Mankhwala "Sotageksal", analogs ndi mayankho pa iwo

Arrhythmia - ndi mtundu wa kugunda kwa mtima, zomwe n'zosiyana ndi wabwinobwino nkusani mungoli. Pamene arrhythmias anthu alipo mmodzi kapena angapo kuyan'anila za mtima. The kudwala akhoza kupereka pafupipafupi ndi mphamvu amveke kugunda kwa mtima (tachycardia) ndi ina, kuchepa kwawo (bradycardia). Disruptions kuti ntchito ya minofu mtima, munthu wathanzi. Komabe, nthawi zambiri, ndi arrhythmia ndi molumikizana ndi matenda ena mtima. Chotero boma ndi yowopsa chakuti excitability kuchuluka kwa minofu mtima - myocardium, tingayambe kenako kulephera mtima ngati sanalandire chithandizo.

pali kukonzekera mwapadera kuti normalization wa kugunda kwa mtima, limodzi ndi "Sotageksal". Analogues wa mankhwala amadziwikanso ankagwiritsa ntchito mu yochizira matenda. Mankhwalawa a gulu la mankhwala kuti ndi ntchito antiarrhythmic, ndi beta-blockers. Pamene ingested, sakuchitira zolandilira beta-adrenergic, zomwe zili mu mnofu yosalala minofu mtima ndipo zimakhala ena, ndipo ali ndi udindo ayankhe thupi zotsatira za maganizo. Cacikulu kardioeffekt ndi kuchepetsa pafupipafupi ndi mphamvu ya mlingo mtima, amachepetsa mtima conduction. Monga zotsatira zokhudza zonse ndi anatinso kutsitsa magazi pa makoma a zotengera inatsekeratu.

mankhwala

"Sotalol» (Sotalol) - anatengedwa ndi dzina lonse mu dziko la mankhwala "Sotageksal". Analogs wa zikuchokera akhoza kukhala osiyana, koma zofanana kwenikweni antiarrhythmic. Waukulu yogwira thunthu "Sotageksal" lili sotalol hydrochloride. Komanso zikuphatikizapo ochepa zigawo wothandiza. Pakati pawo, - mapadi, lactose monohydrate, wowuma chimanga, magnesium stearate ndi binders ena.

Alumali moyo wa mapiritsi kapena njira injectable ndi zaka 5.

"Sotageksal" analogues ndi Kaonekedwe

piritsi limodzi la mankhwala lili 40, 80 kapena 160 mg wa mankhwala yogwira. Chifukwa amapangidwa makamaka ngati miyala White wozungulira mbali imodzi pang'ono otukukira kunja ndi embossed ndi chidule SOT. Pa kumbuyo kwa piritsi ndi bisected mwa n'zimene kwa mayiko kuopsa. Onse ankanyamula mu matuza zidutswa 10, ndi makatoni. Aliyense mtolo lingayambire pakukhala matuza 1 10 (cha ku zidutswa 10 100 miyala).

Komanso, "Sotageksal" amapangidwa mu mawonekedwe a njira jekeseni mtsempha. Aliyense ampoule lili 4 ml ya mankhwala. Mu 1 ml ya yothetsera ndi 10 mg wa mankhwala koyera zofunika. mankhwala ayenera kutetezedwa dzuwa mdima ndi youma, imene ana ndi mwayi yochepa.

Analogs ndi yogwira mankhwala sotalol mapiritsi hydrochloride amapangidwa:

• "Sotaleks" (160 mg).
• "Soritmik" (by 0,16 g).
• "Sotalol Canon" (80 160 mg).
• "Darob" (80 160 mg).
• "Tenzol" (80 160 mg).

zotsatira pharmacological

"Sotageksal" analogues ndi ofanana matanthauzo a mankhwala ndi kutchulidwa odana arrhythmic kwenikweni. Izi zimatheka mwa mphamvu ndi luso lawo kuti asalalikire β-adrenergic zolandilira ndipo ziletsa njira potaziyamu. Mankhwala kuwonjezera nthawi ya nyemba ndi reflex nthawi atria ndi ventricles. Zomwe kamvekedwe ka minofu bronchial yosalala ndi minofu wosanjikiza makoma chotengera. Kuchepetsa m'mnyewa wamtima contractility.

Sotalol hydrochloride ali lonse ya katundu. Ali chronotropic zoipa, dromotropic, batmotroponoe ndi zotsatira inotropic la German mankhwala "Sotageksal". Analogs, zikuchokera amene ali zofanana, mwina dzina lina mtundu. Iwo amatha kuchepetsa mlingo mtima ndipo mphamvu yawo. Chifukwa cha chimenechi cha mowa m'mnyewa wamtima mpweya yafupika kwambiri. Ndipo chifukwa cha zimenezi, katundu pa mtima yafupika.

Mayamwidwe ndi excretion wa mankhwala

mayamwidwe mankhwala mofulumira. bioavailability ake ndi 90%, ndipo mayamwidwe - pafupifupi 80%. Patangopita maola 2.5-4 ndende pazipita yogwira pophika zimatheka atalandira madzi a m'magazi. Pambuyo makonzedwe mtsempha, mmene kale akuoneka pambuyo mphindi 5-10. Mayamwidwe limapezekanso pa 20% bwino komanso waliwiro ngati inu makhwalawa pa chopanda kanthu m'mimba. Chifukwa chakuti solubility wa chinthu mu mafuta ndi otsika kwambiri, sotalol hydrochloride sayenera kumwedwa nthawi imodzi ndi mkaka ndi mafuta chiyambi nyama.

Popanda womangidwa kwa mapulotini magazi, mankhwala ndi anagawira mu zimakhala ndi ziwalo zotumphukira wogawana mu masiku 3-4 kulowa zonse. Pa nthawi yomweyo, ndipo akwaniritsa ndi ubwino oopsa. Mu madzimadzi cerebrospinal ndende mankhwala si oposa 20%. Action pambuyo jekeseni akupitiriza maola 2. zotsatira amalimbikira pambuyo dosing m'kamwa miyala "Sotageksal" maola 12. Analogs wa mankhwala zikuchokera muli sotalol hydrochloride, komanso si atengeke kagayidwe ndi impso ndi excreted mu mkodzo (90%) ndi ndowe pafupifupi pasanathe maola 10-20.

N'chifukwa chake odwala ndi dongosolo mkhutu aimpso ndi mkodzo zikusonyeza mankhwala mlingo wamng'ono. Anthu achikulire kawirikawiri anati obwera ndi ukalamba kuwonongeka kwa ntchito aimpso. Izi zimathandiza chakuti chinthu chimaonetsedwa pa mtengo pang'onopang'ono ndipo akhoza kudziunjikira mu thupi. Choncho, gulu la odwala mankhwala kugwiritsidwa ntchito mosamala ndi mlingo anatsimikiza payekha.

Mankhwalawa amathandiza kuteteza matenda kuwombola mpweya wabwino zimakhala ndi, kumatha irritability, nkhawa, maganizo ndi zinthu zina zimene zimakhudza pafupipafupi ndi mphamvu ya contractions wa mumtima.

"Sotageksal": malangizo ntchito

Analogs cha mankhwala ndi wothandizila ntchito ndi dzina la pachiyambi la arrhythmias symptomatic mtima, zochizira arrythmia yamitsempha yamagazi. Koma pali zotsatira zosiyana odwala ndi diagnoses ofanana. Choncho, kukhala akapitawo dokotala pambuyo bwinobwino ndi mosamalitsa pa umboni.

Kawirikawiri wothandizila ntchito mankhwala odwala amene anali psoriasis (psoriasis) kapena amadwala matenda a shuga ndi mkhutu zimam'patsa kagayidwe. Chenjerani uike anthu amene ali ndi mbiri ya ziwengo alipo, amatanthauza "Sotageksal". Analogues komanso amatha kubisa tilinazo thupi zikuchitika matupi awo sagwirizana. Mosamala mankhwala amagwiritsidwa ntchito pofuna kuchiza odwala matenda a mtima, wokonda matendawa, kawirikawiri. Odwala amene anali infarction m'mnyewa wamtima, arrhythmia chiopsezo mukhale pa phwando "Sotageksala".

Mlingo ndi chithandizo nthawi

Malinga kukula kwa matenda watsimikiza ndi nthawi ya mankhwala "Sotageksal". Malangizo ntchito (analogs mwina malangizo ena phwando) muli malangizo otsatirawa:

• piritsi ndi kuwameza lonse, osati fodya ameneyu amatafunidwa ndi madzi ambiri;
• Phwando imagwiridwa kwa maola 1-2 pamaso chakudya;
• kumwa mankhwala 2-3 pa tsiku.

chithandizo mwamsanga mlingo tsiku sayenera upambana 80 mg (piritsi 1) oopsa ndi tachycardia. Komabe, pakalibe kufunika achire zotsatira mlingo kuchuluka. Pang'onopang'ono, ndi imeneyi ya masiku 2-3 ndi kusintha kwa 240-320 mg ndi patsiku, koma kuchipatala. The yabwino kwambiri ndi kuchuluka pang'onopang'ono mlingo wa mg ndi 80 pa sabata.

Mlingo pazipita kungakhale mapiritsi 6 patsiku mankhwala "Sotageksal". Analogues, mlingo umene amathanso ziwonjezeke ngati dotolo amaona kuti n'kofunika, adzakwapulidwa yoikidwiratu payekha. Ngakhale pali choopsa pa moyo, chiwerengero cha yogwira pophika sayenera upambana 480 mg wa pa tsiku.

Ngati wodwala pano matenda aimpso zinchito, mankhwala kamwedwe asankhidwa ngati ntchito ya creatinine chilolezo. Kuchulukitsa kwake (30 mg / mphindi), mlingo ambiri yafupika nthawi ziwiri kapena zinayi.

jakisoni mtsempha anapanga kawiri patsiku, ogaŵikana awiri ampoule jekeseni wa 2 ml. Yankho jekeseni pang'onopang'ono mphindi 5-7. Pa mankhwala, zinafunika kulamulira magazi, zimachitika, a impso ndi dongosolo mkodzo, creatinine chilolezo ku seramu.

umboni

Ndalama anasankha zochizira matenda awa:

• tachycardia, yamitsempha yamagazi;
• Wolff - Parkinson - White;
• cardiomyopathy;
• yamitsempha yamagazi kumenyedwa msanga;
• mitral vavu prolapse;
• Paroxysmal matenda fibrillation ndi atria;
• oopsa (kuthamanga magazi);
• Kupewa ndi chithandizo cha infarction m'mnyewa wamtima (zina).

Mu ntchito aakulu mkhutu aimpso, dokotala ayenera kupereka kuyan'ana ndende ya mankhwala yogwira mu seramu magazi ndi kusintha mlingo "Sotageksal" mankhwala. Analogs mwa zizindikiro yopemphera ofanana. Koma, ngakhale, awo wogwirizira chimodzi mankhwala kwa ena koletsedwa. Kulipira chithandizo lizisunga nthawi yomweyo, koma pang'ono ndi pang'ono. Mwadzidzidzi polekezera zingachititse kuwonongeka kwa chikhalidwe matenda.

contraindications

Aliyense wothandizila antiarrhythmic sangathe nthawi zonse ingaperekedwe kwa mtima, kuphatikizapo "Sotageksal". Analogs contraindications ndinu yemweyo, iwo sangathe ntchito pa zinthu zotsatirazi:

• hypersensitivity kapena mbali yapadera mankhwala zofunika kapena chigawo wothandiza;
• kufooka nkusani ngodya;
• Amowabu kuchepetsa mlingo mtima (bradycardia);
• aakulu obstructive m'mapapo mwanga njira;
• aakulu bronchial mphumu;
• aimpso kulephera;
• pachimake m'mnyewa wamtima infarction;
• yopweteka kwambiri kapena yokhalitsa mtima kulephera;
• cardiogenic mantha;
• elongated QT imeneyi syndrome ;
• zaka ana;
• ziwengo, matupi awo sagwirizana rhinitis;
• mimba ndi yoyamwitsa;
• yafupika kuthamanga (hypotension);
• ambiri ochititsa dzanzi;
• chilonda;
• zotumphukira mtima matenda;
• chitukuko cha tachycardia mtundu "pirouette" (amawapeza zambiri mu akazi kusiyana ndi amuna).

zinachitikira mokwanira ndi mankhwala pa mimba si. Only "Sotageksal" amasankhidwa zikuonetsa kwambiri. Akhristu mu trimester komanso kusokoneza moyo yoopsa, ndi kuwatengera kungachititse kuti mimba. kafukufuku deta zodalirika chikuonetseratu wa mankhwala akazi adzabala mwana akadali alibe.

Mu miyezi yomaliza ya mankhwala tidzakwatulidwa anachepetsa pang'onopang'ono kwa masiku 2-4 asanayambe yobereka, ngati mkazi Amachichitira pa nyengo yonse ya mimba. Izi zachitika kuonetsetsa kuti akhanda analibe kupondereza ntchito kupuma, bradycardia kapena hypotension chifukwa mankhwala "Sotageksal".

Analogues zochokera hydrochloride sotalol ayenera anasiya kutenga ngati mayi wachitsikana ndi yoyamwitsa, monga thunthu amatha kudutsa mu mkaka wa m'mawere ndi kufikira magawanidwe mkulu kumeneko. Ngati zizindikiro za chithandizo ayenera anapitiriza kuti yoyamwitsa bwino kusiya, m'malo dziphunzitsiranso osakaniza mkaka mogwirizana ndi msinkhu wa mwanayo.

Zotsatira zoyipa za mankhwalawa ndipo ambiri osokoneza

Zingabweretse mavuto kwa mtima, endocrine, mkodzo, kupuma, m'mimba ndi chapakati mantha dongosolo ntchito nthawi yaitali mankhwala "Sotageksal". Analogs kuyambitsa zotsatira ofanana mbali. Wodwala akhoza kuona:

• kufupika kwa mpweya, akuukira angina, zizindikiro za matenda a mtima, kupweteka mtima, vasospasm, syndrome Raynaud ndi ;
• nseru, kusanza, kutsekula m'mimba, kupweteka m'mimba, amaika gassing, flatulence, zovuta matumbo kayendedwe, youma mucous nembanemba mkamwa;
• nkhawa, mukubwadamuka, mantha matenda, kuyerekezera zinthu m'maganizo, mkhutu galimoto kuyenda, kumva imfa, mmene alili, kenaka utentha mamba, kutopa, kupweteka kwa mutu, chizungulire, kusagona tulo kapena, Tikawonetsetsa kuchuluka tulo, nkhawa maloto, maganizo;
• conjunctivitis, keratoconjunctivitis, kapena youma diso syndrome (makamaka odwala amene amavala magalasi kukhudzana zonse), kutupa kwa diso, ndi kuchepa mu kukoma ndi kununkhiza, kupweteka kwa maso, photophobia, mkhutu masomphenya acuity, kumva;
• hypoglycemia (anthu ndi shuga);
• bronchospasm, laryngitis, tracheitis;
• urticaria, dermatitis, khungu kuyabwa, erythema, psoriasis, angioedema, kuchuluka thukuta;
• mwamuna potency maganizo, ululu umuna, akazi - utachepa libido ndi matenda kusamba;
• malungo, minofu kufooka, khunyu, cyanosis wa malekezero.

Pankhaniyi cha mankhwala osokoneza bongo angayambe:

• yimitsira ntchito mtima;
• kufupika kwa mpweya;
• asystole, kukomoka, kufooka, chizungulire;
• cyanosis wa malekezero;
• omangana minofu;
• bradycardia kwa mtima kumangidwa zonse;
• mtima mantha;
• bronchospasm;
• tachycardia.

Ngakhale zizindikiro choopsa cha mankhwala osokoneza bongo, imfa ali osowa. Pamene mankhwala poyizoni choyamba tiyenera kusiya kumwa mankhwala "Sotageksal". Analogs ndi generics sotalol hydrochloride efficiently linanena bungwe kuchokera thirakiti m'mimba pambuyo ingestion mankhwala absorbent. Pankhaniyi cha mankhwala osokoneza bongo mankhwala symptomatic kukuonetsedwa. Nthawi ya aakulu poizoni zofunika lavage muzituluka ndi kusanza, kukhalabe ntchito zofunika kwambiri moyo wa ziwalo. Mlingo Kugwiritsa kwathunthu anachotsa hemodialysis. Kagayidwe kachakudya kutsitsa shuga kumachitika odwala amene amatsatira zakudya ovuta kapena njala.

Analogs ndi generics "Sotageksala"

Sotalol hydrochloride ali mankhwala opangidwa ku Switzerland ndi Germany, pansi pa malonda dzina "Sotageksal". Analogues kwake amaoneka ndi mankhwala ena ndi zosiyanasiyana, zomwe kuwonjezera zimakhudzanso antiarrhythmic kuthetsa spasms minofu, kuchepetsa magazi ndi bwino kugwira ntchito kwa atria lapansi. Njirazi ndi monga:

• "Inderal" "Inderal", "obzidan", "Pranolol" (yogwira pophika - propranolol) ntchito zochizira ischemia, arrhythmia ndi matenda oopsa.
• "Pumpan" - mwanjira wothandizila zochokera zigawo zikuluzikulu masamba.
• "Magnerot" lili mankhwala enaake a orotate dihydrate ntchito pochiza arteriosclerosis, matenda a kagayidwe zamadzimadzi.
• "Korvitol" (metoprolol tartrate) ndi zothandiza mutu waching'alang'ala.
• "Nebilet" (nebivolol hydrochloride) akusonyeza kuti matenda oopsa, matenda ischemic.
• "Qudesan" (dontho) - ndi enaake kwachilengedwenso zochokera coenzyme Q10 kuti kupewa ndi kuchiza wa arrhythmias.
• "Etatsizin" (etatsizin) umagwiritsidwa ntchito pa tachycardia ndi;
• "Arrhythmia" "Amiodarone" (amiodarone hydrochloride) amagwiritsidwa ntchito mu mtima, tachycardia, matenda arrhythmia.
• "Propanorm" (propafenone hydrochloride) ntchito pamene yamitsempha yamagazi ndi arrhythmias supraventricular.
• "Neo-Giluritmal" (praymaliya bitartrate) akusonyeza kuti arrhythmias yamitsempha yamagazi, tachycardia.
• "Korgard" (nadolol) ndi anatengera zochizira pectoris angina, migraine.

Russia umabala "Sotalol Canon" ndi "Tenzol" ndi chimodzimodzi yogwira pophika ngati "Sotageksal". Analogues mu Moldova, Ukraine ndi maiko oyandikana mu pharmacies opepuka kuposa mankhwala pachiyambi. Mtengo wa mankhwala zimadalira dziko ndi Mlengi. mankhwala zoweta zambiri ndi mtengo kwambiri poyerekeza kunja.

Reviews

Panali kuchepetsa kwambiri kulanda pafupipafupi pa fibrillation matenda, akamwedwa mosalekeza "Sotageksal". Analogs ndemanga mtima simuli wotsimikiza. Si nthawi zonse mankhwala kuchokera opanga osiyana ofanana, ngakhale ali zikuchokera chomwecho. Ambiri amaganiza kuti opanga oipa zimasonyeza ndende wamkulu wa yogwira pophika pa piritsi kuposa kwenikweni. Chifukwa cha mankhwala Sangabweretse zotsatira kuyembekezera. Ndemanga za "Sotageksale" Mosiyana ndi Hava, kusangalala. Iye anagwiritsira ntchito mankhwalawa zovuta za matenda a mtima pamisinkhu yosiyanasiyana.

Nthawi zambiri pali kusintha pang'onopang'ono m'chigawo ambiri odwala nkhani mankhwala zovuta. The mankhwala ndi yofunika onse cupping, ndi kupewa. Kuweruza ndi ndemanga odwala ndi matenda a "paroxysmal fibrillation," mankhwala kumathandiza kusunga yachibadwa mtima mungoli (anapereka, akamwedwa mosalekeza monga mankhwala yokonza). Komabe, odwala kuti sanayese n'komwe kulera mlingo zawo popanda kuimilidwa ndi dokotala chifukwa chiopsezo zotsatira zina zoyipa.

Ena mwa ndemanga si zotsatira zabwino kwambiri pa mbiri ya mankhwala. Akukhulupirira kuti anthu afalitse ndipo sangathe kuchiza kuchepa magazi, arrhythmias tating'onoting'ono, hypokalemia ndi hypomagnesemia. Iwo ananena kuti sotalol hydrochloride zopangidwa achilendo n'kovuta kupeza mu pharmacies m'deralo. Anthu anazolowera kugwiritsira ntchito njira m'mavuto ndi kupeza ake. Choncho, musanayambe chithandizo, onetsetsani kuti adzatha kupitiriza kwa nthawi yaitali.

Kodi si pamodzi phwando "Sotageksala"

Pa odwala mankhwala ndi zofunika kusiya galimoto, kupalasa njinga yamoto. Komanso oopsa ndi ntchito zonse zimene zikuyenela chidwi ndi psychomotor ndende ndi cholinga. Pamene kulandira ndalama zina kwa kuchepetsa kuthamanga ndi Zikuoneka kuti hypotension. Ndi zoletsedwa kuphatikiza "Sotageksal" ndi mankhwala:

• insulin, monga kale kumawonjezera ndende zake magazi;
• ayoni ndi calcium muzikangana;
• zikutanthauza kuti ambiri kapena inhalation mankhwala ochititsa;
• Mao zoletsa;
• ayodini munali mankhwala;
• okodzetsa;
• ergot alkaloids;
• tetracyclic antidepressants.

mankhwala si kutumikiridwa imodzi ndi antiarrhythmics a kalasi Ine ndi III. Amagwiritsidwanso contraindicated kulandira mankhwala chomwa mankhwalawa, mankhwala ndi mankhwala, antipsychotics, coumarin, relaxants. Iwo amathandiza kuti mphamvu chapakati mantha dongosolo maganizo. Munthawi yomweyo ochititsa dzanzi kumabweretsa kuthamanga magazi ndi depresses minofu m'mnyewa wamtima. Ndi zoletsedwa kuchita mayeso khungu kudziwa mitundu ya allergens. Izi kumaonjezera ngozi ya anaphylaxis, angioedema, ndi asphyxia.

Mankhwala "Sotageksal" anamasulidwa mu pharmacies ndi mankhwala. Osiyana chithandizo cha arrhythmia kuti zikhoza zochita kwambiri chowawa. Choncho, musanayambe mankhwala, nthawi zonse muyenera kukaonana ndi dokotala.