Mankhwala "Avastin" umboni

Mankhwala "Avastin" ndi chida chamakono ndi khansa. Iwo amagwiritsidwa ntchito pofuna kuchiza zosiyanasiyana khansa, zimathandiza kuti akathetse maonekedwe a metastasis, kuchepetsa microvascular permeability ndi kusiya kupitirira kwa matenda. Masiku ano, anthu ambiri odwala khansa asonyezedwa mankhwala "Avastin". Reviews za izo ndi zosiyana. Pali zitsanzo za mphamvu abwino zochizira matenda ndi ndemanga zambiri za kulephera kwa mankhwala. Anthu ena "Avastin" amayambitsa zotsatira zina zoyipa.

kapangidwe

Waukulu yogwira pophika "Avastin" - bevacizumab. mankhwala ndi kugulitsidwa ngati maganizo, amene anapanga njira kwa kulowetsedwa mtsempha. "Avastin" ndi colorless kapena ali kuunika bulauni mtundu. Sales angapezeke mitundu iwiri ya "Avastin" zosiyana mu ndende ya waukulu yogwira pophika: 100 mg / 4 ml ya 400 mg / 16 ml.

umboni

mankhwala akusonyeza matenda otsatirawa:

• khansa mu magawo pofotokoza metastasis wayamba.
• Aimpso selo carcinoma.
• m'matumbo khansa.
• Non-ang'ono khansa selo m'mapapo.
• Glioblastoma (kobwereza).
• Age zokhudzana macular alibe (AMD), chotupa mbali okolomakulyarnoy, ashuga rinopatiya.
• Panopa ndi ikupita patsogolo ntchito "Avastin" mu pochiza matenda a maso. Reviews zochizira matenda diso zokhudzana ndi pathological kukula mtima, positive.

contraindications

Mogwirizana ndi malangizo kwa mankhwala sayenera kugwiritsidwa "Avastin" mu Zikatero:

• Pamaso pa kuchuluka tilinazo wodwalayo chimodzi munali yokonza.
• Pa mimba ndi yoyamwitsa. Studies pa zotsatira "Avastin" kwa gulu la odwala akhala akufufuza. Amadziwika kuti mankhwala mankhwala umalowa mu nsengwa, kungachititse yimitsira wa angiogenesis mwana wosabadwayo. Akazi amene ali wobereka zaka, Ndi bwino kugwiritsa ntchito njira zolera odalirika miyezi mwina isanu ndi umodzi pambuyo mankhwala ndi mankhwala. Komanso, ngati n'koyenera, "Avastin mankhwala" analimbikitsa kutha kwa yoyamwitsa, monga zingayambitse kukula mkhutu ndi chitukuko cha ana akhanda. Komabe, kafukufuku sikuti zatsimikiziridwa.
• zaka ana.
• Mu kulephera aimpso ndi chiwindi. Studies zotsatira za mankhwala kwa gulu la odwala kunachitidwa.

zosiyanasiyana chokhwima

Odwala ena kuona zotsatira zoyipa pamene apatsidwa mankhwala "Avastin". Reviews amati poyankha mankhwala zikhoza kukhala zoopsa kwambiri:

• Perforation pa mundawo m'mimba.
• Kukha mwazi mu Vol. H. m'mapapo.
• Wolumikizira thromboembolism.

Komanso limapangidwa zotsatira zina mbali mankhwala "Avastin" malangizo Buku. Reviews a iwo Tingaone zambiri. Ali:

• Kuwonjezeka magazi.
• Zikamera wa ululu ndi kutupa mu pamimba.
• Kuona kufooka.
• Asthenia.
• Mtima kulephera.
• Neutropenia, leukopenia, magazi m'thupi.
• Kuyambitsa nseru, kusanza, stomatitis.
• Chitukuko cha matenda a anorexia.
• Thumbo magazi.
• Hypoxia.
• ileus.
• Rhinitis, dyspnea.
• Khungu amakhala ouma ndi kusintha mtundu.
• Mkhutu masomphenya.
• Kufooka mwa minofu.
• Chitukuko cha matenda thirakiti mkodzo.
• Iwo kumawonjezera thupi kutentha.
• Ululu, ndi kutanthauzira osiyana.
• Sepsis - matenda a thupi.
• Hemoglobin yafupika.

Kusamala

Popereka chithandizo cha mankhwala "Avastin" ndipo kumapeto kwa ntchito kwake kwa miyezi zina asanu akulimbikitsidwa kugwiritsa ntchito njira zolera. Gwiritsani ntchito mankhwala, komanso kudziwa mlingo wake akhoza kupanga yekha katswiri wodziwa. The mankhwala ndi yosemphana ndi dextrose njira.

ntchito

Kukonzekera "Avastin" umayamba basi / kukapanda kuleka, utsogoleli mu / ndege koletsedwa. Mlingo zimadalira mtundu wa matenda. Anakonza "Avastin" zizichitidwa yekha pansi zinthu sterility pazipita. Mlingo anakhumba "Avastin" kuchepetsa kwa 100 ml ya sodium kolorayidi 0,9% njira (odwala ndi lalikulu okwana kulemera afike 200-250 ml).

The kulowetsedwa loyamba "Avastin" ayenera lolimba kwa mphindi 90. Ikani mankhwala motere pambuyo mankhwala amphamvu. Ngati pambuyo pa makonzedwe loyamba, lachiwiri nthawi kulowetsedwa akhoza kukhala mphindi 60, ndipo kachitatu - mphindi 30. Ngati muli ndi mavuto, kutukula si analangiza kuchepetsa mlingo wa mankhwala. Ngati mukufuna, ndiye mufunika kuleka chithandizo "Avastin" nthawi zina kusiya amenewo.

ambiri osokoneza

Pamene kugawa "Avastin" pa mlingo pazipita (20 mg / kg pa thupi, thupi 2 masabata imeneyi) kumachitika odwala zizindikiro za mankhwala osokoneza bongo. Odwala ena panali chifundo cha migraine kwambiri. Kodi kuvutika zizindikiro za zotsatira zoyipa.

zinthu yosungirako

Yosungirako kutentha kwa mankhwala ndi 2-8 madigiri Celsius. alumali moyo - maola 24. "Avastin" mukhoza amaundana kapena kugwirana. Yankho lilibe mchere; kutetezera, ngati icho chiri, ziyenera kuwonongeka.

mfundo mapiri ndi ndemanga zabwino ndi zoipa za mankhwala. Amene amakhulupirira?

Mankhwala "Avastin", ndemanga imene pali zabwino ndi zoipa mwamtheradi, ndi kudutsa chaka ndi chaka zambiri zotchulidwa dokotala. Zatsimikiziridwa mwasayansi matenda efficacy mankhwalawa zosiyanasiyana khansa.

Kuweruza mphamvu ya mankhwala a odwala akhoza kupeza nkhani mankhwala "Avastin". Reviews odwala tione pafupi pa.

Izi mankhwala ali mkulu mtengo zokwanira. Nthawi zambiri, amayamba ndi 15 zikwi. Opaka. Choncho, pamene odwala matenda aakulu anakumana ndi dokotala kuchitira mankhwala, nthawi yomweyo anayamba kufufuza zambiri za mankhwala "Avastin" umboni mtima, kugwiritsa ntchito mankhwala, komanso malangizo pa ntchito yake.

Nthawi zambiri mukhoza kupeza zokhudza wosaloleka chithandizo "Avastin" Zikavuta kwambiri. Tisaiwale kuti si nthawi zonse dokotala n'kukulemberani mankhwala, kufufuza bwino zina zabwino zonse zimene atakhazikitsa mankhwala "Avastin" malangizo. Reviews za ubwino wa mankhwala mu milandu - chodabwitsa osowa. M'pofunika kuganizira thanzi lawo, ndi kukumbukira kuti mankhwala a matenda aakulu monga khansa, ayenera kuchitika kokha ndi anthu oyenerera.

Pa nthawi iliyonse, pali zifukwa zambiri "Avastin" silingafanane ndi mtima ndi atsogolere zochita za matenda. Choncho muyenera kuganizira bwinobwino osati kutsogoleredwa kokha mwa ndemanga negative.

Taonani ena mwa maganizo a mankhwala ndi mankhwala.

Reviews za mankhwala "Avastin"

Monga tanenera kale, ndemanga mankhwala mankhwala ndi zotsutsana kwambiri. Komabe, odwala ambiri amanena kuti mankhwala a matenda limapezeka patsogolo kwambiri. Mu ena pali kuchepa kukula chotupa. Koma, mwatsoka, kuchira bwino sayenera kuyembekezera. "Avastin" ndi wokhoza kutalikitsa moyo wa wodwala ndi kuzipanga izo bwino kwambiri.

Kanafotokoza kwambiri milandu mavuto. The kaŵirikaŵiri anati kulimbitsa mutu, kuthamanga kwa magazi kapena kukakhala. Majekeseni "Avastin" pamaso pa odwala ena kuyambitsa imfa masomphenya ndi ngakhale khungu.

Mu US, panali mzere kwambiri pa ntchito ya "Avastin" zochizira alibe macular. Jekeseni wa mankhwala mu vitreous inatsogolera ku lonse mavuto. Pa nthawi yomweyo, 16 odwala zidalowa matenda mwana wa diso lalikulu. Ena anayamba khungu mtheradi. Koma "Avastin" kupitiriza ntchito zonse US ndi Europe. Kugwiritsira ambiri mankhwala si pa umboni si kugwirizana ndi kukwezedwa lamulo ndipo ndi mtengo wotsika wa mankhwala poyerekezera ndi malamulo "Lucentis", kulandila chithandizo cha alibe macular.

Kusiyana mu mtengo wa mankhwala n'chachikulu. Ngakhale mu US mtengo wa "Avastin" ndi $ 50 mtengo wa "Lucentis" - madola 2000. Onani kuti pa maganizo a za maonekedwe a mavuto ndi mavuto, komanso chitukuko cha endophthalmitis "Lucentis" si abwino. N'chifukwa chake anthu ambiri ali pa chiopsezo ndi kugula zosavomerezeka "Avastin".

Malingana ndi madokotala ambiri, lonse mfundo jekeseni njira zikutanthauza. Research chofunika mderali. Ena a iwo kale. Choncho, anayerekezera zimene bevacizumab ndi ranibizumab (yogwira zinthu "Avastin" ndi "Lucentis", motero). Pakhala maphunziro awiri malo, koma zotsatira awo adatsutsana, chifukwa pamene woyamba kunapezeka kuti kudzanso bevacizumab, ndipo chachiwiri - ranibizumab.

Pakali pano, Russia loletsa mankhwala ntchito pochiza matenda a maso. Koma mukhoza kupeza wogulitsa ndi dokotala amene adzachita jekeseni. Ophthalmologists amakonda ndi yotchipa "Avastin", monga zoweta mankhwala-malonda akupitiriza kuti zikule bwino. Ndipotu, Atchule wodwalayo kuti njira mtengo zosavuta.

Pankhaniyi, tisaiwale kuti odwala ambiri ndi AMD anali kwambiri patsogolo atatsimikiza akatemera, "Avastin" mu diso. Ndemanga za mphamvu ya mankhwala abwino. Mu chabe jakisoni ochepa mankhwala ataphwera kutupa cha maso, panali kusintha acuity zithunzi. Therapy kuli ndi ubwino nthawi yomweyo koma pambuyo mavuto chichitike. Komanso, kuyembekezera kumaoneka ubwino pambuyo jekeseni loyamba la mankhwala analikodi kwathunthu.

"Avastin" + mankhwala amphamvu: ndemanga, chithandizo

Mosiyana ndi ndemanga zotsutsana pa ntchito mankhwala pochiza matenda a maso maphunziro asonyeza mphamvu ya "Avastin" osakaniza ndi mankhwala amphamvu mankhwalawa khansa colorectal. Mu ntchito regimens muyezo mankhwala amphamvu "Avastin" kumathandiza kuchepetsa kukula kwa m'matumbo zotupa. Komanso, mankhwala izi zotsatira kutha kwa metastases chiwindi 78% odwala. Chifukwa cha zimenezi, pafupifupi gawo limodzi la odwala anali wokhoza ntchito, zomwe pansi Tiyerekezenso zabwino akhoza kupulumutsa miyoyo yawo.

Komanso, kafukufukuyu anapeza kuti "Avastin" liri zothandiza odwala okalamba odwala wamng'ono.

ntchito pamodzi ndi capecitabine mankhwala kumawonjezera moyo amayembekezeka odwala khansa colorectal kwa zaka zitatu mpaka zisanu.

Amathandizanso kutalikitsa moyo ndi kuchepetsa mapangidwe metastases mu khansa ya m'mawere ndi sanali yaing'ono khansa selo m'mapapo ndi osakaniza "Avastin" + mankhwala amphamvu. Reviews wa zimenezi ndi zabwino. Komabe, zinthu zomwezi: mosavuta achire zonse ndi kochepa.

matenda efficacy

• Colorectal khansa - ndi co-mankhwala "Avastin" ndi IFL (irinotecan, fluorouracil, leucovorin) chimafikira kupulumuka ndi pafupifupi 5 miyezi. Ntchito "Avastin" pamodzi ndi mankhwala amphamvu angadwale moyo amayembekezeka pafupifupi 4 months.
• Metastatic khansa. Infusions "Avastin" 10 mg / kg pa intervals wa masabata awiri pamodzi ndi paclitaxel kwambiri pa kuthekera kwa kuyimitsidwa chitukuko cha matenda. Kuchitiridwa nthawi bwino mankhwala amphamvu kwenikweni.
• Non-ang'ono khansa selo m'mapapo. Chithandizo "Avastin" pamodzi ndi mankhwala amphamvu (imene pulatinamu ofotokoza mankhwala) kumawonjezera kuthekera kupulumuka ndi kuonjezera moyo zaka zambiri.
• Aimpso selo carcinoma. Gwiritsani ntchito "Avastin" pamodzi ndi interferon alpha-2a prolongs nthawi kupulumuka kwa poyerekeza pogwiritsa ntchito interferon alpha-2a.
• Mbali chachinayi cha glioma zilonda. Pambuyo chisanadze radiotherapy chithandizo "Avastin" imafika moyo wa pafupifupi miyezi isanu ndi umodzi.

Motero, "Avastin" ndi mankhwala amakono zochizira zotupa zosiyanasiyana. Mmene mankhwala sichinayambe ankafufuza bwinobwino. Komabe, ochuluka zotchulidwa madokotala mankhwalawa zosiyanasiyana khansa.

Anagwiritsa ntchito "Avastin" mu pochiza matenda a maso komwe amatipatsa kwambiri kutchulidwa ubwino mankhwalawa AMD. Mankhwala okwera mtengo kwambiri, komanso angathe kuyambitsa zotsatira ambiri mbali. Cacikulu maganizo akachoka "Avastin" ali abwino, koma palinso negative.

Kwa ena odwala, "Avastin" anali wopanda ntchito, ndi zina amayambitsa zotsatira zina zoyipa. Choncho, mankhwala ayenera kusankha dokotala woyenera, ndi lamulo lililonse la zotheka zonse munthu ayankhe wodwalayo zigawo mankhwala. Komanso, kulowetsedwa ayenera anachita pansi wosabala. Cancer - matenda oopsa zimene zingachititse kuti imfa. Ntchito mankhwala "Avastin" sapereka ndi chitsimikizo mtheradi kuchiritsidwa, koma chingaimitse kupitirira kwa matenda ndi kutalikitsa moyo wa wodwala. Ndipo kwa odwala matenda oopsa ndi akutukwana!