Zizindikiro ndi mankhwala a matenda serotonin

Kuwonjezeka lakuthwa mu mlingo wa serotonin - chikhalidwe m'malo aakulu, amene anatsagana ndi kuyan'anila misa mu ntchito ya chamoyo wonse. Childs, zosintha zimenezi zili zotsatira za kumwa mankhwala ena kapena ambiri osokoneza ndi mankhwala osiyanasiyana. Popeza chithandizo yake imeneyi ndi zinadzala ndi ngozi, zotsatira zina sizingasinthe. Choncho n'kofunika kuganizira zokhudza zomwe zimayambitsa ndi zizindikiro za matenda serotonin. Kodi mankhwala akhoza kupereka mankhwala amakono ndi zambiri zinadzala ndi kusowa chithandizo?

Serotonin syndrome: ndichiyani?

Ndipotu mfundo koyamba za boma anaonekera osati kale. Mu 1960 mu United States maphunziro oyamba zinatuluka pa nkhani imeneyi. chakuti zimayambitsa matendawa, chimenenso, limodzi ndi kuwonjezeka lakuthwa mu kuchuluka kwa thunthu mu maselo mitsempha, amakhala osiyana, imakhudzana ndi antidepressants.

Amadziwika kuti serotonin akusowa syndrome kumabweretsa kukula kwa maganizo. Ndipo m'zaka za m'ma otsiriza kupangidwa mankhwala kuyan'anila zimenezi, panopa limatchedwa "antidepressants". Mankhwalawa kuthandiza kuonjezera mlingo wa serotonin, wodziwika yotchuka ngati "chimwemwe timadzi". Muulamuliro awo, kutopa ndi mphwayi zayamba kutha, ndipo anthu pang'onopang'ono ndi moyo wabwinobwino. Komabe, lalikulu zedi kwambiri serotonin amachita ngati poizoni, ndi ingafooketse maselo mitsempha, kuchititsa kulemera chisokonezo mu chamoyo. A matenda ofanana mwina chifukwa cha antidepressants, ndi osakaniza antidepressants ndi mankhwala ena (mwachitsanzo, ena mwa mankhwala chifuwa ndi zina zotero. D.).

Ndipotu, masiku ano, milandu syndrome serotonin zinalembedwa si kawirikawiri. Koma, malinga ndi madokotala ndi akatswiri, chimachitika kokha chifukwa matenda ananamizira ngati misa zizindikiro imperceptible, omwe kawirikawiri akuwachititsa kupsyinjika mitsempha kapena kutopa. Choncho n'kofunika kudziwa za chifukwa syndrome serotonin kumachitika, ndichiyani ndi zizindikiro namtsata.

Ntchito yaikulu ya serotonin

M'pofunikanso kudziwa limagwirira cha zochita za "chimwemwe timadzi", musanaganize funso bwanji ndiponso kukulitsa serotonin syndrome. Kodi zinthu izi? The Ntchito yaikulu ndi lamulo ntchito serotonin mu manyuroni ena mu ubongo. Kudutsa mphanga synaptic ku ubongo wina, mankhwala amachitira ndi maselo achindunji nembanemba wa pafupi selo mitsempha, mphamvu ndi kuwombera mitsempha mtima.

Pali kachitidwe angapo kuti akhoza malangizo kuchuluka kwa serotonin mu thupi. Makamaka, reuptake lino, m'mene molekyulu akubwerera pokonza ndi minyewa choyamba (poyamba antidepressants kwambiri ndi zoletsa wa serotonin reuptake) ndi enzymatic lamulo, limene wapadera yogwira mankhwala Mamatirani timadzi molekyulu.

Serotonin nthawi njira zambiri mu thupi, kuphatikizapo:

• nthawi ya kugona ndi maso;
• kudya;
• chitukuko kapena mofulumira a kumverera kwa nseru;
• kugonana;
• thermoregulatory njira;
• amaonera kuwawa;
• thandizo minofu kamvekedwe;
• motility pa mundawo m'mimba;
• lamulo la kamvekedwe mtima;
• Inatsimikizira kuti serotonin kumafuna mu njira ya migraine.

Monga mmene taonera, "mahomoni osangalala" kupereka thupi la munthu si kumverera kwa euphoria. Ataphunzira ntchito ya mankhwala, n'zotheka ndikulingalira ena zizindikiro za matenda serotonin. Mwa njira, pazipita anati ndende ya timadzi mu tsinde ubongo ndi mapangidwe reticular.

Serotonin syndrome: sayansi. Kodi zingakubweretsereni kuphwanya ndi?

Monga tanenera kale, kuphwanya izi, kwa gawo lalikulu anayamba pamene mukumwa mankhwala, kapena osakaniza zace. Chotero kodi mankhwala lingachititse chitukuko cha matenda oopsa monga syndrome serotonin?

• "Tsipraleks" ndi zina kupanga serotonin reuptake zoletsa ndi monoamine oxidase.
• Munthawi yomweyo chithandizo ndi zoletsa monoamine oxidase timadzi chithokomiro, "clomipramine", "carbamazepine", "imipramine" ndi "Amitriptyline".
• Mao zoletsa ndi osakaniza zina mankhwala ntchito kuwonda, makamaka "Dezopimona", "fepranona".
• Kuphatikiza ndi SSRI kapena Mao zoletsa kukonzekera okhala L-tryptophan, St. John wa liziwawa Tingafinye ndi chisangalalo.
• Kuphatikiza lifiyamu ndi mankhwala antidepressant, makamaka "Kontemnola" ndi "Kviloniuma".
• Munthawi yomweyo phwando zoletsa ndi dextromethorphan (zinthu zimene zimapezeka mu mankhwala ambiri a chifuwa, kuphatikizapo "Kaffetin Cold", "Glikodin", "Tussin Plus" ndi ena.
• Kuphatikiza zoletsa serotonin reuptake ndi mankhwala monga "dihydroergotamine", "sumatriptan" (migraine mankhwala), "Levodopa" (ntchito matenda Parkinson).
• Pali umboni kuti serotonin syndrome kumachitika ndi mowa pa maziko a mankhwala antidepressant.

Pomwepo ndi ofunika mawu amene amaneneratu ngati kukhala syndrome pa maziko a Kusankhidwa mankhwala dokotala, ndi zosatheka. Izi zidalira pa mlingo wa mankhwala, makhalidwe munthu wodwala, m'badwo wake ndi zinthu zina zambiri. Komabe, ngati muli Kwalamulidwa antidepressants, onetsetsani kuti auzeni adokotala za mankhwala onse mukutenga ndipo onetsetsani kukaonana pa oyamba a chiwembu latsopano la mankhwala, kaya ngakhale wabwinobwino otsekemera.

Makhalidwe yaikulu ya chithunzi matenda

Kodi syndrome serotonin? Zizindikiro za theka la milandu kuonekera patatha maola 2-4 pambuyo ingestion. Koma zizindikiro poyamba angaoneke ndi tsiku. Mogwirizana ndi ntchito yaikulu ya serotonin, kuyan'anila n'kotheka anawagawa m'magulu atatu akulu akulu:

• mavuto a m'maganizo;
• mavuto minofu ndi zotumphukira machitidwe wamanjenje;
• matenda autonomic.

Onse zizindikiro zotheka ali pansipa, koma choyamba ziyenera ananena kuti infringements zosiyanasiyana si maziko osiyana chiphunzitso cha matenda amenewa. Only wathunthu thupi bwinobwino maphunziro zasayansi, ndipo ali mu zizindikiro zina ndi zotheka mfundo zoopsa n'zotheka kuti matenda a serotonin owonjezera mu zimakhala mitsempha.

mavuto a m'maganizo pamaziko a matendawa

Kodi kuzindikira serotonin syndrome? Zizindikiro kawirikawiri mumayamba ndi mavuto a m'maganizo, kuphatikizapo:

• maganizo chilakolako chogonana;
• osadziŵika, causeless mantha ndi nkhawa, nthawi zina mpaka kuukira mantha;
• zina pali chithunzi china - munthu amasangalala chifukwa euphoria, chimwemwe mumtima, kufuna kuyenda, kulankhula mosalekeza ndi kuchita chinachake pa icho;
• zotheka kuwonongeka kwa chikumbumtima;
• Zikavuta kwambiri, pali maonekedwe a zinyengo ndi kuyerekezera zinthu m'maganizo.

Dziwani kuti zizindikiro ndi digiri ya kusalekerera mwachindunji amadalira kusalekerera zotsatira poizoni. Mwachitsanzo, nthawi zina chabe malemeredwe pang'ono zimawonedwa. Nthawi zina pali akuchuluka zizindikiro za matenda amabweretsera (mwachitsanzo, maganizo), chifukwa chimene mankhwala ikupitirira. Mu Zikavuta kwambiri, wodwalayo amadwala disorientation, osokonezeka mu dzikoli ndi zinthu, akudwala zinyengo ndi kuyerekezera zinthu m'maganizo osiyana.

Zizindikiro zazikulu vegetative

Pali zizindikiro zina zimene zigwirizana pamodzi serotonin syndrome. Kuwonongeka kwa nyamuka lakuthwa mu mlingo wa mankhwala akhoza kuyang'ana njira zina. Makamaka anaona ndi autonomic matenda, kuphatikizapo zotsatirazi:

• dilated ana, ndi kuchuluka lacrimation;
• kuwonjezera kugunda kwa mtima, tachycardia;
• kuwonjezera mlingo kupuma;
• zina pali malungo (zambiri, ziri zazing'ono, koma analemba malungo a madigiri 42 odwala ena);
• kuwonjezereka lakuthwa magazi ndi zizindikiro concomitant mpaka imfa ya chikumbumtima;
• maonekedwe a dryness mkamwa ndipo ena nembanemba ena mucous;
• mofulumira m'mimba motility, womwe kungayambitse matenda monga kutsekula m'mimba, kunyansidwa ndi kusanza, flatulence, bloating ndi ululu m'mimba ya osiyanasiyana mwamphamvu;
• kumamverera tsembwe;
• Mutu, nthawi zina mutu waching'alang'ala.

Monga mukuonera, zizindikiro za matenda si yeniyeni, chifukwa zizindikiro zomwezo akhozanso kukopeka ndi matenda ena khumi.

matenda Neuromuscular pa maziko a matendawa

Monga tanenera kale, serotonin nthawi kufala kwa zikhumbo za mitsempha. N'chifukwa chake kusintha mlingo wa mankhwala kumakhudzanso ntchito neuromuscular. Nawu mndandanda wa matenda zotheka:

• kuchuluka mphamvu ya bongo tendon (makamaka kutchulidwa asapatsiridwe nthambi bongo);
• kusintha kwa minofu kamvekedwe ndipo nthawi zina akulu chinthu chimodzimodzi;
• mofulumira ndi musanaganizire spasmodic chidule minofu munthu (nthawi zina magulu lonse minofu);
• kunjenjemera ya nthambi;
• kayendedwe musanaganizire la diso (Mwaichi mankhwala akuti "nystagmus" ntchito);
• zina pali otchedwa diso kuphipha, amene anatsagana ndi pomayenda musanaganizire wa eyeballs mmwamba kapena pansi;
• zina olembedwa kukomoka;
• kusowa kwa mugwirizano;
• mavuto ndi mawu, kuti anangotengeka ndi inaccuracy kuti kumachitika chifukwa cha chidule musanaganizire a minofu ya zida articulation.

Iwo ankadziwa kuti onse zizindikiro pamwamba pa matenda serotonin zimachitika kawirikawiri. Nthawi zambiri, odwala zowawa yekha kwa ena kuyan'anila, ndipo chotero matenda a matenda si njira wolemera.

Mlingo wa kusalekerera matenda

Mu mankhwala amakono lagawidwa madigiri atatu azikhala matendawa, monga:

• matenda osawopsa limodzi, monga ulamuliro, kuchuluka thukuta, kugwedeza mphamvu mu manja ndi mawondo, osati kutchulidwa kuwonjezeka kugunda kwa mtima. Bongo komanso kukhala pang'ono kwambiri, ngakhale thupi kutentha sasefukira. Nthawi zina wodwala akhoza zindikirani mwana dilation. N'zosadabwitsa kuti anthu ndi zizindikiro zofanana kawirikawiri kupita kwa dokotala, ndipo kupitiriza kumwa mankhwala, chifukwa ndi zizindikiro pamwamba akhoza chifukwa cha nkhawa kapena mopambanitsa.
• Mu zolimbitsa matenda chithunzi cha matenda ndi yapadera kwambiri. Odwala anati kuwonjezeka lakuthwa kutentha thupi (nthawi zina 40 madigiri), ndipo magazi, kulimbikira dilation kuwatenga ophunzira, kuchepetsa minofu, galimoto ndi chisangalalo maganizo. Childs, zizindikiro zimenezi kuchititsa munthu kupempha thandizo, koma mwatsoka, kuika matenda zolondola Sizotheka.
• Aakulu serotonin syndrome ndi woopsa kwambiri, chifukwa angathe kuyambitsa mavuto. Mu mawonekedwe a kudwala anaona tachycardia amphamvu, kuthamanga magazi, malungo, spasms minofu mpaka stiffness ndi matenda mantha, disorientation. Odwala zambiri kuona kuyerekezera zinthu m'maganizo omveka kwambiri. Popeza thandizo yake akhoza kuonongeka minofu, chiwindi ndi impso. Nthawi zambiri, odwala kugwera chikomokere. Nthawi anayamba angapo limba kulephera, zomwe kawirikawiri itha imfa.

N'chifukwa chake Mulimonsemo sayenera kunyalanyaza zizindikiro chifukwa akhoza masquerade monga munthu wabwinobwino serotonin syndrome chogwira ntchito mopitirira muyeso. Kodi kutuluka boma, ndipo ngati pali mankhwala ogwira?

thandizo ku boma

Kodi ngati munthu amaganiziridwa serotonin syndrome? chisamaliro Emergency zambiri ndi kutha atangochimwa mankhwala, zomwe zinayambitsa vuto limeneli. Mwachibadwa, muyenera ndithudi kutenga wodwala ku chipatala.

Choyamba chapamimba lavage, kukhala kotheka kuti ayeretse thupi la mankhwala sanabadwe ndi nthawi kuti limbikirani. Ndi cholinga chomwecho, odwala Kwalamulidwa mankhwala ndi sorbents ena deducing poizoni m'thupi. Nthawi ofatsa a zochitika zokwanira anthu kuona bwino. Zizindikiro pansi pambuyo maola 6-12.

Kodi mankhwala a matendawa?

Mwatsoka, vutoli ndibwino ndi kuyeretsa thupi ku zinyalala si nthawi zokwanira. Chotero kodi mankhwala amafuna serotonin syndrome? Mankhwala, kumene, zimadalira siteji ndi kuwuma. Childs, wodwala yoikidwiratu serotonin cholandilira muzikangana, kuphatikizapo "methysergide" ndi "Cyproheptadine". Kuwonjezera pamenepo, popeza symptomatic mankhwala, potsata pamaso pa matenda ena.

• Mwachitsanzo, mu khunyu khunyu ndi minofu chinthu chimodzimodzi mankhwala benzodiazepines, kuphatikizapo "lorazepam" ndi "Sibazon".
• Pamaso pa malungo akutsatiridwa rubdown ozizira ndi ena ndondomeko zina. chakuti kuwuka mu kutentha pamene serotonin syndrome ndi kumphatikiza ndi kutupa, ndi kuchuluka minofu contractility, ndi chifukwa ochiritsira antipyretic ndi nonsteroidal odana ndi yotupa mankhwala ziribe mphamvu. Yekha ndi paracetamol, ngakhale kuti ayenera kugwiritsidwa ntchito mosamala.
• Pamene kutentha limatuluka 40 ndi relaxants minofu kwambiri ndi kutumikiridwa kwa wodwala. Mankhwalawa amathandiza kumasuka minofu, kuthetsa malungo, kupewa chitukuko cha matenda osiyanasiyana, kuphatikizapo mavuto ndi clotting magazi.
• Komanso mtsempha kulowetsedwa maphunziro thukuta kwambiri, kutsegula m'mimba, kuphwanya kwa thupi ndi kuyambitsa madzi m'thupi.
• Komanso, m'pofunika kuti aziona magazi ndiponso kugunda kwa mtima wa wodwalayo, ngati n'koyenera normaliziruya Chiwerengerochi ndi thandizo la mankhwala.

Nthawi zambiri bwino imachitika mankhwala akhoza mofulumira kusintha wodwalayo komanso kupewa zotsatira zake. Mwatsoka, nthawi zina, makamaka ngati wodwala sichinayambe anapereka chithandizo yake, serotonin syndrome zingachititse kuti azingokhala minofu minofu, chiwindi ndi vuto la impso, molekezera mitsempha, ndipo kenako imfa. N'chifukwa chake Mulimonsemo sayenera mopepuka kutenga antidepressants ndi mankhwala ena.