"Boudin" inhalation: malangizo ntchito, maonekedwe, zikuchokera ndi ndemanga

Mu mankhwala a mphumu bronchial ndi agonist beta-blockers ankagwiritsa ntchito corticosteroids Mpweya kuti kuchepetsa pafupipafupi ndiponso azikhala nkhani ya bronchospasm. Mwa gulu la mankhwala ndi kupereka "Boudin" kwa inhalation. pa ntchito "Budenita" Buku lili mudziwe zambiri pa nkhani ya mankhwala, kotero ife kulabadira muone zake zazikulu ndi mfundo zina zabwino luso ntchito pa mankhwala nebuliser.

Zikuchokera amatanthauza "Boudin Steri-Neb" (kuyimitsidwa)

Malangizo limasonyeza kuti mankhwala ndi kuyimitsidwa chifukwa inhalation, wopanda mtundu ndi fungo, ankanyamula mu polyethylene vayozi wa 2 ml, munali 1 mg (0.5 mg / ml) kapena 0,5 mg (0,25 mg / ml) ndi yogwira pophika budesonide. Zinthu zimenezi zikukhudzana ndi gulu pharmacological mahomoni glucocorticoid kwa ntchito apakhungu.

pharmacodynamics

Monga umboni wa mankhwala "Boudin" malangizo inhalation, budesonide (waukulu yogwira pophika) ali wotsutsa-siligwirizana, odana ndi yotupa ndi odana ndi edema kwenikweni. Ndi zolimbikitsa mapuloteni lipocortin kupanga budesonide ali zimakhudzanso ochepetsera pa phospholipase kaphatikizidwe, womwe akutitsogolera kuti kuchepa mu kaphatikizidwe arachidonic asidi, kuchepetsa kupanga prostaglandins ndi leukotrienes. Zimene zimachitika pa mlingo ma kumabweretsa kuchepetsa kupanga cytokine, kuchepetsa Kusamuka kwa macrophages ndi kukhala ndi kuchepa kusalola ma. Pamapeto pake zimenezi zimapangitsa kuti kaperekedwe ka owayimira yotupa yoonetsa ndithu pa akuvutika bronchial kuukira mphumu olimba kumene ake matenda kuchepetsa.

Monga umboni wa mankhwala "malangizo Boudin Steri-Neb 'ntchito, ntchito zake zonse kumabweretsa kubwezeretsa tilinazo mtengo bronchial mankhwala, dilates wa bronchi. Izi nayenso amachepetsa multiplicity ntchito atsopano, kuchepetsa kuchuluka kwa kwaiye sputum bronchial katulutsidwe, amachepetsa kudziwa allergens, amenenso ali ndi ubwino njira matenda a matenda.

Mankhwala alibe ntchito mineralocorticoid, ndipo alibe zotsatira zokhudza zonse chifukwa kanthu wamba, omwe amachepetsa pafupipafupi ndiponso azikhala Zotsatira zoyipazi bwino analekerera ntchito yaitali.

Monga medicament a "Boudin Steri-Neb" malangizo Buku, analogs mankhwala ndi bwino analekerera ndipo amayambitsa pakutchulidwa mavuto kugwirizana ndi ntchito corticosteroids zokhudza zonse.

Pambuyo ntchito limodzi la zotsatira achire akufotokozera maola angapo, kufika akuti pazipita pambuyo masabata 1-2 pambuyo chiyambi cha ntchito. Mankhwala ungagwire ntchito kupewa bronchial mphumu nkhawa thupi, koma chifukwa cha yaitali zobisika nthawi, isanayambike ntchito achire pafupifupi si oyenera thandizo la zinthu pachimake yokhudza bronchospasm.

Pharmacokinetics

mankhwala chikuyendetsedwera ntchito nebulizer. Kamodzi Mpweya budesonide chabwino nkhungu zikukhazikitsa padziko mtengo bronchial. 15% ya mankhwala chifukwa mayamwidwe mu lumen bronchial akulowa makope zokhudza zonse ndi zina zimapukusidwa pogwiritsa ntchito dongosolo cytochrome kuti metabolites pafupifupi anafooka (ntchito yawo maulendo 100 zosakwana ntchito za chuma kuyambira). 70% ya mankhwala ndi excreted ndi impso kudzera, ndipo pafupifupi 10% ali excreted kudzera matumbo.

zikuonetsa

Monga maziko budesonide mankhwala ndi analogues ake amaoneka zochizira ndi kapewedwe kuukira mphumu, kupanda ntchito kusankha beta-adrenergic agonist chifukwa kupewa matenda ndi olimba a chithunzi matenda, komanso kuchepetsa mlingo akangofika wothandizila m'kamwa glucocorticoid. mankhwala yakhala ikugwiritsidwa ntchito bwinobwino zochizira laryngotracheitis stenotic ndi aakulu obstructive matenda m'mapapo mwanga.

contraindications

"Boudin Steri-Neb" (kuyimitsidwa chifukwa inhalation) ndi contraindicated mu kukhalapo kwa thupi lawo siligwirizana ndi zigawo chimodzi kapena zingapo zikuchokera mankhwala, komanso ana osaposa zaka 6. Mosamala mankhwala Kwalamulidwa kwa TB m'mapapo mwanga, kugonjetsedwa kwa kupuma tizilombo toyambitsa, mafangasi microflora, chiwindi. Kuwatulutsa ntchito mankhwala pamaso pa matenda chifukwa cha immunosuppressive zotsatira m'dera pa mucous kuti angachotsedwe kuchepetsa mayankho m'thupi ndi kupitirira matenda.

zotsatira zoyipazi

Chifukwa chakuti mankhwala ali tikubweretsazi inhalation ntchito nebulizer, Mwina zosayembekezereka wa mucosal dryness mkamwa ndi chapamwamba Airways, kumverera zilonda zapakhosi ndi mkwiyo, zosasangalatsa ndi zachilendo kukoma, hoarseness kapena hoarseness, chifuwa. Ichi ndi chifukwa subsidence mikrochastichek mankhwala padziko mucosal.

Ndithu kawirikawiri anati matenda ya ubongo, zomwe zimapezeka mu mawonekedwe a mantha ndi kuchuluka excitability wa neuro-maganizo, matenda khalidwe, mutu. Komanso, odwala kutsatira "Boudin" amayambitsa thupi lawo siligwirizana ananena kuti urticaria, kuyabwa kapena redness a khungu, kuphipha minofu bronchial yosalala, ndi chitukuko cha candidiasis wa M'mimbamo m'kamwa ndi kum'mero.

Nthawi ya bronchoconstriction paradoxical ndi kupata dyspnea pambuyo chiyambi cha mlingo woyamba Mpweya chifukwa mtima kanthu za mankhwala pa airway mucosa. Ndi chitukuko cha mbali iyi zotsatira inhalation Ndi bwino kusiya ndi kusankha ndi mankhwala njira.

Ngakhale bioavailability otsika mankhwala ndi zotsatira zake ambiri m'deralo, ntchito nthawi yaitali angathe zotsatira zokhudza zonse za glucocorticoids. Izi owonetseredwa chopinga ntchito za kotekisi adrenal, liwiro kukula ana, kuchepa mu fupa mchere osalimba, chitukuko cha kuyan'anila za maganizo.

Nthawi zina (kawirikawiri) zikhoza khungu likuyabwa pamene ntchito nebulizer chigoba. Pofuna kuteteza vuto ayenera kugwiritsidwa ntchito masaka njira kwa chigoba, ndipo pambuyo inhalation wa khungu pansi akuthamanga madzi ofunda. Mukhozanso kumasula maganizo mphira magulu akugwira chigoba pa nkhope. A njira zabwino angathe kutumikira monga ntchito za kamwa kapena kamwa kwa inhalation.

Ntchito pakati komanso mkaka wa m'mawere

Malangizo pa "Boudin" akuonetsa mankhwala kugwiritsidwa ntchito mosamala mu akazi apakati ndi nthawi yoyamwitsa (ngakhale deta pa mankhwala umalowa kwina mkaka mayi). mankhwala tikulimbikitsidwa kuti ntchito kokha pamene phindu kwa mayi zimatiyendera zotheka mavuto ndi mavuto kwa mwana wosabadwayo. Choncho ndikofunikira ntchito osachepera ogwira budesonide mu mlingo kuti limalola kulamulira matenda.

Mwanjira mankhwala

Pa mlingo wa zimachitika pakati pa chiphunzitso mankhwala n'zogwirizana ndi njira isotonic wa sodium kolorayidi, komanso ena Mpweya beta-agonists, mucolytics ndi expectorants. Pofuna kuonjezera efficacy ndi zotsatira achire pa kuphipha akuvutika mankhwala bronchial maguluwa akhonza adzaikidwa limodzi mu chipinda nebulizer. Kuuza bronchodilators osati bwino otaya "Budesonide" mu mtengo bronchoalveolar, komanso kumathandiza kuti malowedwe ake zambiri lumen wa.

Chifukwa cha zimene a cytochrome P450 michere gulu kagayidwe wa budesonide mlingo ayenera ndemangayi ntchito mankhwala omwe nkhawa kapena zolimbikitsa ntchito enzyme ndi. Osavomerezeka ntchito olowa mankhwala ndi mankhwala antifungal monga "ketoconazole" ndi "Itraconazole", monga zimenezi zingayambitse kuwonjezeka mu ndende ya "budesonide" plasma.

Medicaments omwe amaonjezera ntchito michere microsomal ( "Phenobarbital", "Phenytoin", "Rifampicin") kuchepetsa ntchito "budesonide".

dosing

Wokongola yosavuta kugwiritsa ntchito, "Boudin" kwa inhalation. Malangizo ntchito zikusonyeza kufunika kwa ntchito nebulizer mankhwala. Mankhwala aikidwa mu chipangizo nebuliser, ndi inhales. Kutalika kwa inhalation ndi mlingo ayenera kusankhidwa pa nkhani iliyonse kutenga nkhani chikhalidwe matenda a mtima kwakukulu ndi matenda pogwiritsa ntchito mankhwala "Boudin" inhalation. Malangizo kwa ana kuchokera zaka 6 miyezi 12 anatchulapo poika budesonide kawiri mlingo wamng'ono. Kwa odwala wamkulu kuposa zaka 12, ntchito yokonza mlingo ayenera kusintha payekha.

Ngati ndi kotheka, "Budenita" limodzi ndi mankhwala m'kamwa glucocorticoid tikulimbikitsidwa kuwonjezera mlingo wa "Budenita" chifukwa kupewa yatsoka ndi kuchepetsa zovuta mavuto.

Reviews

Muzilemekeza madokotala ndi odwala kukhuta efficacy wa mankhwala. Izi zikuonekera bwino ndi ndemanga za (kuyimitsidwa chifukwa inhalation Teva «Boudin" - wokongola wotchuka mankhwala) chiphunzitso. A maganizo abwino anapanga m'munsi zochitika mavuto ndi chithandizo kwambiri zothandiza. Maganizo za "Boudin" chiphunzitso kwa inhalation ana (malangizo, mlingo anapatsidwa m'nkhani) ndi amai zabwino, amenenso chifukwa cha zochitika otsika mavuto. Sabweretsa chisoni inhalation ntchito nebulizers (omwe angathe kuchitidwa mu zosiyanasiyana zidole) ana ananenanso mokomera ntchito mankhwala kapena analogues ake.

ambiri osokoneza

Mu ambiri osokoneza pachimake aakulu zizindikiro matenda omwe unkachitika. Mankhwala symptomatic, ndi chiyembekezo chakuti mankhwala ndi kuikidwa kwa kanthawi-akuchita mtundu bronchodilator kanthu.

Ziyenera adzanyamula kukumbukira kuti ntchito yaitali "Budenita" pa mlingo sredneterapevticheskih choposa angathe mavuto pa mlingo zokhudza zonse (hypercortisolism, maganizo a ntchito adrenal). Izi zikuonekera bwino ndi "Boudin" malangizo inhalant. mtengo wake ndi logwiritsidwa ntchito nthawi yaitali mankhwala monga mankhwala chachikulu mphumu bronchial.

malangizo osiyana ndi malangizo

Malangizo ntchito mankhwala "Boudin" likunena kuti si choti kuthetsa pachimake kuukira kwa bronchospasm. Nthawi avareji zotsatira achire pafupifupi 10 masiku, koma akhoza chinawonjezeka ndi kukhalapo mu lumen wa mtengo bronchial kapena wambirimbiri viscous ntchofu katulutsidwe. Pankhaniyi n'zotheka kuchita mankhwala osakaniza glucocorticoid m'kamwa ndi wotsatira kusintha yekha "Boudin Steri-Neb" inhalation.

Malangizo kwa mankhwala limanena kuti ngakhale Mwina mavuto pa mlingo dongosolo kwambiri m'munsi, m'pofunika kuti titrate osachepera ogwira achire mlingo zotsatira pazipita. Mu ntchito mankhwala ana ncholinga chizindikiritso yake ya mavuto ayenera nthawi zonse kuwunika kukula mwanayo pa nthawi yaitali. Ndi chitukuko mavuto ayenera kuchepetsedwa kwa mlingo wochepetsetsa ogwira, amene amalola kulamulira matenda a mphumu.

Pakuti kupewa matenda a mafangasi mu M'mimbamo m'kamwa wodwalayo azidziwitsidwa za kufunika muzimutsuka pakamwa ndi kuchotsa zatsalira nthawi iliyonse inhalation. Zimenezi zimathandiza kubwezeretsa chitetezo chokwanira m'dera ndi m'kamwa mucous.

mbali luso Gwiritsani

Inhalation "Budenita" ntchito nebulizers akupanga contraindicated. Mlingo bwino mankhwala ayenera kuchita masamu kutenga nkhani imeneyo mbali luso nebulizer ndi (amaganizira mlingo otaya mpweya, buku la nebuliser ndi T. D.) Ndipo alili.

Musanagwiritse ntchito mankhwala "Boudin" inhalation nebulizer mu malangizo nebulizer ndi kuvomerezedwa ayenera kuphunzira. Izi kupewa kugwirizana zosayenera chipangizo ndi ntchito inefficient mankhwala. Ngati nebulizer ntchito kwa nthawi yoyamba, izo tikulimbikitsidwa kuti ayese ntchito thupi sodium kolorayidi njira kuonetsetsa operability ake ndipo kenako ntchito mankhwala osokoneza bongo.

Pamaso inhalation bokosi anachira ampule pulasitiki, ndi chinatseguka akugwera chivindikiro, mankhwala aikidwa mu nebulizer chapadenga cha zida, kuvala chigoba kwa nkhope (kapena clamped kamwa) ndi kudyetsedwa kwa otaya mpweya. Pa inhalations ntchito kamwa timafunika kupuma kudzera pakamwa panu (ankavala pa mphuno kopanira wapadera). Pamene ntchito kupuma chigoba ntchito optionally mphuno kopanira.

Pakuti inhalation Ndi bwino kugwiritsa ntchito nebuliser kwa chipangizo valavu amene amathandiza jekeseni wa chabwino mankhwala aerosol mwachindunji pa nthawi inhalation ndi kutseka kubwereketsa mankhwala pa nthawi ya atapita. Zimenezi yobereka mankhwala nkhuni bronchoalveolar ndipo kumachepetsa imfa ya mankhwala pa mpweya.

"Boudin Steri-Neb": analogues, mtengo

Mankhwala analogues "Boudin Steri-Neb" mankhwala monga "Pulmicort" ndi "Pulmicort Turbuhaler", "Kortimen", "Tafen", "Budoster", "Budenofalk" ndi ena ambiri. Pa mankhwala, monga yokonza "Boudin" inhalation, malangizo ndi zofanana chifukwa kukhalapo kwa yemweyo yogwira pophika. Data mtengo wa mankhwala zimadalira zopezera mankhwala ndi dera, komanso mlingo. Pafupifupi mtengo ranges ku rubles 650 kwa 2550.

Pomaliza

Kwambiri zothandiza medicament zochizira ndi kapewedwe kuukira mphumu ndi "Boudin" inhalation. Malangizo kwa mankhwala amapereka mudziwe zambiri za mlingo ndi zikhalidwe za ntchito za mankhwala. Zoperekedwa budesonide ntchito mogwirizana ndi malangizo ndipo analimbikitsa Mlingo wa medicament kumapereka mankhwala. Ngati pazifukwa zina simungathe kugula wapachiyambi, pali analogues. "Boudin Steri-Neb" (malangizo mtengo inu tsopano kudziwika) adzakupulumutsa ku matenda ambiri a dongosolo kupuma.