Malangizo "Gonal-F." Kufotokozera lokonzekera, contraindications, analogs ndi ndemanga

Imodzi mwa njira wamba kukhala osabereka mankhwala yotithandiza ovulation. Mazira angapo oyenera umuna, m'pofunika kuchita wapadera chisanadze mankhwala mankhwala. "Gonal-F" ndi chimodzi cha mankhwala zothandiza kwambiri m'dera limeneli. Malangizo "Gonal-F" mwamphamvu akuonetsa chithandizo moyang'aniridwa okhwima zachipatala.

Kufotokozera za

Aliyense akudziwa kuti popanda ovulation mimba sangathe zimachitika. Choncho, ambiri mwa kugonana chilungamo, anakumana ndi lakula zovuta kuthetsedwa kuti kukondoweza ndi mu umuna m'galasi. Dokotala kupezeka choyamba tiyenera kugwira kufufuza mankhwala, kukatenga chiwembu lolingana wochita ndi kukonzekera yoyenera.

The zida kwambiri otetezeka ndi ogwira zochokera follicle popatsana timadzi - FSH (zophatikizananso), umene uli udindo kusasitsa wa follicles mu akazi. Malangizo "Gonal-F" akusimba kuti mankhwala limabweretsa gulu ili, ndi limagwirira kanthu ndi pafupi kwa FSH achilengedwe. Kugula mankhwala yekha mankhwala dokotala.

zikuonetsa

kufunika mankhwala m'munda matenda ndipo anatumizidwa pamene yambitsa kukula follicles. Zikuonetsa ntchito "Gonal-F" ali zotsatirazi:

• Pakalibe ovulation ndiponso osagwira kuthira "Clomiphene".
• Polycystic yamchiberekero matenda (kudwala zokhudzana ndi matenda m'thupi kuchititsa wonongeka wa thumba losunga mazira ndi).
• Kufunika kukondoweza wa follicles kangapo lidzawagwiritsenso.

Ambiri maphunziro a zachipatala anatsimikizira efficacy mankhwala ngati kuli kofunika chitukuko cha follicles angapo m'kati hyperstimulation yamchiberekero (ankalamulira). Icho chinakhazikitsidwa kuti pophika yogwira amalimbikitsa kukula kwa follicles, motero kwambiri amachepetsa chiopsezo hyperstimulation yamchiberekero.

Yofunsira amuna

Pamene anthu omwe sanali kugwilizana ndi ntchito zoyambirira za gonads wamwamuna wa ndondomeko spermatogenesis - mapangidwe ndi chitukuko cha umuna - wathyoka. Follicle zolimbikitsa timadzi koyenera kuti "kuyamba" njira imeneyi, amene kumatenga masiku 75. Azindikire boma pathological n'chotheka pambuyo ndime ya diagnostics zachipatala ndi yobereka umuna.

Kukondoweza (kapena abwezeretse) mapangidwe yachibadwa ya gametes chiwalo chachimuna zina imatenga nthawi yaitali kuposa njira zofanana pa akazi. Pakuti chifukwa zabwino za chithandizo ayenera kutsatira kwathunthu ndi malangizo andrologist. Muyenera kutsatira zakudya mwapadera, kusiya mowa ndi fodya. Ndi kuvomerezedwa kuti asankhe kukonzekera mwapadera. Malangizo "Gonal-F" akusonyeza kuti mankhwala akhoza ntchito kumapangitsanso spermatogenesis anthu amene kobadwa nako kapena kugula hypogonadism. Therapy akhale moyang'aniridwa nthawi zonse katswiri wodziŵa mankhwala osabereka.

mankhwala

Yogwira zikuluzikulu za mankhwala amachita follitropin alfa - chinthu kumene kumapangitsa kukula follicles mu akazi ndi chisokonezo mu dongosolo hypothalamic-pituitary. The bioavailability wa mankhwala pamene kutumikiridwa subcutaneously anali pafupifupi 70%.

Yogwira pophika ayamba kudziunjikira mu chamoyo pambuyo makonzedwe mobwerezabwereza. Pa tsiku loyamba masiku 3 anati zitatu kuonjezera mgwirizano ndende ya follitropin alfa, amene akuyamba kukondoweza ndondomeko.

zigawo Wothandiza womwe uli mu mankhwala a hydroxide ndi sodium ndi wa hydrogen mankwala dihydrate, asidi phosphoric, methionine, sucrose, polysorbate 20.

Fomu kumasulidwa

"Gonal F" imatulutsa Italy kampani mankhwala "Makampani Farmasyutika Serono Spa". Fomu kumasulidwa wothandizila - njira jekeseni subcutaneous ndi lyophilisates kwa madzi.

The syringes mu mawonekedwe a zolembera akhoza ali 0.5, 0,75 ndi 1.5 ml. Mlingo wotsikitsitsa lolingana micrograms 22 follitropin alfa (300 IU), sing'anga - 33 mg wa yogwira pophika (450 IU). Kuchuluka waukulu wa woukitsa ali 1.5 ml - 66 micrograms ( "Gonal-F 900"). Mtengo wa mankhwala zimadalira ndende ya mankhwala yogwira.

Cholembera ali dispenser wapadera ndi sikelo, kumakuthandizani kulamulira mlingo. Mu mawonekedwe mankhwala kugula zikomo kwambiri kopindulitsa Mlingo zosiyanasiyana. ubwino akhoza zimachitika, ndipo kulibe yokonza njira musanadye jekeseni.

Lyophilizate kwa yokonza njira jekeseni wasukuluka ndi madzi musanadye mpheto. Chofunika mlingo wa chisanadze linaŵerengera katswiri pa nkhani iliyonse payekha.

Kodi mankhwala a "Gonalom-F"?

Mu pakalibe ovulation mankhwala akuyamba mlungu woyamba wa kuzungulira kusamba, malinga menses zonse (ena kupatuka zotheka pafupipafupi). The ndondomeko ya kukondoweza ayenera akuyendera pansi pa ulamuliro wa ultrasound kuphunzira, amene amalola inu kulamulira kukula kwa follicles ndi. Kuyambira mlingo - 0,13-0,25 ml ya mankhwala "Gonal-F 75". Price njira munali 5.5 mg wa follitropin alfa, ndi wotsikitsitsa ndi kuzungulira 110 rubles. Kuwonjezera mlingo pa masabata 1-2 ndi 225 IU (pazipita).

Ngati mwa mwezi umodzi chithandizo sapereka zotsatira zabwino, mankhwala ayenera anasiya. mlingo woyambilira udzakhala wautali mankhwala zina.

Pamene kufunika ankalamulira yamchiberekero hyperstimulation mankhwala ndi kutumikiridwa mu mlingo wa 150-225 IU. The pazipita tsiku mlingo sayenera upambana 450 IU. Therapy akuyamba ndi masiku 2-3 cha kuzungulira kusamba. Mothandizidwa ndi ultrasound katswiri liyang'anire kukula follicles. Kutalika kwa chithandizo zingakhale za masiku 5 kapena 20. Pambuyo kulowetsedwa otsiriza, maola 48 Patapita jakisoni chorionic anthu gonadotropin.

Amuna amene ali ndi mavuto ndi ndondomeko spermotogenez limasonyezanso kukondoweza. "Gonal-F" Pankhaniyi ntchito limodzi ndi chorionic anthu gonadotropin. Mwachizolowezi chithandizo kamwedwe ndi jekeseni subcutaneous mankhwala katatu pa mlungu (mlingo 150 IU). Nthawi mankhwala ayenera kukhala miyezi 4, ndipo munthuyo ayenera kuyezedwa. Ndi kusintha pang'ono kapena ayi mu zotsatira za mankhwala akhoza kuwonjezera kwa miyezi 18.

dosing

Jekeseni loyamba la mankhwala liyenera kukhala katswiri mu chipatala. Popeza kulangizidwa, m'tsogolo wodwala ntchito cholembera ndi kupanga kuwombera, "Gonal-F." Ayenera bwino malangizo kwa mankhwala.

The mungachite ntchito palokha wa mankhwala:

1. Pamaso koopsa ndi, "Gonal-F", azisamba m'manja bwinobwino ndi sopo komanso mwina zina kukonzedwa antiseptic.
2. Linakwiriridwa pa oyera pamwamba chofunika zinthu: cholembera syringe, nsupa ya ufa ndi madzi a jekeseni, mowa swabs.
3. Ndi zofunika kukonzeketsera cholembera, kuchotsa chipewa, anapereka mlingo anakhumba ndi angagwirizanitse singano.
4. Lyophilisate (ufa) kuchepetsedwa ndi madzi a jekeseni mwa kuyambitsa madzi mu nsupa ndi mankhwala youma. The jombo chivundikiro ayenera kukhala puncture singano kutsegula botolo si koyenera. madzi ayenera anayambitsa pang'onopang'ono.
5. Ndi kuti oyimba mu syringe mpweya mpaka mlingo chofunika, kulowetsa singano mu mbale ndi yankho la (poyamba anazondoketsedwa), kuti atchule mpweya ndi imbani kuchuluka Napempha kwa mankhwala.
6. The syringe sayenera mpweya thovu. Kuti tichotse iwo, muyenera ndikupeza chala chanu pa makoma a syringe ndi thovu kusuntha pamwamba. Ndiye m'pofunika kulikankhira plunger ndi kumasula mpweya owonjezera.
7. Khungu ayenera kusonyezedwa ndi antiseptic (mowa) pa malo jekeseni.
8. Jekeseni zachitika subcutaneously pa madigiri 45 kapena 90. Zikuchepa kupitiriza plunger Sikuti. Mankhwala ayenera kuperekedwa pang'onopang'ono.
9. Pakuti makonzedwe "Gonal-F" kudzera zolembera syringe akukwana kupitiriza chiyambi batani. The singano mu chipangizo ichi ndi wochepa thupi ndi ang'ono, ululu wofatsa kapena pafupifupi kwina.
10. Pambuyo jekeseni malo a jekeseni ayenera limodzi ndi thonje swab ankawaviika antiseptic.
11. Disposable syringe kutayidwa pakatha ndondomeko.
12. Ndi singano syringe amangomvera ayenera kuchotsedwa, kuvala chipewa cha. Pakuti mpheto lotsatira n'kofunika kugwiritsa ntchito singano watsopano, umene umabwera wangwiro ndi mankhwala.

zotsatira zoyipazi

Kukonzekera "Gonal-F" Mwina kuyambitsa zotsatira zoyipa pa chithandizo. Ena akazi taonera zizindikiro zotsatirazi:

• Zoberekera - Nthawi zambiri kukhala cysts yamchiberekero.
• The zoyipa za mankhwala imene ingakhudze ziwalo thirakiti m'mimba. Tisonyeza zimenezo mwa maonekedwe a nseru, kusanza, kutsekula m'mimba, ululu komanso ululu pamimba.
• Jekeseni malo kumachitika kutupa kapena redness a khungu.
• milandu thupi lawo siligwirizana n'zochepa kwambiri: totupa, kuyabwa, amavutika kupuma, totupa.
• Pa mbali ya chapakati mantha dongosolo - angakhale pafupipafupi mutu.
• Nthawi zambiri osachepera pali milandu kungasokoneze dongosolo mtima (thromboembolism).

Malangizo "Gonal-F" akusonyeza kuti amuna ndi chithandizo angaoneke ziphuphu zakumaso, pang'ono kuchuluka thupi. Pali nthawi zina pa varicocele, gynecomastia.

contraindications

Mankhwala amakhudza kwambiri m'thupi ndipo kotero, sanali kuperekedwa popanda mankhwala isanafike. Thunthu yogwira ndi mbali zina ndi zofooka pamene ntchito. dokotala ayenera kutenga zimenezo ndi kusintha chithandizo chakudya.

Malangizo "Gonal-F" limatichenjeza kuti mankhwala ndikoletsedwa ntchito kwa anthu ndi tsankho kapena hypersensitivity ndi zinthu mu chiphunzitso cha. Pankhaniyi, angathe aakulu awo sagwirizana anachita kapena mavuto ena. Komanso contraindications monga:

• Uterine magazi a etiology osadziwika.
• Oncologic kudwala a kumaliseche mkati.
• cysts ayi yamchiberekero yomwe yapangidwa maziko a polycystic.
• Mimba ndi mkaka wa m'mawere.
• Kobadwa nako kuvutika ziwalo, amene ali osayenerana ndi mimba.

katswiri A amaganizira comorbidities zonse zilipo mbiri wodwalayo. Nthawi zina, palibe kufunika kwa ntchito zipangizo, "Gonal-F." Price yoperekera chithandizo kumatengera pa nthawi ya mankhwala ndi mlingo wa mankhwala, koma ngakhale mankhwala okwera mtengo osati kubweretsa zotsatira amafunika pathologies monga fibroids uterine, msanga kusintha, kutsekeka kwa machubu mazira.

Features ya ntchito

Musanayambe perekani mankhwala yotithandiza ovulation kapena ndondomeko spermatogenesis, dokotala okhazikika mankhwalawa osabereka, ayenera kukhala zachipatala matenda banja, kuthandiza akatsimikizire pamaso pa contraindications ndi chithandizo. M'pofunikanso ndi mlingo chiwembu adzakhala anaika.

Odwala amene kukumana kukondoweza "Gonalom-F" pamaso lidzawagwiritsenso kumawonjezera mwayi kutenga pakati pa mapasa. dokotala ayenera kudziŵitsa mkazi isanayambe chithandizo.

Munthawi yomweyo kugwiritsa ntchito mankhwala ndi atumiki zimene zimakhudza kukula follicles, kungakhale chitukuko cha hyperstimulation. Kuyambira mankhwala n'kofunika kuchita matenda akupanga ndi kuyan'ana kukula follicles.

"Gonal-F": mtengo ndi ndemanga

Chitaliyana mankhwala yotithandiza ovulation kale kwa nthawi yaitali analamula kuti mankhwala a osabereka amuna komanso akazi. Ichi ndi chimodzi mwa zida zothandiza kwambiri (madokotala ambiri amanena kuti 'zida zankhondo lolemera "). "Gonal-F" anasonyeza zotsatira zabwino ngakhale pa nthawi imene njira zina kudziwika inali yopanda mphamvu. Ulamuliro zofunika kutsata ndi odwala, ali ndi mphamvu zonse zachipatala ndondomeko follicles ukalamba ndi spermatogenesis.

Mu mlingo chithandizo akhoza kusinthidwa mu ang'onoang'ono ndi mu njira chachikulu. Mtengo wa mankhwala zimasiyanasiyana 1100 rubles. mpaka 16 000 rubles. ( "Gonal-F" 900 IU). Kuwonjezera pa ntchito zipangizo zodula, m'pofunika kutsatira malamulo chakudya ndi kwathunthu kuthetsa zakudya zosapatsa thanzi, theka-yomalizidwa mankhwala.

Pa mankhwala choletsedwa kumwa mowa, amene ali kungasokoneze kupanga umuna, okhudza pituitary England ndi ubongo imene imalamulira kutentha, kusokoneza kagayidwe wa mankhwala kugonana. Kuchuluka tilinazo mu umuna ndi chikonga.