Othandizira a Interferon, kukonzekera ana: mndandanda, zochita. Mapulogalamu othamanga kwambiri a interferon osakwanira

Chifukwa cha kupewa ndi kuchiza matenda tizilombo interferon inducers ntchito. limagwirira zochita amagwirizana ndi chitukuko cha mapuloteni zinthu kuteteza chulutsa tizilombo toyambitsa matenda. zochokera inductors mankhwala akhoza kulimbana ndi matenda popuma, nsungu ndi matenda kwa chiwindi ndi fuluwenza.

Khama la interferon

Choncho ndi gulu la mankhwala ndi chiyambi mapuloteni. Iwo Maselo amene ali ndi tizilombo toyambitsa matenda tizilombo.

Interferon zinthu zinthu za si yeniyeni limagwirira chitetezo m'thupi ndi bakiteriya, chlamydial, matenda osadziwika mafangasi nyumba chotupa maselo. Iwo ndi mbali ya owongolera wa intercellular ankachita chitetezo chokwanira zokhudza zonse. Iwo amatchedwa immunomodulators ndi chikhalidwe amkati.

Pali njira zosiyanasiyana za interferon zinthu anthu leukocyte kapena-interferon, fibroblast, kapena B-interferon, ndipo m'thupi kapena ga-interferon.

Galimoto limagwirira ntchito imayamba ndi mapuloteni kumanga ndi maselo maselo a chikhalidwe makamaka. Amenewa mogwirizana ndi apanga zedi mwa makumi atatu. Ndi kukondoweza kwa mapeputisayidi zolimbana anagwira ntchito ya T-lymphocytes ndi nyumba macrophage-mtundu amapezeka kuteteza ingress wa tizilombo mwa selo nembanemba ndi kubalana awo. Ndi iwo amene ali ndi udindo katundu atetezeke.

Natural interferon inducers - maselo tizilombo kuti walowerera mu thupi. Ndi yamphamvu ndi ofooka stimulators ya ulimi wa mapuloteni zozitetezera. Ambiri mwa nthumwi za matenda aakulu ndi inducers osauka. Zikuphatikizapo cytomegalovirus ndi HIV, nsungu, chiwindi C ndi mtundu B Koma ambiri tizilombo toyambitsa matenda amene amayambitsa kupuma matenda tizilombo, amaonedwa stimulators amphamvu kupanga mapulotini zozitetezera.

Interferon inducers (mankhwala): icho chiri

Childs amanena za gulu la kupanga mankhwala immunomodulators. Iwo amapangidwa ndi makampani opanga mankhwala. Interferon inducers (mankhwala) ndi pachikhalidwe monga gulu lalikulu la osiyana dongosolo mankhwala mankhwala. zigawo yogwira angakhale otsika ndi mkulu-maselo mankhwala, ndi magwero kupanga kapena zachilengedwe. Ali nawo mbali wamba, amene amalola thupi kupangira ku maselo a anu, kapena amkati interferon. zinthuzi akhoza kuonetsa mavairasi oyambitsa ndi immunomodulating chikoka.

Kodi kutsatira

Inducers wa amkati interferon - kukonzekera umalimbana, nthawi zambiri, kulimbana ndi matenda tizilombo. Limagwirira cha mmene zachokera kukhudzana ndi yogwira mankhwala mankhwala zili ma ndi minofu zotsatira mu ulimi wa mapuloteni zozitetezera.

Interferon inducers - asatayike chikhalidwe kuti kumapangitsanso kudzipatula mapuloteni ndi chongopeka. Kwenikweni ndi yofanana ndi ogalamutsa zachilengedwe, monga tizilombo toyambitsa maselo ndi zinthu zosiyanasiyana.

Ntchito inducers interferon zingachititse hyporesponsiveness. Mu chikhalidwe ichi, pa mobwerezabwereza utsogoleli wa mankhwala sinditi kukhala zoteteza ayankhe mapuloteni anati yimitsira ake. Pa nthawi imeneyi kosathandiza kupereka mankhwala. Kutalika kwa boma anatsimikiza mtima inductor lapansi. Change wa pophika yogwira, komanso kusokoneza mankhwala ndi thandizo chimodzimodzi wothandizila kuthetsa hyporesponsiveness.

Kusankha mankhwala kuti kupangidwa kwa mapuloteni zoteteza sayambitsa mavuto aakulu zofuna kuchotsa awo.

The ntchito inducers wa amkati mapuloteni

Pali njira ziwiri patsogolo chitetezo chokwanira interferon. pawiri Izi angathe kuperekedwa mwachindunji kapena exogenously mu chamoyo. Njira ina ikukhudza interferonizatsiyu amkati ndi kukhazikitsa zinthu kupangidwa kwa interferon yake. mapuloteni Izi sakusonyeza antigenicity, omwe si zophatikizananso interferon. Pomalizira utsogoleli wa mankhwala yomalizidwa mapuloteni kumabweretsa chitukuko cha zochita chowawa.

Inducers wa amkati interferon mu kuphunzira mogwira awo anasonyeza ntchito pharmacological mu sipekitiramu waukulu matenda. Anapeza malo awo bifunctional, yodziwika ndi zotsatira kutchulidwa mavairasi oyambitsa, ndi immunomodulating kwenikweni.

Zimene inducers interferon kumabweretsa kaphatikizidwe mapulotini, amene zochita zawo monga mapulotini wokonzeka oteteza. ndondomeko otere moyenera, ulamuliro wake kuti makinawa bwino kuteteza chamoyo kuchokera mapangidwe kwambiri mankhwala awa.

Pakuti ntchito limodzi za kukonzekera kumukopa interferon ndi mwachilungamo yaitali kufalitsidwa kwa mapuloteni woteteza chofunika achire mlingo. Kuti mupeze ngati mlingo poika ndi mapuloteni exogenous ayenera mobwerezabwereza kutumikiridwa mu mabuku lalikulu. Mankhwalawa akuti ndi okwera mtengo kwambiri.

Mndandanda wa mankhwala

Panopa, madokotala akugwiritsa ntchito interferon inducers - mankhwala omwe lembani chaka kuwonjezera mankhwala atsopano. A ambiri immunomodulating wothandizila limakupatsani amalimbana ndi matenda ambiri.

Monga mbali ya chitetezo cha m'thupi alipo zimagwirira ntchito inakula zigawo zikuluzikulu zomwe achitezo kuwonongedwa kwa zachilendo chamoyo chiyambi mankhwala antigenic. Aliyense amafotokozera ali enieni wothandizila m'thupi. Ikufotokoza kusiyana kwa mankhwala amathandiza kuti chitukuko cha mapuloteni zozitetezera.

Pali inducers zosiyanasiyana interferon (mankhwala), mndandanda wa yemwe walunjika ndi mankhwala "Poludan". chida ichi akuganiza stimulator mapuloteni woyamba woteteza, amene anayamba ntchito ngakhale mu 70s lapansi. Pamafunikanso poliuridinovaya acid polyadenylic. nchito zake ndi kukhala interferon yaing'ono. Diso madontho jekeseni wa mankhwala "Poludan" kuchitira herpetic keratitis ndi keratokonyunktivity. njira mankhwala amapanga ntchito zochizira nsungu vaginitis ndi vulvovaginitis.

Interferon inducers - mankhwala "Aktaviron", "Lavomax", "Tilaksin" "dihydrochloride tilorona", "Amiksin", "Tiloram" - mu dongosolo ali ndi yogwira pophika tilorona.

Mankhwala "Ridostin" ndi "ndi sodium mchere asidi awiri Shackleton ribonucleic" chopangidwa ndi sodium wochuluka ribonukleat akuchita chinthu.

mankhwala umifenovir m'gulu la "Arbidol" asatayike, "Arbivir", "Immustat" ndi "Arpeflyu".

Pali komanso interferon inducers, mankhwala amene amatchedwa ndi dzina la mankhwala yogwira. Zikuphatikizapo "Kagocel" miyala ndi "tilorona".

Yachokera akridonatsetata meglumine chopangidwa mankhwala "Meglumine akridonatsetat" ndi "TSikloferon" ndi oksodigidroakridinilatsetat ndi sodium chili mwa mankhwala "Neovir".

The zikuchokera amatanthauza "Jodantipyrin" zikuphatikizapo 1-phenyl-2,3-dimethyl-4-yodpirazolon, ndi "Alpizarin" mapiritsi zili magniferrina mchere.

Inductors interferon ana, kufotokoza awo

Pali zambiri wamkulu mankhwala angaperekedwe mwana, koma akakula. Mwachitsanzo, mankhwala "TSikloferon" anayamba kuchitira zoyambira chaka anayi, ndipo limatanthauza "Ridostin" zoikidwa ndi zaka zisanu ndi ziwiri. mankhwala onse ali osiyanasiyana zotsatira. Iwo ali oyenera zochizira matenda kupuma zachilengedwe tizilombo, boma fuluwenza, chiwindi aakulu, matenda nsungu. sangathe awo ndi zotheka osafunika mbali zosiyanasiyana.

Interferon inducers - kukonzekera amene apangidwa makamaka ana mu mtundu wa mwanayo. "Arbidol" Ena mwa iwo ndi njira. Izo ntchito ndi zaka ziwiri. Ana medicament mawonekedwe chopangidwa mu mawonekedwe a makapisozi kwa makonzedwe mkati. lokonzekera nazo zotsatira mavairasi oyambitsa ndi immunomodulatory.

Izi zikufanana ndi wothandizila mavairasi oyambitsa kuti ziletsa HIV selo B ndi mtundu A. Ndi sachita analimbikitsa yopanga interferon mkati, amene kumathandiza kukhudzana ndi malowedwe mu matenda cha ndende. Mu zochita za atetezeke zamadzimadzi tizilombo envelopu mapuloteni sangathe kugwirizana ndi selo nembanemba.

Interferon inducers ana chinathandiza kuwonjezeka chitetezo chokwanira kwa humoral mtundu pa ntchito matupi awo amasandulika zambiri zosagwira kuti wothandizila opatsirana, chepetse chiwerengero cha matendawo.

Mankhwala "Kagocel" ali kuchita chimodzimodzi thupi mwanayo. Izo zinabala mu mawonekedwe a mapiritsi ntchito mkati. Age malire ntchito mankhwala - ndi zaka zitatu.

Chithandizo cha matenda kupuma

Interferon inducers - mankhwala kuchitira SARS, zimene zimachititsa mapangidwe ku maselo a chamoyo mapuloteni zozitetezera. Iwo amaikidwa ndi matenda fuluwenza.

The njira zambiri amaonedwa mankhwala pogwiritsa tilorona, monga mankhwala "tilorona" ndi "Amiksin". Mankhwala fuluwenza ndi matenda pachimake kupuma tizilombo Ndi bwino ntchito wamkulu mkati mwa 125 mg pa nthawi imodzi. mankhwalawa ndi anagawira pa masiku awiri oyambirira, ndiye 125 mg anatengedwa tsiku lina. Inde kuchuluka kwa medicament ndi 750mg.

Yokwaniritsira zodzitetezera ntchito ndi 125 mg pa nthawi, ndiye masiku 6 kutali. yotero akubwerezedwa pafupi masabata sikisi.

zochokera mankhwala tilorona ali contraindicated mu tsankho wogwila payekha, pa mimba ndi pamene kuyamwitsa mwana wanu.

Kulandira mankhwala amenewa angachititse nseru, malungo, matupi awo sagwirizana anachita.

Kukonzekera "umifenovir" ali interferon-kulimbikitsa ntchito, kukondoweza kwa ma mtundu chitetezo chokwanira utithandize mtendere wa chamoyo wonse wothandizila opatsirana.

Pakuti zodzitetezera pamene anakumana ndi anthu odwala Kwalamulidwa mlingo tsiku la 200 mg kwa sabata imodzi. Nthawi nyengo ya fuluwenza ndi matenda kupuma ntchito mlingo tsiku la 100 mg pa nthawi yochepa, kenako kupanga yopuma kwa masiku awiri. Maphunzirowa kumatenga masabata atatu. Zochizira chimfine anatumizidwa 200 mg kanayi pa tsiku kwa masiku atatu.

Mankhwala ndi umifenovir si ntchito tsankho wogwila munthu pa choopsa somatic kudwala. Kuvomereza mankhwala amenewa angachititse thupi lawo siligwirizana.

Chithandizo cha matenda autoimmune

matenda monga limati pathological imene kukhala chitetezo kapena kuchulukitsa autoaggressive oyeserera wakupha selo poyankha minofu wathanzi. Apa tikutengegeredwa kuwononga ndi kuwonongedwa kwa minofu wathanzi chifukwa cha zomwe ndi autoimmune kutupa.

Sichinasiyane mankhwalawa inducers interferon. Formulations kutumikiridwa mu matenda autoimmune, amene ali kanthu immunosuppressive.

Zochizira ntchito mankhwala angapo sclerosis anabalalitsidwa "Amiksin". Zizindikiro pang'ono pachimake kupuma matenda chilengedwe zomwe kukuwonjezera chikhalidwe anatumizidwa mlingo wa 125 mg kapena 250 mg wa mankhwala pambuyo ingestion. Mapiritsi kumwa tsiku, phwando nthawi - kuchokera masiku 6 mpaka 12.

Pakuti kupewa anamwazikana sclerosis exacerbation akapatsidwa 125 mg wa mankhwala, nthawi 2 pa masiku 7.

Pamene zovuta za gawo yogwira matenda kuchitira zizindikiro alipo mankhwala pachimake chojambulidwa 10 125 mg lililonse masiku 30 kwa miyezi 6. Kukonzekera "Amiksin" akapatsidwa ndi peputayidi bioregulators chonse zotsatira zomwe kumachepetsa tilinazo thupi kuchuluka myelin mapuloteni.

Tikaphatikiza mankhwala "TSikloferon" limakupatsani kulimbana ndege ndi nyamakazi ndi rheumatoid, matenda zokhudza zonse zokhudza minofu connective. ntchito yake umalimbana pa yimitsira njira autoimmune, amene amathandiza odana ndi yotupa ndi analgesic zotsatira za chilengedwe. Ntchito njira malamulo chikhalidwe chitetezo pa zolakwika zosiyanasiyana immunodeficient. "TSikloferon" mankhwala The amapangidwa mu mawonekedwe piritsi, mu mawonekedwe a njira injectable ndi liniment.

Zochizira nyamakazi mankhwala chikuyendetsedwera m'nsinga kapena intramuscularly 1 nthawi patsiku. Mlingo wa 250 mg ntchito choyamba kudzera tsiku akhumi pa masiku ngakhale. Mu matenda pachimake amanena chinawonjezeka mlingo woyambilira wa 500 mg.

Therapy wa Matenda Atamwa

Mankhwala "Amiksin" amatanthauza interferonovym inductors fluoreonovogo kulemera onyozeka maselo. Ndi sachita anapanga mitundu yonse ya mapuloteni zodzitetezera zomwe mlingo tsiku lina pambuyo ntchito medicament ukufika phindu lake lapamwamba pa plasma lapansi.

mankhwala ali ndi mulingo lalikulu kanthu mavairasi oyambitsa. Kuwonjezera matenda kupuma, amagwiritsidwanso ntchito pa matenda a chiwindi C ndi pachimake ndi aakulu, kobwereza nsungu maliseche, matenda cytomegalovirus ndi mtundu chlamydial.

Ambiri mavairasi oyambitsa mankhwala - inducers interferon, nazonso ndi njira "Neovir". Ndi sachita, amabala wambirimbiri mapuloteni zoteteza, makamaka fibroblast-mtundu, lomwe limafotokoza immunomodulatory, odana ndi tizilombo ndi odana ndi chotupa zotsatira za mankhwala. Mankhwala "Neovir" azichitira encephalitis, chiwindi C ndi B, urethritis, cervicitis, salpingitis chifukwa cha mauka.

Wina inducer ofanana mapuloteni zoteteza ndi otsika maselo kulemera mankhwala "TSikloferon", amene ntchito kaphatikizidwe karboksimetilenakridona methylglucamine mchere. Ndi nawo anapanga wake Alpha interferon, zili chimene kusungidwa mu minofu lymphoid kwa masiku atatu.

B lymphocytes T ndi macrophages B-mtundu ndi mapangidwe zoteteza mapuloteni kutsegula mu nyumba ubongo tsinde fupa, kukondoweza kupanga mayunitsi granulocyte. Mankhwala ntchito Mafunso Chongani ofalitsidwa encephalitis, nsungu, matenda a chiwindi, cytomegalovirus, kamene kamawononga chitetezo m'thupi ndipo papillomas.

Komanso mavairasi oyambitsa kukhudzana njira kugwira ntchito mu pachimake ndi aakulu bakiteriya chlamydia, kutupa erysipilatous chikhalidwe, matenda, mavuto postoperative, matenda genitourinary, zotupa anam'peza.

Zikuoneka pa msika mankhwala mankhwala "Lavomax" anabala "Nizhpharm" tsopano. Iwo ali zotsatira immunomodulatory, angathe kumukopa interferon, mavairasi oyambitsa zotsatira osiyanasiyana lalikulu.

Monga mbali ya "Lavomax" mapiritsi munali 125 mg tilorona monga pawiri yogwira. The mankhwala ndi analogue a mankhwala "Amiksin". ntchito zake walangizidwa mangolomera m'badwo wa mitundu itatu interferon mu T-lymphocytes, hepatocytes, maselo zaminyewa a linga matumbo.

Mphamvu ya immunomodulating zotsatira ndi chifukwa kuti abwezeretse bwino pakati maselo mthupi ndi normalization kupanga oteteza. Maziko a limagwirira cha zochita mavairasi oyambitsa ndi chopinga mapuloteni kaphatikizidwe mavairasi yeniyeni m'madera kachilombo wa thupi. Izi kumaphwanya kubalana kwawo zambiri.

Chimfine mankhwala bwinobwino kuchitira chikhalidwe, matenda, chilengedwe kupuma, tizilombo matenda a chiwindi ndi nsungu totupa.

Inductors mwamsanga

Nthawi zambiri, utsogoleli wa mankhwala amenewa amatsogolera kudya chitukuko cha mapuloteni zozitetezera.
Fast wotenga inducer wa amkati interferon mkati maola ochepa anakhala mu thupi zingachititse mapangidwe mapuloteni izo zikutsimikizira mogwira awo.

tilorona mankhwala ukuwonjezeka pambuyo ntchito mkati mwa ndende mapuloteni mpaka mtengo pazipita kale pambuyo 4 h. Pali mapangidwe mwapang'onopang'ono interferon mu intestine choyamba, kenako chiwindi ndi usiku - m'magazi.

Kukonzekera "TSikloferon" induces mapuloteni pambuyo maola 4, ndipo panasonkhana zimawonedwa pambuyo maola 8, kenako pali kuchepa pang'onopang'ono ndende.