Interstitial nephritis: zizindikiro ndi kuchiza kutupa impso

Interstitsionalny nephritis ndi yotupa matenda a impso, kumene kumachitika makamaka zokhudza minofu wapakatikati ndi tubules impso.

matenda angayambe pa mankhwala mankhwala (mankhwala zambiri, kuti okodzetsa wamng'ono, sulfonamides) komanso atadziŵa tizilombo toyambitsa matenda,, matenda m'thupi. kudwala zachokera lymphohistiocytic kusalola akuchita pa wapakatikati aimpso minofu kuwonongeka zinachitika chapansi nembanemba wa tubules. Mu mawonekedwe maofesi m'thupi ndi autoantibodies kuti Kakhungu mapuloteni. Chifukwa cha edema oziziritsa ndi kutupa wosanjikiza impso minofu ndi psinjika makina Mitsempha ndi tubular, yafupika aimpso magazi, kuchuluka kuthamanga vnutrikanaltsevoy, kenako akufotokozera oliguria.

Pamene matenda a zizindikiro interstitial nephritis ali motere. Isanayambike matenda - ndi pachimake, kudutsa malungo, polyuria, kapena hematuria akufotokozera impso kulephera, pali ululu mu m'munsi kumbuyo. Zizindikiro zoyambirira za mitundu mlingo wa pachimake interstitial nephritis protrude kachiwiri kuwonjezeka thupi kutentha, lomwe likhoza kulumikizidwa ndi eosinophilia ndi khungu kuphulika. Matendawa yodziwika ndi proteinuria zolimbitsa, hematuria, mu nthawi zina, oliguria.

Pachimake interstitial nephritis mitundu tizilombo pamafunika malo malungo hemorrhagic ndi matenda aimpso.

Matenda a matenda wapangidwa ndi matenda a impso, pachimake glomerulonephritis. Ngati osauka impso kulephera Tisawasale zinthu zina.

N'zovuta kwambiri ndipo nthawi zina n'zosatheka kudziwa chifukwa cha matenda tubulointerstitial nephritis kugwirizana ndi kukhudzana mankhwala, tizilombo toyambitsa matenda m'thupi.

Zizindikiro za aakulu interstitial nephritis zigwirizana matenda tubular, mwamsanga osauka amadzimadzi electrolyte chisokonezo (hyperkalemia, acidosis) Nkhanza ndende impso. Nthawi zina, nkotheka oopsa ndi proteinuria. Mu zochitika muyezo nephrotic syndrome kwina, koma ngati kupitilira matenda interstitial nephritis pafupifupi neolichim wa glomerulonephritis. The mankhwala owopsa, zikubweretsa mawonekedwe aakulu a matenda ndi analgesics phenacetin, analgin, aspirin.

Nthawizina akazi zaka 35-40 zakubadwa, migraine, maganizo, zilonda zam'mimba, anati analgesic interstitial nephritis. Mu kuphatikiza lililonse ndi aseptic leukocyturia kugonjetsedwa nkhani aimpso colic ndi hematuria aakulu, aimpso kuchepetsa kukula, polyuria, magazi m'thupi.

Matendawa akufotokozera molumikizana ndi matenda ena, ndi bwino m'thupi pathogenesis (yogwira aakulu chiwindi, lupus zokhudza zonse lupus erythematosus).

Interstitial nephritis ana tingathe kukulitsa pa minofu dizembriogeneza aimpso, mkodzo thirakiti anomalies, kuyan'anila za asidi uric ndi calcium oxalate kagayidwe.

Pofuna matenda ntchito mankhwala etiological a zotupa bakiteriya anayamba kuthetsa cholinga cha matenda. Pamene mlingo mawonekedwe - kusiya kumwa mankhwala, mankhwala ndi zakudya olemera ndi mavitamini ndi mowa. Popeza zotsatira zabwino Kwalamulidwa glucocorticoids kuchita hemodialysis, nadzatonza ntchito okodzetsa mu chitukuko cha kulephera pachimake aimpso. M'pofunikanso kupewa kugwiritsa ntchito kwambiri analgesics ndi kumwa kwambiri.