Popanga madzi a gamma-interferon: udindo ndiponso kufunika thupi

Kuteteza thupi ku mavuto aakulu tizilombo toyambitsa matenda - mavairasi, pali limagwirira mu chitetezo cha m'thupi, kupereka ulamuliro kwa matenda opatsirana. Ndi maselo kupanga, monga T-lymphocytes zinthu zenizeni, mmodzi amene ali Popanga madzi a gamma-interferon. Zimapezeka chitetezo cha m'thupi, kugwirizana amachita ngati chitetezo ndi ma. N'chifukwa chiyani kuli kofunika monga fano, ndipo maziko nanga umphumphu wa thupi lathu - mafunso awa lidzayankhidwa m'nkhani ino.

Kapangidwe mankhwala ndi kulandira

Chifukwa cha chinthu - ndi glycoprotein - zokhudzana peputayidi zimam'patsa. Biochemists allocated njira ziwiri zosiyana kwa amino asidi zikuchokera 139 ndi monomer choyamba mu unyolo polypeptide. Iwo amatchedwa Popanga madzi a gamma-interferon 1a ndi 2a. The maselo kulemera avareji dongosolo la 20 - 25 kDa. Anapanga poyankha malowedwe a zimakhala ndi maselo a wothandizila tizilombo ankaimira particles tizilombo. Mu m'galasi mankhwala akamagwira umisiri ndi kukonza majini ntchito tizilombo ta bakiteriya a Escherichia coli, ndi pulasimidi muli jini kwa interferon anthu. Izi Popanga madzi a gamma-interferon otchedwa zophatikizananso ndi mbali ya zokonzekera: "Immuneron" "Ingaron" "Immunnomaks".

Limagwirira mayankho m'thupi

Maonekedwe a thupi mlendo tizilombo toyambitsa matenda chosakaza nthawi zonse limodzi ndi dongosolo la njira zodzitetezera mmodzi amene ndi kutupa. Ali ngati chikhomo ndi, kusonyeza chiyambi cha matenda onse ndiponso mmene selo poyankha antigens wa tizilomboto lapansi. Pali zimachitika zovuta pakati pa miyambo ya minofu matenda kapena chiwalo. Bukuli lili ndi zinthu imatulutsidwa ndi maselo a minofu lymphoid: cytokines (lymphokines). Mwachitsanzo, maselo a anthu interferon-Popanga madzi a gamma, interleukin 2 mwa kulimbikitsa ankachita Kakhungu kuti alibe matenda ayamba kaphatikizidwe wa chitetezo, ndipo kwenikweni kusonyeza mapuloteni. Tiyeni tione iwo mwatsatanetsatane.

katundu lymphokines

The anthu asakhale ndi vutoli 6 awiri ili locus kupanga akonzedwa a majini, onyamula zambiri pa katundu antigenic wa Kakhungu plasma ndi organelles ena ma: phata, mitochondria, etc. Lymphokines sangathe kwa mwachindunji zimakhudza antigens cha mavairasi, koma mofulumira popereka mauthenga za kukhalapo kwa zinthu zachilendo kwa chipinda wina ndi mzake. Mwachitsanzo, lilime la maselo Antigen-mthandizi ndi T-lymphocytes wo- tsogolera induces ndi chizindikiro okhudza maselo ambiri, awiri yeniyeni activating mapuloteni. Komanso mu minofu lymphoid kumatheka mitotic magawano ndondomeko - KUCHULUKA, ndi kutetezedwa selo nkhoswe ali kwambiri. Mofanana ndi lymphokines zina, interferon-Popanga madzi a gamma kumabwezera mmbuyo njira ya galamafoniyo asidi tizilombo mkati komanso kumabwezera mmbuyo khamu la limagwirira wa zedi tizilomboto. Tikhoza kunena kuti mankhwala mapuloteni, kuonedwa ndi ife, ndi maziko a chitetezo chokwanira humoral.

Kodi chitetezo cha m'thupi

Thymus, lymph mfundo, tonsils, zakumapeto - malo lymphocyte mapangidwe. maselo zoteteza umatulutsa mankhwala akupha kuti ziletsa chitukuko cha thupi la chiyambi opatsirana. Mu magawo oyambirira a chitukuko cha maselo chitetezo otchedwa zilizonse, simungathe mungawononge antigens yachilendo, mabakiteriya ndi tizilombo tina. Iwo ayenera okhwima ndi kukhala immunocompetent - kumachitika mu thymus lapansi. Dongosolo la chamoyo kuti umabala onse maselo yekha chitetezo: macrophages, maselo T, maselo wakupha, komanso mitundu yosiyanasiyana ya Popanga madzi a gamma-interferon pansi pa ulamuliro wa malo apamwamba yokhudza kotekisi ubongo.

ntchito yake komanso motsatira zopangitsa adrenal, pituitary England ndi ubongo imene imalamulira kutentha. Psycho-maganizo matenda zakudya m'thupi ndi zizolowezi zoipa kuchepetsa anachita chitetezo ya thupi, nthawi zambiri izi zikuchitika ndi maziko a maganizo aakulu. Popeza zimene lake ndi chifukwa cha zochita zonse za machitidwe ake, aliyense kuphwanya homeostasis m'thupi zinadzala ndi zolephera ndipo amadwaladwala.

Chitetezo kwa interferon anthu Popanga madzi a gamma

Mu yochizira matenda monga prophylactic ndi achire wothandizila ntchito zinthu zokhala ndi mapulotini zoteteza umatulutsa Katemera wa nyama ndi interferon zophatikizananso. mamolekyulu oteteza woterowu kuchokera ku seramu wa magazi, woyeretsedwa ndi ntchito ngati mankhwala mavairasi oyambitsa. Iwo akhoza patsogolo ntchito za mankhwala thupi lomwe zoteteza, mwachitsanzo, Popanga madzi a gamma-globulins, ndi kuchepetsa zizindikiro za matenda kupuma: rhinitis ndi m'mphuno kuchulukana, chifuwa.

Zotsatira akangofika interferon

glycoprotein zoteteza kumabwezera mmbuyo chulutsa mavairasi ndipo kumapangitsa michere selo, monga mapuloteni kinase adenilatsintetazu ndi kupereka yimitsira wa kaphatikizidwe zidulo mkati ndi mapuloteni kwa emvulopu tizilombo. thunthu ali ndi mphamvu yosokoneza tilinazo mapuloteni Kakhungu kuti lymphokines cha ndende, T. E. Kodi immunomodulators. Popanga madzi a gamma-interferon ana ndi akulu ntchito kwa kupewa ndi kuchiza matenda fuluwenza ndi kupuma, ndi zitsanzo zabwino pamaso pa Bacillus Koch mu thupi. Nthumwi achire adzamasulidwa mu mawonekedwe a mapiritsi, zodzola, suppositories ndi jekeseni.

Kugwiritsa ntchito mankhwala zotchulidwa dokotala, ana angayambe kwa miyezi 6, anapatsidwa kusowa zochita mwana matupi awo sagwirizana ndi pathologies kwambiri dongosolo mtima. Contraindication kuti kuchiza amai amatenga mimba ndi ziwengo. mankhwala Current makamaka ntchito Pediatrics, muli zoteteza zophatikizananso mapuloteni ndi chiyero okwezeka ndi anasiya zidutswa polypeptide.