"Theophylline": malangizo ntchito. "Theophylline": zikuonetsa ntchito analogues

Ngati munthu amadwala airway kutsekeka, izi zingasonyeze pamaso pa aakulu obstructive m'mapapo mwanga matenda (COPD). matenda ndi zachilendo. Nthawi zambiri pakutchulidwa za matenda m'zimene osuta. Chitukuko cha matenda amayamba ndi matenda kugunda, kapena zimene ena kuwonongeka m'mapapo. Munthu ndi airway constriction sangathe kutulutsa. Chifukwa, zizindikiro zazikulu ndi kuwonekera kwa matenda dyspnea, chifuwa, ndi kupanga sputum. Nkofunika kudziwa. Ambiri ndi chitukuko cha mitundu ina ya COPD. Izi yatsoka mphumu, chifuwa, ndiko kumayambitsa bronchiectasis. Mu mankhwala amenewa ndi ambiri matenda ena kuthandiza mankhwala monga "theophylline". Malangizo ntchito mankhwala zikakambidwe pa nkhani iyi. mumve zambiri za izi.

mafotokozedwe

"Theophylline" amene zikuchokera adzakhala pansipa, ndi woyera crystalline ufa. Ndi pang'ono sungunuka m'madzi ozizira (mu chiŵerengero 1: 180), koma mosavuta kotero mu madzi otentha (mu chiŵerengero cha 1:85). Komanso dissolves alkalis ndi zidulo.

kapangidwe

Mu chiphunzitso ichi waukulu yogwira pophika ndi theophylline. pano mulinso zina zigawo wothandiza. Ndicho - lactose monohydrate, mankhwala enaake a stearate, talc, asidi methacrylic.

Fomu kumasulidwa

Pali mitundu yambiri pankhaniyi. "Theophylline" chopangidwa monga miyala wolingalira-kumasulidwa (0,1 ga, 0,25 g), makapisozi (0.125 G 0.5 g), ndi suppositories (0.2 g).

zochita pharmacological

Magwiridwe a chiphunzitso anati ndi Mipikisano faceted. "Theophylline", ndemanga zimene ziri zabwino, zosangalatsa thupi la bronchi, ali popatsana ndi vasodilator kanthu. kukonzekera Izi zipangitsa ntchito wabwinobwino wa pakati kupuma. Kuthetsa ululu zakulera ndi bwino kugwira ntchito kwa minofu intercostal kumathandiza kuti "theophylline". ntchito popanga ndondomeko yake amachepetsa Mwina chiwonetsero cha thupi lawo siligwirizana ndi kupuma matupi dongosolo mtundu. Anati kukonzekera likhoza zotsatira diuretic. Kupezeka kwa zinthu za kalikiliki medicament umalimbikitsa ndi normalization wa ntchito kupuma, kuchepetsa mlingo wa mpweya woipa ndi kuchuluka mpweya wabwino. "Theophylline" mwaluso kumawonjezera makope inatsekeratu. kumathandiza kuchepetsa kamvekedwe ka zipangizo za ubongo, impso ndi mtima. Pamene tikugwira chithandizo yaitali likukula biliary thirakiti, normalization microcirculation ndi erythrocyte kukana kuti kuchuluka mapindikidwe. Mu odwala matenda hypotension, akhoza magazi kutsitsa. Kukhazikitsa kulandira kukonzekera monga "theophylline", pamodzi ndi beta-blockers, ndi mankhwala kumachititsa chiopsezo mavuto kuchuluka.

zikuonetsa

Perekani anati mankhwala pa zosayembekezereka wa bronchial mphumu, mphumu udindo, matenda obstructive, ndiko kumayambitsa m'mapapo mwanga. Kwalembedwa amagwiritsa ntchito makanda obadwa kumene ndi apnea. Gwiritsani ntchito "theophylline" makamaka ngati bronchodilator a. Komanso, iwo ntchito monga cardiotonic zolimbitsa (kuonjezera mphamvu ya contractions mtima) ndi diuretic (diuretic) mankhwala chifukwa cha mawonetseredwe congestive chiyambi aimpso ndi mtima. Nthawi kutumikiridwa pamodzi ndi yotupa zina ndi bronchodilators.

nkhani ya sipekitiramu wa chiphunzitso anati

Poyamba, mu mankhwala a COPD ndiwo utumiki bronchodilators. Iwo amanyamula Kuwulura Airways. Mmodzi wa mankhwala, monga tanenera kale pamwambapa, pochita ndi monga "theophylline". Malangizo ntchito amadziwika ngati bronchodilator mankhwala, zomwe akuchita otchedwa Letsani ya maselo purine. Kupezeka kwa oterowo limagwirira amadza zipangitsa kuchotsa spasms mu mnofu yosalala bronchi ndi kuwonongedwa kwa ululu chifundamtima, kutsegula kwa mpweya m'mapapo, kuwongolera ntchito ya minofu intercostal. Chifukwa, Airways kutsegula, munthu kupuma mosavuta.

Iwo ali ndi mwayi kotsimikizika, "theophylline". Malangizo ntchito akusonyeza kuti mankhwala akhoza ndithu zimakhudza osati pa mundawo kupuma, komanso machitidwe ena a m'thupi. Izi mankhwala amathandiza kukuza inatsekeratu ndi zotumphukira mitsempha saphunzira ndondomeko kupatsidwa zinthu za m'mwazi guluu wolimba, ndi wofatsa diuretic kanthu. Imakhala kukondoweza kudulira ntchito za minofu mtima (myocardium) m'munsi magazi, komanso zotsatira zopindulitsa pa chapakati mantha dongosolo. Chifukwa, mankhwala akhoza kuchita mosalekeza, imodzi ndi antiasthmatic, bronchodilator, diuretic, spasmolytic, vasodilatory ndi katundu cardiotonic.

"Theophylline": malangizo ntchito

Pofuna kudziwa mlingo, pali muyezo ambiri. "Theophylline", malinga ndi malangizo, muyenera ana kwa zaka 14 ndi akulu, 300 mg pa tsiku 2-3. Pankhaniyi, mankhwala ayenera kumwa madzi lalikulu zedi. Ngati ndi kotheka, mlingo akhoza ziwonjezeke kwa 500 mg nthawi 2 tsiku, ngati analimbikitsa ndi dokotala. Ngati wodwalayo thupi osachepera makilogalamu 60, mlingo akhale 100 mg 2 pa tsiku. Pankhaniyi, yoikidwiratu m'mawa ndi madzulo phwando kukonzekera ichi monga "theophylline". Malangizo limanena kuti mankhwala n'kofunika kuyamba ndi Mlingo ang'ono ndi pang'onopang'ono kuwonjezera iwo kuti akhale. Izi mankhwala iyenera kuchitikira fupipafupi. Iwo ayenera kukhala masiku 2-3. Malinga ndi malangizo amenewa, ngati ndondomeko mankhwala ndi zofunika kuchita njira zonse matenda. Ndicho - kukhazikitsa kusanthula magazi, magazi muyeso kuthamanga, X-ray, ECG, kudziwa mlingo wa mafuta ndi hemoglobin. Chionetsero cha mphamvu akangofika anati njira akubwera pambuyo pa masiku awiri. Nkofunika kudziwa. Mu phwando anzake a mankhwala ndi MANKHWALA OLETSA VUTOLI akhala kuwonjezera dzuwa la ndondomeko mankhwala. "Theophylline" amachepetsa kanthu za mankhwala m'mimba wothandizira. Nthawi machiritso kusamala posankha mankhwala aliwonse caffeinated ndi antidepressants.

Kutenga mankhwala pa mimba ndi yoyamwitsa

"Theophylline" amasintha mwana wosabadwayo mu gulu "C" ndi FDA. Chida likulowerera chotchinga placental. Amayi oyembekezera tinganene mankhwala pokha pokha pamene ankayembekezera phindu mayi ali wamkulu kuposa chiopsezo kuthekera kwa mwana wosabadwayo. Mu nthawi ya ine trimester ndi masabata otsiriza wa mimba ayenera kutenga mankhwala, poona zizindikiro kwambiri. Nkofunika kukumbukira.

Wa kuzipenya ambiri amati theophylline chilolezo pa III trimester mimba yafupika. Izi kungafune mtima pafupipafupi wa ndende ya thunthu mu magazi ndi kuchepetsa zotheka kwa mlingo.

Kuyamwitsa "theophylline" igwera mu mkaka ndi angayambitse zizindikiro za irritability makanda kapena zizindikiro zina kawopsedwe. Nkofunika kudziwa. Anthu ambiri anati thunthu mu mkaka wa m'mawere pafupifupi ofanana ndi wokhutira mwa wa seramu magazi a mayi. Komanso, izi zikutanthauza kwambiri kumabwezera mmbuyo contractions uterine.

contraindications

"Theophylline" malangizo ntchito monga tafotokozazi, ndi contraindicated ngati pali:

• Mbali yapadera.
• Hyperthyroidism.
• Pachimake m'mnyewa wamtima infarction.
• Subaortic stenosis. Izi sanali yotupa matenda a ventricle kumanzere kwa mtima minofu minofu. Iwo amakhala ndi mawu a kuchepetsa zakuthwa M'mimbamo ake.
• Arrythmia.
• Khunyu ndi zinthu zina convulsive.
• Mimba.

Mosamala m'pofunika kuchita phwando ya mankhwala pa chiwonetsero cha matenda anam'peza za m'mimba ndi duodenum.

i yeniyeni

Kusuta kwambiri amakhudza likhale la kagayidwe ndi excretion wa zinthu zina monga theophylline. Tiyenera kukumbukira. Anthu amene ankasuta mapaketi 1-2 ndudu tsiku, ndi wotsikirapo theka moyo nthawi. Odwala ndi kwa chiwindi, mtima kapena kupuma kulephera umaonetseredwa, komanso matenda tizilombo hyperthermia amapezeka deceleration Kupha mankhwala yogwira. Phwando la mowa ndi tiyi kapena khofi-mtundu mankhwala ali ndi zotsatira kwambiri pa kagayidwe wa theophylline.

mogwirizana

Mankhwala "theophylline" amalimbikitsa potentiation zotsatira za β2-agonists. Kungatithandizenso kugwedeza, amene amayambitsidwa ndi mtundu sympathomimetic mankhwala ndipo akhoza ziletsa ndondomeko ya mayamwidwe phenytoin. Wosakwiya Kupha njira amapezeka mogwirizana ake ndi "mankhwalawa" ndi "phenobarbital." Amatanthauza "theophylline" amatipatsa kuwonjezeka mu excretion aimpso wa lifiyamu. Pankhaniyi, muyezo achire anawawidwa odwala amene akutenga kuphatikizapo lolingana. Mankhwala "cimetidine" kumathandiza kuti anthu ambiri mu milingo magazi theophylline, ndi kuonjezera nthawi ya achire ake. Mankhwala ndi mavuto ofanana adzakhala ali m'munsiwa.

Pamaso mavuto

Pamene kulandira mankhwala anati angakhale ndi zizindikiro zosiyana negative. akuti:

• Mukhoza kuona zizindikiro za chizungulire, tulo, mutu, kukomoka, nkhawa, kugwedeza, chisokonezo, khunyu.
• Mu dongosolo mtima - arrhythmia, tachycardia, angina onyenga, kuchepa mwadzidzidzi magazi, angina pectoris.
• Ku dongosolo m'mimba - zikamera wa nseru, kusanza, kutentha, m'mimba, flatulence, matenda a m'matumbo, gastritis.
• Pamene ntchito ya phwando njira zingaoneke ena maonekedwe a thupi lawo siligwirizana mu mawonekedwe a kuyabwa, moto, urticaria, dermatitis, malungo, thukuta ndi khungu totupa.

ambiri osokoneza

Pankhaniyi, pali zizindikiro zina. Pansi mawonetseredwe ameneŵa amakhudza:

- mukubwadamuka;

- chisokonezo;

- kupweteka;

- tachycardia;

- arrhythmia;

- hypotension;

- nseru;

- m'mimba;

- kusanza ndi kusakanizikana kwa magazi;

- hyperglycemia;

- kagayidwe kachakudya acidosis.

Pamene zizindikiro zimenezi akapatsidwa mankhwala ena. Ndicho, kuyendetsedwa ndi:

• Adamulowetsa makala njira.
• Ulimi wothirira kudera matumbo osakaniza a mchere ndi polyethylene glycol njira.
• Mtsempha phwando "MCP" kapena "Ondansetron" ndi zizindikiro amalembedwa cha kunyansidwa ndi kusanza.
• Phwando "benzodiazepines", "Phenobarbital" (kapena thiopental ndi sodium) ndi relaxants zotumphukira minofu pa zosayembekezereka wa khunyu.

"Theophylline": Anzawo

Pali mankhwala osiyanasiyana a mtundu uwu. Pankhaniyi, talingalirani mankhwala zotsatirazi:

- "Teobiolong" ( "Theobilongum").

- "Spofillinretard" "(Spophillin achigonjetse").

- "Perfillon" ( "PerphyUon").

- "Neoefrodal" ( "Neo-Efrodal").

- "Franol" ( "Franol").

yosungirako

The ufa ndi miyala ( "theophylline") kusungidwa mu mdima, youma. Awo moyo alumali ndi zaka zisanu. makandulo yosungirako zizichitidwa mu firiji. Pa nthawi yomweyo iwo sayenera zii. Awo alumali moyo zaka zinayi.

chifukwa

Nditawerenga pamwamba, zodabwitsa zimene mankhwala monga "theophylline", mtengo umene alandiridwa (mkati 70-160 pakani.). Komanso mu lemba anauzidwa za malangizo ntchito mankhwala ndi anzake ake ndi njira zina.