"Chloramphenicol": malangizo ntchito. Akutsikira "Chloramphenicol"

ndi pawiri mankhwala ngati ndi chloramphenicol chiyani? Malangizo ntchito formulations nkhani imeneyi, Adzaperekedwa pansipa. Ifenso kukuuzani zimene zimatha chida ichi, dzina malonda, ndi, kuchokera umene kutumikiridwa, ndi zina zotero. D.

mwachidule

Kodi katundu ndi chibadidwe mankhwala monga ndi chloramphenicol? Malangizo ntchito akusimba kuti ndi nthumwi wowala wa gulu la mankhwala amphenicols. Wamkulu antibacterial ali isomer ake laevorotatory.

Anati pawiri ndi galasi popanda fungo ndi mtundu. Ndi bwino sungunuka m'madzi, koma mosavuta sungunuka propylene glycol, pyridine, ethylene glycol ndi Mowa. Nkhanizi anali ntchito ngati mankhwala osati mankhwala komanso ulimi nyama.

Mu dzina zimene zikhoza kugulidwa pa mankhwala ndi chloramphenicol? Trade dzina la chida zikumveka ngati "Chloramphenicol".

chigawo ankaona koyamba apanga mu 1940 ku Streptomyces venezuelae. Today mankhwala kukonzekera kwa styrene tsatane 10 kaphatikizidwe.

Akuti mankhwala othandiza okwanira. Komabe, poizoni kwambiri ndipo nthawi zambiri chifukwa cha zochita chowawa.

Medicaments munali ndi chloramphenicol (tradename inali kuperekedwa pamwamba) amatuluka mu mawonekedwe a mafuta ndi, akutsikira, njira yothetsera mu mnofu ndi mtsempha boma komanso miyala ndi makapisozi.

pharmacodynamics

Kodi ndi chloramphenicol? Malangizo malipoti ntchito kuti wothandizila ndi waluso kusokoneza mapuloteni kaphatikizidwe njira mabakiteriya ndi inhibiting puloteni monga dioxo-peptidyl transferase. Sitingathe kunena kuti ndi chloramphenicol ali olemba zotsatira bacteriostatic. Iye akugwira streptococci, mavairasi lalikulu, mabakiteriya galamu alibe ndi stafilokkok. Mbali khalidwe la mankhwala n'chakuti kuti limakhudza anthu mitundu zimene kugonjetsedwa ndi sulfonamides Penicillin ndi streptomycin. Pankhani kulolerana, mankhwala ankaona akufotokozera pang'onopang'ono.

Pharmacokinetics

Kodi ndi chloramphenicol odzipereka? Malangizo ntchito inanena kuti utsogoleli m'kamwa mwa thunthu mofulumira odzipereka kwa thirakiti m'mimba ya mankhwala. Zolemba malire ndi chloramphenicol ndende akwaniritsa pambuyo maola atatu, ndipo bioavailability ake ndi 90%.

Pafupifupi theka la mankhwala chimamanga kuti mapuloteni plasma.

Chloramphenicol ndi zimapukusidwa mu chiwindi ndi linanena bungwe kwa maola atatu ndi impso, ndi pamodzi ndi ya ndulu ndi ndowe. Iwo ayenera kukumbukira kuti pawiri izi hydrolyzed m'matumbo, chifukwa mu mapangidwe metabolites kulalikira.

The ntchito m'dera la medicament kapena kukhudzana ake ndi conjunctival ndi sac ali umakondera wa zokhudza zonse mayamwidwe. Koma pa mankhwala yomweyo amalenga padziko khungu kapena madzimadzi diso ndende zokwanira kupereka kanthu bacteriostatic.

zikuonetsa

Kodi cholinga Kwalamulidwa makapisozi kapena miyala "Chloramphenicol" n'chiyani? Chloramphenicol ntchito m'kamwa mwa mankhwalawa typhoid, paratyphoid, salmonellosis mu mawonekedwe zowombetsa mkota, matenda osiyanasiyana rickettsial, brucellosis, tularemia, kamwazi, abscesses ubongo ndi matenda meningococcal.

Komanso izi zikutanthauza kawirikawiri Kwalamulidwa kwa odwala ndi chlamydia, trachoma, matenda pyogenic bala, peritonitis, ehrlichiosis, inguinal lymphogranuloma, matenda osiyanasiyana, ya ndulu ndi matenda thirakiti mkodzo, yersiniosis.

Amene amachitira matenda chloramphenicol akunja? Mafuta analamula kuti mabala, matenda ena a pakhungu, zilonda, zilonda zamoto, zilonda venous ndi bedsores. Ndiponso ntchito mu ming'alu pa nsonga zamabele amayi unamwino.

Akutsikira "Chloramphenicol" anaika mu za sac conjunctival kuchitira keratitis, matenda bakiteriya diso, blepharitis, conjunctivitis, scleritis, ndi episcleritis keratoconjunctivitis.

contraindications medicament

Mankhwala, monga chloramphenicol, ali osavomerezeka chifukwa:

• paubwana (kwa mwezi umodzi);
• matenda magazi;
• zotupa mafangasi pa khungu, psoriasis ndi chikanga;
• anthu amene ali ndi vuto la shuga, 6-mankwala dehydrogenase, ndi chiwindi matenda;
• akumuyamwitsa amayi ndi amayi apakati;
• ngati matupi awo sagwirizana ndi thunthu kapena wothandizira zina mankhwala cha gulu ili.

Muyenera kusamala kwambiri anamuona pa matenda a mtima ndi mitsempha ya magazi, komanso chizolowezi thupi lawo siligwirizana.

"Chloramphenicol": malangizo ntchito mankhwala

Monga tanena zida zochokera mankhwala ntchito intramuscularly, m'nsinga, timitu, pakamwa ndi conjunctival.

Chiwembu mankhwala ndi nthawi yake zimadalira pa chiphunzitso cha mankhwala ndi matenda. Atsimikiza ndi dokotala amachitira anthu paokhapaokha.

Mapiritsi "Chloramphenicol" ayenera kumwedwa Mphindi 30 musanadye kapena ola limodzi pambuyo.

Pamene mtsempha kapena mu mnofu jekeseni ndi yoyendetsa m'kamwa odwala wamkulu anatumizidwa 2 ga mchitidwe yogwira patsiku (mbali 4).

Mlingo pazipita mankhwala patsiku ndi zaka 4 ndi mankhwala ochuluka, onetsetsani kuti ulamuliro wa impso ndi magawo magazi.

Ana mankhwala Kwalamulidwa malinga ndi kulemera kwa thupi:

• kwa zaka 3 - 10-15 mg wa pa makilogalamu;
• zaka 3-8 - 15-20 mg wa pa makilogalamu;
• zaka zoposa 8 - 20-30 mg wa pa kg.

Pafupipafupi ntchito njira kapena miyala ana ndi chimodzimodzi kuti a akulu.

Nthawi thandizo anati maantibayotiki ndi masiku 7-11. Kutalika pazipita mankhwala - 2 masabata.

Pamene ntchito timitu kukonzekera umagwiritsidwa ntchito pa zinkakhala m'dera kangapo patsiku, ntchito gauze. Ngati ndi kotheka, njira angagwiritsidwe ntchito limodzi ndi munthu occlusive bandeji. Mu nkhani zimenezi, kuvala aliyense masiku 3 mpaka bala ndi mwaukhondo ndi sukhalitsa.

Pankhani kusiya, iwo ntchito mu mawonekedwe a 0,25 ndi njira 1% limodzi ndi mankhwala ena.

zotsatira zoyipazi

Ntchito pansi review, mankhwala zingachititse:

• kuyabwa ndi mkwiyo (pamene ntchito timitu);
• agranulocytosis, thrombocytopenia, aplastic magazi m'thupi, leukopenia;
• Chotupa chija;
• kuona zilubwelubwe, neuritis, kuyerekezera zinthu m'maganizo zosiyanasiyana, mutu, chisokonezo, kukhumudwa;
• gipogemoglobinemiyu, reticulocytopenia;
• Angioedema, urticaria, totupa pakhungu;
• nseru, flatulence, kutsekula m'mimba, kuyabwa m'kamwa, kusanza, kudzimbidwa;
• matenda a mafangasi, dermatitis;
• kuziziritsa kumva ndi masomphenya, mkhutu maganizo a kununkhira.

Ana kwa miyezi 12 angathe kugwa mtima.

Price, ofanana ndi analogues

Kodi kukuyerekezeredwa amatanthauza "Levovinizol", "sintomitsina" "Chloramphenicol" "Chloramphenicol Aktitab", chloramphenicol ndi sodium succinate, "Chloramphenicol-Lect" mowa njira "ndi chloramphenicol", chloramphenicol ndi sodium succinate wosabala, "Chloramphenicol-Akos".

Iwo ayenera kukumbukira kuti pharmacies ndi analogues akhoza kukumana mankhwala "Levometil", "Levomekol" (ndi chloramphenicol + dioksometiltetragidropirimidin) "Levosin" (sulfadimetoksin dioksometiltetragidropirimidin + + Chloramphenicol + trimekain).

Monga mtengo, ndiye amati ndi mankhwala si kwambiri. mtundu uliwonse wa mankhwala zikhoza kugulidwa kwa 40-90 rubles.

Ndemanga za mankhwala

Ngakhale ambiri mavuto ndi kawopsedwe wa mankhwala okhala ndi chloramphenicol, iwo ntchito nthawi zambiri. odwala ambiri amakopeka ndi mtengo wotsika wa mankhwala, komanso kuchuluka kwa mlingo mtundu uliwonse.

Malinga ndi luso, maantibayotiki zimenezi nthawi analamula kuti ntchito apakhungu kuthetsa ziphuphu zakumaso ndi kuphulika zina khungu.

Pamene unavailability zipangizo ntchito ofanana matanthauzo analogi monga "Levomekol" (ndi chloramphenicol + dioksometiltetragidropirimidin). Koma kutero yekha atakambilana ndi dokotala.