The ntchito ndi zotsatira za "Cefotaxime." "Cefotaxime": ndi analogue mankhwala

Mankhwala "cefotaxime" - ngati mankhwala osokoneza bongo zochizira matenda opatsirana ndi kupewa mavuto postoperative. Mankhwala anadzetsa m'thupi kudzera jekeseni, nthawi zambiri analamula kuti akuluakulu komanso ana. Ndi semisynthetic maantibayotiki ndi yogwira mankhwala sefotaksim ndi sodium.

zotsatira pharmacological

"Cefotaxime" - Woimilirako cephalosporins, kanthu bactericidal anaonetsetsa ndi yimitsira la mapangidwe makoma khungu la bakiteriya.

Antimicrobial cholinga ntchito parenteral, ndi ogwira atadziŵa galamu alibe mabakiteriya kuti ndi kugonjetsedwa ndi maantibayotiki ena, sangathe kuchita galamu HIV cocci, koma layamba kuposa mabakiteriya galamu-negative.

Pharmacokinetics

mankhwala mofulumira odzipereka, malingana ndi mlingo wake ndi mu madzi a mphindi zisanu kapena theka la ola pambuyo jekeseni ndipo amakhala woipa bactericidal magazi kwa nthawi yaitali maola 12. The mankhwala ndi kulowa minofu ndi madzimadzi, komanso anagawira mu iwo. Pamene ntchito mankhwala mkaka wa m'mawere angakhoze kulowamo mkaka wa m'mawere. The pazipita zotsatira "Cefotaxime" zimatheka pamene woipa agwire ntchito synovial, peritoneal ndi madzi pleural. Derivation imagwiridwa zikutsatiridwa mu mkodzo (60%) ndi mu mawonekedwe a metabolites. Pakuti theka moyo chifukwa cha V / mamita ndi / mu chofunika 1 hr.

Zikuonetsa ntchito medicament ndi

Zikuonetsa ntchito mankhwala ndi matenda chikhalidwe cha kutupa chikwiyire ndi yaying'ono-zamoyo amene kusagwirizana zosiyana "cefotaxime" (makamaka galamu-zoipa). Inakhazikitsa zimangotanthauza kuti jakisoni "Cefotaxime" analogs mapiritsi zilipo, mankhwala ntchito kudziwa limati ngati:

• matenda okhudza zinthu zonse m'mimba;
• zotupa pa khungu, mafupa, minofu zofewa ndi fupa;
• matenda a m'mapapo thirakiti, mphuno, pakhosi, makutu;
• matenda okhudza dongosolo mkodzo;
• Lyme matenda;
• yotupa njira ya matenda chilengedwe ziwalo m'chiuno, chinzonono;
• amayaka, matenda zilonda;
• meninjaitisi, endocarditis, septicemia;
• matenda a immunocompromised;
• kupewa matenda opatsirana pambuyo opaleshoni njira (ntchito pa ziwalo m'mimba thirakiti, obstetric ndi matenda ndi njira Urological).

contraindications

"Cefotaxime" analogues mu jekeseni ali contraindications zina zimene tiyenera kuziganizira isanafike utsogoleli wa mankhwala.

mankhwala ali contraindicated mu nkhani ya hypersensitivity kwa penicillin, carbapenems ndi cephalosporins ena. Ake mosamala Kwalamulidwa kwa chiwindi ndi impso matenda, anam'peza matenda a m'matumbo, mkaka wa m'mawere. Amayi apakati ndi Kwalamulidwa pokhapokha ngati pali chiopsezo chachikulu kwa mwana wosabadwayo kapena mayi wa thupi akuyenera kupindula kwambiri kuposa kuopsa zotheka. Pamene ntchito poyerekezera ndi ana osaposera zaka 2.5, saloledwa ntchito njira jekeseni mu mnofu.

Ntchito ya mankhwala, mlingo

Kudziwa momwe kawetedwe "cefotaxime", m'pofunika kuwerenga nkhani anapatsidwa malangizo ntchito mankhwala. Mankhwala oti / mamita ndi / kumayambiriro (kudzera ndi dropper kapena bolus).

mankhwala Kwalamulidwa kwa odwala wamkulu kuposa zaka 12, pamene thupi ndi makilogalamu kuposa 50:

• matenda opatsirana pa mundawo mkodzo milandu ndipo anthu pamene matenda amapezeka popanda mavuto chamoyo mwa njira iliyonse imene angathe kupereka 1 g lokonzekera ndi intervals wa maola 8-12;
• wopepuka mitundu chinzonono pachimake kutumikiridwa singly ndi mu mnofu njira 1 g wa mankhwala;
• ntchito mankhwala mankhwala matenda a chikhalidwe opatsirana, zovuta zomwe ndi sing'anga, njira n'zotheka wa 1-2g chikuyendetsedwera ndi periodicity kumatanthauza maola 12 (pamaso mbewu "Cefotaxime", m'pofunika mosamala malamulo malinga ndi zomwe njira za kukonzekera jekeseni) ;
• molimba zikuchitika matenda, mwachitsanzo, kakhosi, amafuna oyamba mu mtsempha 2 ga mankhwala pa intervals wa maola 4-8, ndi mlingo pazipita patsiku akhale osapitirira 12 ga; Kutalika kwa chithandizo anatsimikiza ndi zovuta za moyo;
• patsogolo ntchito pa ochititsa dzanzi kuthetsa mosavuta matenda chikuyendetsedwera 1 g wa mankhwala, zina maola 6-12 ikuchitika reintroduction zikutanthauza;
• gawo cesarean imagwiridwa ndi kuyambitsa 1 g wa "Cefotaxime" Patapita ndondomeko akubwerezedwa.

mankhwala amagwiritsidwanso ntchito m'nsinga poyerekezera ndi ana azionera akhanda:

• zaka zosakwana 1 sabata - ntchito 50 mg pa 1 makilogalamu thupi ndi pafupipafupi maola 12;
• zaka milungu 4 1 - 50 mg pa makilogalamu 1 thupi ndi periodicity wa 8 h.

Ana amene kulemera makilogalamu zosakwana 50 pa zaka 2.5, kusankha 4-6 Chiyambi Imodzi mwa njira zotheka kwa 50-180 mg wa pa kilogalamu ya kulemera kwa thupi (bwino monga "cefotaxime" mtundu novocaine, muyenera kuwerenga malangizo mosamala) . Ngati pali njira choopsa cha matenda, ntchito 100-200 mg / kg. Pa tsiku zovomerezeka kwa 12 ga mankhwala.

Kukonzekera njira jekeseni

mtsempha jekeseni

The wosabala madzi a jekeseni (4 ml) anali kuchepetsedwa ndi 1 g wa mankhwala. Yankho chikuyendetsedwera pa mphindi 3-5, ndikofunika kupereka yobereka pang'onopang'ono mu thupi.

Mtsempha kulowetsedwa (kukapanda kuleka)

Pa 50-100 ml ya zosungunulira (dextrose 5% kapena sodium kolorayidi TH 0,9%) sitimadzipereka 1-2 ga mankhwala ndi kulowetsedwa ikuchitika kwa mphindi 50-60.

mu mnofu

Mu 4 ml ya njira (1% novocaine njira -th, madzi a jekeseni) kutenga 1 g wa mankhwala, kupanga jakisoni ku matako, ndi singano ayenera kulowa kwambiri mu minofu kuti.

Compliance ndi malangizo mankhwala ntchito

"Cefotaxime" analogues mapiritsi limene zilipo, ntchito mogwirizana ndi malangizo. Patsogolo ntchito mankhwala zofunika kuchotsa mosavuta chifuwa. Odwala amene akhoza kukhala matupi awo sagwirizana anachita penicillin, mankhwala ayenera kugwiritsidwa ntchito mosamala kwambiri. Ngati pali kudziwa zinthu zili mankhwala mankhwala ntchito yake ndinayima. Mankhwalawa kwa masiku opitirira 10 kumafuna nthawi anayendera zotumphukira magazi. Kuthetsa zochita osafunika pa chithandizo ayenera kusiya mowa.

Overdosing mavuto

"Cefotaxime" analogues mu kuyimitsidwa ndi ambiri mavuto:

• thupi lawo siligwirizana (urticaria, kuyabwa zidzolo, malungo, kuzizira, bronchospasm, anafillaksiya, eosinophilia, angioedema, poizoni epidermal necrolysis ndi Stevens-Johnson);
• dyspepsia (ululu pamimba, dysbacteriosis, flatulence, nseru, kusanza, kudzimbidwa kapena m'mimba, matenda a chiwindi, mu nthawi zina - pseudomembranous matenda a m'matumbo);
• glossitis, stomatitis;
• chisokonezo dongosolo hematopoiesis (hypocoagulation, hemolytic magazi m'thupi, thrombocytopenia, granulocytopenia, neutropenia, leukopenia);
• kuvutika mu ziwalo mkodzo (interstitial nephritis, anuria, oliguria, azotemia, mpweya wambiri wa urea m'magazi);
• chizungulire, mutu;
• njira zoipa mu dongosolo mtima (arrhythmias onyamula kuopseza lingathe moyo);
• zochita osafunika m'deralo (adzalowerera kupweteka / m, phlebitis);
• kusintha mu magawo zasayansi (zabodza zabwino Coombs 'mayeso);
• superinfection (m'kamwa candidiasis, candida vaginitis).

"Cefotaxime" analogue mankhwala pamene ntchito mlingo waukulu kungachititse kuti ambiri osokoneza, kenako khunyu ndi zizindikiro zina, pakati pawo - nkhawa, kenaka utentha mamba, encephalopathy (zambiri chizindikiro ichi zimawonedwa mu odwala matenda kulephera aimpso). Kuthetsa zotsatira za ambiri osokoneza mankhwala symptomatic ntchito.

mogwirizana mankhwala ndi mankhwala ena

Ngati mukufuna kupeza njira ndi zikuchokera ofanana zikuchokera ndalama "cefotaxime" analogue Sankhapo sadzakhala kovuta. Koma ziribe kanthu, mothandizidwa ndi mankhwala amachitidwa ntchito analogue zoyambirira kapena, Mulimonsemo, muyenera kuganizira mogwirizana kwa mankhwala ndi mankhwala ena.

Pamene "cefotaxime" akuphatikizapo onse mankhwala zingakhale nephrotoxic monga furosemide, mankhwala aminoglycoside, ndikofunika kusunga ntchito ya impso, chifukwa cha ngozi mmene nephrotic.

Zochizira matenda ambiri ndi kupewa chitukuko zambiri ntchito "cefotaxime". Malangizo ntchito, analogues mankhwala kuti kuti ankaphunzira, monga chida ichi zingachititse chifuwa, ali kwambiri mavuto ndi zina. The njira ya mankhwala akhoza kugwiritsidwa ntchito molumikizana ndi njira zina za mankhwala, iwo sangakhoze olumikizidwa kwa chipinda kukapanda kuleka ndi syringe.

analogs

Kutanthauza kuti "cefotaxime" analogi ayenera kusankhidwa kwa thunthu yogwira. Wa analogues structural tingaone:

• cefotaxime ndi sodium;
• cefotaxime vial, Sandoz, sodium ndi lek;
• tsefosin;
• tsefantral;
• tsefabol;
• tsetaks;
• tirotaks;
• tartsefoksim;
• taltsef;
• msonkho ndi zothetsera;
• spirozin;
• rezibelakta;
• oritaksim;
• oritaks;
• liforan;
• klafotaksim;
• klaforan;
• klafobrin;
• kefoteks;
• intrataksim.

Popeza kuti zipangizo zosiyanasiyana kukonzekera "cefotaxime" analogi kusankha zosavuta, koma T. Kwa. The analogs zingakhudze mmene ena mbali, ndi machiritso mmene angakhale ofooka, kuchotsa mankhwala choyambirira ayenera loyenera kwambiri. Kupewa mavuto osafunika, ayenera kuphunzira mfundo zambiri za mankhwala amene anakonza ntchito.