"Rosuvastatin": malangizo ntchito, ndemanga. Cheap analogue "rosuvastatin"

Mankhwala "Rosuvastatin" wakhala kuyambira 2003 ndipo anapereka monga statin Generation IV. Ndi masiku ndi apamwamba woletsa wa Popanga madzi a gamma-methylglutaryl-CoA reductase. enzyme Ichi ndi udindo kaphatikizidwe wa mafuta m'thupi la munthu. chopinga ake kumabweretsa kuchepetsa wa amkati mafuta ndi kuchepetsa kufala kwa matenda a mtima.

Kuwonjezera "rosuvastatin" pali Akhristu angapo kalasi, mamembala a gulu statin. Izi "Simvastatin" "Pravastatin", "cerivastatin," "Lovastatin," "Fluvastatin," "Atorvastatin", "pitavastatin." Chipatala efficacy ndi liwiro kuchepetsa okwana mafuta ndi otsika kachulukidwe "Rosuvastatin" yokha "pitavastatin," amene sanayambebe ntchito ambiri chifukwa Nawonso achichepere zochepa anasonkhanitsa mayesero matenda.

Chibwenzi, "atorvastatin" amagwiritsidwa ntchito kuposa statins ena chifukwa ndi wopambana kwambiri kufufuza m'munsi umboni wa nchito zake matenda. Komanso, iye ndi generics ake mtengo kwambiri, "rosuvastatin". Koma monga mmene lomaliza (normalization wa zamadzimadzi mbiri ya madzi a m'magazi) uli wachangu, ndiyeno iye akuyamba ntchito zambiri ndipo anthu ambiri. Izi ndi zoona mankhwala khalidwe, chomwe ayenera kulipira mtengo.

Ikani "rosuvastatin" mu pharmacotherapy

Pokonzekera "Rosuvastatin" ntchito, ngakhale kuli Anzawo kalasi, zinthu zambiri. Iwo limanenedwa zizindikiro ndi contraindications okha. The zikuonetsa alipo pafupifupi mitundu yonse ya hypercholesterolemia ndi matenda a kagayidwe zamadzimadzi. The kuchepa atherogenic zamadzimadzi tuzigawo twa ndi zotsatira zabwino pa chamoyo. Chifukwa cha ichi, mosavuta kukula kwa zotupa atherosclerotic yafupika, ndi moyo amayembekezeka (ndi khalidwe) kuonjezera penapake.

Kukonzekera "Rosuvastatin" akhoza ntchito kupewa matenda a mtima, ndi kuwachitira. Last kagawo kakang'ono pharmacotherapy alipo chifukwa kupondereza njira ya atherosclerosis ndi za indofeliyamu olimba a zolengeza. Popeza infarction ndi mtima oziziritsa kukhala kuchokera thrombosis pachimake kutsogolera mitsempha, ndiye zotsatira matenda kwenikweni kumathandiza zochitika pachimake inatsekeratu.

Malangizo ntchito

Mayina mankhwala "Rosuvastatin" malangizo Buku (analogues zolembedwa ngati alipo) lili yopapatiza osiyanasiyana zikuonetsa ntchito. Komabe, lilibe mfundo iliyonse mtima kuti chofunika asanayambe ntchito kudziwa nusu ya mafuta. M'tsogolo, kusintha awo adzakhala amayang'anitsitsa matenda efficacy wa mankhwala mu mlingo zina. Komanso mawu kakunena za tipewe ngozi ndi mbali ya chithandizo, contraindications, ndipo zotsatira zambiri ndi yofunika mbali.

zikuonetsa

Ena mwa matenda onse kucheza ndi anthu plasma zamadzimadzi tuzigawo twa, zikusonyezanso zinthu zina zikuonetsa matenda:

• heterozygous kumtundu (banja) hypercholesterolemia;
• wachinsinsi ndi Fredrickson polygenic hypercholesterolemia mtundu IIa;
• ophatikizana dyslipidemia, wachinsinsi ndi Fredrickson mmene IIb;
• Homozygous banja (banja) hypercholesterolemia;
• inatsekeratu oziziritsa kapena aimpso arteriosclerosis, occluding wa lumen wa mtsempha wamagazi ndi;
• Atherosclerosis a mitsempha ya m'makona m'munsi, kuphatikizapo matenda Leriche ;
• (Mtundu IV malinga Fredrickson) hypertriglyceridemia;
• mankhwalawa infarction m'mnyewa wamtima ndi ubongo, kuyambira nthawi pachimake;
• kupewa infarction m'mnyewa wamtima ndi sitiroko.

contraindications

Aliyense mtengo analogi "rosuvastatin" ali ndi zotsatira chomwecho mbali monga chapachiyambi "Crestor". Pamaziko a sipekitiramu contraindications awo anapanga, amene ali motere:

• kwa chiwindi cytolysis syndrome matenda ndi hepatocytes ndi oposa atatu khola kuwonjezeka woipa transaminase;
• chiwindi kulephera, matenda enaake ndi zambiri 9 Child-Pugh;
• aakulu aimpso ntchito kulephera chizindikiro ndi creatinine chilolezo zosakwana 30 ml ya \ min.;
• Myopathy chiyambi uliwonse;
• thupi lawo siligwirizana ndi zigawo chiphunzitso kapena "Rosuvastatin".

Pali gulu contraindications ena 40 mg wa mlingo:

• aakulu aimpso kulephera ndi chizindikiro creatinine chilolezo osachepera 60 ml ya \ min.;
• myopathies aliyense cholowa;
• ntchito concomitant ndi fibrates;
• uchidakwa;
• Mongoloid mtundu;
• ntchito statin kwa nthawi yoyamba.

Features mankhwala

Onse "rosuvastatin" - mankhwala, analogues amene ali m'zinenero pa msika. Ndipo kusankha inayake mtundu dzina, wodwala ayenera kumwa mankhwalawa ndi pa. Kutanthauza kusintha kwa mankhwala wina wodzikweza. Sam mankhwala akutengedwa mosatengera chakudya nthawi iliyonse tsiku. Pali zingapo malangizo ena a akatswiri amene poyamba ankagwira ntchito ndi statins m'badwo woyamba. Iwo ali zomwe statins ayenera kumwedwa pa nthawi yogona. Ngakhale kuti si wofunika kwambiri, malinga ngati mankhwalawo anatengedwa pa nthawi yomweyo ndipo mosalekeza.

Kupsa boma awo ayenera mosalekeza mpaka anaulandira "Rosuvastatin" (analogues). Reviews kulola akatswiri ntchito machenjerero bwino chidwi. Makamaka pambuyo pa kukhazikitsidwa cha kukhalapo hypercholesterolemia kuyamba kutenga mankhwala ndi mlingo amodzi. Patapita miyezi 2 kuunikira - lipidogram mobwerezabwereza anachita ndi ayesedwa ntchito ya aminotransferases.

Ngati pali normalization wa zamadzimadzi mbiri ya madzi a m'magazi, ndi kuti tipitirize kulandira mlingo chomwecho. Ngati okwana mafuta amakhalabe mkulu, ndi kuchuluka kwa otsika kachulukidwe mafuta kwambiri yafupika, kuwonjezera mlingo chofunika. Ngati transaminase kuchuluka katatu, pamafunika kuchotsa statins. Kuyenera makamaka kudziŵika kuti chizolowezi zing'onozing'ono kupangitsa cytolysis wa statins onse ndi "Rosuvastatin." Analogs (Ukraine komanso pang'onopang'ono kusuntha kwa "atorvastatin" kuti "rosuvastatin") kalasi sakhala otetezeka. A "pitavastatin" amakhalabe wamng'ono anaphunzira.

Analogs "rosuvastatin"

Monga kufanizira ndi, "rosuvastatin" ( "Crestor") kale amapereka mankhwala oposa 10. Pakati pawo, "AKORT", "Merten", "Rozart", "Rozistark" "Rosuvastatin Canon", "Rosuvastatin SOTEX" "Rosuvastatin NW", "Rozulip", "Rozukard", "Roxer", "Rustor" " Tevastor ". Mtengo wa kuwachitira ndi osiyana, komanso dzuwa. Pakuti mtengo wa mankhwala akhoza kugawidwa m'magulu atatu:

• zotchipa (kuchokera rubles 250 mpaka 650), "Rosuvastatin NW", "Rosuvastatin Canon", "AKORT" "Rosuvastatin SOTEX";
• Avereji ya mitengo (kuchokera rubles 400 900), "Merten", "Rozart", "Roxer", "Rozukard", "Tevastor", "Rozulip";
• kukwera mtengo (kwa rubles 1100 ndi 2200): "Crestor".

mtengo kusanthula chitachitidwa amayerekezera mtengo wa mankhwala, thupi pawiri yogwira amene anali 10 mg. Mtengo osiyanasiyana amasonyeza mtengo wa mwezi umodzi mankhwala mafuta-kutsitsa. Yotsika mtengo analogi "rosuvastatin" chopangidwa ndi "Kumpoto Star". "Rosuvastatin Canon" ndi "AKORT" ndi osiyana pang'ono mu mtengo. mtengo awo ndi zokayikitsa kusintha malinga kusinthasintha kusinthitsa ndalama.

Kufotokozera mwachidule yotsika mtengo generic "CRESTOR"

Mankhwala "Rosuvastatin" anamasulidwa ndi Astrazeneca, amatchedwa "Crestor". Izi ndi mankhwala pachiyambi, umene uyenera poyerekeza ena onse. N'chimodzimodzinso ndemanga: khalidwe la makamaka generic mankhwala zikhazikitsidwe poyerekeza ake ndi "Krestorom". Koma chifukwa cha mtengo wake ndi mkulu, odwala ambiri yomweyo anayamba mankhwala a hypercholesterolemia ndi generics mtengo.

Cholinga zambiri akatswiri chokha mu ndemanga, amene nthawi zambiri anakumana ndi ntchito generics ndi "rosuvastatin" ndi original "CRESTOR". A ntchito mankhwala "malangizo Rosuvastatin 'ntchito, pamene umboni uperekedwa mtima ndi zinachitikira matenda adzalola odwala kusankha makamaka dzina malonda.

Reviews akatswiri "Crestor" ndi generics

Yerekezerani "CRESTOR" ikuchitika yekha ndi akatswiri a Russian Society of Cardiology. Mfundozi zambiri m'magazini yotchedwa "zomveka pharmacotherapy mu cardiology." Kwenikweni, akulankhula nkhani bioequivalence wa generic mankhwala "Crestor". Malinga ndi zotsatira za maphunziro pharmacoeconomic asonyeza kuti mankhwala "Merten", "Rozart", "Roxer", "Rozukard" ndi "Rozulip" bioequivalent "Crestor".

Izi zikutanthauza kuti aliyense "rosuvastatin" kufanizira izi kumakhudza achire ofanana ndi mankhwala choyambirira ali nambalayi ndi kuwuma mavuto. Ngakhale mankhwala "Rosuvastatin NW", "Rosuvastatin Canon", "Rosuvastatin SOTEX" ndi "AKORT" mu mayesero amenewa ntchito. Chifukwa maphunziro awa zowerengera si ndalama zolipirira ndi makampani opanga mankhwala, mfundo chifukwa ndi cholinga kukakumana ndi mbali matenda a mankhwalawa hypercholesterolemia. Komabe, zotsatira okha generics yachilendo.

Reviews akatswiri wotchipa generics "rosuvastatin"

Modern analogue a "rosuvastatin" wotchipa azikhala bioequivalence awo "Crestor" ndiyeno basi afika ulemu akatswiri. Popanda maphunziro bioequivalence akatswiri amanena kungotchulapo mbali matenda a ntchito. Mmodzi wa iwo ndi uyu: ngati ntchito zonse mtengo Anzawo "rosuvastatin" (mankhwala tatchula), pafupipafupi zochitika chowawa ofanana ndi asunga ntchito generic bioequivalent "Crestor".

Kusinthasintha mu plasma ndende "rosuvastatin" akuwuka kwa ntchito olimba mawonekedwe mlingo ndi zosiyanasiyana, amaonedwa zonyozeka mu nkhani iyi. Chifukwa wotchipa Russian analogue a "rosuvastatin" kwenikweni m'malo pachiyambi mankhwala "Crestor" ndi mankhwala ake generic zochizira hypercholesterolemia.

Kaperekedwe odwala ndemanga

Malinga ndi mayankho cha odwala amene kugawana maganizo awo olakwika okhudza ntchito ya mankhwala ndi dokotala, pali zingapo kwanzeru. Choyamba, odwala ziweruzo za khalidwe la mankhwala okondera. Kachiwiri, chifukwa cha imperceptible kwa wodwala zotsatira matenda a kutsatira mankhwala ndi otsika, ngakhale mankhwala n'kofunika kupewa ngozi zochitika pachimake inatsekeratu. Chachitatu, odwala amakonda kufunikira mavuto ndi kuchepetsa mphamvu ya mbiri plasma zamadzimadzi.