ACAT ndi AlAt - ponseponse akuluakulu ndi ana

AlAt (anenedwanso - alanine) - puloteni opangidwa mu chiwindi ndi watenga mbali mu kagayidwe kwa amino acid. Ngati mlingo wa AlAt magazi kuposa, ili likhoza kukhala chizindikiro cha matenda. The enzyme ndi kuchuluka kwambiri kusungidwa mu chiwindi, minofu chigoba, impso ndi minofu mtima. Ndipo kuli izo mu seramu magazi, chifukwa AlAt mlingo magazi ankaimira ndi negligible kuchuluka kwa thunthu. Chopitirira izo zikhoza kukhala chizindikiro cha kudwala aliyense, koma osati nthawi zonse.

Ngati matupi selo muli zinthu chifukwa ena amayamba kuphwanyaphwanya, ndiye magazi lalikulu zedi akubwera AlAt. Ponseponse mu seramu magazi - za 0.1 kuti 0,68 mmol / ml ya maola 30-40 kapena mayunitsi pa lita .. Ndiko kuti, mu thupi lathanzi munthu zedi ochepa pano AlAt. Ponseponse kwa akazi ndi mayunitsi mpaka 31 pa lita, amuna - magawo 41 pa lita. Kuwonjezeka AlAt zingachititse matenda monga a chiwindi, poizoni choipa chiwindi, kapena khansa chiwindi, ndi matenda enaake, uchidakwa, matenda a mtima - ndi infarction m'mnyewa wamtima kapena kulephera mtima, imfa ya minofu chigoba. Komanso, pambuyo mantha aakulu kapena amayaka achuluke AlAt. mwakale nthawi zambiri kuposa pamene nthenda yaikulu ya mtima. Ndipo ndi lalikulu kuchuluka pa nthawi makulitsidwe matenda a chiwindi B.

ACAT (dzina lake lonse - lutamat oxaloacetate transaminase kapena aspartate) - enzyme ndende ali wamkulukulu mu myocardium, chiwindi, impso ndi minofu chigoba. enzyme Izi yogwira anthu kuposa akazi. Ngati ACAT ntchito magazi kwambiri chifukwa, kungasonyeze kuwonongeka kwa maselo a thupi, osachepera - kuphwanya ntchito za ulamuliro. Ngati pakhala kuwonongeka kwa minofu mtima, mu nkhani iyi pali uyenderere chachikulu cha ntchito ACAT - zochita zake angadwale maulendo 20. The foci zambiri necrosis mu myocardium, m'pamenenso okhutira wa enzyme m'magazi. Magazi ponseponse AlAt ana kwambiri m'munsi pafupifupi kuposa akuluakulu. M'mwazi wa atsikana a zaka zaka 7 mpaka 12, mlingo wa 13-21 limafanana chimodzi, ndi anyamata a zaka zofanana, lamba ili, m'munsi ndi chapamwamba akhoza kukhala apamwamba ndi avareji mayunitsi 4. Mu achinyamata mlingo wa magazi AlAt kungakhale poyerekeza kuti ana pansi. Choncho, atsikana zaka 13 mpaka 17, ndi ranges mlingo ku mayunitsi 10 mpaka 13 pa lita, anyamata a yemweyo msinkhu - 10 15. Imeneyi ndi avareji chithunzi achinyamata AlAt. wakudziko ake kwa akulu sasintha, ndi akazi achikulire - anatsika ndi mayunitsi 2-3 pa lita.

Ndipo alt, ndi Ast ndi michere - aminotransferase. michere Awa ndi achangu mu thupi la munthu aliyense. Ambiri alt mu chiwindi, ndi ACAT - mu zimakhala minofu - makamaka minofu m'mnyewa wamtima a minofu mtima. ACAT wapangidwa wa cytoplasmic ndi kwa mayitirokondiriyoni isozyme isozyme. 80% ntchito za ACAT imagwera pa isoenzyme cytoplasmic. Mu seramu magazi a isozymes awiri anthu amati cytoplasmic yekha.

Normal Ast, alt kuposa kwa zotupa osiyanasiyana a m'chiwindi. Makamaka, zotupa za mowa, mankhwala kapena poizoni, matenda enaake, matenda a chiwindi, ndi zina zotero. Ngati pali poizoni chiwindi poizoni chifukwa ingestion mankhwala ena, ndiye ACAT ponseponse AlAt kuposa. Aliyense zotsatira poizoni pa chiwindi ungathe zimenezi chifukwa. Norma Ast, alt, ndi kuchuluka chifukwa zinthu zimene ndiribe kanthu kochita ndi mavuto mu chiwindi. zinthu zimenezi ndi monga zaka khanda - mpaka miyezi isanu ndi umodzi (kuwonjezeka mlingo wa michere izi ana yachibadwa), mtima minofu minofu kuwonongeka, kutentha sitiroko, Inde matenda FOBS ana, kutupa minofu, amapatsira mwana wake, kunenepa ndi ena ambiri.

Norma Ast, alt, ndipo anachepetsa mu thupi. Izi zimachitika chifukwa cha kulephera impso, pyridoxine akusowa, mwachitsanzo, vitamini B. Komanso mwina kungakhale chifukwa cha hemodialysis mobwerezabwereza. Izo zikhoza kukhala zachilendo wonse kuti pakati understated (anakweza) ACAT kapena Alat. wakudziko ake pa mimba kawirikawiri linaphwanya chifukwa chakuti dongosolo la kukonzanso kukuchitika mayi woyembekezera.