Short mapeputisayidi ndi polypeptides mbali ya zakudya masewera. Kodi kusankha?

Mapeputisayidi ndi njira otchuka omwe ntchito mu kachitidwe pokonza masewera zakudya mwa akatswiri mu masewera a zofufuzafufuza ndi akatswiri [3]. mapeputisayidi onse - masewera zigawo zakudya - zikhoza kugawidwa m'magulu 2: yochepa (zing'onozing'ono) mapeputisayidi ndi polypeptides ( "chachikulu"). mapeputisayidi ndi lopangidwa ndi zigawo yosavuta - amino zidulo. Ngati peputayidi okhala ochepa amino zidulo, mwachitsanzo 3 kapena 4, - ndi kochepa peputayidi. Ngati peputayidi ndi 20-30 kwa amino zidulo, ndi zambiri - ndi polypeptide. Polypeptides - ili pafupi zofanana ndi mapulotini - mamolekyulu ofunika m'thupi mwathu. N'chifukwa chiyani kuli kofunika magawano mu mapeputisayidi lalifupi ndi polypeptides? Kuyambira kutalika kwa peputayidi chimadalira pa ntchito yake, dzuwa ndi chitetezo pamene ntchito zakudya masewera.

Panopa otchuka monga masewera zakudya zigawo ndi polypeptides zimene zimalimbikitsa wotentha mafuta, kuwonjezera minofu misa, kuwonjezera chitetezo chokwanira, thanzi akukhudzidwira. Komabe, iwo ndi zovuta kwambiri. Polypeptides, makamaka peputayidi mahomoni, mwina atakwatirana ndi mzake, kusokoneza mahomoni chibadwidwe thupi. Komanso, onse "chachikulu" mapeputisayidi ndi ena thupi ndi angachititse thupi lawo siligwirizana. ntchito yapamwamba thupi kuti zonse likuyesetsa opambana, nthawi zambiri zimathandiza kuti kuchepa chitetezo chokwanira, zomwe zina kumawonjezera mbali thupi lawo siligwirizana ku ntchito polypeptides. Chifukwa polypeptides ndi zambiri olekanitsidwa nyama chamoyo [2, 3, 9], chamankhwala kukonza luso mu zosafunika zoipa akhoza kupezeka - mapuloteni yachilendo, DNA makombo, mavairasi, prions, amene adzalandira immunogenicity (mphamvu kupangira ziwengo) ndi kungachititse kuti chitukuko matenda.

Kodi n'zotheka kutero, kusunga katundu zothandiza polypeptides bioregulatory ndipo nthawi yomweyo kuchotsa zolakwa zawo? Inde, tsopano wakhala zotheka. Chifukwa cha zaka za kafukufuku, chinapezeka kuti aliyense polypeptide ndi pakati yogwira - kuti mbali yaing'ono, zomwe ndi udindo ntchito ya peputayidi lapansi. Yachokera pa kusanthula zikuchokera polypeptides malinga ndi luso lapadera labwino Pharma GmbH mapeputisayidi lalifupi zinalengedwa, wopangidwa mwa 2, 3 kapena 4 zatsalira kwa amino asidi [5, 6, 7]. Chotero mapeputisayidi lalifupi Sikuti kupeza kuchokera zimakhala nyama, ndipo iwo akhoza apanga mankhwala. Ndi otetezeka chifukwa mapeputisayidi kupanga mulibe zosakaniza amene amayambitsa chifuwa. Choncho IPH mapeputisayidi yochepa kapangidwe kwathunthu ndi zimene yogwira (zinchito) polypeptide mamolekyulu malo achilengedwe ndipo si anazindikira ndi thupi ngati zinthu zachilendo. Nkofunika kudziwa kuti lalifupi mapeputisayidi IPH, pokhala lofunikira "ntchito" ya polypeptide molekyulu ntchito mu zakudya masewera misinkhu poyerekeza ndi "mapeputisayidi lalikulu."

Ubwino wina ofunika a IPH mapeputisayidi lalifupi luso lawo bwino chosakanikirana ndi thupi poyerekeza polypeptides lapansi. Kodi zimenezi zimachitika? Mapulotini polypeptides kulowa thupi ndi chakudya, kulowa m'mimba ndi intestine. Apo iwo ali mothandizidwa ndi michere wapadera (peptidases) "kudula" mu zidutswa ang'onoang'ono - mapeputisayidi lalifupi ongokhala zatsalira 2 kapena 3 kwa amino acid. Ndiye mapeputisayidi lalifupi kulowa magazi ndi kusamutsidwa kwa minofu ndi ziwalo zina ndi zimakhala, amene anakhudzidwa zolimbana. Ambiri polypeptides, amene timalandira monga mbali ya zakudya masewera adzakhala "kudula" peptidase ndipo alibe zotsatira anakhumba, kapena zotsatira zake zofooka. Mu yochepayi IPH mapeputisayidi ali mbali ya zakudya masewera yomweyo kuchokera m'mimba ndipo matumbo kulowa m'magazi ndipo zimakhala, popanda kuswa. Panopa labwino Pharma GmbH cholinga ndi apanga mndandanda wa mapeputisayidi lalifupi, wotchedwa IPH, kwa mankhwala, chakudya, zodzikongoletsera ndi masewera mafakitale, zomwe Zimachititsa m'thupi, kachitidwe mantha ndi endocrine, ndi antioxidant katundu, yambitsa kagayidwe ndi kutumikira kupewa a khansa kuchuluka moyo wautali [5, 6, 7, 8]. Tikumbukenso kuti polypeptides kuti si nthawi zonse kudziwa limagwirira chenicheni cha ntchito kwachilengedwenso, koma kwa mapeputisayidi lalifupi IPH Maphunziro amenewa kugwira zosavuta ndipo tingathe kuti majini mme- limagwirira lonse peputayidi kanthu [1, 5, 6, 7, 8, 10 ]. Zimenezi zimathandiza kuti atiyankha pokonzekera efficacy ndi chitetezo cha lalifupi IPH mapeputisayidi opangidwa ndi labwino Pharma GmbH (Germany).

Choncho, mapeputisayidi lalifupi IPH, ndi onse zotsatira zamoyo polypeptides, otetezeka, si immunogenic, ndi limagwirira sayansi ofotokoza za kanthu ndipo ndi yabwino yothetsera monga zigawo masewera zakudya [4] ndi vekitala chitukuko cha mankhwala amakono ndi mankhwala maselo.

Magwero atsimikizire efficacy ndi chitetezo cha mapeputisayidi lalifupi

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