"Cymbalta": malangizo ntchito. Ndemanga, mitengo, zikuonetsa

Today ife kukuuzani kuti ndi mankhwala "Cymbalta." Malangizo ntchito mankhwala, kapangidwe kake, mavuto, ndi kuwerenga adzakhala pansipa. Komanso ku nkhani yanuyi, muphunzira za mtundu umene mankhwala alipo, mtengo, ngati iye ali contraindication ndi mmene tingagwiritsire ntchito moyenerera.

Fomu kumasulidwa

Mu mawonekedwe zimene mukhoza kugula mankhwala "Cymbalta" malangizo amene unazunguliridwa mu phukusi? Panopa mankhwala ndi anamasulidwa mu mawonekedwe a makapisozi enteric. Omwe muli pellets, amene loyera kapena grayish mtundu woyera.

mankhwala

Kodi zigawo zikuphatikizapo mankhwala "Cymbalta?" Malangizo ntchito makapisozi limati yaikulu mchitidwe yogwira ndi chinthu duloxetine. Iwo ayenera kukumbukira kuti Kapangidwe ka medicament ankaona ndipo zikuphatikizapo zinthu zina monga sucrose, hypromellose, talc, succinate, woyera colorant, hypromellose nthochi, titaniyamu dioxide, triethyl citrate, gelatin, sodium lauryl sulphate ndi chikasu chitsulo okusayidi pigment.

Makapisozi anyamula 60 30 mg wa mankhwala. Iwo ankanyamula mu matuza a makapisozi 14 kapena 7. Mu umodzi paketi katoni kungakhale 1, 2 kapena 6 matuza.

Pharmacological makhalidwe a mankhwala

ndicho chikhazikitso yogwira monga duloxetine chiyani? Malangizo ntchito makapisozi mankhwala limanena zimenezo akuchita mankhwala ndi mchitidwe anati kwambiri wabwino antidepressant. Ndi woletsa wa reuptake wa norepinephrine ndi serotonin. Iye ofooka kumabwezera mmbuyo dopamine kutengedwa ndipo palibe kuyandikana kwa dopamine, histamine, ndi maselo adrenergic holino-.

Kodi Duloxetine? Guide muli mfundo zotsatirazi pa phunziro ili mfundo zimene thunthu ndi ziletsa reuptake wa norepinephrine ndi serotonin. Chifukwa cha zimenezi, kwambiri kumawonjezera noradrenergic ndi serotonergic neurotransmission mu wamanjenje dongosolo. Iwo ayenera kukumbukira kuti duloxetine msanga kubisa ululu.

Pharmacokinetics mankhwala

Formulations wa maganizo a "Cymbalta" odzipereka kwa mundawo m'mimba, mayamwidwe zimayambitsa maola angapo pambuyo utsogoleli. Ndende pazipita zimatheka pambuyo maola 6. Munthawi yomweyo phwando chakudya si maganizo ndi kumawonjezera nthawi kukwaniritsa maola 6 mpaka 10. Akatswiri amanena kuti kungotchula kumachepetsa mlingo wa mayamwidwe (11%).

KUMANGA mankhwala kwa mapulotini plasma ndi mkulu zokwanira ndipo kenako oposa 90%.

The theka moyo wa mankhwala ndi maola 12. Pa nthawi yomweyo iye akupita mu mkodzo monga metabolites.

Malinga ndi maphunziro, pali kusiyana pakati pa njira pharmacokinetic zimene zimachitika mu akazi ndi amuna. Choncho, ambiri chilolezo kwa pophika yogwira m'munsimu kugonana fairer. Komabe, kusintha mlingo Sikuti.

Iwo ayenera kukumbukira kuti kusiyana njira pharmacokinetic kuti chidzachitika odwala okalamba ndi wazaka zapakati inakhazikitsidwa pa pofufuza. Iwo anaulula kuti theka moyo wa mankhwala ndi apamwamba okalamba kuposa achinyamata. Palibe kusintha mlingo si chofunika mwina.

Odwala ndi insufficiency aakulu aimpso mu gawo osatha, amene ali pa dialysis, anthu ambiri ntchito ndi AUC wa ukuwonjezeka duloxetine pa ndendende nthawi 2. N'chifukwa bwino kuganizira anaiyamba kuchepetsa mlingo wa mankhwala odwala ndi matenda aakulu a ntchito aimpso.

Odwala ndi zizindikiro za kulephera chiwindi amachepetsa kagayidwe ndi kuwonongedwa theka moyo wa duloxetine.

Zikuonetsa ntchito ndalama

Pamene prescribers "Cymbalta?" Malangizo ntchito monga mndandanda zotsatirazi kuwerenga:

• ashuga neuropathy ululu mawonekedwe;
• maganizo ndi maganizo limati;
• Nkhawa matenda;
• ululu aakulu minofu ndi mafupa matenda, kuphatikizapo chifukwa cha m'minofu ndi nyamakazi.

Contraindications ntchito ndalama

Pamene inu simungakhoze kutenga mankhwala "Cymbalta?" Malangizo ntchito monga mndandanda kutsatira contraindications:

• munthawi yomweyo kugwiritsa ntchito zoletsa amphamvu isoenzyme CYP1A2 (mwachitsanzo, enoxacin, ciprofloxacin kapena fluvoxamine);
• Kuchuluka kudziwa mtima zikutanthauza zigawo;
• ana osaposera zaka 18;
• phwando akanthawi ndi Mao zoletsa;
• Wolumikizira oopsa ndi kusalankhula;
• uncompensated kutsekedwa khungu;
• aakulu aakulu aimpso kulephera (ndi CC zosakwana 30 ml ya / Mph);
• isomaltase akusowa kapena saccharase, shuga-galactose malabsorption ndi fructose tsankho;
• matenda chiwindi amene anatsagana ndi insufficiency kwa chiwindi.

Pamene ayenera kugwiritsidwa ntchito mosamala mankhwala

Ayenera kugwiritsidwa ntchito mosamala anati mankhwala matendaŵa ndi kukonda, kupweteka chiopsezo cha kuukira njingayo-kutsekedwa khungu. Komanso, chisamaliro ayenera kumwedwa pamene ocular oopsa, maganizo ofuna kudzipha hyponatremia, chiwindi ndi impso.

Mankhwala "Cymbalta": malangizo ntchito

Mtengo wa mankhwala ndi mkulu. Komabe, nchito zake kosamugonjera kukayika kulikonse.

mankhwala anapereka Kwalamulidwa okha makonzedwe m'kamwa. makapisozi ayenera kuwameza lonse popanda onongani kapena kutafuna iwo. Tikumbukenso kuti Mulimonsemo sangathe zidzawonjezedwa kwa mankhwala kapena zakudya kusakaniza ndi madzi wina aliyense, popeza zimenezi mosavuta kuvulaza ❖ kuyanika enteric.

Formulations maganizo ayenera kumwedwa pa mlingo woyambilira wa 60 mg tsiku lililonse. Pofuna kukwaniritsa zotsatira zabwino odwala ena kuwonjezera anati kuchuluka kwa mlingo pazipita 120 mg ndi kawiri pa tsiku.

Odwala matenda ndi kulephera aakulu aimpso, lomwe limapezeka mu gawo osatha, mlingo woyambilira wa medicament ndi 30 mg wa kamodzi pa tsiku. Ngati odwala ndi chiwindi wonongeka, anasonyeza kuchuluka kwa mankhwala tikulimbikitsidwa kuchepetsa kapena kuchepetsa multiplicity wa phwando.

Iwo ayenera kukumbukira kuti kupewa kusuta mwadzidzidzi kulandira medicament. Kuchuluka kwa mankhwala zofunika kuchepetsa pang'onopang'ono 1-2 masabata. Ngati maziko awa, pali zizindikiro kutchulidwa kwa matendawa, izo tikulimbikitsidwa kuti apitirize chithandizo mlingo kutchula. Kenako, adokotala akhoza kupitiriza ndichepe mlingo, koma pang'onopang'ono.

Nthawi cha mankhwala osokoneza bongo

Kodi akatswiri amanena za milandu mankhwala ambiri osokoneza, "Cymbalta?" Reviews madokotala ali ndi mfundo deta ngati alipo kale. Pakali pano, pali milandu cha mankhwala osokoneza bongo ndi ingestion wa mankhwala ndalama mpaka 3000 mg, ndipo pamene pamodzi ndi atumiki. Zodabwitsa ndizakuti, atathana ndi imfa imodzi.

Zizindikiro cha mankhwala osokoneza bongo kapena akutali ophatikizana monga chikhalidwe zotsatirazi: zopweteka clonic, somnolence, kusanza, chikomokere, syndrome serotonin ndi tachycardia. Koma kafukufuku preclinical (zatsopano nyama), zizindikiro zazikulu za kawopsedwe kugwirizana ndi kusalankhula kulandira medicament, ndi matenda a dongosolo mantha ndi m'mimba kwambiri. Komanso, odwala amaoneka kugwedeza, ataxia, kupweteka clonic, kusanza ndi kukana kudya.

Kodi kuchita ngati mankhwala osokoneza bongo? Ndi chitukuko cha matenda serotonin ayenera yomweyo ikuchitika kukonza mankhwala cyproheptadine, komanso njira ntchito matenda a wodwalayo thupi kutentha.

Wodwala chofunika kupereka mpweya wabwino. Muyeneranso kuwunika ntchito ya mtima ndi kuwunika zizindikiro kwambiri. Zonsezi zizichitidwa molumikizana ndi likhale chithandizo ndi kulandira mankhwala symptomatic.

Ngati utsogoleli wa mankhwala sikunali motalika, m'pofunika kusambitsana kunja m'mimba. Komanso, pofuna kuchepetsa zakudya mankhwala wodwala linafunsidwa kumwa adamulowetsa makala.

mbali zotsatira

Kodi kungasokoneze thanzi la munthu wa atapatsidwa anati mankhwala? Taganizirani mavuto mankhwala antidepressant mwatsatanetsatane:

• Nthawi zambiri (pa 10% milandu) mu maphunziro a matenda, odwala ndi mayiko otsatirawa: chizungulire, kupweteka mutu, pakamwa youma, kugona tulo, nseru, kugona ndi kudzimbidwa.
• Pasanathe okwana (1 kuti 10% milandu) Odwala anati ankatenthetsa, kutsekula m'mimba, kusawona bwino, kusanza, thukuta, kugwedeza, kuchuluka anorgasmia, utachepa kudya, imfa ya libido, kuwonda, kutopa, erectile kukanika, komanso sachedwa kapena umuna nthenda.

Sitingathe kunena kuti mavuto monga chizungulire (nthawi zina mutu ndi nseru), zimachitika ndi Kulipira mwadzidzidzi wa medicament a. Mwa njira, odwala ndi zopweteka mitundu ashuga neuropathy akhoza kumva kuwonjezeka shuga magazi pa chopanda kanthu m'mimba.

Reviews a medicament

Malinga ndi akatswiri, ndi odwala ankaona mankhwala kwathunthu kupirira ntchitoyo. Pa Zakukumana kumatha ndi odwala matendawa, komanso kulimbikitsa mofulumira ndi mayiko maganizo. Komanso, yogwira medicament bwino relieves ululu syndromes mu dongosolo minofu ndi mafupa.

Mogwirizana ndi njira zina

Kodi n'zotheka Co-ka mankhwala ena mankhwala "Cymbalta?" Akatswiri Mlendo kuti njira ananena ndi zimakhudza mwachindunji pa mphamvu ya mankhwala.

Choncho, pali chiopsezo serotonin syndrome, duloxetine ngati ntchito limodzi ndi MAOIs.

Chifukwa CYP1A2 isoenzyme ndi kukhala wochitachita mu kagayidwe wa "kukonzekera Cymbalta, ntchito zawo munthawi yomweyo kungachititse kuti kuchuluka kwa otsiriza.

Osavomerezeka chifukwa anati medicament pamodzi ndi mankhwala ena amene amakhudza chapakati mantha dongosolo. Komanso pa anavomereza kuti simuyenera kumwa mowa.

Nthawi zina, pamene ntchito SSRIs ndi wothandizila serotonergic odwala anati serotonin syndrome. Choncho, muyenera kusamala kwambiri pamene ntchito mankhwala ndi antidepressants serotonergic.

Chifukwa chakuti pali kuthekera kuchuluka chiopsezo magazi sayenera kugwiritsa ntchito duloxetine ndi anticoagulants (antithrombotics).

Kuyamwitsa ndi mimba

Ndingatani ntchito mankhwala "Cymbalta", mtengo umene Adzaperekedwa, pa nthawi ya mimba? Chifukwa cha kusowa mfundo zokwanira, kugwiritsa ntchito duloxetine mankhwala pa gestation mankhwala akhoza kutumikiridwa pokhapokha ngati phindu kwa mayi woyembekezera ndi apamwamba kuposa ngozi mwanayo.

Tiyeneranso anati odwala kutenga wothandizila uyu ayenera kuonetsetsa kuti awadziwitse dokotala wanu za pakutchulidwa kapena akukonzekera kukhala ndi pakati.

Kafukufuku wasonyeza kuti amai antidepressants mu boma, makamaka mu magawo kenako, kumawonjezera kwambiri chiopsezo kulimbikira m'mapapo mwanga matenda oopsa a ana akhanda. Pankhaniyi, matendawa komanso Kawirikawiri ana mu nkhani ya amasiya mwadzidzidzi ntchito duloxetine mayi m'tsogolo pa siteji mochedwa mimba. Ambiri mwa zizindikiro za chikhalidwe ichi unkachitika pa yobereka kapena mu masiku oyamba pambuyo.

Chifukwa duloxetine akhoza kulowa mu mkaka m'mawere si zofunika kuyamwitsa mwana wanu pa mankhwala. Apo ayi, anthu ambiri thunthu mu mwana wosabadwayo adzakhala ndi kuchuluka kwa 0,14% ya ndende mu mayi.

malangizo enieni kugwiritsa ntchito mankhwala

Potumiza mankhwala kwa mtima wake "Cymbalta", dokotala ayenera anamuuza kuti mosapita m'mbali amaletsa limodzi nthawi chikuonetseratu wa wothandizila ndi Mao zoletsa. Apo ayi, ungathe kusokoneza mavuto oopsa ndi lalikulu hyperthermia, myoclonus ndipo anasonyeza malemeredwe kusintha mu chikomokere.

Iwo ayenera kukumbukira kuti choletsedwa kulandira anati mankhwala masabata awiri pambuyo mankhwala Mao zoletsa.

Malinga ndi maphunziro, odwala ndi boma wosangalala monyanyira ntchito mankhwala ena amene amakhudza wamanjenje dongosolo, molumikizana ndi njira "Cymbalta" Mwina kuvutika matenda alipo.

Chifukwa chakuti limati maganizo pali mosavuta kufuna kudzipha, ayenera makamaka kuwunika odwala a gulu chiopsezo.

Kuvomereza mankhwala kungakhale N'zosavuta kupangitsa kusinza. Choncho, odwala amene mankhwala, muyenera kusamalira owonjezera pamene galimoto ndipo pamene akugwira ntchito makina oopsa avundulidwe.

Price ndi analogues wa mankhwala

Mochuluka bwanji ndi "Cymbalta" makapisozi enteric? mtengo zingasiyane. Izo zimatengera wopanga ndi mankhwala unyolo masamba. Komabe, tisaiwale kuti pafupifupi ndalama mankhwala za 1.050 Russian rubles (30 mg, 14 zidutswa). Ngati mukufuna kugula mankhwala mu yofanana, koma pa mlingo wa 60 mg, ndiye inu kulipira za 1150 rubles.

Tsopano inu mukudziwa momwe zingati duloxetine. mtengo wake achuluke kapena kuchepa malinga zinthu zina. Panopa, kugula amatchedwa mankhwala si vuto lililonse. Komabe, mukhoza kugula okha ndi mankhwala.

Koma bwanji ngati inu chifukwa ena sangakhoze kugula "Cymbalta" makapisozi mankhwala? Analogs za mankhwala akupezeka pafupifupi aliyense mankhwala. Ngakhale kupeza Ziyeneranso kukhalapo kwa dotolo kwa dokotala.

Mankhwala akhoza m'malo "Cymbalta?" Mwa anzake angakonde makamaka kuunikila mankhwala zotsatirazi:

• "Tsamba loyambilira";
• "Azafen" (mapiritsi);
• "Duloxetine Canon" (Enteric makapisozi);
• "Venlafaxine Sandoz";
• "Alvent";
• "Mirtazapine Canon";
• "Eprobemide" (yothetsera mu / ndi / m);
• "Wellbutrin";
• "Eprobemide" magome;
• "Agomelatine";
• "Neyroplant";
• "Velafaks";
• "Calixtus";
• "Venlaksor";
• "Vensuert";
• "Dapfiks";
• "Venlift od";
• "Despres;
• "Efevelon achigonjetse";
• "Doppelgerts Nervotonik" monga elixir ndi;
• "Inkazana";
• "Efevelon";
• "Coaxil";
• "Esprital";
• "Lerivon";
• "Trittiko";
• "Normazidol";
• "Mirzaten";
• "Tetrindol";
• "Mirtazonal";
• "Remeron";
• "Mirtalan";
• "Pirazidol";
• "Negrustin";
• "Nyuvelong";
• "Noksibel".

The njira yosungirako ndi alumali moyo

alumali moyo wa mankhwala Kodi "Cymbalta?" Malinga ndi malangizo, ndi tsiku pa ma CD, chida ichi sayenera kumwedwa kwa nthawi ya zaka zitatu. Pankhaniyi ziyenera kusungidwa pa malo a mdima pamene kutentha si upambana madigiri 20.