Mankhwala "El-Thyroxine": malangizo ntchito, analogs, ndemanga

Mankhwala "Al-thyroxine" - kupanga chithokomiro timadzi, thyroxine analogue a zachilengedwe. Pa kulandira medicament ndi kutembenuka tsankho la thyroxine kuti triiodothyronine, iodo timadzi kuti kumatanthauza njira zonse kagayidwe kachakudya ndipo ali kwambiri kuti ntchito za ziwalo zambiri. Mankhwala ntchito pa nthawi imene kwambiri yafupika chithokomiro ntchito.

Kugwiritsa medicament kumaonekeranso pambuyo kuchotsedwa kwa chithokomiro England ndi minofu yake Mphukira pamene England ntchito si chakhungu. Nthawi zina mankhwala Kwalamulidwa kwa anthu amene anakwezedwa chithokomiro ntchito, koma choyamba kuchita mankhwala kupondereza katulutsidwe mahomoni ayodini munali. Odwala amenewa, pambuyo ntchito ya "El-Thyroxine" kuletsedwa TTG m'badwo ndondomeko zomwe zimafunika kaphatikizidwe wa thyroxine.

Fomu kumasulidwa zosakaniza mankhwala

"El-Thyroxine" amapezeka mapiritsi. Thunthu yogwira ndi levothyroxine ndi sodium. The zikuchokera mankhwala kungabweretse nambala osiyana zigawo zikuluzikulu zofunika, mankhwala abwino zotchulidwa dokotala. Wothandiza zosakaniza kuperekedwa ndi sodium wowuma glycolate, calcium wa hydrogen mankwala dihydrate, kuleza unyolo tsankho glycerides, dextrin ndi microcrystalline mapadi. Zosiyana opanga Kapangidwe ka zosakaniza wothandiza zingasiyane pang'ono.

Pharmacodynamics, pharmacokinetics, "El-Thyroxine"

The yogwira pophika mankhwala ndi thyroxine, lomwe linanena bungwe kumachitika m'thupi, kuchita ntchito yofanana. "El-Thyroxine" kumathandiza kuti normalization njira kagayidwe kachakudya, njira ya chitukuko ndi kukula. The kanthu mankhwala anatsimikiza mtima zili wa chinthu yogwira. Ntchito mlingo wochepa "El Thyroxine" kumayambitsa chitukuko cha zotsatira anabolic, apamwamba - ayenera kuwonjezera khungu ndi minofu mpweya kufunika, mangolomera zako zobwera chifukwa cha okosijeni, mofulumira kagayidwe ndi kuwonongedwa kwa chakudya, mapuloteni, mafuta. Komanso pa mlingo waukulu wa mankhwala imayendetsa dongosolo chapakati mantha, dongosolo mtima.

The medicament akuyamba kuchita pambuyo pa masiku asanu ntchito choyamba. Kwa miyezi itatu kapena isanu ndi umodzi wa mankhwala mosalekeza n'zotheka tichotse khosi lotupa akakufunsani kapena kuchepetsa kukula kwake.

Mayamwidwe kumachitika makamaka intestine ang'onoang'ono chifukwa cha kulandira kusala kudya piritsi si oposa 80%, ndi ntchito chakudya yafupika. Chabwino olumikizidwa kwa mapulotini plasma, "El-Thyroxine" mawu limasonyeza kuti pali kugwirizana ndi pafupifupi 100%, kotero mankhwala sikumangotikhudza kapena hemodialysis kapena hemoperfusion.

Ndende pazipita wa chigawo chachikulu chili mu thupi pambuyo maola asanu pambuyo ingestion mankhwala. Tsankho kuchotsa mankhwala odwala kumachitika m'njira zosiyanasiyana, malingana ndi msinkhu wa mahomoni chithokomiro mu thupi.

Mu hypothyroidism kuchotsa ake ikuchitika masiku asanu ndi anayi kapena khumi, ndi euthyroid - sikisi kapena seveni, thyrotoxicosis theka moyo uyenda mwamsanga - masiku atatu kapena anayi.

Pafupifupi gawo limodzi pa mlingo mankhwala waukulu pophika waikamo mu chiwindi, pamene ndikulemba zimachitika mofulumira ndi thyroxine amene ali pano mu magazi. Zimachitika mapangidwe metabolites pambuyo ingestion miyala "El Thyroxine". Malangizo ntchito malipoti kuti kagayidwe yaikulu ya gawo mankhwala imagwiridwa mu ubongo, minofu, impso ndi chiwindi. Excretion wa metabolites opangidwa ndi impso ndi matumbo.

Zikuonetsa ntchito yokonza "El Thyroxine"

M'MALO mankhwala zachokera ntchito mankhwala zotchulidwa odwala limati hypothyroid wa etiologies osiyana, T. H. Hypothyroid (pulayimale, sekondale) zikuchitika pambuyo opareshoni ndi chikwiyire ndi phwando njira zimene wapangidwa radioiodine . "El-Thyroxine" malangizo ntchito limakupatsani perekani milandu zotsatirazi:

• matenda cerebro-hypophyseal;
• Hypothyroidism kobadwa nako ndipo anaphunziranso;
• euthyroid goitre;
• matenda Hashimoto ndi, matenda manda '(chithandizo zovuta za);
• ndi zizindikiro za kunenepa kapena hypothyroidism cretinism, limodzi ndi mbali yomweyo;
• euthyroid hyperplasia (kuphatikiza mankhwala);
• kobwereza nodular khosi lotupa pambuyo resection mu matenda pakalibe England (mapiritsi ntchito ngati medicament prophylactic);
• chotupa chotupa chija (M'MALO ndi mankhwala suppressive);
• neoplasms, amene yodziwika ndi lofunika kwambiri kusiyanitsidwa, timadzi, ndi chikhalidwe zilonda.

Mankhwala ntchito kuchita mayesero matenda. Nthawi zina anthu "El Thyroxine" slimming pakalibe mavuto ndi chithokomiro England, koma madokotala sagwirizana ntchito medicament kwa cholinga chimenechi.

Contraindications kulandira mankhwala, "El-Thyroxine"

medicament si kutumikiridwa odwala kudziwa zigawo zake. Contraindications monga:

• m'mnyewa wamtima infarction (pachimake siteji);
• akuthamanga gipokortitsizm kale Popanda kuchitapo kanthu kapena thyrotoxicosis;
• kutupa mtima minofu pachimake chikhalidwe;
• cholowa galactosemia;
• syndrome, zomwe zina ndi mayamwidwe mu intestine ya;
• lactase akusowa.

mankhwala ntchito mosamala odwala ndi shuga, pamene zovuta loyenda hypothyroidism, yomwe ndi nthawi yaitali osati matendawa, ndi matenda kugwirizana ndi zotupa mtima:

• sredtsa matenda a mitima;
• oopsa;
• arrhythmia;
• m'mnyewa wamtima infarction (mbiri);
• atherosclerosis.

Ngati wodwalayo ena matenda amenewa, mlingo yafupika kapena analogue anasankha.

mankhwala

Pa mankhwala, njira "El-Thyroxine" Mlingo amasankhidwa payekha kwa wodwala aliyense malinga ndi umboni. Mapiritsi musati kutafuna, kumwa pa chopanda kanthu m'mimba, mphindi zosachepera 30. asanadye. Odwala matenda a dongosolo mtima ndi wafika zaka makumi asanu pa makilogalamu 1 kulemera akapatsidwa munthu pazipita 0,9 mg wa mankhwala. zina zasonyezedwa kuchokera 1.6 .mu.g kwa 1.8. Pa siteji yoyamba ya mankhwala, mlingo wa mankhwala kwa odwala ndi hypothyroidism ali motere:

• Odwala amene ali ndi mavuto ndi dongosolo la mtima, zotchulidwa mankhwala kwa 75 mcg 150 womwe ndi mlingo tsiku.
• Mu zotupa mtima, komanso odwala achikulire kutumikiridwa mankhwala mu kuchuluka 25 g. Patadutsa miyezi iwiri mlingo ziwonjezeke kwa 50 mcg. Kenako, izi kusintha chizindikiro ndi imeneyi chomwecho, zikuchuluka 25 ga, mpaka anatsimikiza akadakwanitsira kuchuluka kwa chiphunzitso ndi TSH bwinobwino.

Bwanji Mng'oma "El-Thyroxine" milandu yosiyanasiyana, m'pofunika kuzindikira dokotala. Ngati mkhalidwe wa ziwiya ndi mtima n'lalikulu, m'pofunika kubwereza njira zochizira matenda a dongosolo mtima.

Pamene hypothyroidism kobadwa nako chikhalidwe cha mlingo wa mankhwala amasankhidwa molingana ndi zaka. Odwala laling'ono (miyezi 6) kutumikiridwa 25 micrograms mankhwala, koma palibe zoposa 50, chofunika mlingo tsiku ndi ku micrograms 10 mpaka 15 pa kilogalamu. Ana osakwana zaka zosaposa 1 chaka, kusankha 50 mg pa kg. Ngati m'badwo wa wodwalayo mu uthunthu wa zaka imodzi asanu, mlingo osachepera ndi 75 mcg, koma palibe micrograms zoposa 100. Patapita zaka zisanu ndi chimodzi zakubadwa (ana osaposa 12) amaloledwa kugwiritsa ntchito 100 mcg ndalama osati choposa mlingo 150 mcg. ana ena anakhumba mlingo amusankha mu osiyanasiyana micrograms 100 200.

Pa mankhwala mankhwala, "El-Thyroxine", monga momwe malangizo ntchito ana osaposera zaka zitatu mlingo tsiku amatanthauza kupereka kamodzi. Pambuyo makonzedwe mankhwala kudya akhoza kuchitika pa theka la ola. Mankhwalawa ana ntchito njira anakonza kuchokera miyala.

Nthawi zambiri, anthu amene amadwala hypothyroidism, kutenga mankhwala moyo. Amene anawulula thyrotoxicosis, pambuyo chitukuko cha euthyroid boma "Thyroxine" akulangizidwa kuti ntchito molumikizana ndi antitireoidinymi zikutanthauza kuti nthawi zotsimikizika ndi dokotala.

Kugwiritsa ntchito mankhwala kwa kuwonda

Kuchotsa kulemera owonjezera ntchito 50 micrograms pa tsiku imatanthauza. The ntchito tsiku mlingo wa zinthu ziwiri zimene ziyenera kuperekedwa m'mawa. Pamodzi ndi amatanthauza "El Thyroxine" kutenga β-blocker mu mlingo chosankhidwa zochokera zimachitika pafupipafupi. Mu mlingo zina escalation analoleza "Thyroxine" 150 micrograms. Kuwonjezera mlingo pang'onopang'ono pambuyo kuenjezera phwando kumatanthauza lagawidwa katatu. Mu nkhani iyi, njira masika ayenera kuchitidwa palibe pasanafike 18:00. Komanso, kuwonjezera mlingo β-blocker, kofunika kuchuluka kwa mankhwala amasankhidwa payekha, pa mlingo zina mtima ayenera kukhala mu osiyanasiyana kumenyedwa pa 60 ndi 70 pa mphindi.

Nthawi zina muyenera ndichepe mlingo amatanthauza "Al-thyroxine". Zotsatira zake zoyipa zikusonyeza kufunika kufufuta kapena kuchepetsa mankhwala mlingo. Inde ayenera lolimba pafupi mwezi, musatenge mankhwala yaitali kuposa masabata asanu ndi awiri.

Musati mwadzidzidzi kusiya ntchito mankhwala, chiyembekezo chakuti ake opangidwa pang'onopang'ono, pang'onopang'ono kuchepetsa mlingo kuti intervals iwiri. Pamene kutsekula ndi zina chakumwa wothandizila "Loperamide" mu makapisozi limodzi kapena awiri pa tsiku. Bwerezani Maphunzirowa umalimbana kuchepetsa thupi, zikhoza kukhala masabata atatu kapena anayi kenako.

chingachitike mbali

Zina zosiyanasiyana chokhwima kumachitika pa mankhwala ndi "Al-thyroxine". Zotsatira zake zoyipa ntchito mankhwala pa mlingo analimbikitsa n'zochepa kwambiri. Chifukwa cha njala kuchuluka achuluke kulemera, tsitsi ukhoza kugwera kunja, n'zotheka zikamera wa mavuto ndi impsozo. Ana ndi khunyu ndi chiopsezo khunyu kuchuluka, matenda kungakhale kwambiri ngati upambana kuika mlingo "Thyroxine". Mu mankhwala ndi Mlingo mkulu ndiye kuti chitukuko cha zizindikiro za hyperthyroidism.

Mwa zotsatira mbali inayo - nkhawa, matenda nkhawa, maonekedwe a nthambi kugwedeza, tulo, zizindikiro za arrhythmia ndi tachycardia. Komanso, pangakhale kuwonda ndi chitukuko cha kutsegula m'mimba, pamaso pa kusanza. Mwina thukuta, pamaso pa zizindikiro zimene zigwirizana pamodzi ndi kuukira kwa pectoris angina. Odwala ena ndi dermatitis matupi awo sagwirizana. Ndi chitukuko cha zochita chowawa thupi m'munsi mlingo "Thyroxine" kapena mongoyembekezera kuletsa mankhwala ndipo kenako ntchito mlingo ang'onoang'ono.

Kuphatikiza mankhwala ndi mowa

Childs, mlingo umodzi wa pang'ono mowa linga otsika alibe chikoka pa zotsatira za wothandizila ndi "Al-thyroxine". Reviews kuti kumwa mowa pa chithandizo kuti anthu okhawo amene alibe vuto ndi mitsempha ya magazi ndi mtima. Nthawi zina, kuphatikiza kwa mankhwala ndi mowa kumabweretsa mavuto osafunika. Mwinamwake osati kuchepa mphamvu ya mankhwala, komanso kuphwanya chiwindi, chapakati mantha dongosolo.

Mankhwala analogues "El-Thyroxine"

Wa analogs structural m'malo "Al-thyroxine" angagwiritsidwe ntchito "Eutiroks", "Bagotiroks". Kwambiri zambiri anasankha mankhwala "Eutiroks" limene zizindikiro zofanana, contraindications ndi mlingo. Kuchokera "El-Thyroxine" kumasiyana kokha mwa ndende ya mankhwala yogwira. Ngati wodwala siyabwino, "El-Thyroxine" analogues yoikidwiratu Katswiri kutenga peculiarities chifukwa cha chamoyo.

Reviews kukonzekera "El-Thyroxine"

Mu review, izo inanena kuti mankhwala pamene ntchito mlingo wochepa amalimbikitsa wotentha mafuta chifukwa mathamangitsidwe wa kagayidwe, yimitsira kudya ndi kuonjezera ndalama caloric. Kuchepetsa maonekedwe mavuto kapena kupewa thandizo lawo chitukuko ndi β-blockers. Reviews akusonyeza kuti anthu ambiri kuphatikiza mankhwala ndi njira imeneyi. Ngakhale kuti "Thyroxine" nthawi zambiri amathandiza kuchepetsa thupi, ntchito kuwonda ali osavomerezeka. Pakuti anthu athanzi, mankhwala zikhoza kukhala zoopsa.

Mankhwalawa matenda kugwirizana ndi mkhutu chithokomiro ntchito, mankhwala ambiri othandiza, umboni ndi review lapansi. Akulongosola zida kumabweretsa bwino yachibadwa mahomoni, kotero odwala bwino. Pali ndemanga zoipa chifukwa amatha kukhala mavuto. Ngakhale mankhwala ndipo amatha kuyambitsa ambiri ndithu zochita zoipa, izo amathandiza pammero limene thupi likugwira bwino ntchito.

Ntchito "El-Thyroxine" pa nthawi amachotsedwa pa matenda a chithokomiro matenda kapena kuchepetsa zovuta zizindikiro moyo wawo wonse.