Kukonzekera "Divigel": ndemanga, kufotokoza, ntchito

Gel transdermal ntchito "Divigel", zomwe zowonongeka ndizochuluka kwambiri, ndi mankhwala odana ndi mankhwala omwe amachititsa kuti zizindikiro za kusowa kwa estrogen kwakukulu. Mwachidziwitso, ndiyo njira yothandizira kupititsa patsogolo mahomoni, chifukwa chogwiritsiridwa ntchito kake - mankhwala opangidwa ndi estradiol - ndi amachimake ndipo amakhala ofanana kwambiri ndi mahomoni a chilengedwe.

Mankhwalawa "Divigel", omwe ma ndemanga amatsitsimutsa kwambiri, amathandiza kwambiri pa nthawi yayitali kapena chithandizo chamakono cha amayi pa nthawi ya msambo. Chifukwa cha kuchepa kwa maselo a estrogen mu gawo lino, zovuta zina za thupi zimawonetseredwa, zimawonetsedwa ndi vuto la kugona, kusasinthasintha kwapang'onopang'ono, kupweteka kwapang'onopang'ono kwa machitidwe oyambitsa matenda komanso kufooka kwa msana. Kukhala ndi mphamvu zambiri, zofanana kwambiri ndi zochita za mahomoni achilengedwe, ndi kulimbikitsa chitukuko cha vaginja, mazira ndi chiberekero, kukonzekera "Divigel" (ndemanga izi zimatsimikiziranso) kumathetsa kwathunthu kapena kuchepetsa kwambiri chizindikiro ichi.

Ma pharmodynamics a gel iyi ndi motere. M'maselo omwe ntchito yokonzekera "Divigel" imayendetsedwa, kupanga maselo amadzimadzi amalowa mu chigwirizano cha mankhwala ndi mapulogalamu enaake, kupanga mapangidwe a receptor-ligand ndikugwirizanitsa ndi zigawo za estrogen-effector za genome, komanso ndi mapuloteni apadera opangidwa ndi mavitamini. Izi zimayambitsa kukopera kwa i-RNA kaphatikizidwe ndi kumasulidwa kwa mitundu yosiyanasiyana ya cytokines.

Choncho, transdermal "Divigel" imayambitsa kukana kwam'tsogolo kwa endometrium ndi kuyeretsa nthawi zonse. Mankhwala ambiri angathandize kuti chitukuko cha endometrial hyperplasia chizikulirakulira, kuponderezedwa kwa lactation , kuchepetsa kupuma kwa mafupa, ndipo kumapangitsa kuti mapuloteni ena aziyenda bwino (thyroxin-binding globulin, transcortin, transferrin).

Kugwiritsira ntchito kwa "Divigel" (ndemanga zimatsimikizira izi) mwachiwonekere sichikhala ndi zotsatira zotere monga kuwonjezeka kwa kuthamanga kwa magazi. Izi, ndithudi, ndizopindulitsa kwambiri poyerekeza ndi mitundu yosiyanasiyana ya isradiol yomwe imamwa mankhwala.

Ntchito ya transdermal "Divigel" yomwe imapezeka ndi IVF imayesedwa ngati ikufunika kuti ikhale yoyenera ya estradiol. Mlingo uli wofunikira payekha ndipo umatsimikiziridwa ndi akatswiri a kuchipatala komwe njirayi ikuchitika. Maphunziro a zachipatala za kukonzekera "Divigel" adatsimikiza kuti zimakhala bwanji mogwirizana ndi mankhwala ena. Choncho, zinadziwika kuti mankhwala ake amathandiza kuchepetsa mphamvu ya antihypertensive, antidiabetic mankhwala ndi anticoagulants. Kugwiritsira ntchito mankhwalawa ndi kukonzekera komweko komwe kumakhala ndi tizilombo toyambitsa matenda komanso tizilombo toyambitsa matenda (carbitzepine, "griseofulvin", "rifampicin" ndi ena), akhoza kuchepetsa kuchepa kwa estradiol m'magazi a magazi.

Njira yothandizira ndi mankhwala "Divigel", mtengo umene uli wochepa kwambiri, uyenera kutsatiridwa ndi mayeso ozolowereka. Dokotala amatsimikizira nthawi ndi njira zomwe zimagwiritsidwa ntchito mogwirizana ndi zosowa za munthu aliyense payekha. Koma, monga lamulo, mamemografia amalembedwa mu milandu yambiri.

Monga momwe malangizo akunenera, mankhwala "Divigel" ali ndi zotsutsana. Makamaka, amapezeka kapena akudzidzimutsa pa chiphunzitso cha mammary gland, ziwalo zoberekera za ziwalo zoberekera (uterine myoma, chiberekero, vulvar, ovarian, etc.), endometrial hyperplasia, matenda osokoneza bongo, matenda a chizungu, chiwindi , chiwindi Kufalikira kwa ubongo, matenda a shuga ndi matenda ena. Choncho, mutengere mankhwalawa muyenera kuuzidwa ndi dokotala komanso muyezo woyenera.