"Moxifloxacin": malangizo ntchito, maonekedwe, zikuchokera

The medicament "Moxifloxacin" pharmacological zotsatira za tikambirana hereinafter, amatanthauza gulu la quinolones. Chida ali bactericidal, zotsatira antibacterial. Kenako, tikambirana chimene chimapanga mankhwala "Moxifloxacin". Malangizo ntchito, analogues adzakhala koteroko nkhaniyi.

zotsatira

Kodi yogwira wothandizila "Moxifloxacin"? Kufotokozera za mankhwala ayenera kuyamba ndi malongosoledwe a limagwirira cha zotsatira mabakiteriya. zotsatira bactericidal kumatanthauza kugwirizana ndi chopinga (yimitsira) wa bakiteriya topoisomerase IV ndi II. Izi, mu zingathandize kuti chisokonezo njira kugawanika kwa galamafoniyo, DNA kukonza biosynthesis maselo tating'onoting'ono. Chifukwa, apo pakubwera kuonongeka kwawo. Medicament "Moxifloxacin" malangizo Buku limafotokoza chachikulu sipekitiramu mankhwala.

kukaniza

Pa ntchito antibacterial mankhwala "Moxifloxacin" musati bwanji kuti makinawa imautsa kukana kuti tetracyclines, macrolides, aminoglycosides, cephalosporins ndi penicillin. Iwo unalibe bwino ndi zotsatira za mtanda kukana. Mpaka pano milandu bata plasma anali sakudziwika. azikana mankhwala "Moxifloxacin" osauka pang'onopang'ono kwambiri ndi masinthidwe angapo.

osiyanasiyana ntchito

Amatanthauza "Moxifloxacin (malangizo Buku - umboni) amakhudza mitundu yambiri ya bakiteriya galamu HIV ndi galamu alibe, asidi-kudya tizilombo, anaerobes, atypical tizilombo (mycoplasma, chlamydia, etc), ndi mabakiteriya amene kugonjetsedwa macrolide ndi beta-lactam mankhwala opha tizilombo .

suction

Pamene kulandira mayamwidwe m'kamwa wa mankhwala "Moxifloxacin" mofulumira ndi pafupifupi kwathunthu. Mtheradi bioavailability pamene kutumikiridwa m'nsinga ndi kugwiritsa inwards - a dongosolo la 91%. Pamene kutumikiridwa pakamwa (50-1200 mg ndi mlingo, 600 mg / tsiku kwa masiku 10) pharmacokinetics liniya mankhwala. Ndende pazipita ndi 400 mg anati pambuyo maola 0.5-4. Pamene ntchito imodzi ndi chakudya kukwaniritsa kuwonjezeka mu nyengo nthawi Cmax (maora awiri) ndi kuchepetsa ake ndi pafupifupi 16%. Nthawi mayamwidwe motero amakhalabe sichinasinthe. Komabe, deta izi zilibe phindu matenda amene amalola ntchito mankhwala "Moxifloxacin", kaya chakudya. Zotsatirazi limodzi mtsempha kulowetsedwa a 400 mg kwa ndende ola pazipita limapezeka kumapeto kwa kulowetsedwa.

yogawa

Mkati mwa masiku atatu ntchito kukufika mgwirizano. KUMANGA zonsezo plasma - pafupifupi 45%. Linanena yogawa mwachilungamo mofulumira mankhwala "Moxifloxacin" ziwalo ndipo zimakhala. magawanidwe Wamkulukulu ali m'mapapo minofu ndi mucous bronchi, khungu ndi subcutaneous nyumba, sinuses, yotupa foci. The malovu ndi interstitial madzimadzi medicament opezeka mu mapuloteni unbound, free mawonekedwe. ndende yake ndi apamwamba kuposa plasma. Pamodzi ndi mankhwala opezeka mu yambiri ziwalo ziwalo peritoneum zimakhala mkazi maliseche ndi madzimadzi peritoneal.

kagayidwe

Medicine "Moxifloxacin" (ofotokoza za mankhwala mu deta Zamkati limapangidwa mudziwe) apatsira chachiwiri biotransformation gawo. Aimpso excretion akuyendera dongosolo ndi intestine unaltered mu mawonekedwe a mankhwala sulpho ndipo anafooka glucuronide. The metabolites zimapezeka plasma. maganizo awo poyerekeza wa pawiri pachiyambi. Kafukufuku akusonyeza kuti mankhwala amenewa kudzitsitsa mulibe kuchita zoipa thupi.

Amatanthauza "Moxifloxacin", kumene izo Kwalamulidwa?

mankhwala akulimbikitsidwa pathologies opatsirana yotupa akuluakulu chikwiyire ndi tizilombo ndi tilinazo thereto. Makamaka, kuwerenga adzafotokoze exacerbation la matenda otaya aakulu, pachimake sinusitis, dera anapeza chibayo (chifukwa cha tizilombo ta bakiteriya naonetsere kukaniza angapo mu T. H. The mankhwala). Amatanthauza "Moxifloxacin" malangizo ntchito akulimbikitsidwa matenda a minofu zofewa ndi khungu, nyumba subcutaneous kobvuta zotupa (matenda ashuga phazi komanso), ndipo kwapakati pa-m'mimba matenda (njira polymorphic, abscesses intraperitoneal ndi zina zotero). Akapatsidwa pamene medicament ku Streptococcus pneumoniae kugonjetsedwa antibacterials angapo, kuphatikizapo pamaso pa mitundu kugonjetsedwa ndi penicillin, magulu awiri kapena kuposa mankhwala a wachiwiri m'badwo cephalosporins, macrolides, tetracyclines. Ndi zizindikiro mulinso zotupa yotupa mu ziwalo m'chiuno wopepuka chikhalidwe. Pamene endometritis ndi salpingitis Amalimbikitsidwanso kuganizira njira (monga momwe Ufumuyo mankhwala "Moxifloxacin" malangizo ntchito). Diso madontho analamula kuti conjunctivitis bakiteriya, chikwiyire ndi tizilombo tcheru medicament lapansi. M'pofunikanso kuganizira mankhwala alipo a pathologies utsogoleri opatsirana.

Medicament "Moxifloxacin": mlingo ndi njira za makonzedwe

Ndalama anasankha inwards (pakamwa) ndi m'nsinga. . Nthawi mankhwala medicament "Moxifloxacin", mlingo umene - 400 mg / tsiku, malingana ndi mtundu wa matenda ndi ukulu wake, komanso anaona zotsatira achire:

• Exacerbation cha matenda matenda N'zoona - masiku 5-10.
• Community-anapeza chibayo - masiku 7-14 yotsatana mankhwala (mtsempha akutsatiridwa ndi madyedwe m'kamwa).
• Zofewa minofu, khungu (wopepuka), ndi pachimake sinusitis - masiku 7.
• Pamene kwapakati pa-m'mimba matenda (zovuta) - masiku 5-14 yotsatana mankhwala.
• Pamene zovuta zotupa ndi nyumba subcutaneous wa khungu - masiku 7-21.
• Mu pathologies yotupa ziwalo m'chiuno - masiku 14.

Kuti mudziwe zambiri, lili Ufumuyo mankhwala "Moxifloxacin" malangizo Buku. Mapiritsi sayenera kuloledwa kutafuna. Sambani pansi ndi madzi n'zofunika buku laling'ono.

ntchito m'dera

Medicine "Moxifloxacin" (madontho) Mwina kuperekedwa kwa odwala ndi chaka. Khalani limasonyeza kuti kusintha abwera pa tsiku lachisanu. Pambuyo kuti muyenera kupitiriza mankhwala masiku 2-3. Odwala diso akhudzidwa anaika dontho katatu patsiku. Ngati palibe zotsatira kwa masiku asanu awukitsa funso la kulondola mankhwala kapena matenda. Kutalika kwa nthawi yoperekera chithandizo kumatengera ndi bacteriological ndi matenda Inde ndiponso azikhala kudwala lapansi.

Komanso pa njira yothetsera kulowetsedwa

Medicament "Moxifloxacin" malangizo Buku akuonetsa kuti alowe kwa ola. Mankhwala Choncho mukhoza kukhala undiluted kapena mu mawonekedwe sitimadzipereka. Yankho n'zogwirizana ndi mankhwala enaake ndi sodium 0,9%, madzi a jekeseni, dextrose yankho pa ndende 10% ndi 40%, 20% xylitol, "Ringer". Gwiritsani zakumwa bwino kokha. Pambuyo dilution wa medicament akhala khola masiku firiji. Sayenera kusungidwa mu njira firiji. Ngati kulowetsedwa ndi kutumikiridwa ndi atumiki, iliyonse ili kutumikiridwa payokha.

zotsatira zoyipazi

Chifukwa cha mankhwala mankhwala "Moxifloxacin" angayambe matenda a mafangasi, leukopenia, kuchepa magazi, thrombocytopenia. Nthawi zina mankhwala kumeneko ndi kuwonjezeka mu nthawi prothrombin, woipa thromboplastin kusintha. Odwala ena mankhwala angachititse thupi lawo siligwirizana, laryngeal edema, urticaria, anaphylactic mantha, pruritus, eosinophilia, totupa. Nthawi zina, pali hyperglycemia, hyperlipidemia, hyperuricemia. Mankhwalawa matenda Nkosatheka maganizo. Makamaka, odwala akhoza kuona ofuntha, nkhawa, amavutika maganizo depersonalization, kuyerekezera zinthu m'maganizo, zochita psychotic pamodzi ndi maganizo ofuna kudzipha. Zotsatira Common mbali monga mutu, chizungulire, kenaka utentha mamba, kugona, chisokonezo, matenda kukoma tilinazo, kugona zipolowe, disorientation. Nthawi zina, pa mankhwala ndi mankhwala akhoza kuwona mgwirizano, khunyu, limodzi ndi mawonetseredwe zosiyanasiyana matenda, hypoesthesia, matenda kununkhiza. chiwerengero cha odwala anali akuchuluka wa kulankhula tcheru, neuropathy zotumphukira, amnesia, polyneuropathy. Pamene ntchito timitu, masomphenya akhoza poipa mpaka imfa yake. Komabe, iwowa akuti ndi chikhalidwe chosakhalitsa.

Mphamvu pa dongosolo mtima

Part wa mmene tingagwiritsire ntchito mankhwala "Moxifloxacin" ndi QT-imeneyi prolongation odwala ndi hypokalemia, palpitations, vasodilation, tachycardia. Zotsatira osowa mbali monga matenda oopsa ndipo hypotension, tachyarrhythmias yamitsempha yamagazi, syncope. kawirikawiri anati mtima kumangidwa. Last makamaka mmene anthu predisposed kuti ischemia pachimake, bradycardia (kukomoka kwambiri).

Impact pa machitidwe ena ndi ziwalo

Nthawi zina, mankhwala angachititse kupuma movutikira, kuphatikizapo chikhalidwe cha mphumu. chiwerengero cha odwala amene asunga matenda kapepala kakuti m'mimba. Makamaka, ndi maziko a mankhwala-emergent nseru, kusanza, kutsekula m'mimba, kupweteka m'mimba. Ndi zotsatira ochepa mbali amaonedwa kudya osauka, dyspepsia, flatulence, gastroenteritis (kupatula erosive), kudzimbidwa. Odwala ena mwazindikiritsidwa stomatitis, dysphagia, pseudomembranous matenda a m'matumbo. chithandizocho mwina mukhoza kuwonjezera pa transaminases, kwa chiwindi kukanika, kukula kwa chiwindi fulminant, kwa chiwindi kulephera zikubweretsa moyo pachiswe. kawirikawiri anati bullous cutaneous zochita (poizoni epidermal necrolysis, Stevens-Johnson syndrome). Odwala ena anakumana myalgia, arthralgia, khunyu, kuchuluka minofu kamvekedwe, tendonitis, kufooka minofu. tendon utaphulika angayambe Nthawi zina, nyamakazi, gait chisokonezo chifukwa cha kuwonongeka kwa dongosolo minofu ndi mafupa. Odwala pa mankhwala ndi mankhwala akhoza kukhala matenda ananena za dongosolo mkodzo. Makamaka, amalembedwa madzi m'thupi (chikwiyire m'mimba kapena kuchepa mu buku madzi ankadya), aimpso kukanika, insufficiency. Zotsatira Common mbali monga thukuta, kupweteka nonspecific, malaise. Mu mtsempha ayenera thrombophlebitis kapena phlebitis.

Amene sanagaŵiridwe njira?

Mankhwala "Moxifloxacin" contraindications ali motere:

• Tendon kudwala mu mbiri imene inabuka chifukwa cha mankhwala quinolone mankhwala gulu.
• Kapezekedwe elongate QT-imeneyi (kobadwa nako kapena kugula).
• Electrolyte chisokonezo (makamaka hypokalemia uncorrected).
• Bradycardia (kukomoka kwambiri).
• Mtima kulephera ndi wotsikirapo ejection ntchito mu ventricle kumanzere.
• Kuphwanya mtima mungoli (m'mbiri).

Pamene lactose tsankho, shuga-galactose malabsorption, lactase akusowa amadziwikanso osavomerezeka medicament "Moxifloxacin" (mankhwala zikuchokera limapangidwa lactose, kotero pathologies otchulidwa aphatikizidwa mndandanda). Sanagaŵiridwe kumatanthauza oyembekezera kapena lactating. Mapiritsi ndi njira analoledwa kopita odwala zaka 18. Analimbikitsa mankhwala ngati hypersensitivity kwa zigawo zikuluzikulu.

Nthawi yapadera

Tiyenera kusamala poika mankhwala odwala chapakati kuvutika mantha dongosolo kuti odana ndi chitukuko cha kukomoka. Gulu chiopsezo zikuphatikizapo odwala limati proarrhythmic. Zikuphatikizapo, makamaka monga pachimake ischemia, makamaka achikulire akazi. Kusunga kusamala odwala ndi matenda enaake chiwindi. kusintha mlingo ukafunidwe pa nthawi imodzi mankhwala njira kutsitsa ndende ya potaziyamu.

Kuti mudziwe zambiri,

Khalani limasonyeza kuti mankhwala ndi bwino analekerera odwala ambiri. Akatswiri amakonda kulemba ndi chida zotupa opatsirana. Ichi ndi chifukwa chakuti mankhwala ali ndi dzuwa ndi mkulu mabakiteriya ambiri. Komabe, pali nthawi zonse chiopsezo mavuto omwe m'gulu ndi mankhwala akuchenjeza "Moxifloxacin" malangizo Buku. Analogs mankhwala vuto la kusowa ayenera kukatenga dokotala payekha. Sinthanitsani chida mungathe mankhwala monga: "Avelox", "Vigamoks", "Rotomoks", "Moksifur", "Moksin" ndi ena. Pamene mavuto, ndi kuwonongeka lakuthwa yatsoka ndi zizindikiro zimene limafotokoza mwachidule, muyenera kupempha chithandizo mwamsanga. Pamene ntchito madontho ayenera musayandikire yambiri maso mankhwala a. Ngati zimenezi zachitika, muyenera mwamsanga ndi madzi ambiri. Pankhaniyi cha mankhwala osokoneza bongo kuwongola mavuto.

pomaliza

Mankhwala "Moxifloxacin ankaona" mokwanira amphamvu antibacterial. Mogwirizana ndi iyi kwambiri ndi osavomerezeka kuswa mankhwala a dokotala. Kwenikweni, nkhawa chiwerengero ndi pafupipafupi ntchito njira. Musalumphe mlingo. Mtsempha jekeseni ayenera idzachitika kuphunzira mwapadera ndi oyenerera membala ndodo amene angathandize ngati kuli kofunika. Suyenera kudziletsa medicate. Popeza zotsatira za mankhwala n'kofunika kuwona dotolo. Patangotsala pang'ono kugwiritsa ntchito mankhwala "Moxifloxacin" azitha kuwerenga malangizo.