Prednisolone: malangizo ntchito, katundu pharmacological

Kumasulidwa mawonekedwe "Prednisolone" mankhwala: zofewa mitundu mankhwala - mafuta.

Farmsvoystva

Prednisolone ndi analogue dehydrogenated wa hydrocortisone. Antiallergic, antiinflammatory, antiexudative ndi antipruritic zotsatira pamene ntchito timitu mafuta "prednisolone" malangizo zimayambitsa kuchepa mu mapangidwe, kumasuka ndi ntchito kutupa owayimira (kinin, ndi histamine, michere lysosomal, prostaglandins). Komanso imathetsa selo kusamuka kwa yotupa panayambira amachepetsa vasodilation ndi kuchuluka mtima permeability kuti amapezeka kutupa. Kuchepetsa exudation ndi chifukwa vasoconstrictor kanthu za "Prednisolone" mankhwala. Buku limasonyeza kuti mankhwala ndi zotsatira immunosuppressive ndi inhibiting ntchito ya zovuta Antigen-oteteza ndi wambirimbiri pa Mitsempha ndipo chifukwa cha matupi awo sagwirizana vasculitis. Mankhwala kumabwezera mmbuyo ntchito ya macrophages, cytokines, maselo chandamale amene amayambitsa chitukuko cha matupi awo sagwirizana anachita mtundu opatsirana dermatitis. Choncho kupatsa T-lymphocytes ndi macrophages simungapeze mwayi maselo chandamale.

Pharmacokinetics

Pamene ntchito mafuta "Prednisolone" odzipereka ndi mankhwala yogwira ali m'magazi. Mu madzi a m'magazi prednisolone mbali ndi ofanana ndi albumin ndi transcortin. Biotransformation prednisolone amapezeka ndi makutidwe ndi okosijeni, makamaka chiwindi, kumene glucuronidation kapena sulfation amapezeka mitundu oxidized. Mu mawonekedwe a metabolites excreted mu mkodzo ndi ndowe, gawo - mu chigawo unmodified. Prednisolone umadutsa chotchinga placental mu woipa laling'ono, angapezeke mu mkaka wa m'mawere wa amayi.

Prednisolone: umboni

mankhwala ntchito milandu:

- matupi awo sagwirizana ndi irritant kukhudzana dermatitis,

- chikanga,

- atopic dermatitis,

- seborrheic dermatitis,

- psoriasis.

Prednisolone: malangizo

mafutawo umagwiritsidwa ntchito pa chilonda malo wogawana nthawi 1-3 / tsiku. Nthawi chithandizo amayamba ndi chikhalidwe cha matenda ndi zambiri kumatenga masiku 8-14. Mafuta mu mankhwala a ana nthawi ya mankhwala ayenera kuchepetsedwa kwa masiku 3-7, chifukwa thupi la mwanayo ndi womvera mankhwala "Prednisolone". Malangizo akuonetsa kusiya kutentha, kukhazikitsa ndi Mavalidwe occlusive.

Features ya ntchito

Kutalika kwa mankhwala ndi mafuta sayenera masiku opitirira 14 akulepheretseni chingachitike mbali kugwiritsa ntchito "Prednisolone" mankhwala. Malangizo n'kukulemberani kuchitira kokha moyang'aniridwa ndi achipatala.

zotsatira zoyipazi

Kawirikawiri mankhwala bwino analekerera. Kawirikawiri, makamaka ntchito kwa nthawi yaitali, mwina kuyambitsa kuyabwa, moto kutengeka, erythema. Odwala ena mavuto akhoza kusonyeza kuti folliculitis, hypertrichosis, perioral dermatitis, thupi lawo siligwirizana ndi zigawo mankhwala. Zizindikiro pamwambapa popanda chithandizo mwamsanga kuchotsedwa pa kuchotsa ntchito mankhwala. Tiyenera kukumbukira kuti ntchito ya mafuta wonunkhira bwino kuti khungu akhudzidwa ndi ntchito nthawi yaitali (makamaka kugonjetsedwa kwa malo akulu a pakhungu) angaoneke mphamvu ya chikhalidwe zokhudza zonse.

Mwanjira ndi mankhwala ena

Prednisolone ali chuma polimbikitsa anticoagulant zotsatira za anticoagulants. Izo kumawonjezera kuthekera kwa magazi tikadwala salicylates. Iwo kumachititsa matenda electrolyte kagayidwe yoyang'anira concomitant wa okodzetsa. Pali chiopsezo kukula kwa kawopsedwe ntchito glycosides mtima. Utachepa hypoglycemic antidiabetic zotsatira ndipo amachepetsa ntchito antibacterial wa rifampicin. Osavomerezeka ntchito molumikizana ndi Mankhwalawa ayenera kumwedwa.

contraindications

Chithandizo "Prednisolone" mafuta malangizo zomangidwa:

- hypersensitivity;

- bakiteriya, tizilombo, mafangasi zotupa;

- chifuwa chachikulu, chindoko, zotupa pa khungu, mimba, wamba ziphuphu zakumaso ndi pinki ziphuphu zakumaso.

ambiri osokoneza

Nthawi cha mankhwala osokoneza bongo sakudziwika.

zinthu yosungirako

Anapulumutsidwa pa mndandanda B, pa 5-15ºS. Alumali moyo - zaka 2. Atapita moyo alumali kugwiritsa ntchito.

zinthu kotunga

Mankhwala.