Allopurinol, malangizo a zizindikiro, zowonongeka, zotsatirapo ndi zotsutsana

"Allopurinol", malangizo amasonyeza, kumasulidwa ngati mapiritsi a 100 mg. Mankhwalawa amatanthauza mankhwala osokoneza bongo, omwe amaletsa kusakaniza kwa uric acid. Malinga ndi chikhalidwecho, "Allopurinol" ndi analogi ya hypoxanthin, yomwe imalepheretsa muyeso wambiri, umene umayambitsa kupanga uric acid. Mankhwalawa "Allopurinol", ndemanga zimatsimikizira izi, zimakhudza kusungunuka kwa mchere wamchere, kutha kwa mapangidwe awo m'thupi ndi impso.

"Allopurinol", malangizo kwa zizindikiro

Mankhwalawa akulamulidwa:
Pofuna kupewa, kuchiza gout ndi hyperuricemia (kuphatikizapo kuphwanya kwa impso), matenda a nephrolithiasis, urate nephropathy;
Ndi mitsempha ya oxalate-calcium pamodzi ndi hyperuricosuria;
Pamwamba pamtundu wa urate, wopangidwa chifukwa cha matenda a enzymatic;
Pofuna kupewa nthepropathy yovuta m'nthawi ya cytostatic, mankhwala ochizira poizoni a chifuwa ndi khansa ya m'magazi;
Pa njala yachipatala.

"Allopurinol", malangizo a dosing

Dokotala amayika mlingo wa mankhwala payekha, malingana ndi
Mlingo wa urate umapezeka m'magazi ndi mkodzo, komanso uric acid. Akuluakulu amapatsidwa 100 mg ya "Allopurinol" mpaka 900 mg pa tsiku. Mlingo wa tsiku ndi tsiku uzigawidwa mu 2-4 kulowetsedwa. Matabwa ayenera kutengedwa pambuyo pa chakudya.
Kwa ana osapitirira zaka 15, mlingo wa mankhwala tsiku ndi tsiku ukuwerengedwa molondola 10-20 mg pa 1 makilogalamu a kulemera kwake kwa mwana kapena kuperekedwa kwa 100 mg ya "Allopurinol" mpaka 400 mg.

Mlingo waukulu kwa odwala omwe ali ndi vuto lopwetekedwa ndi nkhumba ndi 100 mg. Dokotala akhoza kuonjezera mlingo ngati, pambuyo pa chithandizo chamankhwala, chiwerengero cha mitsempha yapamwamba yopezeka m'magazi ndi mkodzo sichikhala chosasinthika.

"Allopurinol", malangizo othandiza

Nthawi zina, panali zolakwa m'maganizo a mtima, omwe anawonetseredwa ndi matenda oopsa kwambiri, a bradycardia.
Pakhoza kukhala zosokoneza mu dongosolo lakumadya, limene likuwonetseredwa:
Nsowa, kusanza, kutsegula m'mimba, kuwonjezeka kwanthawi yayitali mu ntchito ya transaminases yomwe imapezeka mu seramu ya magazi;
Kuchepa kwa chiwindi, kutayirira kwa chiwindi;
Stomatitis (mwa odwala okha);
Steatoriey.

Nthawi zina, mankhwala a "Allopurinol" amachititsa kuti matenda asokonezeke, omwe amawonetseredwa:
Zofooka, kuwonjezeka kutopa, kupweteka mutu, chizungulire;
Ataxia, kugona, kupanikizika;
Coma, paresis, paresthesia;
Kusokonezeka, matenda a ubongo;
Kuonongeka kowonetsa; Cataract;
Kusintha kwa mapangidwe a papilla a mitsempha ya optic;
Osalaba kukoma mtima.
Kawirikawiri panalibe zolakwika m'ntchito ya hematopoiesis, yomwe inkawonetsedwa ndi thrombocytopenia, agranulocytosis ndi aplastic anemia, leukopenia (gulu loopsya limaphatikizapo odwala omwe ali ndi vuto losagwidwa ndi nkhanza).

Pakhoza kukhala zosavuta mu dongosolo la mkodzo, zomwe sizikhala zosiyana pakati pa nephritis; Odwala amodzi - edema, uremia, hematuria.

Kusokonezeka kwa dongosolo la endocrine kumawonetsedwa m'matenda amodzi mwa kusabereka, kusowa mphamvu, gynecomastia, shuga ya matenda.
Matendawa amadziwoneka m'madera ochepa a hyperlipidemia.
Zomwe zimawoneka ngati zowonongeka kapena zowonjezera.

"Allopurinol", malangizo othandizira kutsutsana

Simungathe kulamula mankhwalawa:
Ndi kuphwanya m'chiwindi, impso;
Pakati pa mimba ndi lactation;
Ndikumvetsetsa kwambiri kwa "Allopurinol".

Kuchita zamankhwala, ana osakwana zaka 12, "Allopurinol" amangolembera okha mankhwala opatsirana, omwe ali ndi khansa ya m'magazi, monga matenda a enzymatic, mwachitsanzo, matenda a Lesch-Nichin.