Zoletsa purotoni mpope: limagwirira cha zochita ndi ntchito mankhwala

Ndi zoletsa purotoni mpope ndi gulu la wothandizira pharmacological kuti kuchepetsa mlingo wa katulutsidwe wa acid amathiridwa mmimba. Kukhala ndi zotsatira mwachindunji pa canaliculi secretory, iwo kutsogolera moyenera kuti kufunika zilonda achire zotsatira, erosive gastritis, GERD. Gulu kumaphatikizapo ndi kuchuluka kwa mankhwala a ofanana dongosolo mankhwala, koma ndi magawo osiyana pharmacodynamic, i.e. pafupifupi mankhwala yemweyo kanthu pa maselo secretory, koma kuchita zimenezi woipa osiyana ndi imathamanga osiyana.

zoletsa purotoni mpope: mbali maselo kukonzekera chikoka

Purotoni mpope ndi zovuta mapuloteni dongosolo bungwe malowedwe a ayoni wa hydrogen mu lumen muzituluka. Amakhala ndi awiri zinthu mankhwala yosiyana, mwinamwake otchedwa subunits. Loyamba ndilochokera yekha mapuloteni ndi wamangidwa kwa amino zidulo. Mu selo nembanemba stuffer izo khalidwe m'njira yapadera, nawoloka nthawi 10, imbaenda kuna mapangidwe zingwe zopota 5-secretory njira. Kudutsa M'mimbamo wa ayoni kugwa mu lumen muzituluka ndi kupereka acidification sing'anga ndi kugwa index wa hydrogen. Pankhaniyi ali mmodzi wa zingwe zopota ndi likulu yogwira mapuloteni ndi - ndi ndondomeko ya 800 kwa amino zidulo, amene catalyzes kuwonongedwa kwa ATP, waukulu mphamvu selo gawo lapansi.

Other kagawo kakang'ono ndi puloteni zovuta kuti wapangidwa ndi akuyambira polypeptide, motero wina analamula kapangidwe ndi unyolo glycoprotein. The mbali yaikulu ya molekyulu ndi kunja cytoplasm, ndi gawo la glycoprotein mwina ekstratsitoplazmaticheskim cholandilira zovuta kuti amanyamula mbendera ya kutsegula kwa enzyme H + \ K + -ATPase. Pankhaniyi mapuloteni gawo la molekyulu ndi mitanda Kakhungu kamodzi, kutanthauza kuti mtengo wake monga chinthu kulumikiza pakati pa akunja woyamba cholandilira kagawo kakang'ono udindo kuchititsa othandizira zimene kaphatikizidwe mapulotoni.

Choncho, dongosolo la purotoni mpope tubules secretory maselo parietal tinganene bwanji losavuta unsembe akhoza kupondereza katulutsidwe wa H + kuti patsekeke thupi. Kwambiri wolungamitsidwa chimake - ndi chopinga wa enzyme udindo kaphatikizidwe kuti kupanga zoletsa purotoni mpope.

Ntchito zoletsa kuchita ntchito yachipatala

Mu mankhwala, zoletsa purotoni mpope ankagwiritsa ntchito kwambiri, makamaka gastroenterology, amene zokhudzana ndi luso kuchepetsa acidity wa chapamimba katulutsidwe, motero kuchepetsa mphamvu ya kuipa pa khoma m'mimba, umene uli wofunika makamaka pamene kuvutika. Pankhaniyi zotsatira achire zimadalira wa etiology za ndondomeko yotupa, monga kuchotsedwa ndi chikoka anthu ankhanza chilengedwe pa kukhulupirika kwa thupi. Ndiponso sipekitiramu wa pathologies zomwe mankhwala ntchito bwino purotoni mpope zoletsa wakhala kukodzedwa ndi chilonda muzituluka ndi mmatumbo chilonda, erosive ndipo sanali erosive mitundu GERD.

Mwa mankhwala ambiri monga purotoni mpope zoletsa zotsatirazi maina generic omeprazole, rabeprazole, pantoprazole, lansoprazole, esomeprazole, ndi ena. Ena mwa iwo ndi maina malonda kuoneka, monga "Omez". Mankhwala alembedwe kapisozi. Iwo anatengedwa pakamwa pa mlingo yoikidwiratu imene katswiri, amene mosiyanasiyana malingana ndi mtundu winawake wa matenda. Ngakhale kulola kudzikonda makonzedwe, ngati pali gulu la odwala amene amadandaula exacerbation nyengo zilonda aakulu chapamimba kapena mmatumbo. Nthawi zina, phwando ndi negotiated ndi dokotala pa nthawi yopemphera.