Mankhwala "salofalk": analogs ndi malangizo ntchito

Thupi la munthu akulimbana ndi zosiyanasiyana matenda, yosavuta ndi zovuta, mu moyo wake. M'malo mokhala kwambiri posachedwapa pa nkhani ya matenda zatenga yotupa matenda matumbo. Kulimbana ndi kukhala ndi chiwerengero cha mankhwala osiyana ndi mfundo zosankha zake.

Mankhwala mesalazine ndi olemekezeka zikuluzikulu za gulu mokwanira lalikulu la mankhwala ( "salofalk" analogs) kulimbana yeniyeni matenda yotupa matumbo.

Zikuchokera "salofalk", pharmacodynamics

Monga tanena kale, waukulu yogwira pophika ndi mesalazine medicament. Wothandiza akutumikira angapo zigawo, makamaka monga carbonate sodium, glycine, povidone, microcrystalline mapadi, silicas, ndi titaniyamu, calcium stearate, croscarmellose sodium, hypromellose waukulu butylmethacrylate copolymer.

"Salofalk" (granules, mapiritsi, suppositories, kuyimitsidwa) kumabwezera mmbuyo (depresses) ndondomeko ya neutrophil ndi lipoxygenase kaphatikizidwe anthu prostaglandins ndi leukotrienes. Thunthu yogwira kumachepetsa mlingo wa kusamuka, phagocytosis ndi degranulation wa neutrophils, amachepetsa katulutsidwe wa lymphocytes. Komanso, medicament angathe kumanga ufulu ankafuna kusintha zinthu mopitirira ndipo kenako kuwaononga, i.e. akusonyeza antioxidant kwenikweni. Komanso mesalazine angathe kumanga ndi ankafuna kusintha zinthu mopitirira ufulu anapanga ku mitundu zotakasika mpweya.

Zikuonetsa ntchito

M'dera yaikulu imene anapeza ntchito "salofalk" - mankhwala kwa anam'peza matenda a m'matumbo ndi matenda amene amatupitsa.

The matenda oyamba ndi aakulu yotupa ndondomeko sanabadwe Mukalongosola chikhalidwe. chitukuko amayamba ndi anzake a majini ndi mmene chilengedwe.

matenda amene amatupitsa akhoza yodziwika monga aakulu granulomatous kutupa thirakiti m'mimba. Ntchito imeneyi analanda mbali zonse za dongosolo m'mimba, sukhala zigawo zonse za chubu m'mimba. Chotsatira kungakhale chitukuko cha lymphadenitis, ulceration ndipo amamuyambitsa timabala wa matumbo khoma si.

Fomu kumasulidwa mankhwala

Opanga kupereka makasitomala awo mankhwala "salofalk" (ofanana pankhani imeneyi zingasiyane) mu njira zochepa zosiyana kupanga.

Mu piritsi mawonekedwe akhoza muli mg wa 250 kapena 500 waukulu chigawo yogwira - mesalazine. Mu sachet wina akhoza muli 500 mg kapena 1 g wa chinthu chachikulu. The medicament mu mawonekedwe a suppositories (suppositories kwa makonzedwe thumbo) likupezeka mu Mlingo awiri - 250 ndi 500 mg wa chigawo chachikulu. Komanso zikhoza kugulidwa mu pharmacies ndi thovu kuyimitsidwa chifukwa makonzedwe thumbo. The yabwino kwambiri munthu aliyense wodwala kumasulidwa mawonekedwe zingakuthandizeni kusankha dokotala amachitira.

mapiritsi n'zimene kamwedwe

Standard mlingo akuluakulu - katatu patsiku 500 mg. Ngati anapezeka ndi digiri choopsa cha matenda, dokotala nawo ali ndi ufulu kuwonjezera mlingo kuti ga 3-4 pa tsiku. The njira ya mankhwala zikhoza kwa miyezi 2 kapena 3. Ngati mankhwala amatengedwa ngati muyeso njira, zachitika mwa chiwembu muyezo (1.5 ga pa mlingo atatu pa tsiku).

Wamng'ono odwala salofalk "wogwiritsa Phunziro pankhaniyi (analogs zingasiyane mu mlingo kamwedwe) akuonetsa kuti kupereka malinga ndi kulemera kwa mwana. Makanda ndi thupi osati choposa makilogalamu 40, dokotala n'kukulemberani 250 mg wa mankhwala katatu patsiku. Ngati kulemera kwa mwanayo kuposa makilogalamu 40, izo zikusonyeza mlingo mofanana akulu: 500 mg katatu patsiku.

Miyala yabwino anatengedwa nditamaliza chakudya, osati kutafuna ndi kumamwa kowirikiza madzimadzi (makamaka madzi).

Chiwembu cha granules wa

Mawonekedwe amasulidwe mankhwala "salofalk" (granules) akusankhidwa ndi dokotala kupezeka makamaka payekha, zochokera okwana chithunzi matenda a thanzi wodwalayo. Nthawi zambiri pa exacerbation wa anam'peza matenda a m'matumbo wodwala akapatsidwa kulandira mlingo wa 500 mg kapena 1 g katatu pa tsiku (T. E. Voliyumu tsiku la medicament ndi kuchokera 1.5 kuti 3,0 g). Inu mukhoza kutenga mlingo umodzi kamodzi matumba 3. Ngati wodwala ku chikhululukiro, "salofalk" kutenga muyezo wa 1.5 ga patsiku: zikhoza kugawidwa Mlingo 3 anatengedwa kapena zonse za mankhwala nthawi yomweyo.

Ngati tikulankhula za exacerbation wa anam'peza matenda a m'matumbo mwa ana (kwa zaka 6 achikulire) sing'anga kupezeka n'kukulemberani mankhwala pa mlingo wa 30-50 mg wa mesalazine pa makilogalamu 1 kulemera. mlingo onse kumwedwa pa nthawi imodzi kapena ogaŵikana Mlingo 3 tsiku lonse.

granules ayenera kuvala lilime, popanda kutafuna, Pomeza. Mankhwala ayenera kumamwa kowirikiza madzi. Zotsatira achire anali kugonjetsedwa granules ayenera kumwedwa nthawi zonse ndi zonse. Pachimake siteji ya anam'peza matenda a m'matumbo zambiri amafa pasanathe miyezi 2-3, zambiri zovomerezeka tsiku mlingo yafupika 1.5 ga patsiku.

Cholinga ndi akafuna kugwiritsa ntchito suppositories

"Salofalk" (makandulo) malangizo Buku akuonetsa mlingo wa 500 mg (1 thumbo suppository 500 mg kapena 2 - 250 mg) katatu patsiku. Ngati matenda siteji pachimake, mlingo tsiku lililonse kawiri. Ngati wodwala anatuma Inde yaitali mankhwala kapena chandamale phwando - mwangwiro prophylactic (muyambirenso kupewa), mlingo mwachizolowezi mu nkhani iyi ndi 250 mg (1 kandulo) katatu pa tsiku.

Kwa odwala wamng'ono mlingo zimadalira thupi. Ana yolemera makilogalamu zosakwana 40 "salofalk" (makandulo) malangizo ntchito nthawi anaika ½ mlingo munthu wamkulu, T. E. Nthawi 250 mg katatu pa tsiku. Ngati kulemera kwa mwanayo kuposa makilogalamu 40, kuti amagwira ntchito mlingo mankhwala monga odwala wamkulu (katatu patsiku 500 mg).

thumbo kuyimitsidwa

Mankhwala "salofalk" - kuyimitsidwa likupezeka mu mabotolo anapereka kwa Dongosolo la thumbo. Ndondomeko anachita kamodzi madzulo pamaso yogona. Wodwala isanafike utsogoleli wa mankhwala tikulimbikitsidwa kuti amasule matumbo. The tsiku kuchuluka kwa mankhwala amasankhidwa potengera kulemera kwa wodwalayo (mawu a 30-50 mg / kg). Ngati matenda ndi chachikulu kapena m'kati kuchuluka, mlingo pazipita masana angafikire kwa zaka 3 kuteteza zisadzachitikenso akatswiri zambiri amalangiza wochotsa "salofalk" pakamwa (mapiritsi). Pankhaniyi mlingo (tsiku) Komanso anatumizidwa kulemera kwa - 15-30 mg / kulemera makilogalamu thupi. Onse tsiku buku la mankhwala tsiku lonse tikulimbikitsidwa kuti kugawidwa mu magawo awiri.

Contraindications kulandira "salofalk"

Ntchito mankhwala "salofalk" (analogues - yotero) ali contraindicated anthu ndi hypersensitivity kwa Gawo ndi wothandiza mankhwala. Ndi zosavomerezeka zoika mapiritsi ana osaposa zaka 3 zakubadwa, granules - 6 wazaka. Mulibe kumwa mankhwala ndi mavuto wodwalayo aakulu insufficiency aimpso kapena kwa chiwindi.

Musati adzaika "salofalk" Anthu amene ali ndi chizolowezi kukhala magazi, matenda osiyanasiyana dongosolo hematopoietic. Akudwala hemorrhagic diathesis chikhalidwe cha matenda chilonda pa mundawo aliyense m'mimba komanso sayenera kumwa mankhwalawa pa maziko a mesalazine.

The granules zosavomerezeka medicament kutumikiridwa kwa odwala matenda phenylketonuria (kumtundu matenda kugwirizana ndi mkhutu kagayidwe wa phenylalanine kumabweretsa zotupa aakulu CNS mu mawonekedwe kulumala aluntha).

Ndi kwa akazi apakati ndi lactating, kugwiritsa ntchito mankhwala mu miyezi 3 mimba ayenera kuyesedwa wolungama mwa zizindikiro kwambiri. Mkati 2-3 trimesters Kusankhidwa "salofalk" n'chotheka milandu pamene ananena ubwino thanzi la mayiyo ukulamulira zikanasokoneza mwanayo. Malinga ndi umboni chomwecho alandiridwa ntchito granules 'salofalk "mkaka wa m'mawere. Komabe, ngati mwana ali m'mimba, m'pofunika kusiya yoyamwitsa. Ndipo ambiri, optimally anakonza pamaso pa isanayambike mimba, siyani kumwa "salofalk" kapena, pafupifupi, kuchepetsa mlingo analandira.

chingachitike mbali

Zotsatira zake zoyipa pafupifupi mankhwala osokoneza bongo. Panali zosiyana ndi "salofalk" (Russian Anzawo komanso). CNS mavuto ndi zizindikiro n'zotheka mutu, chizungulire, kenaka utentha mamba, tinnitus, maganizo, khunyu, paraesthesia. thirakiti m'mimba angayankhe ntchito "salofalk" ululu pamimba, bloating, kutsekula m'mimba, nseru, kusanza. N'zotheka chitukuko cha matenda a chiwindi, kwa chiwindi transaminase mfundo kusintha. Cardio-mtima dongosolo alandire tachycardia, fluctuation magazi (hyper- kapena hypotension), kupweteka m'chifuwa, dyspnea.

Nthawi zina, odwala akhoza anamva pa zomwe myalgia, arthralgia. Komanso, mankhwala zingachititse magazi m'thupi, leukopenia, thrombocytopenia, anuria, oliguria, hematuria, crystalluria.

Angapo a thupi lawo siligwirizana ndi zotheka kuyabwa, zotupa pa khungu erythema, bronchospasm, pericarditis ndi myocarditis. Odwala ndi hypersensitivity kuti mesalazine angathe matenda monga nephritis interstitial, syndrome nephrotic, pachimake gawo la kapamba. Mu gulu osiyana odwala "salofalk" (ofanana wake komanso) zimapangitsa zizindikiro zofanana ndi matenda a zokhudza zonse lupus erythematosus.

mankhwala analogues

The "salofalk" kuchuluka okwanira mankhwala analogues wa chachikulu chigawo yogwira. Kodi Mwachitsanzo, m'malo "salofalk" - makandulo? Analogues, zomwe nthawi zambiri zofuna za ogula ndi ogwira ntchito zaumoyo amaikidwa - ndi suppositories "Pentas" ndi "Samezil". Izi mankhwala yaikulu yogwira pophika ndi mesalazine, kotero iwo ndi ofanana zotsatira pharmacological pa thupi la munthu.

"Mesakol" - wina chimagwiritsidwa ntchito analogi "salofalk" (mu granules, mapiritsi).

Kuwonjezera chigawo ntchito analogi, pali gulu lalikulu la mankhwala ofanana tingati achire. Mankhwalawa angathe bwinobwino kunyamula "Azathioprine" ndi "Alginatol", "hydrocortisone" ndi "Dexamethasone" "Diprospan" ndi "Irmalaks", "prednisolone" ndi "Sulfasalazine". mndandanda akupitiriza.

ayamikira yeniyeni

Musanayambe mankhwala ndi pa mankhwala ndi pambuyo wosamalira ake kuchotsa amalangiza magazi ndi mkodzo mayesero ofanana. Pamaso chithandizo ndi ndondomeko m'pofunika kuti aziona magawo a boma zinchito chiwindi. Kuyang'anira bwino anachita patapita masiku 14 ukatha mwambo wa mankhwala, ndiyeno wina 2-3 pa intervals wa masabata 4. Ngati zotsatira ndi malire wabwinobwino, kuyan'anila Kafukufuku ikuchitika pa miyezi 3. Ngati mwadzidzidzi mtundu wa kupatuka udzachitika pa kuwunika, m'pofunika kuchita mayesero ulamuliro yomweyo.

Poika mtundu uliwonse wa mankhwala "salofalk" (makandulo, analogues miyala, granules, suspensions) kuti odwala matenda a mphumu bronchial, dokotala chofunika mosamala kuyan'ana mkhalidwe wa odwala pa mankhwala. Ngati wodwalayo mbiri akuoneka kuthekera mavuto pamene mukumwa "Sulfasalazine" ukupeza anthu oterowo ayenera kuunikira mosamala kwambiri mu koyamba gawo wa mankhwala "Salofalk." Ngati iwo anasonyeza zochita pachimake tsankho (zopweteka, kupweteka m'mimba, zotupa malungo), kugwiritsa ntchito mankhwala ayenera anasiya pomwepo.

Pamene galimoto kapena ntchito zimene amafuna liwilo psychomotor zochita, odwala kulandira "salofalk", ayenera kusamala kwambiri.