Mankhwala "Carboplatin": malangizo ntchito, analogs ndi ndemanga

Kodi m'malo mankhwala monga "Carboplatin"? Analogs za mankhwala adzakhala ali m'munsiwa. Komanso zipangizo za nkhaniyi Adzaperekedwa zokhudza ntchito molondola za ndalama anati, zizindikiro zake, mavuto ndi contraindications.

Zikuchokera kufotokoza, mawonekedwe a medicament ndi

Mu mawonekedwe zimene zilipo mankhwala "Carboplatin"? Mlengi amanena kuti chida zikhoza kugulidwa monga woyera lyophilized ufa anafuna yokonza njira mtsempha. pophika wake wamphamvu ndi carboplatin, ndi zina - mannitol.

Mu malonda a jekeseni maganizo "Carboplatin", zikuchokera taonera pamwambapa, akubwera mu mabotolo kuti anayikidwa mu makatoni ma CD.

katundu pharmacological

ndi mankhwala "Carboplatin" n'chiyani? Malangizo lipoti ntchito, maganizo kuti ndi zovuta zochita kupanga pawiri munali heavy monga pulatinamu.

Akatswiri amati limagwirira cha zochita za chida ichi ndi chifukwa umatha kumumanga kuti DNA. Chifukwa cha zimenezi, anapanga vnutrispiralnye crosslinking kusintha DNA kapangidwe ndi ziletsa kaphatikizidwe ake. A kuchita chimodzimodzi amapezeka kaya gawo selo mkombero. Tikumbukenso kuti hydration carboplatin, imene anapanga thupi lithe mankhwala msanga kuposa hydration wa cisplatin.

magawo kayendedwe wa medicament ndi

Kodi thupi "Carboplatin" kameredwe mankhwala? Malangizo ntchito limanena kuti pambuyo boma limodzi la wothandizila izi mu mawonekedwe a kulowetsedwa (iv) mphindi 60, mu ndende mwazi wa ufulu (i.e. amenable ultrafiltration) ndi okwana amachepetsa pulatinamu malinga ndi ziwiri gawo chitsanzo cha pharmacokinetics kuti poyamba.

Kuyambira nthawi ya ufulu pulatinamu moyo pafupifupi 2 hours ndi osachiritsika T1 / 2 - 3-6 maola. Iwo ayenera kukumbukira kuti pulatinamu okwana amakhala ndi ofanana koyamba theka moyo, koma pamapeto-izo yaitali (za tsiku).

Mobwerezabwereza utsogoleli wa mankhwala kwa masiku 4 pa mzere mu kudzikundikira magazi a pulatinamu unkachitika. Lidapita tsiku limodzi pambuyo ntchito mankhwala pafupifupi 85% ya pophika mwakhama plasma limakhudza kuti chikhalidwe mapuloteni.

Kodi kuwonongedwa kwa mankhwala "Carboplatin"? Guide amanena kuti kukonzekera amatengedwa makamaka impso (pafupifupi 30% ya mlingo anamasulidwa mu mawonekedwe unmodified).

Anthu CS 60 ml ya / Mph ndi pamwamba pafupifupi 65% 70% ya ntchito metering linanena bungwe kwa 11 ndi 23 maola, motero.

Popeza Kupha "Carboplatin" chikuchitika pafupi kwathunthu ndi kusefera glomerular okha ndende yaing'ono anati mu tubules ndi aimpso, lomwe limafotokoza otsika nephrotoxic angathe mankhwala poyerekeza cisplatin.

Anticancer mankhwala "Carboplatin" umboni

Nthawi zina, umaonetsa ntchito mankhwala pansi pa cikwati? Malinga ndi malangizo, ndi zochizira ya zotupa zotsatirazi:

• khansa yamchiberekero;
• khansa khomo lachiberekero;
• zotupa nyongolosi selo amuna ndi akazi;
• osteogenic sarcoma;
• m'mapapo khansara;
• medulloblastoma;
• kutupa kwa khosi ndi mutu.

Ziletso ntchito njira kulowetsedwa

Kodi contraindications mankhwala ali "carboplatin"? Kugwiritsa ntchito mankhwala ndikoletsedwa ngati:

• mukuyamwitsa;
• kwambiri impso pathologies (mwachitsanzo, CC zosakwana 15 ml / Mph);
• mimba;
• hypersensitivity kuti carboplatin ndi mankhwala ena, kuphatikizapo pulatinamu ndi;
• aakulu myelosuppression;
• kwambiri magazi imfa, kuphatikizapo anati m'mbuyomu posachedwapa;
• paubwana.

Komanso mosamala mankhwala Kwalamulidwa kwa:

• ndi katemera posachedwapa;
• kumva kuwonongeka;
• matenda aimpso;
• maganizo mafupa hematopoiesis, kuphatikizapo zinthu pambuyo radiotherapy ndi mankhwala amphamvu;
• kufanana ntchito mankhwala nephrotoxic (mwachitsanzo, "Cisplatin");
• matenda pachimake cha tizilombo mafangasi ndi chiyambi bakiteriya.

Medicament "Carboplatin": malangizo ntchito

Mmene Tiyenera ndi anticancer mankhwala ayenera kugwiritsidwa ntchito? Malinga ndi akatswiri, medicament izi ingagwiritsidwe ntchito monga monotherapy, kapena osakaniza ndi njira zina ndi kuchita chimodzimodzi (mwachitsanzo, osakaniza ndi "Paclitaxel" yokonza).

Malinga kukula zimene ndi kumene mtima wa isanafalikire chotupa, madokotala amagwiritsa ntchito zosiyanasiyana dosing "Carboplatin". Iwo ayenera kuperekedwa kudzera m'mitsempha ngati kulowetsedwa pa mphindi 17-55.

Kodi ndimagwiritsa ntchito mankhwala "Carboplatin"? Atsogolereni mfundo Mlingo zotsatirazi chida:

• 100 mg / lalikulu mita mtima thupi tsiku lililonse kwa masiku 5;
• 300-400 mg / mita lalikulu la wodwalayo, kamodzi pa masabata 4.

Tikumbukenso kuti imeneyi pakati ka mankhwala, pa chiwerengero cha 100 zikwi othandiza magazi kuundana / mamilimita ndi 1.5 zikwi neutrophils / mm, ayenera kukhala masabata osachepera 4.

Isanayambe kapena itatha ntchito ya "carboplatin" zakumwa zina kuchititsa komanso wozengereza simuchita diuresis chofunika.

Ngati wodwala akudwala kwambiri hematological kawopsedwe kapena zolimbitsa angafunike kuchepetsa mlingo wa mankhwala kwa 26%.

Pamene pathologies aimpso kwambiri kumaonjezera ngozi ya zotsatira poizoni mankhwala, choncho kuchepetsa mlingo zochokera pa mlingo CC.

Okalamba, komanso kale wochitidwa ndi mankhwala myelosuppressive, mlingo ayenera kuchepetsedwa ndi 22-25%.

Isanafike ntchito, yankho kulowetsedwa ayenera kukhala anayendera ake zooneka kuti aone ngati pali tchimo lirilonse mu mtundu wake kapena zinyalala.

Kodi kusakaniza ufa mankhwala "Carboplatin"? Malangizo ntchito amanena kuti yogwira mankhwala ayenera kuchepetsedwa mu shuga njira 5% kapena mankhwala enaake ndi sodium 9%. Pankhaniyi anthu ambiri anaona ayenera 0.5-1 mg / ml.

The njira mankhwala ayenera kukhala okonzeka basi pamaso ntchito, popeza pazipita alumali moyo kukonzekera losakanizika ndi wofanana tsiku lina.

Zochita ndi-khalidwe

anachita zoipa amachititsa mankhwala "Carboplatin"? Reviews za chida ichi amanena kuti kungakhale chitukuko cha zotsatirazi mavuto:

• ziwalo m'mimba: pasanathe maola 11-12 pambuyo ntchito mankhwala, wodwala akhoza kuona kunyansidwa ndi kusanza. Yafupika chiopsezo zosiyanasiyana emetic ntchito yapita phwando antiemetics, komanso makonzedwe likukulira wa medicament kwa masiku 5 kapena yothandizira mtsempha kulowetsedwa kwa masiku. Komanso, odwala ena anali zosiyanasiyana chokhwima monga kutsekula m'mimba, kupweteka m'mimba, kutupa m'kamwa ndi kudzimbidwa.
• hematopoietic dongosolo: ntchito mlingo waukulu wa "carboplatin" akhoza kuletsa ntchito ya mafupa hematopoiesis. Komanso, ambiri odwala zizindikiro ziwonekera a magazi m'thupi, mphamvu ya potsata pa mlingo wa mankhwala ntchito. Kawirikawiri ankakumana ndi mavuto matenda monga matenda, malungo, magazi ndi septic mantha.
• Na zotumphukira ndi chapakati mantha dongosolo: pali mosavuta mkulu kukhala neuropathies zotumphukira, komanso kuchepetsa bongo kwambiri tendon, makamaka anthu zaka 65. Komanso nkutheka zizindikiro za CNS matenda opareshoni. chithandizo yaitali ndi mankhwala zingachititse chokhala neurotoxicity.
• Ziwalo masomphenya: kugwiritsa ntchito ndalama, ndiye kuti kuwonongeka zosakhalitsa kapena imfa kwathunthu kwa masomphenya, ndi imfa ya kutha kuona kuwala ndi kusiyanitsa mitundu. Pamaso kubwezeretsa ndi kusintha zambiri amapezeka mkati mwa masabata angapo pambuyo discontinuation mankhwala. Mu anthu ndi ntchito mkhutu impso, amene ankapatsidwa mlingo waukulu wa mankhwala, anati khungu yokhudza kotekisi.
• Ziwalo kumva: pamene kutumikiridwa "Carboplatin" odwala ena pali ototoxicity, amene kumaonekera mwa mawonekedwe a kumva imfa ndi tinnitus.
• Chifuwa: malungo, zidzolo erythematous, pruritus, anaphylactic anachita, urticaria, hypotension ndi bronchospasm. Zimenezi zingachitike mu maminiti pang'ono pambuyo makonzedwe mankhwala. Komanso, nthawi zina, odwala akhoza kuona dermatitis exfoliative.
• Aimpso dongosolo: kumayambiriro "Carboplatin" odwala ena amakhalanso ndi kuchuluka kwa kanthawi ndi wofatsa mu magazi mankhwala ndi urea woipa. Pankhaniyi, pachimake choipa kwa impso ndi chosowa kwambiri. Chiopsezo nephrotoxicity pa maziko a ntchito wothandizila ichi kumawonjezera ndi mlingo, komanso anthu kale mankhwala cisplatin.
• Electrolyte bwino: hypocalcemia, hypokalemia, hypomagnesemia, ndi hyponatremia.
• Chiwindi: kuwonjezeka afika woipa bilirubin, kuchita ndi phosphatase zamchere m'magazi zingaoneke. Anthu amene achitiridwa ndi mlingo waukulu wa mankhwala kuti autologous mafupa kupatsidwa zina, anati monyanyira mu chiwindi.
• Machitidwe ena: hemolytic-uremic syndrome, kutopa, alopecia, congestive kulephera mtima, zizindikiro za chimfine, myalgia / arthralgia, thupi lawo siligwirizana, matenda cerebrovascular.

tsatanetsatane

Kodi odwala ayenera kudziwa musanagwiritse ntchito mankhwala "Carboplatin"? Malangizo, ndemanga amati kulowetsedwa wa mankhwala yekha kuyang'aniridwa zonse achipatala angathe kuchitidwa, amene imakhazikika mu mankhwalawa wothandizila cytotoxic. Mu ichi optional polojekiti zotheka zotsatira poizoni, makamaka pamene mkulu Mlingo wa mankhwala.

Mu njira ya mankhwala ndi wothandizila ichi ndi pa miyezi itatu yotsatira, odwala ayenera kugwiritsa ntchito kulera odalirika.

Pakuti yokonza ndi yoyendetsa wotsatira wa njira mankhwala zofunikira kugwiritsa ntchito mankhwala kuti mulibe zotayidwa. Ichi ndi chifukwa chakuti pamene interacts ndi precipitate mankhwala likakhazikitsidwa komanso amalembedwa kuchepetsa efficacy mankhwala.

Pa mankhwala, "Carboplatin" chofunika nthawi mayeso ubongo, kuphatikizapo anthu okalamba kale mankhwala cisplatin.

Ntchito mankhwala zingachititse kuti pakhale zotsatira ototoxic, choncho chisanadze mankhwala ayenera kuchitidwa mayesero audiometric.

Kuyang'aniridwa wa kuyan'anila kukomoka chidwi kumva ayenera mlingo kusintha "Carboplatin" kapena chiyembekezo chakuti yake.

Ngati mankhwala akulowa khungu kapena maso, nadzatsuka pomwepo ndi madzi ambiri. Ngati kuwameza, njira zofunika kuthana thandizo oyenerera.

mankhwala ofanana

Kodi mankhwala analogues akhoza m'malo "Carboplatin"? Malangizo ntchito lilibe chikutanthauza palibe uthenga. Kumbuyo mungathe kupeza dotolo odziwa. Monga ulamuliro, akatswiri kulengeza ntchito analogues awa "Carboplatin" "Tsitoplatin", "Teksalok", "Displanor", "Oksiplat", "Oxaliplatin", "Platinol", "Cisplatin", "Eloxatin", "Platikad", "Plaksat "" Oksitan "," Oksatera "," Ekzorum ".

Reviews mankhwala anticancer

Tsopano inu mukudziwa chifukwa chake muyenera mankhwala monga "Carboplatin" ( "Carboplatin Teva"). Malangizo ntchito mankhwala wakhalanso tafotokozazi.

Aziona odwala kawopsedwe ndi efficacy wa mankhwala "carboplatin" ndi maganizo. Anthu ena amayankhula za zotsatira zabwino mankhwala a khansa zosiyanasiyana ndi zina zambiri amatchula zotsatira poizoni mankhwala ziwalo zosiyanasiyana ndi kachitidwe, komanso zinthu zina zochitika negative. Akatswiri amanena kuti amagwirizana ndi munthu wodwala kulolerana wa chinthu yogwira mankhwala ndi chikhalidwe ake onse. Mulimonsemo amafuna kuti ndikhale khansa. Ngati mankhwala "Carboplatin" wodwalayo siyabwino chifukwa ena kapena wina, ndiye m'malo ndi analogs. Izi mankhwala m'malo antitumor amathandiza 90% ya milandu.