Mankhwala "Pentas": malangizo ntchito, analogs ndi ndemanga

Mu mlingo wa mankhwala akuchipatala "Pentas"? Malangizo ntchito, ndi ndemanga za mankhwala pansipa. Komanso m'nkhani zipangizo zambiri za mitundu ya kumasulidwa kwa mankhwala ndi katundu wake.

The zikuchokera, mawonekedwe medicament

Pali njira zosiyanasiyana za kumasulidwa ankaona mankhwala. Ife kupereka iwo tsopano.

Kukonzekera "pentasil" - Mapale (500 mg, 100 mg) kanthu yaitali. Mwayera ndi kum'chitira grayish, komanso yamawangamawanga zambiri za kuwala bulauni, olondola ozungulira mawonekedwe, ndi Valium, bevel ndi zolemba mbali zonse ziwiri.

Amafotokozera yogwira mankhwala ndi mesalazine. Komanso njira ali mu mawonekedwe a anafooka zosakaniza povidone, ethylcellulose, magnesium stearate, talc, ndi microcrystalline mapadi.

Mu kugulitsa mankhwala "Pentas" (mapiritsi), chithunzi chimene anapereka m'nkhani umaperekedwa mu mapaketi chithuza kuti ali mu makatoni pepala.

Iwo ayenera kukumbukira kuti nkhani medicament zikhoza kugulidwa mu mawonekedwe a suppositories, chosunga-kumasulidwa granules ndi thumbo kuyimitsidwa.

mankhwala mankhwala

ndi mankhwala "Pentas" n'chiyani? Malangizo ntchito limanena kuti wothandizila ndi odana ndi yotupa kanthu ndi ntchito pofuna kuchiza anam'peza matenda a m'matumbo ndi matenda amene amatupitsa.

Anti-yotupa katundu wa mankhwala akuwonetseredwa yekha ntchito wamba. Zimenezi zimachitika chifukwa cha kaphatikizidwe leukotrienes ndi prostaglandins, komanso chopinga wa ntchito lipoxygenase (neutrophil). Komanso, chida amatha kudodometsa mchitidwe wa katulutsidwe wa immunoglobulin ndi lymphocytes ndi ziletsa degranulation, ndi phagocytosis wa neutrophil kusamuka.

wothandizila makamaka m'mimba

The medicament "pentasil" (phale), zikuchokera zomwe zinakambidwa pamwamba, zinaonetsedwa pa chionetserocho kutchulidwa ntchito antibacterial ndi ena cocci ndi Escherichia coli. Komanso ali ndi zotsatira antioxidant chifukwa umatha kumanga chinthu wachangu ankafuna kusintha zinthu mopitirira ufulu (mpweya) ndi kuwononga iwo.

Kugwiritsa ntchito bwino chida ichi kwambiri kuchepetsa kufala kwa chofookacho ku matenda amene amatupitsa, kuphatikizapo anthu ndi ileitis (ndi yaitali nthawi matenda).

Mfundo ntchito kuchipatala

Kodi mankhwala "Pentas"? Malangizo pa ntchito ananenetsa kuti zotsatira achire mankhwala yomweyo pambuyo apakhungu mesalazine kukhudzana ndi mucosa matumbo.

Atakhala m'kamwa piritsi zikutanthauza yomweyo limaphwasuka kusandulika mu microgranules amene zinthu m'njira zosiyana ndi wolingalira yogwira mankhwala kumasulidwa - mesalazine. Izi zimabweretsa kukongola mankhwala pakati 12- kwa rectum pa mfundo zonse pH.

Pharmacokinetics njira

Kodi mayamwidwe mankhwala "Pentas"? Malangizo ntchito malipoti kuti microgranules miyala ndisungunuka 12 umalandira duodenum mu mphindi 60 choyamba.

Pafupifupi 30-50% ya mlingo odzipereka ya mankhwala mu intestine yaing'ono. Communication mesalazine ndi mapuloteni plasma ndi 43% ndi asidi N-acetyl-zisanu aminosalicylic - 73-85%.

Mesalazine ndi ena ofanana chiyani mkatikati za BBB. katundu chokhala mankhwala ndi kuwonetseredwa kokha pamene ntchito mlingo waukulu (1500 mg wa pa tsiku).

Acetylation mesalazine poyera mu mucosa matumbo ndi chiwindi. mankhwala lachokera ku mkodzo, mkaka wa m'mawere ndi ndowe.

Zikuonetsa ntchito mankhwala

Nthawi zina, mankhwala akhoza anasonyeza "Pentas" (mapiritsi)? Akatswiri Mlendo kuti mankhwala amachita bwino pamene:

• anam'peza matenda a m'matumbo;
• matenda amene amatupitsa.

Ziletso ntchito mankhwala

Kodi zinthu kugwiritsa ntchito chida monga "Pentas"? Malangizo (mapiritsi ndi zina mankhwala ndi contraindications yomweyo) limati malamulo oletsa izi:

• hemorrhagic diathesis;
• matenda magazi;
• mkaka wa m'mawere;
• M'mimba zilonda thirakiti;
• otsiriza masabata 2-5 mimba;
• kusowa kwa shuga-6-mankwala dehydrogenase;
• zaka ziwiri;
• aakulu aimpso kulephera;
• hypersensitivity kuti wothandizila zinthu;
• aakulu kwa chiwindi insufficiency.

kusamalidwa tiyenera kuziganizira mankhwala ntchito trimester mimba, komanso chiwindi ndi impso kulephera.

Medicament "Pentas": malangizo ntchito

Posankha mlingo mawonekedwe a mankhwala zimadalira kutanthauzira kwa waukulu pathologic ndondomeko, komanso kutalika kwa zotupa m'mimba.

Suppositories "pentasil" ndi kuyimitsidwa anali kutumikiridwa pa mitundu wapotalikira wa matenda (proctosigmoiditis). Pa nthawi yomweyo makandulo atatu ntchito pa tsiku la 500 mg.

Kodi mankhwala m'kamwa "Pentas" (mapiritsi)? Malangizo ntchito limanena kuti mtundu uwu wa mankhwala tikulimbikitsidwa okha mitundu ya matenda. Pakuti kupewa musabise ku matenda amene amatupitsa ndi medicament umagwiritsidwa kanayi pa tsiku (1 g mesalazine). Ponena za kupewa muyambirenso cha UC, mu nkhani iyi, mankhwala Kwalamulidwa katatu patsiku 500 mg.

Pa exacerbation wa Inde matenda a chithandizo ayenera kwa milungu 8-12. Pa nthawi yomweyo tsiku lililonse ayenera kutenga 400-800 mg wa mankhwala (katatu patsiku).

Mu matenda aakulu achuluke mlingo tsiku la ga 3-4

Miyala "pentasil" ayenera makamaka itsegu- pambuyo chakudya, madzi cholizira madzi wamba.

Zochita ndi-khalidwe

Nthawi zina, mankhwala mu funso ndi zotsatira zotsatirazi mbali:

• stomatitis, kugwedeza wa miyendo, youma pakamwa, chizungulire, kunyansidwa, maganizo maganizo;
• kusafuna kudya, kumverera palpitations, kutentha, kufupika kwa mpweya pa zolimbitsa thupi, kusanza;
• hematuria, m'mimba matenda, tachycardia, matenda a chiwindi, kupweteka m'chifuwa;
• kuwonjezeka chiwindi michere, kusinthasintha magazi, kapamba, polyneuropathy;
• crystalluria, tinnitus, proteinuria (mapuloteni excretion), migraine mutu;
• oliguria, leukopenia, anuria (pakalibe pokodza), thrombocytopenia, mapangidwe nephrotic syndrome ;
• hypoprothrombinemia, agranulocytosis, eosinophilia, magazi m'thupi.

Iwo ayenera kukumbukira kuti zakudya za mankhwala mu mtima zikhoza anati: olisgospermiya, alopecia, photosensitivity, kufooka mu miyendo lupus-monga matenda, yafupika yopanga lachrymal madzimadzi, parotitis.

Ambiri osokoneza mankhwala

amachita ambiri osokoneza ndi njira zochita chodziwa tulo, nseru, gastralgia, kusanza ndi kufooka thupi lonse. Kuthetsa zizindikiro izi zimafunikira mwamsanga chapamimba lavage komanso poika Mankhwalawa mankhwala ndi posindromnoy mankhwala.

Mwanjira mankhwala

The medicament "pentasil" amatha msanga mlingo wa mayamwidwe cyanocobalamin. Mesalazine Komanso kumawonjezera dzuwa la wothandizira uricosuric (kuphatikizapo blockers wa katulutsidwe tubular).

Tiyenera kuona kuti ukuwonjezeka yogwira mankhwala ulzerogennosti glucocorticosteroids amachepetsa zotsatira za rifampicin ndi timapitiriza kawopsedwe wa methotrexate ochitachita zotsatira hypoglycemic pa opangidwa kuchokera sulfonylurea, spironolactone, furosemide ndi sulfonamides.

tsatanetsatane

Pa kuvomera mlingo umodzi wa mesalazine Ndi bwino kutenga pamodzi ndi zotsatirazi kapena posachedwapa. Ngati wasowa ndi mlingo pang'ono, muyenera yomweyo kufunsa dokotala. Iwo ndikoletsedwa kusiya mankhwala paokha.

Nthawi zina maziko a wothandizila malipoti pa odwala anati mkodzo banga ndi magalasi kukhudzana mu lachikasu lalanje hue.

Mankhwalawa mesalazine amafuna zonse achipatala ntchito ya dongosolo aimpso wodwala. Komanso kusanthula mkodzo wodwalayo ndi magazi ayenera nthawi zonse (mu njira ya mankhwala komanso nditamaliza ake).

Mwina yatsoka mosiyanasiyana chowawa odwala kulandira mankhwala ndi kuchuluka kwa anthu amene ali "acetylators pang'onopang'ono".

Ndi chitukuko cha matenda pachimake cha tsankho kwa yogwira pophika kukonzekera "Pentas" yomweyo linathetsedwa.

mankhwala ofanana ndi ndemanga ogula

Kodi mukudziwa zimene tinganene kuti m'malo mankhwala? Pa muyenera kudziwitsa dokotala nawo. Tinganene, kuti analogues chida monga mankhwala zotsatirazi: "Mesakol", "Salozinal" "Salofalk", "Mezavant", "Mesalazin" "Asacol".

Zimene anthu amanena zokhudza chida ichi, ogula? Malinga ndi mayankho awo, anati medicament ndi mankhwala kwambiri zothandiza kuti zikhoza kugulidwa pa mankhwala aliwonse. Odwala amati mesalazine ndi amasonyeza bwino kwambiri wokha osati mankhwala komanso kupewa matenda amene amatupitsa ndipo anam'peza matenda a m'matumbo.