, ndalamazo mankhwala ndi kuchita masamu pa kilogalamu ya kulemera kwa thupi. Tsiku mtima ndi ambiri kutumikiridwa 1 kapena 2 makapisozi. mlingo Final kwa wodwala aliyense anatsimikiza ndi kulemera kwake, zimadalira kuchuluka kwa mankhwala limene maselo othandiza magazi kuundana ndi milingo hematocrit mfundozi yachibadwa.

n'kofunika thrombocythemia

Mlingo koyamba pa kilogalamu ya kulemera kwa thupi lolingana 15 mg. The tsiku mlingo kusintha payekha kotero kuti zinthu zofunika anali pa mlingo bwino. Ngati zoletsedwa mankhwala "Hydrea" malangizo ofanana matanthauzo dokotala ikufotokoza ndipo amasankha njira yoyenera kwambiri.

khansa

Ndi zotupa zazikulu mankhwala akhoza kukhala mwina likukulira kapena mosalekeza, motero, mlingo kofunika medicament pa kilogalamu imodzi ya kulemera ndi 80 mg kapena 20-30. Pa masabata atatu, nthawi ya mankhwala mosalekeza mankhwala tsiku ndi tsiku kumwa kamodzi. Ngati mankhwala ikuchitika intermittently kwa masiku atatu, kumwa kamodzi kwambiri, koma pa mlingo wokwererapo.

Carcinoma (khomo lachiberekero chotupa, mutu kapena khosi)

Pa kilogalamu thupi ndi pa mg wa 80 wa mankhwala. Mlingo Napempha kwa mankhwala kumwa masiku atatu (kamodzi).

zotsatira zoyipazi

Pamene mankhwala "Hydrea" malangizo, ndemanga anenapo zotsatira zina mbali dongosolo hematopoietic, mantha, mkodzo, kupuma ndi machitidwe m'mimba. Komanso, khungu angakhudzidwe ndi zokhudzana awo n'zotheka kukulitsa matenda, monga chilonda. Kodi adzadziwika ndi zochita zina chokhwima.

Mtengo wa mankhwala, analogues

Kugula phukusi "Hydrea" kungakhale kwa 243-250 rubles. (20 makapisozi). Pakati pa mmalo - kukonzekera amene ali yemweyo yogwira pophika ngati "Hydrea" ndi mankhwala kuti kuchita chimodzimodzi.

Wa ofanana ndi mugule "hydroxyurea" kapena "Hydroxycarbamide Medak." Pamene limaletsa chithandizo "Hydrea" mtsogoleri, analogs akhoza osankhidwa ambiri medicaments, monga "Tromboreduktina" "amyl FS", "Kolotekana", "Milanfor", "Prospidin", "iritis", "halava", "Estratsita" "Irinotela", "Kamptotekana" kapena "Estratsita". Mugule mmalo monga "Agrilin", "Kamptera" kapena "Erivedzh". Mwa zipangizo muli zochita zofanana "Aranoza", "Irinaks", "Arglabin". List mankhwala ofanana amapanga "Zaltrap", "Irnokam", "Geksalen". Litha kuchizika "Proksifeinom", "Gikamtinom", "Campto", "Verotekanom", "Hloditanom", "prospidin", "Onkofagom", "irinotecan" kapena "Velcade".

Reviews

odwala ambiri amakhulupirira kuti musanayambe mankhwala ayenera kufufuza kufotokoza amatanthauza "Hydrea" malangizo. Photos patsogolo ndipo mukhoza penyani positi mankhwala. Tikayang'ana ndemanga, anthu amakonda kuchitiridwa kokha moyang'aniridwa ndi achipatala ndi chiopsezo osati kudzimvera medicate, monga uyu ndi woopsa, kumamwa kowirikiza madzi. Ngati osati kutenga mankhwala pamodzi ndi mankhwala poizoni mavuto kapena kuoneka (pa nthawi imene kale kwina), kapena kukhala kukuonekera. Koma sikuti kuchitika.