Antiplatelet wothandizila: mndandanda wa mankhwala. Anticoagulants ndi wothandizila antiplatelet, makhalidwe awo

Chulukitsani magazi zimayambitsa thrombosis, imbaenda mavuto aakulu, kuphatikizapo imfa. Mankhwala patsogolo kulola kupulumutsa miyoyo ya odwala matendawa chifukwa mankhwala yokonza monga kulandira mankhwala antiplatelet.

Kodi anticoagulants?

Rheological katundu magazi phe, kapena coagulation ndi anticoagulation kachitidwe. Mu chingakuthandizeni ichi monga anticoagulant zachilengedwe nawo antithrombin III ndi heparin, amene umagwira ntchito mwachindunji antithrombotic ntchito, kuti, kuteteza mapangidwe magazi aumirira. Limagwirira cha zochita za masika amagwirizana kupanga zovuta ndi antithrombin III, chifukwa mu mapangidwe ndi antithrombin yogwira. Nayenso, ndi udindo kumangidwa kwa thrombin, kupanga izo anafooka - izo kumathandiza kuti chopinga wa thrombus mapangidwe. Antithrombin III nayenso ali katundu anticoagulant ndi inactivating thrombin Komabe, zimene atuluka pang'onopang'ono.

Luso heparin kuonetsetsa inactivation wa thrombin zimadalira kuchuluka kwa antithrombin III m'magazi. kusintha chofunika mlingo chofunika zochokera kuwunika. Nthawi zambiri amafuna poika mankhwala ziwiri nthawi imodzi - heparin ndi antithrombin III, pa mlingo chomwecho amasankhidwa payekha munthu aliyense.

KUMANGA kuti antithrombin - osati ntchito zokha wa heparin. Komanso, iye ali wokhoza kuswa pansi Ulimbo popanda nawo plasmin, amatchedwa sanali enzymatic lysis. Zimenezi ndi mapangidwe mankhwala ndi ntchito zosiyanasiyana za zinthu biologically yogwira, kuphatikizapo mapeputisayidi timadzi. Mwa zina kusiyanitsa ndi yimitsira angapo a michere nawo ndondomeko yotupa (kumachepetsa mwamphamvu ake), komanso kutsegula kwa lipoprotein lipase ndi kusintha otaya magazi mu zotengera mtima.

ndi wothandizila antiplatelet chiyani?

Kukonzekera anticoagulants ndi wothandizila antiplatelet ali bwino ntchito mankhwala. dzina analandira ndalama, amene ziletsa kulumikiza (loitanirana) maselo magazi - maselo ofiira ndi maselo othandiza magazi kuundana. Limagwirira cha zochita za zinthu izi ndi zosiyana, zomwe analola magulu angapo. Antiplatelet wothandizira, mndandanda wa mankhwala amene ali m'magulu motere.

1. muzikangana kashiamu ( "Verapamil").
2. Puloteni zoletsa, kuphatikizapo zinthu kubisa cyclooxygenase (asidi acetylsalicylic, "naproxen", "Indomethacin") ndi adenylate cyclase ndi phosphodiesterase ( "Ticlopidine", "Pentoxifylline").
3. Mankhwala yotithandiza mapangidwe prostacyclin ( "pirazolinov").
4. Prostanoids ( "Prostacyclin" ndi analogues ake chiyambi kupanga).
5. Mankhwala kuti akathetse kumaliseche zinthu zili othandiza magazi kuundana ( "Pyracetam").

umboni

Antiplatelet mankhwala - mankhwala maina ambiri adziwe chifukwa ntchito lonse. The Ntchito yaikulu ya gulu - pa prophylaxis thrombosis. Antiplatelet mankhwala - mankhwala bwino ntchito angapo pathologies mtima, komanso pambuyo opaleshoni (mavavu apulasitiki mtima).

Antiplatelet wothandizila: mndandanda wa mankhwala amene amagwiritsidwa kwambiri yochizira matenda

Mankhwala a gulu ili, ndithu kwambiri, ndipo iwo onse ndi peculiarities awo. Kusankha mankhwala ndi zimatengera pa nkhani matenda. Ndipo, ndithudi, kudzikonda mankhwala imeneyi ndi zosayenera.

"Aspirin"

Mu lamulo la eicosanoids hemostasis amatanganidwa opangidwa wa makutidwe ndi okosijeni asidi arachidonic. Pakati wofunika kwambiri thromboxane A2, ndipo ntchito yake yaikulu - kuonetsetsa kupatsidwa zinthu za m'mwazi loitanirana. Kachitidwe wa aspirin walangizidwa chopinga wa enzyme ndi, wotchedwa cyclooxygenase. Chifukwa cha kaphatikizidwe izi kuletsedwa tomboksana A2 Choncho imathetsa thrombus njira mapangidwe. Zotsatira kumawonjezera pamene adzathe kutenga mankhwala chifukwa kudzikundikira. Kwa chopinga wathunthu wa cyclooxygenase chofunika kudya tsiku ndi tsiku. Mlingo akadakwanitsira amachepetsa imabwera zotsatira zoyipazi, "Aspirin" ngakhale ndi zones. Mlingowu escalation liri losayenera, popeza pali chiopsezo cha matenda oyamba magazi.

"Ticlopidine"

mankhwala zochokera kutsekereza maselo ena kuti ali ndi udindo magazi kuundana. Mwachibadwa, pamene inu akulumikiza iwo pali kusintha ADP kupatsidwa zinthu za m'mwazi loitanirana analimbikitsa ndi mphako, ndi "Ticlopidine" kumabwezera mmbuyo ntchito imeneyi. Nkhani ina nthumwi antiplatelet ndi bioavailability wa Kumwambamwamba, amene zimatheka ndi liwilo suction. Pambuyo achotse zotsatira zimawonedwa ngakhale masiku 3-5. The drawback ndi kuchuluka kwa mavuto, kuphatikizapo nseru wamba, kutsekula m'mimba, magazi m'thupi ndi agranulocytosis.

"Clopidogrel"

wothandizila Antiplatelet malinga ndi mtundu wa ntchito ngati zikufanana ndi "ticlopidine", koma ubwino wake ndi wotsika kawopsedwe. Kuwonjezera pamenepo, ngozi za zotsatira zoyipa pamene mukumwa mankhwala kwambiri m'munsi. Panopa akatswiri kupereka mmalo "clopidogrel" chifukwa pakalibe mavuto monga agranulocytosis ndi thrombocytopenia.

"Eptifibatide"

Mankhwala amapereka loitanirana ndi kutsekereza glycoprotein, limene lili mu Kakhungu kupatsidwa zinthu za m'mwazi. Tapatsidwa bolus mtsempha, kawirikawiri mu angina ndi angioplasty kuchepetsa mosavuta infarction m'mnyewa wamtima.

"Dipyridamole"

Zotsatira waukulu wa mankhwala - yozungulira vasodilatation, mwachitsanzo kukula kwa mitsempha, koma anasonyeza antiplatelet zotsatira zimawonedwa pamene pamodzi ndi mankhwala ena. "Dipyridamole" anapangana ndi "ndi aspirin," ngati pali chiopsezo magazi kuundana. N'zothekanso kuphatikiza ndi "warfarin", amene bwino ntchito pambuyo valavu apulasitiki mtima kuchepetsa mosavuta embolisms. Mu monotherapy zotsatira sichidziwika kutchulidwa.

Antiplatelet mankhwala - mankhwala (mndandanda: "Elikvis", "clopidogrel" ndi ena), chimagwiritsidwa ntchito mchitidwe.

contraindications

Kusankha mankhwala antiplatelet amafuna mbiri mosamala, womwenso mudziwe comorbidity. Pamaso pa matenda kuti ndi contraindication kulandira mankhwala mu gulu ili, kuwukonza dongosolo mankhwala. Zikatero, kusankha mankhwala munthu ndi Mlingo wawo ndi mankhwala ikuchitika moyang'aniridwa okhwima zachipatala. Palibe adzakhala mkumano osadalira pa nthumwi antiplatelet, chifukwa zotsatira zake zingakhale zoopsa.

Mndandanda wa contraindications:

• chifuwa;
• hemorrhagic diathesis;
• kutenga magazi;
• aakulu chiwindi ndi impso insufficiency;
• Mbiri ya arrhythmia;
• oopsa, aakulu;
• matenda obstructive a dongosolo kupuma;
• zaka ana (zopangidwa kwambiri).

Komanso, ambiri wothandizila antiplatelet (mndandanda wa katundu kuwunikira m'nkhani ino) ali contraindicated pa mimba ndi mkaka wa m'mawere. Nthawi imeneyi, ayenera ankakonda mankhwala ndi bwino kuti mwanayo ndi mayi.

Antiplatelet wothandizira. Mankhwala: mndandanda wa mimba

Ngati inu akuphwanya yoopsa makope chiopsezo mimba. zodabwitsazi amatchedwa fetoplacental insufficiency. Ngati inu akuphwanya yobereka mpweya kwa mwazi wa mwana wosabadwayo osauka hypoxia kwambiri, amene agonjetsa osati chakuti chitukuko, komanso imfa. Pamene Kupeza Vuto ndi kudwala amafuna chithandizo mwamsanga, chomwe akulitse magazi, kuchepetsa magazi kukhuthala. Pakuti ichi ndipo anasankha wothandizila antiplatelet Komabe, dziŵani kuti si mankhwala onse gulu ili ndi otetezeka pa mimba. Zotheka kugwiritsa ntchito kokha ena ndalama.

"Kurantil"

Mankhwala chotchuka kwambiri chifukwa chakuti mu mndandanda wake wa contraindications palibe mimba ndi yoyamwitsa. Yogwira pophika "chimes" - kale anafotokoza dipyridamole, amene dilates Mitsempha ndi kumabwezera mmbuyo thrombus mapangidwe. Amathandizanso m'mnyewa wamtima magazi, kuonetsetsa yobereka kuchuluka ofunikira oxygen. Mu njira iyi, K "Urantia" angagwiritsidwe ntchito pamaso pa matenda a mtima mwa amayi apakati. Komabe, umboni waukulu pakati ndi placentofetal kulephera. Mwa kuwongolera katundu rheological magazi ndi vasodilatation, kupewa clogging ziwiya latuluka, kotero wosabadwa sikuti amadwala hypoxia. A mwayi winanso wa mankhwala angatchedwe zotsatira immunomodulating. Mankhwala kumapangitsa yopanga interferon, potero kuchepetsa chiopsezo cha matenda enaake a mayi. Ngakhale "Kurantil" ndipo angagwiritsidwe ntchito pa mimba ndi mkaka wa m'mawere, koma ayenera mankhwala ngati anasonyeza. Ngakhale kutenga mankhwala ayenera kuchepetsa kumwa tiyi ndi khofi monga kuchepa nchito zake. Antiplatelet mankhwala - mankhwala (mndandanda pamwamba) kuti sayenera pamodzi ndi chakumwa amenewa. Ngakhale kutenga mimba si anawalangiza kuti agonane njira iliyonse.

wothandizila Antiplatelet, mndandanda wa mankhwala womwenso ambiri maina, ntchito bwino mankhwala a matenda a dongosolo mtima. Komabe, kudziwa mavuto amene angakumane nawo utachepa magazi kukhuthala ndi clotting chopinga. Antiplatelet mankhwala - mankhwala akhoza kugwiritsidwa ntchito kuyang'aniridwa ndi dokotala nawo, iye adzatola mlingo koyenera ndi njira mankhwala.