Mankhwala "Mikosist": ndemanga, analogues, mtengo. Mankhwala "Mikosist": malangizo ntchito

Mankhwala "Mikosist" malangizo Buku lofotokoza ndi wothandizila antifungal. The yogwira pophika mankhwala zochita fluconazole - ndi kusankha woletsa wa sterol kaphatikizidwe ku maselo a mafangasi. Iwo limaleka mu dongosolo anthu cytochrome P450 si kuonetsa ntchito androgenic, ndi zothandiza za tizilombo toyambitsa matenda a mycosis.

Pharmacokinetics

Pambuyo m'kamwa kapena mtsempha medicament "Mikosist" (wosuta limauza) komanso mu madzi m'thupi ndipo zimakhala. Mu sputum, peritoneal madzimadzi ndi articular, malovu, mankhwala mkaka wa m'mawere ndende ofanana kuti akwaniritsa mu madzi a m'magazi. The zili fluconazole mu madzimadzi cerebrospinal odwala ndi matenda oumitsa khosi mafangasi peresenti eyite ya ndende mu madzi amene nawonso, ndi mwachindunji njila kwa mlingo. Pamene ntchito kamodzi tsiku lachinayi ndi lachisanu tsiku la 90 peresenti zimatheka mgwirizano ndende. Ngati tsiku loyamba kutenga muyezo owonjezera nthawi mwachizolowezi awiri, inu mukhoza kukhala tsiku lachiwiri kufika 90 peresenti ya mgwirizano kudzikundikira. Khumi peresenti ya anamanga fluconazole zonsezo plasma khumi. Mu metabolites magazi zotumphukira si wapezeka. Pharmacokinetics zimatengera kwenikweni pa impso, chifukwa mankhwala ndi excreted makamaka amasonyeza iwo, ndi za makumi asanu ndi atatu peresenti - sichinasinthe. Maola atatu a dialysis anthu ambiri yogwira mankhwala mu madzi ndi yafupika ndi theka.

zikuonetsa kuti

Ndi bwino kugwiritsa ntchito mankhwala "Mikosist" thrush, kuphatikizapo zowombetsa mkota, mwiniwakeyo, kumaliseche, pamene mitundu ina candida matenda olanda, candidemia, ndi pamaso pa zinthu zina zimene abwino zikamera wa thrush. Amasonyezanso ndi kugwiritsa ntchito mankhwala kwa anthu ndi mucosal candidiasis: pharynx; m'kamwa candidiasis kuphatikizapo atrophic, akuwuka kuchokera atavala kupeza mano otere; kum'mero. Medicine "Mikosist" malangizo Buku amalimbikitsa kutumikiridwa kwa odwala matenda oumitsa khosi cryptococcal, kapena sepsis, cryptococcosis, cryptococcal matenda a khungu kapena m'mapapo. Iye yofunsira kupewa zisadzachitikenso cha kuvutika izi odwala AIDS ndipo nthawi zina immunodeficiency. Mankhwala ntchito popewa matenda a mafangasi anthu ndi zotupa zilonda, atengeke chifukwa cheza kapena mankhwala amphamvu kuti akunde deta. Komanso, mankhwala "Mikosist" ntchito pa matenda a mafangasi matenda groin ndi torso, chakuya kuderako mycoses, kuphatikizapo paracoccidioidomycosis, coccidioidomycosis, histoplasmosis odwala ndi kachitidwe zachilendo m'thupi.

Mlingo mawonekedwe, ma CD, zikuchokera

Awiri mlingo mitundu ya medicament ali "Mikosist": makapusulo ndi njira yothetsera kulowetsedwa. Makapisozi anapangidwa munali anthu 50, 100 ndi 150 mamiligalamu wa fluconazole. Onsewo ali ovuta gelatin, ndi opaque thupi woyera, ndi amasiyana okha lids mtundu: Y makapisozi munali mamiligalamu 50 yogwira pophika, kuwala buluu kapu 100 mamiligalamu - nofeki, 150 mamiligalamu - buluu. Okhutira ndi ufa olimba misa kapena woyera (zimakhala zoyera) ufa. zosakaniza chowonjezera zinthu mankhwala enaake a stearate, lactose anhydrous, colloidal pakachitsulo dioxide, talc, titaniyamu dioxide, wowuma chimanga, gelatin, enaake carmine. Makapisozi munali 50 100 mg wa fluconazole, ndi akugulitsa phukusi ndi chimodzi, ziwiri, matuza anayi, zidutswa zisanu ndi ziwiri lililonse. Ndipo iwo amene ali mamiligalamu 150 a yogwira pophika - zidutswa imodzi kapena ziwiri.

Kulowetsedwa Njira mawonekedwe a mandala, colorless kapena mopepuka akuda madzi. Wina uli mamiligalamu awiri pa milliliter wa chinthu yogwira. The zigawo zikuluzikulu sekondale ndi madzi a jekeseni ndi sodium kolorayidi. Choperekedwa yothetsera mu galasi Mbale Botolo zana anaikidwa makatoni. paketi imodzi lili botolo limodzi.

Kodi kutenga "Mikosist"? mlingo

Mlingo watsiku ndi fluconazole ku matenda cryptococcal liri tsiku loyamba la mankhwala, 400 mg, mu masiku awa - 200-400 mamiligalamu. Kutalika kwa mankhwala zimadalira anatsimikizira kuphunzira mycological wa ku efficacy matenda, nthawi zambiri osaposa asanu - asanu ndi atatu. Mu meninjaitisi cryptococcal ntchito mankhwala "Mikosist" malangizo ntchito akulimbikitsidwa khumi - masabata khumi pambuyo Zotsatira zake zinali zoipa kuphunzira zitsanzo za madzimadzi cerebrospinal. odwala AIDS nditamaliza mankhwala koyamba akusonyeza kuti kupewa zisadzachitikenso a meninjaitisi cryptococcal kwa nthawi yaitali phwando amatanthauza "Mikosist" pa mlingo wa osachepera mazana awiri mamiligalamu patsiku.

Odwala ndi candidiasis mwiniwakeyo, candidemia ndi matenda ena olanda candida, makamaka mu tsiku loyamba la kutenga mamiligalamu anayi a mankhwala, ndiponso yotsatira masiku angapo - mamiligalamu mazana awiri pa tsiku. Mu nkhani ya aakulu zokhudza zonse yisiti mlingo akhoza ziwonjezeke kwa mamiligalamu mazana asanu ndi atatu patsiku. Chithandizo ayenera chiperekedwe kwa masabata osachepera awiri pambuyo pothetsa zizindikiro ndi kutenga magazi chikhalidwe negative. Ngati candidiasis oropharyngeal, kuphatikizapo odwala ndi chitetezo chokwanira mkhutu, mankhwala mlingo patsiku ndi makumi asanu - zana mamiligalamu, cholanda kukhala nthawi zisanu ndi ziwiri - masiku khumi ndi anai. Mu atrophic candidosis chifukwa kuvala kupeza mano otere zambiri zotchulidwa kudya tsiku mamiligalamu makumi asanu a mankhwala osakaniza ndi antiseptic. Chithandizo anapitiriza kwa masabata awiri. Matenda ena candida (candiduria, esophagitis, khungu ndi mucosal candidiasis) mlingo tsiku la mankhwala ndi makumi asanu - zana mamiligalamu mankhwala ndi zinai - masiku makumi atatu.

Pofuna kuthetsa ukazi candidiasis medicament "Mikosist" malangizo Buku kusonyezedwa kutengera singly mu kuchuluka 150 mamiligalamu. Zingathandize anayi - miyezi khumi kamodzi pamwezi kumwa kapisozi m'modzi (150 mg) kuchepetsa pafupipafupi musabise. Nthawi zambiri analamula kuti candidiasis kuwonjezera mankhwala "Mikosist" makandulo Mwachitsanzo, "Terzhinan", "Clione-D", "Ginezol". Malinga mlingo wa kusatetezeka mafangasi kwa kupewa candidiasis tsiku analimbikitsa mlingo wa mankhwala akhoza zimasiyana makumi asanu ndi mamiligalamu mazana anai.

Pankhani ya mycoses kwambiri kuderako angafunike kuchita mankhwala pa mlingo wa mazana awiri - mamiligalamu mazana anai patsiku kwa zaka ziwiri. Kutalika kwa nthawi yoperekera chithandizo kumatengera pa munthu ndi chithunzi matenda: ndi coccidioidomycosis, zikhoza osiyanasiyana monga khumi kwa miyezi makumi awiri mphambu anai, paracoccidioidomycosis - kuchokera miyezi awiri ndi ziwiri, histoplasmosis - miyezi itatu kapena ziwiri.

malamulo ntchito

Mtsempha kukapanda kuleka kukonzekera ayenera kuperekedwa pa mlingo wa osapitirira makumi awiri Botolo pa mphindi. Palibe kusintha mlingo tsiku pamene posamutsa Odwala mtsempha kuti mankhwala akumwa. yankho A chifukwa kulowetsedwa n'zogwirizana ndi dvadtsatiprotsentnym shuga njira; njira Hartman ndi Ringer; njira ya carbonate ndi sodium wa hydrogen, mankhwala enaake potaziyamu mu shuga ndi, sodium mankhwala enaake (0.9%). Kulowetsedwa akhoza ikuchitika ntchito zida wamba fluconazole kuti apatsidwenso, ntchito imodzi mwa njira zotsatirazi.

zotsatira zoyipazi

Odwala ambiri amene anatenga mankhwala "Mikosist 'ndemanga za izo masamba abwino. Mankhwala makamaka bwino kumatha matenda a mafangasi koma zingachititse mavuto. Chotero, dongosolo m'mimba ndi chiopsezo nseru, flatulence, nthenda chiwindi ntchito, mavuto ndi tanthauzo la kukoma, kutsekula m'mimba. Komanso, anthu ena amanena kuti pakutchulidwa mutu, khunyu, chizungulire. Iwo amanena kuti zochitika zimenezi anayambika Nditangotsiriza mankhwala, "Mikosist". Reviews odwala ena ali ndi mfundo za chitukuko ya mankhwala ziwengo mankhwala mu mawonekedwe a erythema, zotupa angioedema, urticaria. Mwa zotsatira zina zotheka mbali tisaiwale alopecia, fibrillation yamitsempha yamagazi, impso ntchito mkhutu, hypertriglyceridemia, hypercholesterolemia, ndi hypokalemia.

contraindications

Mu mawonekedwe a makapisozi sayenera mankhwala mankhwala kwa ana osaposa miyezi sikisi (kwa ana amaloledwa kugwiritsa ntchito mankhwala mu mawonekedwe a njira yothetsera kulowetsedwa). Musagwiritse ntchito mankhwala "Mikosist" lactating akazi (amayi oyembekezera ayenera perekani ndi chisamaliro), komanso anthu ndi tilinazo mkulu zosakaniza m'gulu zikuchokera. Ndi kuchuluka kufunika kokhala osamala odwala aimpso / kwa chiwindi insufficiency, tsankho asidi acetylsalicylic.

ambiri osokoneza

"Mikosist" zalembedwa milandu mankhwala ambiri osokoneza bongo. Ndemanga za anthu amene anatenga mankhwala Mlingo kwambiri, amasonyeza chitukuko cha kutsegula m'mimba, nseru, kusanza. Zikavuta, pali maonekedwe a khunyu, khalidwe akhate, kuyerekezera zinthu m'maganizo. Munthu amene ali ndi zizindikiro cha mankhwala osokoneza bongo ayenera kumwedwa kuchipatala, komwe chapamimba lavage adzapatsidwa kwa iye, dialysis, anakakamizika diuresis, symptomatic mankhwala.

"Mikosist" kapena "Fluconazole" chimene chiri bwino?

Ndiye funso kawirikawiri adafunsa odwala. Ndipotu, mankhwala onse ali ofanana, tinganene kuti iwo ali ofanana. Kusiyana komwe kulipo ndi mankhwala "Mikosist" zimapangitsa Chihangare kampani mankhwala "Gidiyoni Richter" pamene "Fluconazole" - yokonza kupanga zoweta. Ndithudi, izi kumakhudza mwachindunji pa mtengo wa mankhwala. Kusankha zimene kugula - "Mikosist" kapena "Fluconazole" - ambiri amakonda mankhwala, zomwe ndi mtengo. Ndithudi, kusiyana kwambiri mtengo. Choncho, kwa ma CD a "Mikosista" (wina kapisozi munali mamiligalamu 150 fluconazole) inu kulipira avareji 295 rubles, pamene phukusi yomweyo "Fluconazole" mtengo rubles 8-20 yekha. Mtengo mosaperewera 100 ml botolo la njira yothetsera kulowetsedwa "Mikosist" ndi 311 rubles.

Pa katundu pharmacological mankhwala awiri, iwo ali pafupifupi zofanana, kusiyana Tingaone koma kuti mlingo wa mayamwidwe: malinga ndi kafukufuku alipo, anthu ambiri abwere ku thupi "Fluconazole" Chikupindulidwa pambuyo maola 1-2 pambuyo ntchito ndi "Mikosista" - 0.5 -1,5 maola. Komabe, si odwala amene amalabadira mankhwala awiri mofanana. Ena sindikuwona kusiyana kulikonse pakati pa iwo, pamene yotsirizira amakhulupirira kuti khalidwe zimadalira mtengo, kutanthauza kuti mankhwala okwera mtengo kwambiri bwino. Mukhoza kupeza ndemanga imene akazi amati pambuyo kutenga "Fluconazole" thrush anabwerera, koma "Mikosist" analoledwa kuchotsa izo zonse. Mulimonsemo, kusankha ndi zanu.

analogs

Kuwonjezera "Fluconazole", pali mankhwala ena kuti akhoza m'malo mankhwala "Mikosist". Analogs medicament ndi monga yogwira pophika chinthu chomwecho, ndi bwino zinkaimira. Mu mawonekedwe a makapisozi zochizira yisiti ndi matenda ena mafangasi mungagwiritse ntchito "Diflucan" mankhwala "Flucostat", "mikomaks" ndi ena. Njira ndi "Mikoflyukan" (mapiritsi). "Mikosist" kuchokera analogs zonse zosiyana izi ndi zizindikiro monga bioavailability, theka moyo, mlingo wa mayamwidwe.

Mwanjira mankhwala

M'pofunika mosamala kuyan'ana prothrombin nthawi odwala kulandira fluconazole pamodzi ndi mosadziwika anticoagulants coumarin gulu, chifukwa pali chiopsezo cha kuwonjezeka VWP. Pamene concomitantly ndi sulfonylureas mankhwala "Mikosist" kungachedwetse hafu ya moyo wa iwo, kotero muyenera kuganiza kuti hypoglycemia. Pankhani ya fluconazole ndi kugawana phenytoin mulole kukomoka kwambiri mlingo wa kuwonjezeka kwa ndende otsiriza Choncho, ngati n'koyenera ophatikizana kulandira mlingo ayenera kuchepetsedwa. Pamodzi ndi kuvomereza amatanthauza "Mikosist" ndi rifampicin siidzasoŵa kuchepa ndende ya fluconazole Choncho kumwa mankhwala "Mikosista" chofunika kuonjezera. The ntchito ophatikizana a otumphukira azole ndi medicament ndi osakaniza terenadinom contraindicated, ngati angathe kwambiri, moyo pachiswe arrhythmia. Ngati makhwalawa "Mikosist" pamodzi ndi cisapride, angasonyeze zochita osafunika ya mtima, kuphatikizapo tachycardia yamitsempha yamagazi. Ndi ntchito munthawi yomweyo fluconazole ndi theophylline yafupika pafupifupi mlingo chilolezo kuchokera m'madzi a m'magazi otsiriza, choncho kumachititsa chitukuko cha zotsatira zake poizoni ndi ambiri osokoneza.

Kusamala

Kodi kupitiriza mankhwala ndi "Mikosist" mpaka matenda ndi hematological chikhululukiro. Msanga discontinuation mankhwala ndi zinadzala ndi musabise. Monga tanenera kale, odwala insufficiency aimpso ayenera kugwiritsa ntchito mankhwala mosamala pazipita, chifukwa excreted makamaka ndi impso ndi. Mlingo pa chithandizo yaitali ikhale, kutenga nkhani ya CC. Nthawi zina fluconazole kumafuna zotsatira poizoni pa chiwindi, choncho m'pofunika kuti aziona kugwira ntchito kwa thupi ili. Pa kudziwika zizindikiro zotupa ayenera kusiya mankhwala.

Odwala pa maziko a "Mikosist" kumatanthauza akhala kawirikawiri Zipangizo exfoliative cutaneous zosiyanasiyana, monga poizoni epidermal necrolysis ndi matenda Stevens-Johnson. Odwala neoplasms zilonda ndi AIDS ali sitichedwa zikamera mosiyanasiyana khungu ntchito yokonzekera munali fluconazole. Ngati pa matenda a mafangasi matenda kungotengeka ndi zidzolo limapezeka, mankhwala mukufuna kuletsa. Ngati mwakumana ndi zotupa pa anthu ndi matenda olanda kapena zokhudza zonse mafangasi dokotala ayenera kulimbikitsa kuyang'aniridwa ndi repeal mankhwala kukachitika kuti chidzasintha erythema multiforme, kapena zotupa bullous. Pa mankhwala, mankhwala "Mikosist" (ndemanga titsimikizire kuti) angayambitse chizungulire, kotero odwala ayenera kusamala makamaka pamene akugwira ntchito njira ndi kasamalidwe ka magalimoto.