Statins - ndichiyani? Statins (mankhwala): dzina

Statins - mankhwala kuti angathe kuperekedwa pokhapokha dokotala ndipo patapita mndandanda wa MAGAZI akanadziŵa milingo mafuta. Zikatero, cholinga chawo chachikulu - kuteteza dongosolo mtima kwa matenda ndi pathologies zinazake. Pamene wakuuzani dokotala afunika kulangiza wodwala pa zinthu zotsatirazi:

• statins - izo ziri;
• Zotsatira zovuta mbali kwa mankhwala.

Komanso, dotolo amakhala kukambirana pa nkhaniyi kuti statins ayenera kumwedwa nthawi zonse. Only pansi chikhalidwe ichi, iwo kwenikweni kuteteza ziwiya mtima ndi magazi ndi ndi kutchulidwa zotsatira achire.

Lingaliro la mafuta m'thupi

Mafuta - ndi zamadzimadzi kukhala chiyambi chachilengedwe: 80 peresenti ndi apanga ndi chiwindi, ndi 20 ali ingested ndi chakudya. mafuta mbali uziyenda bwino za thupi ndi zofunika ndithu: ndi imodzi mwa zipangizo nyumba pa mlingo ma, akuziyambitsa kagayidwe, kuteteza maselo chifukwa cha zinthu zoipa nawo chitukuko zidulo ya ndulu timadzi kugonana. Mafuta ndi "zabwino" ndipo zina "zoipa". Ndipo kwa mfundo chithandizo cha, gulu izi motere:

• HDL - mkulu osalimba lipoproteins. Anthu ndi okhutira mkulu wa mafuta m'thupi m'magazi sangakhale ndi vuto matenda a mtima. Owonjezera HDL mafuta chimadzera kumbuyo kwa chiwindi, kumene chitadutsa kaphatikizidwe, kotero sinditi mafuta mipukutuyi ndipo sanali kusokoneza thanzi. Pankhaniyi, mankhwala statin kuti muthe, chifukwa thupi kuthamanga bwino ndi zogwirizana.
• LDL - otsika kachulukidwe lipoproteins. Kuopsa chachikulu lake ali pamene olumikizidwa kwa mafuta m'thupi mipukutuyi. Kodi kuopsa
  chodabwitsa? Atherosclerotic madipoziti amene kukhazikika mkati chotengeracho (pa makoma), kuononga potero impairing magazi. Zimenezi zimabweretsa hypoxia, sitiroko, matenda a mtima.

Statins - ndichiyani?

Mu m'ma atherosclerosis anamuzindikira monga imodzi mwa ntchito zomwe zikubweretsa imfa, chifukwa iye chifukwa cha infarction m'mnyewa wamtima ndi sitiroko. Kwa nthawi yaitali zinali zolakwika maganizo a madokotala kuti atherosclerosis - ndi kulisiya ndi thupi lachibadwa ukalamba ndondomeko. Kupezeka kwa statins anali kusintha dziko zachipatala iwo anali amphamvu holesterinsnizhayuschim katundu. Zotsatira za atafufuza patangopita zaka 5, anali ndi zizindikiro zotsatirazi:

• Kuchepetsa LDL mafuta (mafuta zoipa) ndi 35%.
• Kuwonjezeka mlingo wa HDL (mafuta abwino) 8%.
• Kuchepetsa sitiroko ndi 30% ndi mtima kuukira 42%.

Statin mankhwala - mankhwala imathandizira ndi zonse kaphatikizidwe wa mafuta m'thupi, kuchepetsa ndende zake ndi inhibiting MMC-CoA reductase.

Kuti mankhwala statins

Malinga ndi maphunziro, pambuyo kumwa mankhwala a tinaonera mphamvu abwino odwala matenda aakulu mitima. Umboni kuti Phindu la statin mankhwala mu pathologies zina ndi matenda kulibe, palibe. Koma zida zimenezi si achire kokha komanso njira. Popeza statins - mankhwala kuchepetsa mafuta m'thupi, iwo amawatumiza anthu a magulu awa:

• Anthu ndi homozygous banja hypercholesterolemia, amene si amenable kuti ndi mankhwala hypolipidemic.
• Odwala matenda matenda ischemic mtima, mosasamala kanthu za msinkhu mafuta.
• Odwala amene anadwala matenda a mtima ndi angina pectoris.
• Odwala matenda inatsekeratu.
• Odwala matenda ashuga kulamulira milingo magazi mafuta.
• Odwala matenda oopsa zofunika pa ngozi ya matenda a mtima.
• Odwala matenda zotupa atherosclerotic mtima. matenda monga atherosclerosis ziwiya oziziritsa ya nthambi m'munsi, mitsempha aimpso ndi kukhalapo kwa mipukutuyi atherosclerotic mu mtsempha wamagazi ndi carotid.
• Anthu amene sakuvutika matenda a mtima, koma ndi mpweya wambiri wa mafuta m'thupi m'magazi.

Statins - mankhwala amene mwa njira zabwino zopewera polimbana ndi matenda a dongosolo mtima. Malinga ndi kafukufuku, m'mayiko kuwonjezeka malonda mankhwala awa, amafa ku matenda kugwirizana ndi kofunikira kwambiri mafuta m'magazi achepetsa.

"Pakuti" ndi "kutsutsa"

Choncho statins. ndi ndi mmene iwo ankafunika - takambirana pamwambapa. Koma madokotala maganizo mankhwala awa ndi osokoneza. Pali wololera "chifukwa" ndi "kutsutsa" pankhani mankhwala. Ngakhale kuti mawu otsatsira malonda analonjeza kuchotsa anthu atherosclerosis ndi onse limeneli matenda, statins si nthawi zonse osati mmene aliyense zothandiza. Makamaka maganizo ndi funso pamene anthu achikulire: Choyamba, statins - mankhwala, amene mtengo alandiridwa onse; Chachiwiri, mavuto zikhoza zoipa koposa zabwino pamene mukumwa mankhwala monga prophylaxis. Yachokera pa zotsatira za mayesero matenda wochitidwa ndi mabungwe osiyana, akatswiri amanena izi:

• Ntchito statins ngati muyeso njira, kuchepetsa chiopsezo cha mtima kapena matenda opuwalitsa ziwalo, alidi mkulu, koma mavuto ndi kukakamiza madokotala kuganiza kaye inu perekani iwo odwala amene kale anakumana ndi matenda a mtima.
• Makamaka mosamala mankhwala statins kwa anthu amene ali ndi zizindikiro mathithi kapena kale akudwala matenda. Malinga ndi kafukufuku, utsogoleli wa mankhwala kumaonjezera ngozi ya ng'ala ndi 52%.
• Izi imakhudzanso anthu okalamba akudwala matenda a shuga. mankhwala Statin kumapangitsa chitukuko cha ng'ala mu nthawi 5.6 mofulumira.

Koma, koma, zatsopano statin mankhwala ntchito yochizira matenda ndi kubweretsa phindu lawo. An dokotala wodziwa ayenera kulangiza wodwala pamaso panu mankhwala ndi mankhwala awa, pa nkhani zotsatirazi:

• Statins - ndichiyani?
• Kodi mungayembekezere kumwa mankhwala: positives mankhwala ndi kupewa.
• Zotsatira zoyipa za mankhwalawa ndi zotsatira za mankhwala.
• Monga zimene Mlingo kutenga mankhwala.

Statins ndi mafuta: mbali pepala

Mankhwala kutsitsa milingo mafuta ndi zotsatira za magazi mu kusintha zizindikiro zina m'thupi:

• Statins kuchepetsa kupanga mafuta osati kokha, komanso kuloŵedwa m'malo - mevalonate. Iye ndiye gwero la zinthu zambiri zofunika kuti ntchito kwachilengedwenso mu thupi. The sangathe wa zinthu zimenezi kungachititse kuti matenda ena.
• A mafuta pamlingo wochepa ukhoza kukhala wowopsa kwambiri kuposa mkulu imbaendesa munthu ku chiopsezo cha khansa, kuchepa magazi, matenda ya ubongo ndi chiwindi kuchuluka.
• Malinga ndi kafukufuku linachita ku US, kuchuluka mafuta m'thupi milingo zinayambitsa otsika mankhwala enaake a zili mu thupi. akusowa ake kumabweretsa angina, matenda oopsa, shuga ndi chitukuko cha arrhythmias.
• "Oipa" mafuta ndi kukhala wochitachita mu minofu kukonza pa mlingo ma. Statins mwina ziletsa nchito imeneyi, zikubweretsa myalgia (kufooka, edema, kupweteka minofu) ndiponso akulu dystrophy.

zotsatira zoyipazi

Kuwononga statins mu nthawi phwando mbali zochitika zawo anafotokoza kuti:

• thupi lawo siligwirizana: kuyabwa, ziwengo, urticaria, anaphylaxis, erythema multiforme, syndrome Lyell a.
• dongosolo m'mimba: m'mimba, nseru, kusanza, chiwindi, kapamba, matenda a chikasu ndiyo.
• Mabungwe a hematopoiesis: thrombocytopenia.
• mantha dongosolo: chizungulire, paresthesia, amnesia, neuropathy zotumphukira, malaise, kufooka.
• dongosolo minofu ndi mafupa: omangana, kupweteka kwa nsana, nyamakazi, myiasis.
• Kagayidwe: hypoglycaemia (kuchepa shuga m'magazi), kufala kwa matenda a shuga.

Yaitali ntchito statins kungachititse kuti tulo, mutu, kusabala, kunenepa kapena matenda a anorexia.

Mfundo zina za statin wosankha

Ngati, pambuyo "ubwino" zonse ndi "kutsutsa" Anagwirizana kuti musankhe munthu statin, ndi bwino kuganizira ena mbali: ngakhale ndi mankhwala ena ndi kukhalapo kwa matenda aakulu.

• Statin mankhwala ndi mankhwala kwa gout, shuga ndi kuthamanga kwa magazi kungayambitse chiopsezo myopathy kawiri.
• Mu matenda aakulu chiwindi ndi kutenga mankhwala ndi zinthu zina chitetezo. Izi otsika mlingo rosuvastatin ndi pravastatin ( "Pravaksol"). Pamodzi ndi iwo kutiletsa kutenga mankhwala ndi mowa.
• Pa ululu nthawi zonse minofu kapena pa thupi, kuti zimachititsa kuwonongeka kwa minofu minofu, izo m'pofunika kuti atenge pravastatin.
• Ndi kusamala kwambiri mankhwala mankhwala odwala matenda aakulu impso. Mwamtheradi sangathe ntchito poizoni kuti impso statins: dzina mankhwala fluvastatin - "Lescol forte", atorvastatin - "Lipitor."

Ngati cholinga cholandira ndi statin - ndi mafuta-kutsitsa otsika kachulukidwe, iwo angagwiritsidwe ntchito osakaniza ndi asidi nicotinic. wothandizila abwino monga rosuvastatin kapena atorvastatin.

Gulu wamba statins

Zochita zawo kuchepetsa mafuta m'thupi statins anawagawa m'magulu 6:

Statins (mankhwala dzina tikungotchula pansipa) amasankhidwa ndi akusankhidwa ndi dokotala, zochokera mlingo wa mafuta m'thupi m'magazi.

rosuvastatin

Wapakati tsiku mlingo ndi 5-10 mg wa rosuvastatin. Kwa odwala mwakayakaya mankhwalawa hypercholesterolemia banja, mlingo tsiku la mpaka 40 mg. Ndi pazipita. Kupanga mankhwala.

pravastatin

Pravastatin tsiku mlingo - ndi 20-40 mg. The pazipita analekerera mlingo (80 mg) anali asanazolowere chifukwa chosakwanira chofufuzidwa kanthu. Theka-kupanga mankhwala.

atorvastatin

Atorvastatin - kupanga mankhwala a mbadwo wachitatu. M'mbadwo wake wa statins ndi zothandiza kwambiri, mwachitsanzo, kuposa dzuwa la theka fluvastatin. mankhwala koyamba ndi analimbikitsa 10-20 mg wa pa tsiku. Popeza anthu a mtima wa mlingo ndi kuchuluka kwa mg ndi 40 patsiku. Atorvastatin ntchito mlingo wa mg ndi 80 patsiku zochizira odwala matenda pachimake inatsekeratu. Kupanga mankhwala.

simvastatin

Simvastatin - theka-kupanga mankhwala kuposa mphamvu ya lovastatin kawiri. Koyamba tsiku mlingo ndi 10-20 mg, pakalibe zotsatira anakhumba akhoza ziwonjezeke kwa 40 mg. The pazipita kololeka tsiku mlingo - ndi mg ndi 80 patsiku.

fluvastatin

Kupanga kukonzekera fluvastatin kutumikiridwa mu mlingo wa 20-40 mg tsiku, koma akadakwanitsira mlingo - 80 mg pa tsiku. Iwo Kwalamulidwa kwa odwala amene amalandira wothandizila cytotoxic pambuyo limba kupatsidwa zina.

lovastatin

Lovastatin - yekha zachilengedwe statin. Yotengedwa bowa Aspergillus terreus. Kuyambira mlingo - 20 mg wa pa tsiku. Ntchito kamodzi, usiku, pambuyo pa chakudya. Nthawi zina, mlingo tsiku kuchuluka kwa mg ndi 40 patsiku. Pafupifupi konse ntchito mchitidwe matenda chifukwa maonekedwe a malonda kwambiri kufika analogi.