Neofilin (mapiritsi): malangizo ogwiritsira ntchito. Neofilin 100 mg: kufotokoza kwa mankhwala

Pofuna kupatsirana matenda opatsirana chifukwa cha kupuma kwapadera, maginito a mankhwala a methylxanthine amagwiritsidwa ntchito. Mtsogoleri wawo wamkulu ndi theophylline.

Mankhwala osokoneza bongo amayambitsa matenda a mphumu mu mphumu yowonongeka, kupwetekedwa kwa mphutsi ndi usiku.

Kufotokozera za mankhwala

Mankhwalawa "Neofilin" (mapiritsi) amafotokoza malangizo ogwiritsidwa ntchito monga mankhwala opangidwa ndi kampani ya mankhwala a Chiyukireniya "Darnitsa" mu magawo awiri: 100 ndi 300 mg. Mankhwalawa ali ndi zotsatira zotalika.

Ntchito pa thupi

Chinthu chogwiritsira ntchito mankhwalawa (theophylline) chimakhala ndi mankhwala a bronchodilator m'thupi, pomwe adenosine receptors imatsekedwa, phosphodiesterase imaletsedwa, zomwe zimachitika m'magulu a cyclic adenosine monophosphate zimakula, ndipo mavitamini a calcium amachepa. Pali kupuma kwa mitsempha yosalala mu bronchi, njira yamagulu, biliary thirakiti, chiberekero, coronary, pulmonary, ziwalo za ubongo, kuchepa kwa mitsempha yamakono, kuchepetsa kwa pulogalamu yazitsulo yazitsulo.

Potsatira mankhwala, pali kuwonjezeka kwa kamvekedwe ka minofu ya kupuma, yomwe imatchulidwa mitsempha yambiri ndi chifuwa. Kuonjezera apo, kukana kwa mitsempha kumachepa, mpweya wa m'magazi umakula bwino, malo opumitsa mu medulla oblongata atsegulidwa, kuti mpweya wa carbon dioxide uwonjezeke, ndipo kutulutsa mpweya wabwino kumakhala bwino.

Chotsatira chake, kuuma kwachepa kumachepa ndipo nthawi zambiri kayendedwe ka kayendedwe ka kupuma kamachepa. Theophylline pokonzekera "Neofilin" (mapiritsi) amafotokoza malangizo oti agwiritsidwe ntchito ngati mankhwala ochotsera odwala angiospasm, kuwonjezereka kwa magazi ozungulira magazi ndi kupuma kwa magazi, kuchepetsa kuperewera kwa magazi komanso kusintha kwabwino kwa ubongo.

Mankhwalawa apangidwa kuti apangitse maonekedwe a magazi, kuteteza mapangidwe a magazi, kuchepetsa kuyika kwa mapaleti, normalization ya microcirculation. Theophylline imasonyeza kuti mankhwalawa amatsitsimutsa, pomwe mast cells amawononga komanso amachepetsa odwala, monga histamine, serotonin, leukotriene.

Mwa kuwonjezereka kwa magazi, zimakhala zochititsa chidwi kuti madzi, ma chloride ions ndi sodium amamasulidwe.

Chimene mankhwalawo amachitira

Ndi mankhwalawa "Neofilin 100" (mapilitsi), buku lophunzitsira limalimbikitsa chithandizo cha mphumu ya khate, matenda a asthmatic, bronchitis obstructive mwachizoloŵezi chosatha, kuwonongeka kwa mapapo, kupweteka kwa mpweya, kutentha kwa usiku.

Malangizowo akutanthauza mlingo wapamwamba wa mankhwala, 300 mg uliwonse.

Momwe mungatengere

Mankhwalawa "Neofilin" (mapiritsi) akulimbikitsidwa kuti agwiritsidwe ntchito pa mlingo womwe umayikidwa pa matenda onse mosiyana ndipo umadalira mofulumira wa njira zamagetsi, zizindikiro za zaka ndi chiwerengero cholemera cha wodwalayo.

Mankhwalawa aledzera 1 nthawi patsiku pa kadzutsa kapena chakudya chamadzulo. Mankhwala a "neofilin" (mapiritsi) amaphunzitsidwa akutsata ulamuliro wolimba. Ndizosatheka kumwa mankhwala tsiku limodzi panthawi ya chakudya, ndipo potsatira - mutatha kudya.

Kuwerengera mlingo ndi chilolezo chodziwika bwino cha nsana

Pofuna kuchuluka kwa mankhwalawa, m'pofunika kudziwa momwe chiwerengero cha kuyeretsa kwa magazi a m'magazi kumakhala kosiyanasiyana kuchokera ku zinthu zosiyanasiyana ndi impso.

Mankhwalawa "Neofilin" (mapiritsi) malangizo kwa ana a zaka zapakati pa 12 mpaka 15 ali ndi thupi lolemera zosakwana 45 kg amalimbikitsa kugwiritsa ntchito masiku atatu oyambirira a mankhwala pa mlingo wa tsiku ndi tsiku wa 12 mpaka 14 mcg pa kilo imodzi ya thupi. Koma simungathe kumwa mankhwala oposa 300 mg.

Pambuyo masiku atatu a chithandizochi, mwachizolowezi cholekerera, mlingo wa tsiku ndi tsiku ukukwera kufika 16 μg pa kilo imodzi ya thupi. Koma sayenera kupitirira 400 mg patsiku.

Patadutsa masiku atatu otsatira, pamakhala chikhalidwe cholekerera, mlingo umakwera kufika 20 μg pa kg ya kulemera kwa thupi. Koma tsopano sayenera kukhala oposa 600 mg.

Mankhwalawa "Neofilin" (mapiritsi) malangizo othandizira ana kuyambira zaka 16 ndi akulu kwa zaka 60 ali ndi thupi loposa 45 kg masiku atatu oyambirira amachilangiza kuti agwiritse ntchito makilogalamu 300 mpaka 400 pamlomo.

Patadutsa masiku atatu, pamene chizoloŵezi cholekerera, chiwindi chimafika 400-600 mg.

Pambuyo masiku atatu mofanana, mlingo wa tsiku ndi tsiku ukhoza kupitirira 600 mg, koma amafunika kuti theophylline ikhale m'magazi a wodwalayo.

Kuwerengera mlingo wosayenerera kwachinyengo ndi anthu okalamba

Momwe mungatengere mankhwalawa "Neofilin" (mapiritsi) ku magulu ena a odwala? Langizo kwa ana limalimbikitsa kulitenga pa mlingo womwe suyenera kukhala oposa 16 mg pa kilogalamu yolemera thupi tsiku lililonse, koma osapitirira 400 mg. Izi zikuthandizira achinyamata omwe ali ndi zaka 12 mpaka 15 omwe ali ndi vuto lachinyengo kapena ngati plasma theophylline siziyang'aniridwa.

Pokonzekera "Neofilin 300" (mapiritsi), malangizo othandizira amagwiritsa ntchito deta yotsatirayi. Amagwiritsira ntchito moyenera za mankhwala omwe achinyamata ali ndi zaka 16 ndi odwala okalamba ali ndi zizindikiro zowonongeka, komanso anthu omwe sadziwa kuchuluka kwa theophylline. Kawirikawiri m'magulu otero a odwala kuchuluka kwa mankhwala othandiza a mankhwalawa sayenera kupitirira 400 mg.

Kuwerengera mlingo wa magazi a theophylline

Malinga ndi zomwe zili mu gawo la plasma, mlingo wa kusintha kwa mankhwala "Neofilin 100" (mapiritsi) ukuchitika. Malangizowo machitidwe oterewa amapereka kuti atulutse komanso akamatenga mlingo waukulu wa mankhwala. Kuchepetsa mlingo wa mankhwala ogwira ntchito ndi kulamulira kuchuluka kwake mu seramu ndikofunikira ngati pali zosafunika, matenda okhudza thupi omwe amalepheretsa mankhwalawa.

Ngati nsonga ya theophylline m'magazi imachepera 9,9 μg pa ml, ndiye kuti kusagwiritsidwa ntchito kwa mankhwala omwe ali ndi chilekerero choyenera kumafuna kuchuluka kwa 25%. Patatha masiku atatu kuti mutenge kusintha kwa mankhwala, mankhwala a theophylline amafufuzidwa.

Ngati zotsatira za chithandizo chafika ndi kulekerera ndi zabwino, chithandizo choonjezera ndi mlingo wapitawo n'zotheka pokhapokha mutapanga chiwerengero cha mankhwala a plasma. Chizindikiro chake chiyenera kukhala 10 mpaka 14.9 μg pa ml. Ngati palibe zotsatira, koma kulekerera ndibwino, onjezerani mankhwala ena.

Ndi liti pamene muyenera kuchepetsa mlingo

Pamene minofu ya theophylline ya plasma ili m'kati mwa 15 mpaka 19.9 μg pa ml, kuchepetsa mlingo wa 10% ndikofunikira.

Ndi chiwerengero cha mankhwala a 20 mpaka 24.9 μg pa ml, m'pofunika kuchepetsa kuchuluka kwa mankhwala ndi 25%, ngakhale ngati palibe machitidwe oyipa akuwonekera. Patatha masiku atatu kuchepa kwa mlingo, ndondomeko ya plasma ya theophylline ikuyang'anitsitsa kuti athe kudziwa momwe mungagwiritsire ntchito mankhwalawa.

Ngati mlingo wa mankhwalawa ndi wochokera 25 mpaka 30 μg pa 1 ml, mlingo womwewo umatsika, komanso kuti mankhwalawo ayenera kuchepetsedwa ndi 25%.

Patatha masiku atatu kuchepa kwa mlingo, ndondomeko ya plasop ya theophylline ikuyang'anitsitsa kuti adziwe momwe mankhwalawa angathandizire. Ngati zizindikiro za zotsatira zoipa zingatheke, tengani zoyenera.

Pa theophylline m'magazi oposa 30 mcg pa ml akhoza kuwonongera. Kuti mugwiritse ntchito, mlingo wafupika ndi theka. Patatha masiku atatu, bwerezani kuchuluka kwa mankhwala omwe ali mu plasma ndipo musinthe mlingo.

Chotsatira cha ntchito

Mukatenga mapiritsi a "Neofilin 100" ndi osuta fodya, malangizo oti mugwiritsire ntchito pochenjeza za kuchepa kwa zotsatira za mankhwalawa.

Kwa anthu omwe ali ndi matenda a mtima, mitsempha ya m'magazi, chiwindi, matenda a tizilombo, okalamba, mlingo wa mankhwalawo wasankhidwa payekha, ndipo mankhwala m'mayeserowa amatengedwa mosamala kwambiri.

Kuchuluka kwa mankhwala

Kwa akuluakulu, kupitirira kwao kwa Neofilin 300 (mapiritsi) ndi mankhwala amadziwika ndi kugwidwa, kutentha thupi, kutaya mtima, kuphatikizapo tachycardia, ventricular arrhythmia, ndi hypotension.

Zizindikilo zomwe zimakhala za ubwana zimaphatikizapo zokondweretsa kwambiri, zovuta za m'maganizo, kutentha kwa malungo, kunyowa, kutentha, tachycardia, hypotension, kumangirira kupuma.

Pochiza, choyamba, siyani kumwa mapiritsi, ndiye tsambani m'mimba, kuthirira matumbo ndi kuphatikiza mankhwala a salt ndi polyethylene glycol, tengani makala opangidwira. Ndikofunika kuti athandize kuchotsa theophylline m'magazi kudzera mwa diuresis yokakamizidwa, hemosorption, plasmosorption, hemodialysis, peritoneal dialysis.

Ngati kunyozetsa ndi kusanza, wodwalayo akupatsidwa mankhwala othandizira, mwachitsanzo, ondansetron kapena metoclopramide. Pofuna kuthetsa vutoli, mukhoza kutenga "Diazepam".

Amene sayenera kutenga

Pa mankhwala "Neofilin 100" (mapiritsi), malangizowa akuphatikizapo mndandanda wa zotsutsana zomwe sizingatheke kumwa mankhwala. Izi zimaphatikizapo hypersensitivity ku zigawo zonse za mankhwala, kwa mankhwala a xanthine, omwe amachititsa kuti tizilombo ta caffeine, theobromine, pentoxifylline.

N'zosatheka kutenga matenda a myocardial infarction, tachyarrhythmia, obstructive hypertrophic cardiomyopathy, matenda oopsa kwambiri, matenda a khunyu, hyperthyroidism, zilonda zam'mimba m'mimba kapena duodenum, matenda aakulu a chiwindi, matenda a porphyrin.

Njira yothetsera vuto la ana osakwana zaka khumi ndi ziwiri.

Zosasangalatsa

Zotsatira zambiri zingayambe kuchokera ku mankhwala "Neofilin" (mapiritsi). Malangizo ogwiritsira ntchito amauza odwala za kuthekera kwa mawonetseredwe a matenda m'matumbo a m'mimba. Amadziwika ndi kupweteka m'mimba, kunyowa, kusanza, kugwidwa , kupweteketsa mtima, kupweteka kwa chilonda, kutsekula m'mimba, kuchepa kwa chilakolako.

Zochitika zosasangalatsa zimawonetseredwa m'maganizo a mtima monga mawonekedwe a palpitation, tachycardia, kusokonezeka kwa mtima, kuchepetsa kuthamanga kwa magazi, cardialgia, angina pectoris.

Theophylline ingakhudze dongosolo lalikulu la mitsempha. Ikhoza kufotokozedwa ndi chizungulire, kupweteka mutu, kupumula kapena kusokonezeka, kusokonezeka tulo, kutenthedwa, kupwetekedwa, kupwetekedwa ndi kupweteka.

Pakulandila kukonzekera kusakanikirana ndi zomwe zimachitika pakhungu, erythema, dermatitis exfoliative, urticaria, malungo angathe.

Zotsatira zina zosayenera za mankhwalawa ndi monga tsitsi kumutu pamutu, kupweteka pachifuwa, kupuma mofulumira, kutentha kwambiri, albumin protein excretion mu mkodzo, kukhalapo kwa mkodzo mu mkodzo, kuwonjezeka kwa diuresis, kuwonjezeka thukuta ndi kutentha kwa khungu.

Zimakhudza theophylline pa zizindikiro za kuyesa ma laboratory. Pamene mankhwala ndi mankhwala "Neofilin" akhoza kusiyana ndi mavitoni a potassium mu seramu ya magazi pansi ndi chitukuko cha hypokalemia. Pa nthawi yomweyi, mlingo wa creatinine, calcium ions , oxalates, omwe ndi salt ya uric acid, ndi shuga zimawonjezeka, zomwe zimayambitsa hypercalcemia, hyperuricemia ndi hyperglycemia.

Pambuyo kuchepetsa mlingo wa mankhwala, mlingo wa zotsatira zake umachepa.

Mimba ndi mapiritsi

Chigawo chogwiritsira ntchito mapiritsichi chimatha kulowa m'kati mwachitsulo ndikulowa mkaka wa m'mawere.

Kwa amayi apakati, phwando n'zotheka kokha pamene zotsatira za kuchiza mayi ndizopambana chiopsezo cha mwana wosabadwa. Pankhani ya chithandizo choterechi, kawirikawiri chidziwitso cha mitsempha ya theophylline ya plasma ndi kuyenera kusintha kwa dosing ya wothandizira n'kofunikira. Ndizosayenera kumwa mankhwala m'miyezi yotsiriza ya mimba chifukwa cha kuponderezedwa kwa mitsempha ya chiberekero.

Azimayi amene amanyamulira ndipo amachizidwa ndi theophylline ayenera kuwona maonekedwe a hypersensitivity mwa mwanayo. Mwinamwake chitukuko cha chisangalalo kapena mavuto ndi kugona, zomwe zimafuna kuchotsedwa kwa mankhwala.