Mankhwala "Metozok": malangizo ntchito, analogs ndi ndemanga

matenda a mtima ndi mitsempha ya magazi kusokoneza anthu ambiri. Kuthetsa matenda awa, mankhwala "Metozok". Malangizo ntchito mpofunikila musanagwiritse ntchito mankhwala awa dokotala ndi Musawachite mankhwala paokha, chifukwa iye anali contraindications kwambiri. Mankhwala amathandizanso pa matenda angina, kulephera aakulu mtima, tachycardia, migraine ndi matenda ofanana.

kapangidwe

Mankhwala ndi njira "Metozok". Malangizo ntchito mwatsatanetsatane zikuchokera miyala.

medicament A ndi mlingo wa 25 mg chikukhudza 23,83 mg wa yogwira pophika metoprolol tartrate, 50 mg ndi za 47,66 mg wa yogwira pophika ndi 100 mg - 95,32 mg.

Adjuvants wapangidwa mankhwala ndi: hypromellose, ludipress LTSE, povidone, colloidal pakachitsulo woipa, magnesium stearate.

Piritsi ❖ kuyanika imakhala ndi okonzeka zopangidwa thunthu "Opadry II», amene utoto lalanje. Pamafunikanso zigawo zikuluzikulu monga polyvinyl mowa, talc, macrogol, titaniyamu dioxide, chikasu chitsulo okusayidi mitundu, ofiira ndi wakuda, ndi enaake.

Mapiritsi kuimira mankhwala yaitali wotenga, iwo ataphimbidwa ndi kuwala wobiriwira m'chimake. Kodi zozungulira, otukukira kunja mbali zonse.

Dragee kuchuluka kwa ndalama 30 ali odzaza mu mabotolo pulasitiki ndi zidutswa 10 matuza zotayidwa. The katoni lili matuza atatu.

Wopanga "Metozoka" ndi Russian kampani JSC "Akrikhin".

Pharmacological kanthu ndi farmadinamika

Fotokozani za cardioselective beta1-blocker mapiritsi "Metozok". Malangizo ntchito kwathunthu pofotokoza kanthu pharmacological mankhwala. Mankhwala alibe Kakhungu ofunika katundu ndi ntchito sympathomimetic. Yodziwika antihypertensive, antianginal ndi antiarrhythmic kanthu.

wochepa β1-adrenergic zolandilira kubweza mtima, Sachita kutsegula kwa catecholamine pawiri msasa ATP, minimizes panopa mu ayoni calcium, imagwiritsidwa chronotropic zoipa, BATM, dromo- ndi zotsatira inotropic. Pa chiyambi cha ntchito mankhwala kumawonjezera wonse ziwiya kukana. Ichi ndi chifukwa kukondoweza kwa α-adrenoceptor Letsani ndi β2-adrenoceptors. Patapita masiku angapo (1-3), akadzabweranso wodwalayo wapachiyambi, koma ndi mankhwala yaitali kumachepetsa zotumphukira mtima kukana.

amadza Antihypertensive amapezeka ndi kuchepetsa chiwerengero cha otaya mphindi magazi, ndi mankhwala renin khama chopinga wa ntchito renin-angiotensin-aldosterone ndi dongosolo chapakati mantha, komanso chitsitsimutso cha chiwopsezo cha baroreceptors wa Chipilala kung'ambika, ndipo kenako anachepetsa zotumphukira kanjedza chisoni. Amachepetsa kukwezeka magazi mu chikhalidwe mpumulo. Anzanu kuchepetsa zidzachitika zolimbitsa thupi ndi maganizo maganizo. Zotsatira antihypertensive kumatenga kuposa tsiku.

katundu Antianginal umakhala ndi kuchepa zosowa m'mnyewa wamtima mpweya, limene pamapeto pake amachepetsa kugunda kwa mtima ndi minofu chiwopsezo kuti chikoka cha innervation chisoni. Amachepetsa chiwerengero cha matenda pectoris angina ndi kucheperachepera nthawi zawo. Kuchita zambiri zokhudza thupi la munthu. Chifukwa cha kuchuluka kwa kutsirizitsa diastolic kuthamanga mu ventricle kumanzere ndi elasticity wa minofu ya ventricles onse kumawonjezera kufunika kwa mpweya anthu akuvutika ndi matenda a mtima.

zotsatira Antiarrhythmic zimatheka yimitsira arrhythmogenic mawonetseredwe kuti chimaonetsera tachycardia, matenda oopsa ndi zina zotero. D. amapezeka kuchepetsa mwadzidzidzi malemeredwe ectopic ndi nkusani mungoli, ndi chopinga wa AV-kuchititsa.

Pamaso pa tachycardia, supraventricular ndi nkusani zooneka kupeza matenda fibrillation, thyrotoxicosis ndi matenda ena zinchito mtima chipangizo amachepetsa kugunda kwa mtima, zomwe zina zimabweretsa kubwezeretsa nkusani mungoli.

The mankhwala ndi prophylactic kwambiri ndi migraine.

Monga ntchito Mlingo m'ma achire, alibe zotsatira kutchulidwa pa ziwalo ndi adrenoceptors β2- ndipo ziribe mphamvu pa njira kagayidwe kachakudya mu mpweya thupi. zotsatira zake ndi ofanana ndi zotsatira za "Propranolol".

Pamene kulandira mankhwala kwa zaka zambiri, angathe kuchepetsa kuchuluka kwa mafuta m'thupi m'magazi. Pamene kulandira Mlingo tsiku la 100 mg mankhwala kumakhudzanso imodzi onse subtypes β-adrenoceptor.

"Metozok" (malangizo Buku akubwera ndi mapilisi) m'mimba mwa 95%. Amtengo sungunuka mafuta. Kumatanthauza loyamba chikudutsa kagayidwe ndi bioavailability 50% pa ntchito yoyamba ya mankhwala ndi 70% - mu njira zotsatirazi. Ndende pazipita chinthu m'magazi anati pambuyo maola 6-12 pambuyo ingestion wa phale. Mu ndondomeko ya mankhwala mosalekeza pang'onopang'ono kumawonjezera bioavailability. Chakudya kumawonjezera bioavailability 40%.

Yogwira thunthu 10% zikugwirizana ndi mapuloteni magazi. M'malo mofulumira odzipereka mu ndi likulowerera magazi ubongo chotchinga, ndi latuluka. A mbali zina za chitadutsa mu mkaka wa m'mawere.

Iwo zimapukusidwa mu chiwindi, ndi awiri metabolites waukulu yodziwika ndi zinthu beta adrenoblokiruyuschey. Kagayidwe mankhwala nawo isozyme CYP2D6.

The ndi zaka theka moyo maola 3.5-7. mankhwala si anamasulidwa ndi thupi pa hemodialysis.

metabolites yambiri alipo odwala ndi CC 5 ml / min., Ndipo mu nkhani iyi, ake beta-adrenoceptor Letsani ntchito si kuonjezera.

The bioavailability chinawonjezeka ndi matenda enaake chiwindi matenda. Komanso chiwerengero cha chilolezo okwana.

"Metozok": zikuonetsa ntchito

Umboni kuti kukonzekera izi relieves tachycardia, kuchepetsa ululu mtima ndi limakhazikitsa thanzi. Zikuonetsa kuti lozenges ndi oopsa, kulephera mtima ndi mawonekedwe aakulu ili gawo chipukuta misozi. Zikatero, mankhwala tikulimbikitsidwa kugwiritsa ntchito pamodzi ndi njira ina cholinga zovuta.

Kwalamulidwa kwa mtima ischemia mankhwala "Metozok". Zikuonetsa zimachitika matenda angina (mu mawonekedwe khola) kuchepetsa imfa ndi amachepetsa imabwera kukonzanso infarction, izi matenda pachimake.

mankhwala akulimbikitsidwa mtima kulephera thupi mungoli, supraventricular tachycardia pomwepo, kuchepetsa pafupipafupi chidule cha ventricles onse pa fibrillation matenda ndi yamitsempha yamagazi arrhythmia.

Mankhwala othandiza kwa matenda zinchito za mtima, amene anatsagana ndi tachycardia kwambiri. Amagwiritsidwa ntchito kawirikawiri kupewa migraine. Izo zinali tikuyivomereza kulandira mankhwala "Mezotok" zizindikiro. Nkhani yotsatirayi tikunena contraindications.

Contraindications ntchito

Mulimonsemo amaletsedwa kujambula mankhwala paokha popanda mankhwala dokotala. Mapiritsi si zinafotokozedwa mantha cardiogenic ndi AV-anatseka misewu II-III mwamphamvu. Musagwiritse ntchito chida mu chipika sinoatrial ndi odwala nkusani syndrome. Ali kuletsa ntchito bradycardia (50 u. / Min) mtima kulephera pachimake ndi aakulu decompensated. Contraindicated "Metozok" (wosuta anafotokoza mwatsatanetsatane ntchito mbali zonse za medicament a) chifukwa hypotension, m'mnyewa wamtima infarction ili ndi gawo pachimake pa chitukuko, mphumu kwambiri, feohromotsite, zipolowe za kufalitsidwa zotumphukira. Mwamphamvu analangiza kuti kuphatikiza kwa mankhwala ndi Mao zoletsa ndi jakisoni mtsempha "Verapamil".

Sikuti ntchito mankhwala kwa ana, amene zaka sizinawakhudze zaka khumi ndi zisanu ndi zitatu zakubadwa, nthawi yoyamwitsa, anthu amene ali ndi vuto ndi nkhanza lactose, komanso matenda malabsorption, hypersensitivity kuti beta-blockers, kuphatikizapo metoprolol kuti.

CHENJEZO Kwalamulidwa medicament pamene shuga, Ine digiri AV-chipika ndi Prinzmetal angina. Tcheru ayenera kuchititsa kagayidwe kachakudya acidosis, matenda ndi mphumu bronchial ndi matenda m'mapapo mwanga, chiwindi ndi dongosolo aimpso. Pafupifupi palibe Kwalamulidwa mankhwala myasthenia, feohromotsite, hyperthyroidism, maganizo, psoriasis, malfunctions mu makope zotumphukira, pa mimba ndi okalamba.

mayesero chipatala pa amayi apakati pa chikoka cha mankhwala akhala akufufuza. Palinso palibe deta pa kuchuluka kwa malowedwe a mankhwala mu mkaka wa m'mawere. Choncho, pa kubala ana ndi mkaka wa m'mawere miyala pamaso ntchito pamafunika kukaonana ndi dokotala.

"Metozok": malangizo ntchito

Ndemanga za ena odwala amanena kuti mankhwala akhoza kuyambitsa zotsatira zoyipa mu mawonekedwe a kutopa. Choncho n'kofunika kutsatira malamulo ndi kulandira mlingo. Ngati dokotala si anatola ankachitira payekha, ayenera kumwa tingachipeze powerenga nkhani mapiritsi "Metozok". Malangizo ntchito akuonetsa kuti ntchito mankhwala kamodzi pa tsiku m'mawa, kaya chakudya. Dragees si fodya ameneyu amatafunidwa ndi kusamba pansi ndi madzi pang'ono. Pofuna kupewa bradycardia, mlingo wa mankhwala pang'onopang'ono kuchuluka.

Pamaso pa angina ndi oopsa, chithandizo amasankha ndi mg ndi 50 patsiku. Ngati mmene anali sanapindulebe, mlingo tsiku anali ziwonjezeke kwa 100-200 mg / tsiku, ndi matenda oopsa - zina - mankhwala yothandizana mankhwala wina antihypertensive.

Kwa anthu ndi aakulu mtima kulephera m'kalasi II malinga NYHA gulu, popanda siteji pachimake kwa miyezi sikisi ndipo popanda kusintha kwambiri mankhwala pa masiku otsiriza khumi ndi zinayi, malinga mlingo woyambilira wa 25 mg tsiku lililonse. Patapita milungu iwiri, ngati n'koyenera tsiku mlingo ziwonjezeke kwa 50 mg, ndipo patatha milungu iwiri, - mpaka 100 mg ndipo nthawi yomweyo (masiku 14) anali chinawonjezeka ndi 200 mg.

Pamene III-IV aakulu congestive mtima kulephera, chithandizo amasankha ndi kalasi ya 12,5 mg wa kamodzi pa tsiku ndipo patapita masabata awiri chiwerengero ziwonjezeke kwa 25 mg ndi zina zotero - mpaka yokhala ndi tsiku mlingo wa 200 mg. Ndi matenda izi odwala ndi kuwonjezeka mlingo achire akhale moyang'aniridwa pafupi zachipatala, kuyambira chikhalidwe akhoza kuvutika odwala ena.

Ikani mankhwala pambuyo kupewa mobwerezabwereza infarction m'mnyewa wamtima ndi kugunda kwa mtima kulephera mlingo achire tsiku la 100 mg.

Odwala matenda zinchito za mtima, imene palinso tachycardia, mankhwala zotchulidwa 50 mg pa tsiku. Ngati ndi kotheka, mlingo tsiku kuchuluka kwa 200 mg.

Pofuna kupewa migraine mankhwala tikulimbikitsidwa kumwa pa 100-200 mg wa pa tsiku.

Musati kusintha mlingo akangofika okalamba ndi odwala ndi kulephera aimpso amene ali pa hemodialysis.

chiwindi matenda bwanji kuwonongedwa kwa metoprolol kwa thupi, kotero mu nkhani iyi, pa nthawi ya mankhwala kusintha mlingo achire, kaya alili.

ambiri osokoneza

Ziyenera kukhala mosamala ndi kokha malamulo dokotala kutenga mankhwala "Metozok". Guide limafotokoza contraindications imene phwando mankhwala sizingatheke. Akatswiri kutsindika kuti sanali kugwilizana ndi malamulo a Mlingo ndi phwando kumachitika overdosing, amene anatsagana ndi extrasystole yamitsempha yamagazi ndi tachycardia, kumverera za kulemera mu mutu manja ndi miyendo, komanso kuchuluka kwambiri magazi.

Chithandizo ikuchitika ndi jakisoni mtsempha wa alpha-blockers ndi beta-blockers ndi.

zotsatira zoyipazi

Monga tanenera kale, nthawi zina, pamene akumwabe mankhwala, "Mezotok" angakhale nayo mavuto. Malinga ndi wodwala, kungakhale nyamuka magazi, kuchuluka kugunda kwa mtima, fibrillation yamitsempha yamagazi, arrhythmia mtima, ndipo bradycardia kardialgiya.

Pa mbali ya chapakati mantha System chizungulire zingaoneke, mosadziŵa kumverera mantha, nkhawa, kugona zipolowe, mutu, omangana minofu, kenaka utentha mamba, kukha mwazi kwa muubongo, paresthesia.

Matenda ena mbali, kuweruza ndi ndemanga madokotala ndi odwala awo ndi zizindikiro monga khungu wotumbululuka, ischemia wa khungu m'dera la jekeseni wa, chifuwa, necrosis, nkhanambo padziko minofu pambuyo ka jekeseni subcutaneous.

Mu nkhani ya mavuto, Bungwe kukwezedwa mankhwala "Metozok" malangizo Buku. Analogs za mankhwala Angakuthandizeni kusankha dokotala amachitira.

Kusamala

Kwambiri poika mankhwala "Metozok" zizindikiro. Analogs ntchito pofuna kuchiza matenda zimenezi si kawirikawiri. zokumbira awo katswiri mosamala poona mmene wodwalayo, kukachitika kuti "Mezotok" pazifukwa zina sichinkagwirizana.

Kwa chithandizo ayenera kwambiri kuunikira kwa zizindikiro za ECG, kuthamanga kwa magazi, magazi mu manja ndi mapazi, komanso linanena bungwe mtima.

Odwala ndi wolumikizira oopsa ndi congestive kulephera mtima, m'pofunika kukhala systolic magazi pa 30-40 mamilimita Hg. Art.

Pamene kuwonjezeka magazi, kenako zizindikiro za tachycardia kapena bradycardia, nthawi zina pamakhala disruptions wa mungoli mtima. Imeneyi, mankhwala ndi "Metozok" (Buku akuchenjeza za chingachitike mbali) ayenera kusiyidwa. Kupewa kuchepa sekondale magazi pambuyo achire mankhwala, mlingo pang'ono ndi pang'ono yafupika, makamaka ngati panali yaitali kulowetsedwa, kukapanda kuleka ndi kupitirizabe kuika mtima ngati zoipazi yafupika mtengo wa 70-80 mamilimita Hg. Art.

Mu anthu okalamba chiwerengero cha zolandilira adrenergic, makamaka atengeke amachepetsa phenylephrine. Nayenso monoamine oxidase zoletsa, kuwonjezera zotsatira compressing wa sympathomimetic, imfayo kupweteka kwa mutu, arrhythmia, kusanza reflex, hypertensive mavuto. Chifukwa, odwala ntchito zoletsa monoamine oxidase, masiku 2-3 kuchepetsa chiwerengero cha sympathomimetics.

Pa nthawiyo, madokotala musati amalangiza njira mankhwala a ntchito woopsawo, ozikidwa pa liwiro anachita - onse maganizo ndi thupi.

Ndi kusamala kwambiri ayenera kumwa mapiritsi munthu amene akudwala matenda a impso, komanso okalamba. mankhwala sayenera kumwedwa kwa ana osaposera zaka khumi ndi zisanu ndi zitatu zakubadwa chifukwa chosadziwa za kuopsa kwake.

mankhwala yamasulidwa pharmacies mosamalitsa pa mankhwala.

Analogs medicament

Kodi ngati "Metozok" sizikugwirizana pa zifukwa zina? Analogs nthawi zonse amapezeka pa mankhwala a. Ali chimodzimodzi yogwira mankhwala ndi njira zimenezi zimakhudza thupi. mankhwala njirazi ndi izi:

• "Betalok".
• "Serdol".
• "Egilok C".
• "Vazokardin achigonjetse."
• "Metoprolol".
• "Korvitol 50".
• "Metokard".
• "Emzok".
• "Atenolol".
• "Lidalok".

Izi ndi zina mmalo "Metozok" analogues akhala bwino ntchito pa matenda a matenda a mtima. ndalama zonse zimene zimafunika njira akuluakulu, ndipo akhoza kumwedwa paokha, popanda kuuzidwa ndi dokotala.

umboni

Kukonzekera "Metozok 'mavoti ndi anthu ambiri positive. Anthu amati omasuka kumwa (mlingo ndi - piritsi limodzi pa tsiku). Iwo amalankhula za izo zotsatira waphindu. odwala ambiri kuti pambuyo kumwa njira kuyiwala za ululu mu mtima mwanga.

Akatswiri a mankhwala mwamphamvu kutamandidwa mankhwala "Metozok". Reviews madokotala akusonyeza kuti mankhwala othandiza ndi abwino, nthawi zambiri zotchulidwa cardiologists odwala awo. Akatswiri amanena kuti pamene mankhwala chinthu chachikulu - kusankha mulingo oyenerera, mwinamwake inu mukhoza kuona zotsatira zoyipa monga kutopa, nseru, kusanza ndi kutsekula m'mimba.