"Clopidogrel": analogues, ntchito, buku, mtengo

Nthawi zina, madokotala mankhwala "Clopidogrel"? Malangizo ntchito, analogs, mawonekedwe kumasulidwa, zikuchokera, mavuto ndi zizindikiro ntchito mankhwalawa Adzaperekedwa mwatsatanetsatane m'nkhani ino. Komanso, mudzaphunzila mtengo wa mankhwala ndi odwala maganizo izo.

mawonekedwe Ndinamasulidwa zikuchokera

inu mukhoza kugula mankhwala "Clopidogrel" ndi thupi lotani? Guide inanena kuti mankhwala adzamasulidwa mu mawonekedwe a mapiritsi, amene TACHIMATA ndi ❖ kuyanika filimu. Mu chithuza uli zidutswa 14, kubanki - 14 kapena 28, mu makatoni mtolo - 1 kapena 2 mbale ndi mankhwala. Waukulu yogwira pophika ndi clopidogrel mu mawonekedwe sulphate wa hydrogen. The zigawo zikuluzikulu wothandiza ali chiphunzitso mankhwala monga lactose anhydrous, mankhwala enaake a stearate, wowuma pregelatinized, hydrogenated Kasitolo mafuta, polyethylene glycol 6000 ndi microcrystalline mapadi. Film ❖ kuyanika, zomwe TACHIMATA piritsi ongokhala titaniyamu dioxide, hypromellose, zotayidwa lacquer (zochokera utoto Ponceau 4 R), ndipo polyethylene glycol 400 ndi 6000 akuyendera medicament 'Clopidogrel' (mtengo adzakhala pansipa) kudzera unyolo drugstores, koma pamaso pa mankhwala.

makhalidwe pharmacological

Mu mankhwala, yafupika kupatsidwa zinthu za m'mwazi loitanirana anachititsa ndi agonists ena. Kumachita mankhwala "Clopidogrel" (malangizo ntchito, mtengo, ndemanga, ndi zambiri zina zothandiza zilipo pa Websites ambiri zachipatala ndi kuperekedwa mu pepala ili) kwa maola awiri, pazipita Mwachangu nkhani kwa masiku 4-7 pansi pa chikhalidwe kulowa 50-100 MG patsiku. zotsatira Antiplatelet kumatenga pakati pa masiku 7 mpaka 10 mu nthawi ya moyo kupatsidwa zinthu za m'mwazi.

Pharmacokinetics

Pambuyo makonzedwe m'kamwa wa mankhwala "Clopidogrel" (75 mg - muyezo mlingo) mofulumira odzipereka kwa mundawo m'mimba, ndi ndende mu gawo madzi magazi kuchuluka pang'ono, koma pambuyo maola 2 nufikira mlingo umene zingadziŵike (0.025 g / L).

Iwo kwambiri zimapukusidwa ndi chiwindi. The metabolite lalikulu ndi wofooka otumphukira asidi ndi carboxylic (pafupifupi 85% zinthu kufalitsidwa plasma likuyamba). The pazipita pafupifupi ndende pambuyo ntchito mobwerezabwereza "clopidogrel" ndi 3 mg / L, izo zingaoneke ola limodzi pambuyo ingestion.

Yogwira chinthu ndi metabolite irreversibly womangidwa kwa mapulotini plasma. Communication amakhalabe losakhutiritsidwa.

Pambuyo makonzedwe m'kamwa mwa 14C-olembedwa kuti "clopidogrel" pafupifupi theka la mlingo pamaoneka pokodza, 46% - pa ndowe maola oposa 120. T1 / 2 wa metabolite chachikulu - maola 8.

Machulukitsidwe metabolite zambiri odwala akafika zaka 75 zakubadwa, izi sizisintha kupatsidwa zinthu za m'mwazi loitanirana ndi nthawi magazi.

The madzi a m'magazi mu ndende aakulu impso wa metabolite ndi 5 mpaka 15 ml / Mph, koma pamene matenda pafupifupi azikhala ndi 30-60. Ngakhale kuti zotsatira ochepetsera odwala ndi adenosine diphosphate - anachititsa kupatsidwa zinthu za m'mwazi loitanirana anachepetsedwa, chinawonjezeka magazi nthawi, komanso odzipereka wathanzi.

umboni

Kodi mukudziwa chifukwa chimene zolinga dokotala zotchulidwa ndi mankhwala odwala monga "Clopidogrel"? Analogs, ndipo iye anasankha medicament kwa kupewa mavuto thrombotic a sitiroko ischemic, m'mnyewa wamtima infarction ndi zotumphukira wolumikizira matenda occlusive. Munthawi yomweyo chithandizo acid acetylsalicylic ndi "clopidogrel" monga momwe kupewa mavuto thrombotic, amene anakhala chifukwa cha matenda pachimake inatsekeratu.

contraindications

'Clopidogrel' (mtengo mu pharmacies Moscow dera ndi m'ma 510 rubles) kutsatira kauntala ndi:

• hypersensitivity;
• pachimake magazi;
• haemorrhagic matenda ;
• aakulu kwa chiwindi kuwonongeka;
• kutsanulidwa intracranial kudwala ndipo zinanso kwa chitukuko cha magazi (m'mapapo chotupa exacerbation wa chilonda zilonda, hyperfibrinolysis, TB);
• lactose akusowa (likamanena mlingo munali shuga mkaka), kumtundu galactose tsankho, malabsorption syndrome shuga-galactose.

"Clopidogrel": ntchito ndi mlingo

Miyalayo malinga ndi malangizo, angathe kumwedwa kaya chakudya. Pakuti kupewa zochitika thrombotic odwala ndi sitiroko ischemic kapena m'mnyewa wamtima infarction, madokotala mankhwala tsiku lililonse "Clopidogrel" 75 mg. Mu matenda pachimake, omwe chifukwa cha chitukuko cha focal ischemic necrosis a minofu mtima, mankhwala ayenera anayamba kwa masiku oyambirira. mankhwala ntchito "Clopidogrel" - palibe masiku oposa 35. Odwala sitiroko ischemic akhoza kumwa mankhwalawa kwa miyezi sikisi. Pamene mavuto thrombotic akuwuka pakati ACS popanda kutukula cha ku Switzerland gawo, chithandizo amasankha ndi kulandira disposable Mumakonda mlingo (300 mg), ndi zina satenga piritsi oposa mmodzi patsiku. Zolemba malire Mwachangu zimawonedwa itapita miyezi itatu. Kutalika kwa mankhwala ndi 'Clopidogrel' (analogs ndi generics anapereka m'munsimu) sayenera upambana chaka chimodzi. Against maziko a syndrome pachimake inatsekeratu ndi cha ku Switzerland gawo okwera zambiri zotchulidwa 75 mg wa mankhwala tsiku ndi tsiku ndi koyamba limodzi ntchito kwa nthawi Mumakonda mlingo osakaniza ndi wothandizila thrombolytic acid acetylsalicylic. Kamodzi zizindikiro kuoneka, muyenera kupita kuphatikiza mankhwala. Odwala zaka 75 mankhwala wapatsidwa popanda Mumakonda mlingo.

ambiri osokoneza

Kulandira mankhwala pa mlingo choposa osavomerezeka, zikuonekera ndi kuwonjezeka mu magazi nthawi ndi mavuto wotsatira. Zikatero, muyenera chithandizo choyenera. Ngati mugwiritse kukonzedwa mwamsanga yaitali magazi nthawi, muyenera kuikidwa TM. Palibe adakalibe yeniyeni.

Mwanjira ndi mankhwala ena

Munthawi yomweyo phwando "clopidogrel" ndi zotsatira warfarin mu kuwonjezeka mu magazi mlingo, nchifukwa chake kuphatikiza kwambiri osafunika. Izo kumawonjezera mwayi magazi ndi mankhwalawa mankhwala ndi limodzi ndi mankhwala nonsteroidal odana ndi yotupa, aspirin glycoprotein zoletsa ndi heparin.

zotsatira zoyipazi

Chithandizo medicament 'Clopidogrel' (wosuta, mtengo, njira oyendetsa mlingo zafotokozedwa mwatsatanetsatane mu nkhaniyi) angakhale ndi zotsatira osafunika:

• dongosolo magazi coagulation: m'mwezi woyamba wa mankhwala zambiri uka kukha mwazi hematomas asaoneke; osachepera - kukha mwazi conjunctive; akutali milandu - intracranial magazi.
• hematopoietic dongosolo: mu nthawi zina - thrombotic thrombocytopenic purpura, granulocytopenia, kuchepa magazi, kuphatikizapo pancytopenia, ndi aplastic magazi m'thupi.
• Mantha dongosolo: Izikhalanso mutu, paresthesia, chizungulire; osowa - vertigo; akutali milandu - chisokonezo maganizo ndi kuyerekezera zinthu m'maganizo.
• Mitsempha ndi mtima, kawirikawiri anapanga hematoma; nthawi zina aakulu kukha mwazi vasculitis, polowetsedwa magazi.
• dongosolo kupuma: epistaxis, bronchospasm, kukha mwazi m'mapapo mwanga, interstitial pneumonitis, hemoptysis.
• M'mimba thirakiti: m'mimba, dyspepsia, kupweteka m'mimba, magazi kuchokera thirakiti m'mimba, gastritis ndi chapamimba chilonda, kusanza, flatulence, nseru, kudzimbidwa, magazi retroperitoneal, matenda a m'matumbo, kapamba, stomatitis, pachimake kulephera chiwindi, matenda a chiwindi, kuchuluka chiwindi michere.
• dongosolo minofu ndi mafupa: arthralgia, myalgia, nyamakazi.
• Khungu: bullous totupa (Stevens-Johnson syndrome ndi poizoni epidermal necrolysis, erythema multiforme), chikanga, erythematous totupa, ndi ndere planus.
• Mkodzo System: hematuria, hypercreatininemia, glomerulonephritis.
• thupi lawo siligwirizana: angioneurotic edema, matenda seramu, urticaria, pseudoallergy anachita.

Pamene mankhwala ndi malungo mankhwala sikawirikawiri anati, amene si anazindikira chifukwa cha kulandira medicament, ndipo monga chizindikiro cha chimfine.

Kusamala

Medicine "Clopidogrel" mosamala kwambiri pamene mukumwa mkulu Mwina wa magazi chifukwa cha zikunena opaleshoni, matenda hemostatic. Ngati opaleshoni chofunika, ndipo antiplatelet zotsatira kwambiri osafunika ku utsogoleli wa mankhwala ayenera kuchotsedwa kwa sabata pamaso nthawi yoikidwiratu opaleshoni. chisamaliro makamaka mankhwala analamula kuti kuyan'anila choopsa cha ntchito chiwindi, yomwe INGATHE kuyambitsa hemorrhagic diathesis. Ngati zizindikiro za magazi ochuluka ayenera kuphunzira dongosolo hemostatic. Komanso, kufunika zonse kuwunika ntchito za ntchito zinchito chiwindi. Chenjezo "Clopidogrel" ntchito ndi heparin, NSAIDs, warfarin. Pochititsa maphunziro experimental sanapeze carcinogenic ndi genotoxic zotsatira za mankhwala, kuwonjezera, musadandaule amene amadza pa mphamvu kasamalidwe magalimoto.

"Clopidogrel": analogs ndi generics

Mau ofanana (analogs) mankhwala - mankhwala ndi kanthu kapena kukhala zikuchokera chomwecho. Kodi mankhwala akhoza m'malo mankhwala "Clopidogrel"? Analogs yokonza thunthu yogwira otsatirawa: "Kardutol", "Detromb", "Agregal", "Trombeks", "Klopilet" "Trocken", "Plavix", "Plagril", "Plogrel", "Targetek", "Egitromb" "Clopidogrel Teva,".

Aliyense mankhwala ali ndi makhalidwe osiyana, kotero ntchito amaloledwa yekha atakambirana ndi dokotala.

Maganizo za mankhwala

Zimene anthu amanena zokhudza kukonzekera monga "Clopidogrel"? Reviews cha odwala amene anali ndi mwayi kusamutsa matenda zikunena opaleshoni ndi zabwino kwambiri. Odwala lipoti mkulu imayenera kanthu za medicament, izo koma sananenedwe kwa phwando kuti kudziletsa mankhwala. Analogues wa mankhwala kuthandiza odwala kusankha njira zabwino mu chiŵerengero cha mtengo ndi quality, koma cholinga ndi mphamvu ya kulamulira ayenera zopatsidwa kwa katswiri wodziwa.