Mankhwala "Remicade": malangizo ntchito kwenikweni

Mogwira amatanthauza "Remicade"? Malangizo ntchito, ndemanga mankhwala wodwala Adzaperekedwa pansipa. Komanso m'nkhani ino, muphunzira za milandu uliwonse, mankhwala mankhwala, kaya iye ali contraindications ndi mavuto, imene zikuluzikulu gawo la ilo ndi zina zotero.

Fomu, zikuchokera

Kukonzekera "Remicade" ndi inakhazikitsa mu mawonekedwe a ufa lyophilized anafuna yokonza njira kulowetsedwa. The yogwira pophika mankhwala ndi infliximab. Lilinso ndi zigawo zina monga polysorbate 80, sodium wa hydrogen mankwala dihydrate, sucrose ndi monohydrate ndi sodium dihydrogen mankwala.

katundu Ofunika

ndi mankhwala "Remicade" n'chiyani? Malangizo Ntchito limanena kuti ndi wothandizila immunosuppressive.

Wotuluka mkati thupi, mankhwala amayamba kucheza ndi sungunuka ndi transmembrane mitundu ya chotupa necrosis Alpha (TNFα), kuchepetsa ntchito yawo ndi mapangidwe kuipidwa khola.

Akatswiri Research zikusonyeza kuti yogwira mankhwala mankhwala kumachepetsa kusalola ma (kutupa), ndipo chiwerengero cha zolembera yotupa m'madera akhudzidwa wa intestine lapansi. Choncho pali machiritso mwachilungamo mofulumira nembanemba mucous.

Pharmacokinetics

Kodi magawo pharmacokinetic ali mankhwala "Remicade"? Dziwani, maganizo boma kuti limodzi mtsempha jekeseni wa infliximab mu kuchuluka kwa 20 mg / kg pa akutsatiridwa ndi kuwonjezeka njila mu ndende wake pazipita.

Mobwerezabwereza ntchito mankhwala zimayambitsa kudzikundikira pang'ono mankhwala yogwira mu seramu wa.

Njira za kuwonongedwa kwa mankhwala sichinayambe sakudziwika.

zikuonetsa

Pakuti zolinga Akhozanso kusankha mankhwala "Remicade"? Kugwiritsa ntchito mankhwala zikusonyezedwa milandu zotsatirazi:

• Nyamakazi mu thupi lithe (ngati ankachitira odwala zofunika mankhwala antiinflammatory anali osamveka). Therapy zinachitikadi osakaniza "methotrexate". kuphatikiza limalola kuchepetsa zizindikiro za matenda, komanso kusintha kwa olowa wonse.
• matenda amene amatupitsa odwala wamkulu. Pankhaniyi bwino "Remicade"? Guide limanena kuti mankhwala ndi yokonza zimenezi ziyenera kuchitikira vuto la tsankho kapena kupanda, komanso ndi contraindications mankhwala muyezo. Mu matenda amenewa "Remicade amalimbikitsa Kupha zizindikiro matenda, kukhalabe chikhululukiro ndi machiritso mofulumira zilonda, fistula ndi kutseka kusintha alili.
• matenda amene amatupitsa mu achinyamata. Chithandizo ndi mankhwala ikuchitika vuto la tsankho kapena kupanda, komanso ndi contraindications muyezo chiwembu cha mankhwala. Medicament "Remicade" kumachepetsa zizindikiro ndi kuthandiza chikhululukiro ndi bwino khalidwe la moyo wa achinyamata amene akudwala.
• Anam'peza matenda a m'matumbo akuluakulu. Mankhwala "Remicade" imene ndemanga anapereka m'munsimu, chikuyendetsedwera kukachitika kuti mankhwala ochiritsira anali osamveka. Chithandizo cha wothandizila imeneyi amachepetsa zizindikiro za matenda, ndi matumbo mucosa machiritso, kuchepetsa kapena chiyembekezo chakuti a GCS Mlingo. Iwo ayenera kukumbukira kuti, pambuyo ntchito chida kumatha kufunika m'chipatala.
• Anam'peza matenda a m'matumbo mwa ana. Chithandizo ndi mankhwala Kwalamulidwa kwa ana zaka 6-18, ngati anatsimikizira osamveka ochiritsira mankhwala.
• Ankylosing spondylitis (ndi mulingo mankhwala inefficiency). Mofanana ndi matenda amathandiza mankhwala "Remicade"? Malangizo ntchito inanena kuti chida ichi amachepetsa zizindikiro za matenda ndi bwino kugwira ntchito kwa malo.
• Psoriasis (ndi mulingo mankhwala inefficiency). Monga psoriasis kuthandiza "Remicade"? Akatswiri Mlendo kuti mankhwala kumachepetsa kutupa mu khungu ndi normalizes ndondomeko keratinocyte zosiyanasiyana.
• Psoriatic nyamakazi (kwa muyezo mankhwala inefficiency). The medicament "Remicade" kutumikiridwa mu osakaniza "MTX" kapena monga monotherapy ndi contraindications kapena tsankho kwa masika. Chifukwa, chithandizo yafupika zizindikiro za nyamakazi, odwala bwino ntchito zinchito, komanso amachepetsa mlingo wa kupitilira radiographic mu psoriatic nyamakazi.

contraindications

Chithandizo "Remicade" analetsa khalidwe pamene:

• aakulu matenda ndondomeko (mwachitsanzo, sepsis, abscess, TB, matenda osadziwika) ;
• kuchuluka tilinazo wodwalayo infliximab ndi mapuloteni murine ndi mbali ina ya mankhwala;
• pansi zaka 6 (anam'peza matenda a m'matumbo ndi matenda amene amatupitsa);
• mimba;
• mtima kulephera;
• pansi zaka 18;
• yoyamwitsa.

Mankhwala "Remicade": malangizo ntchito. Ndipo pamene kulowa (ngati kuchipatala)?

mankhwala ankaona ayenera kuperekedwa yekha kuyang'aniridwa ndi katswiri (ie kuchipatala) amene ali zinachitikira okwanira matenda ndi mankhwala bwino matenda pamwambapa.

njira umayamba dropwise m'nsinga maminiti 120. Mlingo sayenera kuposa 2 ml pa mphindi. Kukhazikitsa ndondomeko zofunika ntchito dongosolo kulowetsedwa.

Mlingo wa mankhwala zimadalira umboni.

nyamakazi

Chonchi matenda ntchito mlingo woyambilira akhale za 3 mg wa pa kg. The medicament chikuyendetsedwera mobwerezabwereza pa masabata 3-6. Ndiye ntchito miyezi iwiri iliyonse.

Kukachitika kuti zotsatira achire sichinayambe akwaniritsa, kuganizira kuchotsa mankhwala.

Kawirikawiri mankhwala ndi "Remicade" ndi nyamakazi kutumikiridwa pamodzi ndi "methotrexate".

anam'peza matenda a m'matumbo

mlingo koyamba pamene matenda amenewa ndi 5 mg pa kulemera makilogalamu thupi. Mlingo wofanana wa mankhwala chikuyendetsedwera masabata 3-6 ina. Ndiye mankhwala ikuchitika miyezi iwiri iliyonse.

Ngati ndi kotheka, mlingo akhoza ziwonjezeke kwa mg ndi 10 pa kg. Zotsatira za mankhwala zambiri ena mwa masabata 14. Zikatero, ngati si, muyenera kupitiriza mankhwala.

psoriatic nyamakazi

Psoriatic nyamakazi mankhwala "Remicade" kutumikiridwa mu mlingo koyamba wa 5 mg pa kg. The medicament chikuyendetsedwera mobwerezabwereza pa masabata 3-6. Ndiye ntchito iliyonse masabata 7-8.

Mankhwala akhoza pamodzi "methotrexate".

matenda amene amatupitsa

Mu matenda amenewa akuluakulu amaoneka Mlingo umodzi wa mg wa 5 pa kg. Ngati zotsatira achire sichinayambe akwaniritsa kale masabata 2, mankhwala linathetsedwa.

Ngati zabwino mankhwala kanthu, njira zotsatirazi:

• Njira yothetsera anali kutumikiridwa mu mlingo mofanana mu kulowetsedwa woyamba, ndipo pambuyo masabata 3-6 reused. Pambuyo pake, kupanga jekeseni wa miyezi iwiri iliyonse. Ngati chofunika, mlingo akhoza ziwonjezeke kwa mg ndi 10 pa kg.
• mankhwala chikuyendetsedwera yekha pa musabise masabata ngati akale kuposa 16 pambuyo ntchito woyamba.

matenda amene amatupitsa ana

Amatupitsa zolimbitsa kwambiri kapena ana osaposa zaka 18 zimaphatikizapo kugwiritsa ntchito mlingo koyamba wa 5 mg pa kg. jakisoni wotsatira ziyenera kuchitika mwa masabata 3-6. Ndiye mankhwala ntchito miyezi iwiri iliyonse ngati chofunika, kusintha kwa mlingo wa mg ndi 10 pa kg.

Childs, mankhwala ali pamodzi immunomodulators 6-mercaptopurine, "azathioprine" kapena "methotrexate". Ngati zotsatira achire sichinayambe akwaniritsa (kwa masabata 10-11), kugwiritsa ntchito mankhwala ndi osafunika.

matenda amene amatupitsa limodzi ndi fistula

A mlingo umodzi wa mankhwala pa matenda amenewa ndi 5 mg pa kilogalamu (akuluakulu). Mankhwala reused pambuyo masabata 3-6. Ngati zotsatira achire pambuyo 3 jakisoni si anati, ndiye chithandizo chowonjezera zosayenera.

Ndi ubwino wa mankhwala, njira zotsatirazi:

• reintroduction pambuyo masabata 3-6 kenako miyezi iwiri iliyonse;
• medicament ndi kutumikiridwa pa muyambirenso ngati zinamutengera pasanathe milungu 16.

ankylosing spondylitis

Mofanana ndi matenda mankhwala ntchito "Remicade"? Malangizo ntchito limati mu matenda mlingo woyambilira wa mankhwala ayenera kukhala 5 mg pa kg. Patatha izi, mankhwala chikuyendetsedwera pambuyo masabata 3-6.

Chithandizo sayenera anapitiriza ngati, mu masabata asanu mmene si noticeable.

psoriasis

Mankhwalawa psoriasis poyambira mlingo ndi 5 mg mankhwala pa kg. Mobwerezabwereza ntchito medicament wovulala pambuyo masabata 3-6, ndiyeno - kamodzi pa masabata asanu ndi atatu.

Ndondomeko yokonza njira kulowetsedwa

The njira ayenera kukhala okonzeka motere:

• Iwo linaŵerengera mlingo ndi chiwerengero cha mbale.
• The ufa mankhwala anali kusungunuka mu 10 ml ya madzi ntchito syringe. Kuti tichite zimenezi, kuchotsa zosungunulira vial kapu (pulasitiki), ndi kupukuta wokambirana ndi mowa. The singano ndi anaika likulu lake, ndi madzimadzi chimatsogoleredwa khoma.
• njira mosamala analimbikitsa (rotational kayendedwe) mpaka ufa uli kusungunuka. madzi mankhwala ayenera kukhala kaya colorless kapena wachikasu kulocha. Ngati pa kusakaniza vial thovu anapanga, m'pofunika adzapatsa njira ya mphindi 5. Mitundu komaliza mlingo akhoza kupezeka translucent zabwino particles.
• Buku okwana mankhwala kusintha kwa 0,9% mankhwala enaake (250 ml) ya njira ndi sodium. Chifukwa chaichi, madzi okonzeka anawonjezera kuti botolo, amene kale lili sodium kolorayidi. zigawo zonse ziwiri bwinobwino osokonezeka.
• Chiyambi lokonzekera ikuchitika pasanafike 3 maola pambuyo yokonza njira mankhwala.

Ndi zoletsedwa kulowa mankhwala ndi wothandizila ena mwa dongosolo lomwelo. Ngati pali zinthu zakunja kapena particles opaque mu njira, kuti ali osavomerezeka.

Makuponi kuchuluka kwa mankhwala kuti ntchito.

zotsatira zoyipazi

Pamene ntchito medicament, zotsatirazi zochita mbali:

• maganizo, mphwayi, kuchuluka nkhawa, chizungulire, somnolence, manjenje, amnesia, psychosis, mutu;
• m'mapapo mwanga edema, sinusitis, bronchoconstriction, dyspnea, thupi lawo siligwirizana, chibayo, epistaxis, matenda, pleuritis;
• conjunctivitis, keratoconjunctivitis, endophthalmitis;
• kutupa ndi kapepala mkodzo matenda;
• mafunde, chosokoneza cha kufalitsidwa zotumphukira, bradycardia, ecchymosis, hematoma, mtima spasms, syncope, palpitations, cyanosis, petechiae, arrhythmia;
• thrombocytopenia, kuchepa magazi, neytrotsitopeniya, leykotsitopeniya, lymphopenia, lymphadenopathy, lymphocytosis;
• cheilitis, kudzimbidwa, cholecystitis, Reflux, diverticulitis, kutsekula m'mimba, kunyansidwa, kudzimbidwa, mkhutu chiwindi ntchito;
• ziwengo, khungu youma, alopecia, seborrhea, kuyabwa, abrasions, zotupa thukuta kuchuluka, dermatitis, mafangasi njerewere, hyperkeratosis, erysipelas, kuphwanya mtundu, bullous kuphulika.

Reviews kukonzekera

Tsopano inu mukudziwa momwe ntchito mankhwala "Remicade". Malangizo ntchito mankhwala wakhala tafotokozazi.

Nthawi zambiri ankaona njira kupirira ntchitoyo. Choncho, maganizo ochokera kwa odwala anapeza makamaka positive. Anthu amene amagwiritsa ntchito njira imeneyi, amanena kuti pambuyo jekeseni wa ululu wapita pafupifupi mwathunthu. Komabe, odwala ena amaopa kudalira, zingayambitse.