"Nebilong": malangizo ntchito. "Nebilong": ndemanga analogues

"Nebilong" ndi mankhwala ochiza matenda a matenda kugwirizana ndi mkhutu ntchito mtima. Kutsata ikatha ntchito kwa mwezi umodzi. Pambuyo ntchito "Nebilonga" dekhetsa kugunda kwa mtima ndi kuthamanga kwa magazi, mtima zosangalatsa kukufika, ndi myocardium umaperekedwa mpweya okwanira. Pafupifupi milandu onse chifukwa zabwino za mankhwala ndi anapitiriza kwa nthawi yaitali.

Zikuchokera, zikuchokera

Mankhwalawa amapezeka mapiritsi. Aliyense piritsi mukhoza ali 2.5, 5 kapena 10 mg wa yogwira pophika. mankhwala wapangidwa pamaziko a nebivolol hydrochloride. Wa excipients alipo zikuchokera povidone, lactose, magnesium stearate. Zikuchokera wodzilemekeza ndi talc, microcrystalline mapadi, sodium dioctyl sulphate colloidal pakachitsulo dioxide, croscarmellose sodium, Woyeselela-cyclodextrin.

zotsatira pharmacological

"Nebilong" malangizo Buku kusonyezedwa monga njira Ndikukhala akuphatikizapo enantiomers awiri (L- ndi D-nebivolol). D-nebivolol - kwambiri kusankha, mpikisano β1-adrenoceptor blocker, L-nebivolol waulemu pa Mitsempha zambiri, ndiye chifukwa ndondomeko mu endothelium mtima (kumasulidwa vasodilating kusinthasintha mawu chinthu).

Nebivolol amachepetsa magazi ndiponso kugunda kwa mtima, chifukwa amasungidwa osati boma quiescent komanso pansi pa katundu. Pambuyo mankhwala kuzungulira ndi yotsiriza diastolic kumanzere yamitsempha yamagazi amakumana yafupika, pali amadza zabwino pa imodzi mwa ntchito anachita ndi mtima - diastolic. Chifukwa ntchito ya "Nebilonga" ejection kachigawo ukuwonjezeka, anthu ndi IBS amalembedwa zotsatira antianginal.

Hypotensive kanthu anatengedwa mapiritsi "Nebilong" mtsogoleri anafotokoza kuchepa ntchito mu dongosolo renin-angiotensin. kanthu Antiarrhythmic zimatheka ndi kuchepetsa AV-conduction ndi kupondereza nthenda automaticity mtima. Olimbikitsidwa zotsatira hypotensive chimachitika mu masiku 7-14 mankhwala, kawirikawiri - pa mwezi. chifukwa khola pakumwa mapiritsi anati pambuyo miyezi wina kwa awiri a mankhwala.

Pharmacokinetics

Mankhwala ingested, odzipereka bwino, ndondomeko ndi mofanana ogwira kaya chakudya. Kagayidwe mu chiwindi ndi anamaliza mapangidwe gidroksimetabolitov yogwira. Wapakati bioavailability pambuyo ntchito ya mkati medicament munthu ndi kagayidwe mofulumira 12%, chithunzi ichi ndi apamwamba kuposa ndi kagayidwe pang'onopang'ono. Popeza kagayidwe odwala angayambe pamlingo wosiyanasiyana, "Nebilong" Buku akulimbikitsidwa kugwiritsa ntchito makhalidwe munthu wa thupi la wodwalayo. Ndi kagayidwe pang'onopang'ono ntchito mlingo wochepa wa mankhwala. Mu nkhani kuwombola mofulumira zinthu chikuchitika theka moyo pafupifupi 10 maola, odwala amene ali ndi kagayidwe pang'onopang'ono, theka moyo chinawonjezeka ndi nthawi 3-5. Pambuyo pamasiku seveni mankhwala za 38% analandira mankhwala excreted ndi impsozo, za 48% "Nebilonga 'chili m'manyi. The zikuchokera mkodzo ndi pang'ono mankhwala zikutsatiridwa - kuti 0.5%.

umboni

Pa ntchito "Nebilong" malangizo angagwiritsidwe ntchito oopsa, chifukwa kukhazikitsa njira zodzitetezera odwala ndi CAD (chifundo cha angina) ndi kugwiritsa ntchito mankhwala zovuta mtima kulephera kwa mawonekedwe aakulu.

Chithandizo ndi mankhwala "Nebilong"

oopsa

odwala wamkulu kutumikiridwa 5 mg "Nebilonga" womwe ndi chiphunzitso piritsi ndi mlingo tsiku. mankhwala tikulimbikitsidwa kugwiritsa ntchito tsiku lililonse pa nthawi yomweyo. A zotsatira ang'ono ndi noticeable pambuyo masabata wina kwa awiri a mankhwala kwambiri chitaperekedwa iye ndi mwezi imene mankhwala amachitidwa. Mapiritsi oyenera kukhazikitsa monotherapy ndi chithandizo zochokera ntchito Integrated mankhwala, amenenso ndi zotsatira hypotensive. Anthu amene 'Nebilong AM ", malangizo tikulimbikitsidwa kuti apeze zotsatira zina kutsatira" Hydrochlorothiazide "wa 12.5-25 mg. Chotero ophatikizana mankhwala patsogolo ntchito ya "Nebilonga", koma izo zikhoza kuchitidwa kokha atalandira malangizo a dokotala nawo.

Mtima kulephera mawonekedwe aakulu

Choyamba mlingo ka medicament, dokotala pang'onopang'ono kumawonjezera, anapatsidwa makhalidwe a wodwalayo. Zochizira mitundu wokonda "Nebilong" si yoyenera, mu Zikatero, mankhwala ena akhala ntchito. Kawirikawiri woyamba Kwalamulidwa kwa 1,25 mg wa mankhwala ntchito kamodzi tsiku lililonse, pambuyo masabata 1-2 mlingo akhoza ziwonjezeke kwa 5 mg, ndipo kenako - mpaka 10 mg. Mlingo tsiku sayenera upambana 10 mg medicament "Nebilong". Malangizo ntchito limasonyeza kuti pa siteji koyamba mankhwala wodwala wasiyidwa pansi kuonerera kwa maora awiri ingestion wa phale, momwemo lililonse kuwonjezeka njira mlingo. Kuchuluka mlingo kungachepe kachiwiri ngati kufunika alipo.

Ngati mtima kulephera zizindikiro anaonekera kwambiri kutchulidwa kapena wodwala tsankho kwa zigawo mankhwala anapezeka, kuchepetsa mlingo wa mankhwala kapena kubala chiyembekezo chakuti ake. Childs, mtima kulephera, mawonekedwe aakulu a "Nebilongom" ankachitira msanga. Pamene mankhwala umalimbana ndi kuthetsa zinthu zimenezi, chiyembekezo chakuti mankhwala kuti pang'onopang'ono, inu simungakhoze kuchita zimenezi zikuchepa, chifukwa vuto akhoza kulimbikitsa. Ngati kuletsa mankhwala mlungu uliwonse mwina ndichepe mlingo ndi theka. Pakuti, kutenga mankhwala "Nebilong AM" malangizo Buku amapereka zoletsa zina.

zoletsa:

• Aimpso insufficiency. Choyamba, chifukwa chithandizocho ntchito 2.5 mg wa mankhwala patsiku, mlingo akhoza ziwonjezeke ina, koma sayenera upambana 5 mg.
• Achikulire zaka. Mlingo woyambilira mwina upambana 2.5 mg ndi ngati n'koyenera, liukitsidwa 5 mg. Patatha zaka 65, amafuna anayendera zonse a impso (mmodzi miyezi inayi mpaka isanu).
• Mimba. akhanda akhoza kukhala matenda ena, kuphatikizapo ziwalo kupuma, hypoglycemia, hypotension, bradycardia, akazi apakati mankhwala Kwalamulidwa kawirikawiri. Ngati mayi wapakati amagwiritsa "Nebilong" Kulipira wake chofunika kwa maola 48-72 pamaso yobereka. Ngati zimenezi sizingatheke, wakhanda chiyenera kuchitika kwa maola 48-72.

contraindications

"Nebilong H" malangizo Buku imaletsa ntchito milandu zotsatirazi:

• zaka zosakwana zaka 18;
• hypersensitivity kwa zigawo mankhwala;
• bronchospasm, mphumu (mbiri);
• pheochromocytoma, amene sichinayambe ankachitira kale;
• kagayidwe kachakudya acidosis;
• molimba zikuchitika chiwindi matenda, chiwindi kulephera;
• hypotension mu anthu amene systolic kuthamanga 90 mamilimita Hg kapena zochepa. Article.
• AV-chipika (kalasi Ine, III), bradycardia, amene anatsagana ndi kugunda kwa mtima lolingana 60 bpm. pamphindi;
• pa kubala ana, kuyamwitsa;
• pachimake mtima kulephera mawonekedwe;
• mavuto ndi makope zotumphukira, ndi expressiveness omveka;
• cardiogenic mantha, mkhalidwe umene m'pofunika kugwiritsa ntchito mankhwala isotropic;
• syndrome, nkusani odwala limodzi.

Chenjezo chofunika pamene kusankha mankhwala odwala ndi zinthu:

• shuga;
• psoriasis (mbiri);
• Prinzmetal angina.

zotsatira zoyipazi

Mu mankhwala amatanthauza "Nebilong" malangizo Buku, ndemanga kunena Mwina zosayembekezereka wa zotsatira zina mbali, amene akuwonetseredwa mu ntchito ya mtima, m'mimba ndi machitidwe mantha. Pakati kuyan'anila ena - bronchoconstriction anachita zokhudza chikhalidwe khungu.

Kusamala

"Nebilong" Mwina kwambiri kudziwa allergens, amene agonjetsa chitukuko cha aakulu anaphylactic anachita.

mankhwala sikumangotikhudza mlingo wa shuga m'thupi pamaso pa shuga, koma odwala gulu kugwiritsa ntchito mankhwala mosamala. Monga matenda a shuga ndi hyperthyroidism mankhwala kungathe kubisa zizindikiro za tachycardia, ndi yapadera kwambiri chifukwa kusiya mwadzidzidzi miyala.

Ngati odwala matenda m'dongosolo kupuma ntchito "Nebilong" malangizo Buku imatiuza za Mwina phindu constriction kwa Airways mu COPD. Kutheka kwa kaphatikizidwe mankhwala ndi mankhwala ena zifunike ndi dokotala.

"Nebilong" amakhudza kuthekera kuyendetsa galimoto, kungachititse kuti kutopa ndi chizungulire.

analogs

N'zotheka m'malo mankhwala kuti salola ntchito mankhwala "Nebilong" malangizo Buku. Mankhwala analogues monga "Nebilet", "Binelol". Ndi mmalo mulinso "Nebikor" ndi "Nebivator".

Reviews

Monga mauniko, mankhwala othandiza pamene ntchito molondola. Nkofunika ntchito mankhwala ndi kutsatira malangizo onse dokotala. medicament ulipo ndi contraindications ndi makhalidwe a mtima, chifukwa mu ubwino. mankhwala sanadutsitse kuti chitukuko mavuto, muyenera zonse kuyan'ana mmene wodwalayo.