Mankhwala 'Divigel. malangizo

Kukonzekera "Divigel" - transdermal gel osakaniza-mowa munali analogue kupanga za estradiol zachilengedwe yofanana ndi iyo (estradiol) ntchito kwachilengedwenso. Limagwirira cha zochita za mankhwala ndi ofanana umene ndi kukonzekera m'kamwa esitirojeni munali. Nthawi zambiri ntchito mankhwala "Divigel" pomanga endometrium.

lokonzekera compensates chifukwa chosowa timafunika, kuchepetsa kukula kwa matenda kugwirizana ndi kusintha kwa thupi ndi ovariectomy.

Amacita ntchito mankhwala "Divigel" ndi progestagen kwa amayi ambiri ndi zonse menstrualnopodobnoe magazi, nthawi imene avareji masiku asanu kapena asanu. Yambani magazi, kawirikawiri pa sabata la mlingo lotsiriza la progestogen. Minor kumasulidwa zalembedwa mu 4-5% odwala. M'chaka choyamba cha mankhwala mu 3-5% ya akazi ndi amenorrhea.

Pamene transdermal (khungu) kutsatira estradiol pamodzi ndi medroxyprogesterone nthochi ndi kuchepa okwana mafuta chizindikiro.

Pambuyo ntchito khungu mowa ukuphwera. Estradiol yatsala chosakanikirana ndi akulowa makope zokhudza zonse. Kugwiritsa ntchito mankhwala "Divigel" pa malo a 400 200 sq. cm (wofanana ndi dera dzanja limodzi kapena awiri), alibe mphamvu pa malowedwe kuchuluka kwa pophika mwakhama m'magazi. Komabe, pamene ntchito akanayesetsa ochulukirapo zigawo mayamwidwe zingasiyane.

wina kuchuluka kwa estradiol ali anapeza mu adipose subcutaneous minofu, kumene pang'onopang'ono akulowa mtsempha wa magazi. Transdermal ntchito amalola kupewa kugwa kwa ziyambe wa mankhwala "Divigel", pa ziyambe kudutsa chiwindi. Choncho kusinthasintha mu milingo plasma estradiol sakhala kutchulidwa ntchito mankhwala poyerekeza kukonzekera m'kamwa.

Amatanthauza "Divigel" Buku akuonetsa zochizira matenda azimayi amsinkhu umenewu amakumana, amene amayamba ndi ovariectomy kapena kusintha, komanso kuti magawowa zinthu chifukwa chakuchepa esitirojeni. Komanso, yokonza akuonetsedwa ngati kupewa chachikulu cha kufooka kwa mafupa.

Mlingo wa mankhwala "Divigel" mtsogoleri amalimbikitsa atakhala payekha. Tinganene, kusankha mamiligalamu 0.5-1.5 patsiku. mlingo akhoza kusintha ndi dokotala. Njira achire mwina mosalekeza kapena cyclical.

Pamene labwinobwino chiberekero mankhwala ndi "Divigel" Buku akuonetsa mkombero tikadwala progestin kwa masiku khumi kapena khumi lililonse mkombero (kwa kupewa njira hyperplastic mu endometrium a). Pa akamaliza njira ya magazi menstrualnopodobnoe muzichita.

Pamene lapachibale kapena yaitali uterine magazi ayenera kupeza chifukwa. Kutalika kwa kuzungulira odwala postmenopausal kungakhale kwa miyezi itatu.

Mlingo wa mankhwala "Divigel" Buku akuonetsa opaka m'munsi pamimba kapena ntchito m'dera matako mu dzanja limodzi kapena awiri, alternating kumanzere ndi kumanja mbali. Kuthira mankhwala ayenera kupatsidwa zilowerere kwa mphindi zochepa.

Kukonzekera "Divigel" contraindicated mu anasamutsidwa, akuti kapena unakhazikitsidwa khansa ya m'mawere esitirojeni amadalira khansa (khansa endometrial, mwachitsanzo), bleedings ukazi zachilengedwe osadziwika. Musati mankhwala ngati sanalandire chithandizo hyperplasia wa endometrium ndi, anasamutsira thromboembolic m'mapapo mwanga embolism kapena thrombosis kwambiri mtsempha, m'mnyewa wamtima infarction mkati zaka ziwiri zapitazi, kukonzanso thromboembolism. Contraindications monga pachimake kapena aakulu chiwindi matenda, hypersensitivity, mkaka wa m'mawere. Mankhwala "Divigel" mimba komanso si anapatsidwa.

Musanagwiritse ntchito mankhwala ayenera dokotala kupeza zotsatira zonse zotheka mbali ya mankhwala.