"Mirapex": malangizo ntchito, maonekedwe, ndemanga

M'nkhani ino mudzaphunzira zonse za kukonzekera "mirapex": mmene m'malo mankhwala, zake tingati contraindications, mavuto, malangizo ndi dzanja lake. Mapiritsiwa zingachititse khalidwe nthenda ndi yaikulu ayankhe wodwalayo. Choncho, asanadye mankhwala "mirapex" malangizo ntchito ayenera ankaphunzira. Ifenso kukuuzani ngakhale wa mankhwala awa ndi mankhwala ena.

Nthawi yaitali "mirapex" ambiri kudziwa za mankhwala komanso nkhani ntchito

Thunthu yogwira ntchito yokonza "mirapex" ndi pramipexole. Wothandiza zigawo Mapale: povidone, mannitol, wowuma, aerosil, magnesium stearate.

Ndi mankhwala ikuchitika idiopathic (osadalira pa zotupa zina) matenda a "miyendo wosakhazikika" ndi matenda Parkinson komanso ena woyengeka galimoto ndi matenda extrapyramidal.

Mankhwala: mapiritsi "mirapex PD" 3 mg, 4.5 mg, 1.5 mg, 0,75 mg, 0,375 mg. Iwo ankanyamula mu matuza zidutswa 10, ndiyeno makatoni.

woyera mankhwala. Iwo ali m'mphepete beveled ndi mawonekedwe lathyathyathya mbali zonse, mmodzi amene ali chiopsezo chachikulu.

Mapiritsi ayenera kumwedwa pakamwa, kaya chakudya. Kudya mankhwala amaloledwa nthawi iliyonse. Mu nkhani iyi, tiyenera kutsukidwa pansi madzi. Analimbikitsa tsiku mlingo lagawidwa masiteji atatu.

Limagwirira kanthu (pharmacodynamics) "mirapex" Mapale

Kugwiritsa pramipexole mankhwala omwe limapangidwa yokonza "mirapex" mwachindunji ndi selectivity mkulu timapitiriza zimene anthu a ku subgroup wa dopamine zolandilira D2. Uyamiko kwa Iye, kulipidwa chifukwa kupanda zolimbitsa thupi mu nkhani ya matenda Parkinson. Ichi ndi chifukwa kutsegula kwa maselo dopamine mu striatum lapansi. Choncho pramipexole kumathandiza alibe wa manyuroni kuti kumachitika chifukwa neurotoxicity kapena ischemia. Iwo kumabwezera mmbuyo kapena kuchepetsa mlingo wa kaphatikizidwe, ndi kupukusa chakudya, ndi kumasula dopamine. Ndiyamika manyuroni pramipexole ndiotetezedwa ku zotsatira poizoni wa wotsutsa-Parkinson wothandizila "Levodopa". Komanso chifukwa zotsatira zake amachepetsa prolactin (mlingo amadalira).

Pankhani ya ntchito yaitali mankhwala "mirapex" zochizira matenda Parkinson (zaka zoposa zitatu) ndi matenda a "miyendo wosakhazikika" (kuposa chaka) sanaulule yafupika dzuwa la pramipexole.

Amuzolengedwa njira zokhudza kukonzekera "mirapex 'm'thupi wodwala (pharmacokinetics)

Yogwira thunthu "mirapex" mankhwala kwathunthu ndipo mofulumira odzipereka pambuyo makonzedwe m'kamwa. Sitingayerekeze kuloŵerera (bioavailability) pafupifupi mtheradi - oposa 90%. Ndende pazipita mankhwala plasma anati pambuyo maola 1-3 mutadya. Pa chakudya pramipexole mlingo mayamwidwe amachepetsa. Pankhaniyi, kuchuluka kwa chakudya zidyeke ndi sanasinthe.

C mapuloteni chimamanga pramipexole pang'ono (zosakwana 20%). Iwo ali lalikulu yogawa buku - malita 400, kutanthauza kuti ndende mu magazi ndi otsika. Pamlingo yaing'ono timakumana ndi ndondomeko kagayidwe mankhwala. Pafupifupi 90% ya mlingo "mirapex" pellets excreted ndi impso, ndi 80% - sichinasinthe. The ndowe pramipexole chikupezeka mu kuchuluka kwa zosakwana 2% kuchuluka ankadya mankhwala. Minofu ndi thupi madzi zimayeretsedwa ku "mirapex" mapiritsi pa mlingo avareji 500 ml / min.

Kugwiritsa "mirapex" mankhwala pa mimba

Ndingaligwiritse ntchito pa mimba "mirapex" piritsi? Malangizo ntchito mankhwala momveka bwino kuti mmene mankhwala pa chitukuko cha mwana wosabadwayo m'mimba ndi mkaka wa m'mawere sichinayambe ankafufuza.

Zotsatira mwina pramipexole pa machitidwe ndi akuluakulu ndondomeko umuna anali kuphunzira mu zatsopano nyama. Zilibe kumawonetsera kuyan'anila za chitukuko yoopsa pa mimba akalulu ndi makoswe.

Excretion wa pramipexole mu mkaka wa m'mawere sichinayambe kuphunzira. Mmodzi kuti inenso mankhwala akhoza ziletsa mkaka wa m'mawere, kuyambira kumabwezera mmbuyo kupanga luteotrophic timadzi. Choncho, musatenge "mirapex" mapiritsi nthawi yoyamwitsa.

Woyembekezera, mankhwala ayenera kumwedwa ngati phindu lingathe mayi n'kosangalatsa chiopsezo mtsogolo kwa mwana wosabadwayo.

Contraindications ntchito mirapex miyala ' "

Mankhwala "mirapex" akhoza kumwedwa ngati hypersensitivity kuti pramipexole, komanso anthu amene anafika ndi zaka 18.

Mosamala wapadera akulimbikitsidwa kugwiritsa ntchito miyala opanikizika yafupika magazi ndi kulephera impso.

Zotsatira zoyipa "mirapex" mankhwala pa wamanjenje dongosolo

Kukonzekera "mirapex" - mapiritsi omwe angachititse wamanjenje dongosolo zotsatirazi zosiyanasiyana:

• chisokonezo;
• kwambiri kufuna kugona kapena kupanda kwake;
• kuyerekezera zinthu m'maganizo;
• amnesia;
• asthenia;
• chizungulire;
• extrapyramidal syndrome;
• hypoesthesia;
• kugwedeza;
• myoclonus;
• dystonia;
• maganizo;
• kuona zilubwelubwe;
• kudzipha zizolowezi;
• hypokinesia;
• ataxia;
• nkhawa;
• neuroleptic zilonda matenda.

Last ndinawona mu mawonekedwe a hyperthermia, zipolowe za chikumbumtima ndipo maganizo, minofu chinthu chimodzimodzi, autonomic lability, akathisia.

Zotsatira zoyipa za mankhwala "mirapex" pa machitidwe ena a m'thupi la munthu

dongosolo minofu ndi mafupa angayankhe ntchito mankhwala "mirapex" mawonetseredwe monga:

• hypertonic minofu, kupweteka awo, kukokana;
• yatsoka nyamakazi, myasthenia gravis kapena bursitis;
• kupweteka pachifuwa, pakhosi kapena msana (mu lumbosacral a).

Iwo angayambe yofanana mu dongosolo m'mimba. Pamene izi zimachitika:

• kusafuna kudya;
• kudzimbidwa;
• nseru;
• dyspepsia;
• flatulence;
• m'mimba;
• kusanza;
• youma pakamwa;
• kudula kumverera mmimba.

Kupuma phwando "mirapex" mankhwala ungabweretse chitukuko cha sinusitis, pharyngitis, rhinitis, chimfine syndrome. N'zothekanso zosayembekezereka ya kupuma movutikira, kuchuluka chifuwa ndi kusintha mawu.

Kodi zotsatira pa mtima dongosolo "mirapex" piritsi? Malangizo ntchito mankhwala imatiuza za zotheka chitukuko tachycardia, arrhythmia, angina pectoris, orthostatic hypotension.

zotsatira zina mbali

Pamene kulandira mankhwala "mirapex" mavuto amenewa kumachitika mu dongosolo urogenital, ngati matumbo kayendedwe pafupipafupi matenda. Choncho ngakhale amayenera imfa ya libido ndi potency.

Komanso, inu mukhoza kuona masomphenya awiri, mathithi, conjunctivitis, ziwalo za malawi, chifuwa, ndi mkhutu kumva, kuthamanga intraocular.

chokhwima zochita zina za thupi:

• retroperitoneal fibrosis;
• pleural effusion;
• kusalola m'mapapo mwanga;
• kuwonda;
• zotumphukira edema.

Mlingo ndi Administration "mirapex" Mapale

Kugwiritsa ntchito mankhwala muyenera mkati, tsiku 3 zina. Koyamba mlingo "mirapex PD" mapiritsi - 0,375 mg wa pa tsiku. Pang'onopang'ono kuwonjezera kuchuluka kwa mankhwala zofunika (masiku 7) kupeza kufunika kwenikweni achire. Mu sabata wachiwiri wa mankhwala tsiku lililonse ayenera kudyedwa ndi 0,75 mg wa wachitatu - kuti 1,5 mg pa wachinayi - by 2,25 mg wa wosowa wachisanu kumwa mankhwala "mirapex" 3 mg ndi tsiku, pa chimodzi - 3,75 mg, ndi chiwiri - 4.5 mg.

Mu kulephera aakulu aimpso, mlingo kusintha zochokera pa mlingo ntchitoyo creatinine chilolezo. Enieni kuchuluka kwa mankhwala adzasankhidwa dokotala.

Zotsatira cha mankhwala osokoneza bongo mapiritsi "mirapex"

Ngati inu ntchito "mirapex" mlingo mankhwala linathyoka, zizindikiro zimenezi zingachitike mwina kuyerekezera zinthu m'maganizo, hyperkinesia, nseru, kusanza, utachepa magazi ndi chilakolako chogonana.

Kuti vuto limeneli, tingadziteteze si anaika. Nthawi ya mankhwala ambiri osokoneza "mirapex" si lokhazikika. Analimbikitsa symptomatic mankhwala chapamimba lavage ndi kuonerera zazikulu. Ngati pali zizindikiro za ambiri osokoneza wa malemeredwe a chapakati mantha dongosolo, m'pofunika kutsatira kukonzekera, neuroleptics.

mapiritsi ankachita "mirapex" ndi mankhwala ena

Pramipexole kugwirizana plasma mapuloteni pang'ono ndi biotransformation. Choncho, mogwirizana ake ndi mankhwala ena amene amakhudza njira izi ndi chodziwikiratu.

Mankhwala amene ziletsa kapena kubisa yopanga yogwira kapena cationic samovyvodyaschiesya kudzera tubules ndi aimpso, akhoza kutani ndi mankhwala "mirapex". Malangizo ntchito anafotokoza kuti mu nkhani iyi kuchepetsa liwiro kuwonetseredwa kuyeretsa zimakhala ndi madzi kwachilengedwenso kapena ku medicaments onsewo kapena mmodzi wa iwo.

Ngati imodzi ndi mirapex ndi mapilisi ' "ntchito mankhwala amenewa, muyenera khutu ku zotheka kuyerekezera zinthu m'maganizo, dyskinesia, mukubwadamuka. Ngati zizindikiro izi zidzachitika, mlingo wa mankhwala ayenera kuchepetsedwa.

mapiritsi ngakhale "mirapex" ndi mankhwala "Amantadine" ndi "L-dopa"

Kodi chimachitika n'chiyani ophatikizana phwando "Levodopa" mankhwala ndi "selegiline" mankhwala "mirapex PD"? Malangizo limanena kuti pharmacokinetics wa woukitsa sikumangotikhudza woyamba kapena wachiwiri. Pa nthawi yomweyo pa kuloŵerera mokwanira ndi excretion wa mankhwala mwachibadwa "Levodopa" piritsi "mirapex" ndi losadziwika.

Pramipexole anali kuphunzira mogwirizana kwa mankhwala "Amantadine". Koma ngakhale n'zotheka mankhwala chifukwa chakuti njira zofanana pa excretion.

Pamene mlingo "mirapex" kukonzekera chinawonjezeka, ntchito kuchuluka "Levodopa" tikulimbikitsidwa kuti ndichepe. Chiwerengero cha mankhwala ena antiparkinsonian ayenera anakhalabe zonse pa mlingo chomwecho.

NKHANI Ngakhale kukonzekera "mirapex" ndi mankhwala ena

Chifukwa kuthekera chifukwa chokhala ndi kusamala kwambiri akulimbikitsidwa kugwiritsa ntchito mapiritsi "mirapex" osakaniza ndi mitsempha, mowa komanso mankhwala othandiza kuwonjezera pramipexole ndende mu magazi (mwachitsanzo, mankhwala "cimetidine").

malangizo apadera ntchito "mirapex" mapiritsi

Ife kufotokoza mankhwala ali osavomerezeka kutenga molumikizana ndi antipsychotics.

Mankhwalawa dopamine agonist zotsatira kudziwika mbali ndi chisokonezo ndi kuyerekezera zinthu m'maganizo. Nthawi ya "mirapex" mapiritsi osakaniza ndi mankhwala "Levodopa" kuvutika ngati anali pafupipafupi mu magawo ina ya matenda kuposa monotherapy oyambirira.

dokotala ayenera kuuza wodwala za pakutchulidwa mwina kuyerekezera zinthu m'maganizo zithunzi. Amenewa mbali amakhudza kuthekera kuyendetsa galimoto ndi kusankha udindo.

Mu discontinuation lakuthwa miyala mu nkhani ya matenda Parkinson anali wapezeka maonekedwe zizindikiro chokhala neuroleptic zilonda matenda.

Khalidwe Anomalous kugwiritsa ntchito "mirapex" mankhwala

Odwala ndi amene kuwasamalira, m'pofunika kudziwa kuti phwando la mankhwala dopaminergic, kuphatikizapo "mirapex" mapiritsi (ndemanga akutitsimikizira izi), nthawi zambiri amayambitsa khalidwe nthenda ya mtima. Mukhoza kuona hyperphagia (kudya zizolowezi), kugula pathological (obsessive akhumba zambiri kugula), kutchova juga ndipo hypersexuality. Zikatero m'pofunika kuchepetsa mlingo wa mankhwala kapena pang'onopang'ono siyani kumwa mankhwalawa.

Chenjezo kugwiritsa ntchito "mirapex" mapiritsi

Medicine "mirapex" ayenera kudyedwa ndi kusamala odwala ndi kukhalapo kwa matenda aakulu a dongosolo mtima. Kuchititsa mankhwala ndi mankhwala dopaminergic pali chiopsezo orthostatic hypotension. Choncho, kulamulira magazi, makamaka pa siteji koyamba mankhwala.

Pamene zithunzi kuwonongeka m'pofunika kumaona nthawi yomweyo pambuyo poika mapiritsi "mirapex" ndi intervals zina kumatanthauza.

Odwala ayenera kuperekedwa chakuti mankhwala mwina ndi zotsatira sedative. Koma nthawi zina tulo mwadzidzidzi kugonagona kwambiri masana ndi zochitika tsiku. Kuphatikizapo kumachitika nthawi iliyonse pa kayendetsedwe ka makina zovuta kapena galimoto galimoto.

Kutheka amadwala khansa ya pakhungu

Chifukwa cha maphunziro AIDS asonyeza kuti odwala matenda Parkinson ali pa chiopsezo khansa. Kodi chimayambitsa matenda, kapena zinthu zina, monga ntchito "mirapex" mankhwala sichinayambe anakhazikitsa.

Kulimbikitsa wa matenda a "miyendo wosakhazikika"

Kodi matenda a "wosakhazikika miyendo" mankhwala "mirapex"? Umboni kusonyeza kuti dopaminergic mankhwala akhoza kuikapo. Izi anawonetseredwa mu mawonekedwe a isanayambike kale zizindikiro mu syndrome madzulo ndipo nthawi zina masana. Pankhaniyi, zizindikiro kufalitsa kwa miyendo ena. Umene unachitikira kwa masabata 26 matenda ankalamulira phunziro, yokonzedwa kuphunzira amenewa, kusiyana kwambiri pakati pa magulu pramipexole ndi placebo mu utithandize mbali ya matenda akhala sakudziwika.

zinthu yosungirako ndi moyo alumali

"Mirapex" piritsi amatanthauza yokonza mndandanda B. Store iwo akhale mu mdima. Pankhaniyi firiji sayenera upambana 30 ° C.

Alumali moyo wa mankhwala - miyezi 36 (zaka 3) kuchokera tsiku kupanga.

Ntchito "mirapex" mapiritsi ana ndi zinthu kugula

mankhwala ali contraindicated ntchito ana. Chilolezo kwapatsidwa kwa anthu kulandira mapiritsi, amene anafika ndi zaka 18. Medicine "mirapex" anamasulidwa mu pharmacies pa ulaliki wa dotolo.

Mankhwala analogues "mirapex"

Inu simungakhoze, chifukwa chirichonse, kuti atenge piritsi ndi "mirapex"? Kodi m'malo mankhwala, muyenera kuwauza pharmacist kapena dokotala. Ndipo ife kupereka analogues zotsatirazi.

1. "Motopram" mankhwala. Zikuonetsa ntchito: matenda Parkinson. Iwo angathe kuchitidwa nokha kapena pamodzi ndi mankhwala mankhwala 'levodopa. Amagwiritsidwanso ntchito kwambiri kapena zolimbitsa idiopathic mawonekedwe a matenda a "miyendo wosakhazikika".
2. "Oprimeya" mankhwala. Cholinga: antiparkinsonian mankhwala stimulant dopaminergic kufala mu chapakati mantha dongosolo.
3. "Pramipexole" mankhwala. Nthumwi achire ntchito matenda Parkinson. Akukhulupirira kuti limagwirira kanthu n'zogwirizana ndi luso la pramipexole mankhwala yotithandiza dopamine zolandilira mu striatum lapansi.

Miyala "mirapex" - analogues kapena pachiyambi? No kudzikonda!

Mndandanda wa pamwambawu umatchula mankhwala omwe ali ofanana ndi mapiritsi a Mirapex. Iwo ali ndi dzina losiyana, losavomerezeka la mayiko apadziko lonse (kapena kachidindo ka ATS) komwe bungwe la WHO (World Health Organization) linalimbikitsa.

Ngati mukufuna kupatsidwa mankhwala ndi mapiritsi a Mirapex, mafananidwe angakhalenso njira yabwino. Koma musanayambe kumwa mankhwalawa, nthawi zonse funsani katswiri. Musamagwiritse ntchito mankhwala okhaokha! Izi zingayambitse mavuto osasinthika pa thanzi lanu.

Chenjerani! Nkhaniyi ndi ndondomeko ya mankhwala "Mirapex" ndizolembedwera ndi zosavuta za malamulo omwe angagwiritsidwe ntchito. Chidziwitso cha mankhwalachi chimaperekedwa chifukwa cha chidziwitso. Musagwiritse ntchito ngati chitsogozo cha mankhwala.