Mankhwala "Nise". Malangizo ntchito

Medicaments yogwira mankhwala omwe ndi nimesulide adzalandira kwambiri odana ndi yotupa ndi analgesic zotsatira. Kwenikweni sanali steroidal mankhwala "Nise". Iwo amagwiritsidwa ntchito pofuna kuchiza nyamakazi, nyamakazi, nyamakazi, myalgia, arthralgia, bursitis, tendinitis, algodismenorei kuti tisaletse postoperative ndi ululu posttraumatic, ululu mano ndi mutu, malungo osiyana chiyambi. Alembedwe miyala ndi mtundu woyera ndi mthunzi chikasu, ndipo gel osakaniza (bwino, kuwala chikasu kapena chikasu) ntchito kunja. miyala ndi kuzungulira, biconvex mawonekedwe ndi yosalala pamwamba. Total 100 mg piritsi 1 lili Nimesulide mankhwala "Naiz". mndandanda malangizo adjuvants: chimanga wowuma, microcrystalline mapadi, wa hydrogen kashiamu wa phosphate, ndi sodium wowuma glycolate, magnesium stearate, mwayeretsa talc, colloidal anhydrous silika. Mu 1 g wa 1% gel osakaniza lili 10 mg wa nimesulide. Gel osakaniza auxiliaries ndi: propylene glycol, N-methyl-2-pyrrolidone, macrogol, carbomer 940 Cha, isopropanol, butylated hydroxyanisole, mankwala potassium thimerosal, madzi, flavoring.

Kwa nthawi yoyamba mankhwala okhala nimesulide linatuluka mu Italy (mwachitsanzo, «Aulin» ndi «Mesulid») mu 1985 ndipo panopa likupezeka m'mayiko oposa 50: France, Portugal, Greece, Switzerland, Belgium, Mexico ndi Brazil . Komabe, mankhwala ndi nimesulide mu United States ali kugulisa. Medicine "Nise" dziko ali zofanana, zilipo pansi zotsatirazi zotetezedwa :

• «Sulide», «Mesulid», «Nimalox» (Brazil, Greece);
• «Aulin», «Mesulid» (Italy);
• «Coxtal» (China, Czech Republic, Bulgaria);
• «Sintalgin» (Brazil);
• «Eskaflam» (Brazil, Mexico);
• «Octaprin» (Pakistan);
• «Nise» (India, Russia, Venezuela, Vietnam, Ukraine);
• «Nilsid» (Egypt);
• «Ainex», «Drexel», «Edrigyl», «Enetra», «Donulide», «Heugan», «Mesulid», «NeRelid», «Nexen», «Minapon», «Nidolon», «Nilden» (Mexico) ;
• «Nimed», «Nimesil», «Nimutab», «Nimedex», «Nimdase», «Nimopen-MP» (India);
• «Nisulid», «Nodard», «Nicip», «Nimcap» (India);
• «Novolid», «Relmex» (Ecuador);
• «Remisid» (Ukraine);
• «Scaflam», «Sulidin», «Scaflan» (Turkey);
• «Modact IR" (Pakistan).

Mankhwala ali mofulumira kwambiri ndi multifactor limagwirira cha zimenezi, kuphatikizapo ali zimakhudzanso ochepetsera pa enzyme Cox-2 (cyclooxygenase isoforms wina wa malamulo mapangidwe prostaglandins ku asidi arachidonic). Choncho, mankhwala "Nise" ntchito mankhwalawa osiyanasiyana zinthu zopsetsa mtima. Buku akuonetsa ntchito zochizira ululu waukulu, mankhwala symptomatic a nyamakazi ndi zapulaimale dysmenorrhoea (ozungulira chikhalidwe pathological mu masiku a msambo, akuwonetseredwa ululu m'mimba) mu unyamata ndi mukadzakula. Nimesulide zatithandiza chitetezo cha mundawo m'mimba poyerekeza ndi NSAIDs ena.

Nthawi yokonza "Nise" akapatsidwa ndi kusamala kwambiri. Guide akuchenjeza odwala matenda a mtima, wolumikizira matenda oopsa, shuga a mtundu II. Koma anthu achikulire safuna kuwukonza dosing chakudya. Yaitali ntchito mankhwala amafuna polojekiti mwadongosolo impso ndi chiwindi. Maonekedwe a zochita chokhwima (mu mawonekedwe a kutentha, nseru, kusanza, kutsekula m'mimba, gastralgia, ulceration wa mucosa m'mimba, mutu, chizungulire, madzimadzi posungira, thupi lawo siligwirizana kuphatikizapo zotupa pa khungu anaphylactic mantha) ndi chizindikiro kukaonana ndi dokotala . Ngakhale kuti mankhwala okhala nimesulide, kwambiri, m'malo "Nise" mu aliyense wa analogues popanda mankhwala dokotala ali osavomerezeka.

"Nise" loopsya mankhwala ambiri osokoneza. Guide limafotokoza zizindikiro zake. Zikuphatikizapo kusinza, ulesi, nseru, kusanza, magazi m'mimba, matenda oopsa. Mukhoza kubva mu dera epigastric, maganizo kupuma, pachimake kulephera aimpso, zochita anaphylactic, ndi chikomokere. Pankhaniyi cha mankhwala osokoneza bongo sangathe kugwiritsidwa ntchito yabwino yothetsera iliyonse, chifukwa kulibe, kotero dokotala n'kukulemberani ndi mankhwala symptomatic. M'nthawi ya maola anayi pambuyo pakutchulidwa aliyense mwa zizindikiro wodwala anasambitsa m'mimba ndi kupereka adamulowetsa makala. Hemodialysis mu nkhani iyi si zothandiza. Kupereka mankhwala kumafuna kusamala ngati imodzi ndi mankhwala nimesulide anatumizidwa monga "Phenytoin", "Digoxin, okodzetsa, mankhwala lifiyamu ndi NSAIDs zina, antihypertensives, antidiabetics," cyclosporin "ndi" MTX ". Choncho kudzikonda "Nise" sikuloledwa.