Azafen 'wodetsa nkhaŵa', malangizo othandizira, zotsatira

Mankhwalawa "Azafen" ndi a gulu la tricyclic mankhwala oponderezedwa. Icho chiri ndi chokwezera chokwanira, chotsutsa-nkhanza ndi nkhawa. Mankhwalawa amagwiritsidwa ntchito kwambiri pofuna kuchiza matenda ovutika maganizo, monga:

- osasamala;

- asthenodepression;

- wosadziwika;

- chidakwa;

- nkhawa;

- imati panthawi ya chikhalidwe chachilendo.

Thupi lopangitsa mankhwalawa "Azafen" limatchedwa pipofezin. Njira yogwiritsira ntchito mankhwalawa imachokera ku chiletso cha norepinephrine ndi serotonin. Izi zimabweretsa kuwonjezereka kwa pipophezin m'katikati mwa mitsempha ya m'mitsempha komanso zizindikiro za kuvutika maganizo.

Pali ubwino umodzi pa mankhwala omwewa omwe amachititsa kuti mankhwala a "Azafen" asokonezeke maganizo. Palinso zotsatira zabwino za mankhwalawa "Azafen" pa matenda opatsirana, kufooketsa matenda osokoneza maganizo, okhudza maganizo ndi odwala omwe amawoneka ndi kuvutika maganizo. Kuchita bwino kwa mankhwala "Azafen" malangizo ogwiritsira ntchito amagwiritsa ntchito asthenia yomwe imapezeka chifukwa cha zovuta zina za munthu psyche. Panthawi ya chithandizo cha mankhwala, kumverera kwa nkhawa ndi nkhawa zimatha odwala. Pali mphamvu zowonjezera kwa odwala omwe ali ndi matenda obwera chifukwa cha mitsempha ya m'mimba, kugona kumakhala kozolowereka komanso kugona kumatha masana.

Mankhwala "Azafen", omwe amagwiritsidwa ntchito ndi mankhwala a pharmacokinetic, amawoneka bwino kwambiri, amatha kupyolera m'mimba, ndipo amakhala ndi 80%, omwe amapezeka m'magazi amatha kufika maola awiri. Mu chiwindi, biotransformation ya pipofepine imapezeka m'ma metabolite omwe sagwiritsidwe ntchito, omwe amawotchedwa makamaka ndi impso. Kutulutsidwa kwathunthu kwa thupi kuchokera ku mankhwala kumachitika patapita maora 16.

Kuchiza kwa zizindikiro za mitundu yosiyanasiyana ya majeremusi ndi chizindikiro chofunikira cha kugwiritsa ntchito mankhwalawa "Azafen", malangizo othandizira amagwiritsira ntchito ndondomeko izi, kutchula mitundu yonse ya zovuta, malinga ndi ntchito ya mankhwala.

Pali zotsutsana zokhudzana ndi kugwiritsidwa ntchito kwa "Azafen" wodetsa nkhaŵa, malangizo othandizira amasonyeza zinthu zotsatirazi zomwe sizigwirizana ndi mankhwala:

- shuga;

- kugawana ndi MAO inhibitors ;

- kuthamanga kwa myocardial, mtima wosayenerera, IHD;

- kulephereka kwachinyengo kapena kuchepa;

- matenda opatsirana ofunika kwambiri;

- Matenda atatha kuwonongeka kwa ubongo (pambuyo pa kupwetekedwa);

- Mimba, lactation.

Ziyenera kuchenjera kuti zitha kuchitika zowonongeka panthawi ya kayendetsedwe ka mankhwala, zomwe zimawonetsedwa ndi chizungulire ndi kumutu, kupweteka, kusanza ndi kunyoza. Tsoka ilo, palibe chidziwitso pa chithandizo pakakhala mankhwala osokoneza bongo, muzochitika zoterezi ndizozizindikiro. Kwa funso la kutsutsana, tiyenera kuwonjezera vuto la "Azafen" ndi mowa. Izi ndizo ziganizo ziwiri zomwe zimagwirizana, panthawi yachipatala ndikofunika kupewa kumwa mowa komanso kumwa mankhwala osokoneza bongo.

"Azafen" alibe cholinolytic, choncho, wina sayenera kukana mankhwala ndi mankhwala kwa odwala glaucoma. Kuwonjezera pa kusagwirizana ndi mowa, pali ngozi yogwiritsira ntchito mankhwalawa pamodzi ndi anticoagulants, antihistamines ndi mankhwala onse omwe amachititsa kuti chisokonezo chisokonezeke. Tiyenera kukumbukira kuti kulamulira komweko kwa "Azafen" ndi mankhwala oletsa antiepileptic kumachepetsanso mphamvu zowonjezereka.

"Azafen" imamasulidwa mwatsatanetsatane malinga ndi mankhwala, maulendo apamwamba omwe ali ndi zaka zisanu, ayenera kusungidwa pa tmax 25.