M'mphuno utsi "Dezrinit": ndemanga madokotala, malangizo ntchito ndi zikuchokera

"Dezrinit" - kupanga glucocorticosteroid (GCS) apakhungu ntchito. Woukitsa ndi mometasone antiallergic ndi antiinflammatory kanthu. Kugwiritsa ntchito mankhwala pa mlingo amene amayambitsa zotsatira zokhudza zonse kumawonetsera apakhungu ntchito zake odana ndi yotupa. Taonani nkhani iyi za "Dezrinit" kukonzekera ayankhe madokotala ndi ogula.

Mankhwala imathetsa amasulidwe owayimira yotupa, kuchuluka kupanga lipomodulin, ndi woletsa wa phospholipase A, ichi ndi chifukwa kuchepetsa wa anamasulidwa arachidonic acid ndi prostaglandin kaphatikizidwe chopinga ndiponso endoperoxides ozungulira. The mankhwala ndi kuteteza kudzikundikira neutrophils, kuchepetsa kupanga yotupa exudate ndi lymphokine, chopinga wa kusamuka macrophage, kuchepetsa njira granulation ndi kusalola, kuchepetsa mapangidwe chemotaxis, mwachitsanzo yaikulu patapita matupi awo sagwirizana anachita amapezeka kusiya chitukuko cha n'kamodzi matupi awo sagwirizana anachita.

Mfundo yotereyi ikutsimikizidwanso pa medicament "Dezrinit 'ndemanga madokotala - akatswiri mu munda wawo. Kapangidwe njira zikuphatikizapo mometasone furoate ndi auxiliaries.

Pharmacokinetics

ntchito Intranasal kumachepetsa zokhudza zonse bioavailability wa mometasone furoate kuti zosakwana 1%. Yogwira mankhwala akhoza kulowa magazi, zedi yaing'ono chosakanikirana ndi mwachangu biotransformed pambuyo ziyambe kudutsa chiwindi. Pa tsiku lokonzekera "Dezrinit" Madokotala ndemanga ndi ambiri positive.

Akusonyeza kuti:

• mankhwala a ana osatha ndi nyengo matupi awo sagwirizana rhinitis kwa zaka 2 ndi abambo akulu;
• pachimake sinusitis, exacerbation wa ana aakulu sinusitis zaka khumi ndi ziwiri ndi akulu, ndi akulu (kuphatikizapo okalamba) ngati adjuvant chithandizo ndi mankhwala;
• mankhwalawa adenoids ana kapena akulu polyposis m'mphuno;
• kupewa nyengo matupi awo sagwirizana rhinitis zinthu zolimbitsa ndi choopsa cha ana kwa zaka khumi ndi ziwiri ndi akulu komanso akulu. Khalidwe akulimbikitsidwa masabata anayi isanayambe nyengo duwalo.

Fomu kumasulidwa

Metered m'mphuno kutsitsi. botolo limodzi lili Mlingo 140. Mawonekedwe Buku la mankhwala mu mawonekedwe a m'malovu kulibe nthawi ya kukonzekera buku. Oyenera "Dezrinit" ana. Reviews madokotala kutsimikizira izo.

The njira ya ntchito ndi malangizo ntchito

Mankhwala chikuyendetsedwera intranasally. Utsi ali vial pa jekeseni m'mphunomo ntchito yapadera dosing chipangizo.

Isanayambe ntchito kutsitsi kuchita 10 mayeso n'kudzandigunda chipangizo dosing. Pambuyo calibration, mankhwala mlingo yobereka wakhazikika, aliyense atolankhani ipitirirabe kuyimitsidwa a 100 mg zomwe zili 50 mcg wa mometasone. Musanagwiritse ntchito mankhwala pambuyo kuposa yopuma masiku 14, ndi calibration ayenera mobwerezabwereza. Aliyense ntchito ayenera kuyambirira kugwedeza vial.

zotsatira zoyipazi

About "Dezrinit» Kukonzekera ndemanga zachipatala izi chingachitike mbali:

• khungu;
• zochita hypersensitivity kuphatikizapo dyspnea, ndi bronchospasm;
• anaphylaxis;
• mutu ana ndi akulu;
• angioedema;
• nosebleeds;
• moto wa m'mphuno;
• ana akhoza kuona kukula kungokhala pamodzimodzi, psychomotor ofuntha, matenda tulo, nkhawa, kupulupudza, maganizo;
• zilonda zapakhosi;
• perforation wa m'mphuno septum ;
• kumverera kwa mkwiyo wa mucous mu m'mphuno;
• Timatha pharyngeal mucosa mkwiyo;
• chapamwamba kupuma thirakiti matenda;
• sneezing;
• kulawa tsoka;
• kuphwanya kununkhiza;
• ng'ala;
• kuthamanga intraocular;
• ulceration wa mucosa mu m'mphuno.

contraindications

Mankhwala "Dezrinit" (ndemanga madokotala titsimikizire kuti) ali contraindicated mu:

• hypersensitivity kuti mometasone kapena aliyense chigawo cha chiphunzitso ndi;
• .. A phukusi zaposachedwapa opaleshoni kapena kupwetekedwa m'mphuno kwa chilonda machiritso, kuti amachita kwa GCS unsembe ochepetsera pa njira ya machiritso;
• ana (ngati m'mphuno polyposis 18; pachimake exacerbations a sinusitis aakulu, pachimake kapena kwa zaka 12; zaka 2 rhinitis ndi matupi awo sagwirizana osatha ndi nyengo).

Kugwiritsa ntchito mankhwala pa mimba ndi yoyamwitsa

Makamaka palibe maphunziro a ntchito otetezeka "Dezrinita" pa mimba ndi mkaka wa m'mawere kunachitidwa. Izi mankhwala ayenera kuperekedwa kwa Kuyamwitsa ndi amayi apakati pokhapokha ngati athanzi mayi upambana kuopsa kuthekera kwa mwana kapena mwana wosabadwayo. Akhanda omwe amayi ntchito corticosteroids woyembekezera, muyenera pochitika kudzifufuza wapadera kudziwa zotheka hypoadrenalism. Mfundo yotereyi ikutsimikizidwanso pa medicament "Dezrinit" ndemanga za immunology zachipatala.

Ntchito mankhwala kwa ana

Ntchito "Dezrinita" ali contraindicated ana ndi m'mphuno polyposis M'mimbamo 18; ndi exacerbation wa sinusitis aakulu kapena mtundu wokonda zaka 12; ndi osatha ndi nyengo matupi awo sagwirizana rhinitis kwa zaka 2. Nthawi zambiri ntchito "Dezrinit" mu adenoids ana. Reviews madokotala chikutanthauza abwino.

malangizo ntchito

Zizindikiro za manja a mucosa m'mphuno mankhwala kwa chaka chimodzi (miyezi 12) sanali anati. Kuphunzira biopsies wa mucosa m'mphuno anasonyeza zotsatira za mometasone kuti makhalidwe a normalization wa histology. Pomalizira ntchito mankhwala, komanso aliyense chithandizo yaitali tiyenera chiphasochi nthawi amphuno mucosa dokotala otorhinolaryngology.

Mu airway TB (zobisika kapena mphamvu); bakiteriya, zokhudza zonse tizilombo (kuphatikizapo nsungu amakhudza maso, kapena Herpes simplex) kapena matenda a mafangasi; chithandizo yaitali ndi corticosteroids; pamaso pa mukuchitika matenda Popanda kuchitapo kanthu za m'mphuno mucosa, komanso kudzera mumkaka wa m'mawere ndi mimba, mankhwala ayenera mankhwala mosamala.

Kuchiza "Dezrinit" analimbikitsa kusiya ndi kuyamba kuchita mankhwala apadera chitukuko cha mafangasi matenda wamba a pharynx kapena mphuno.

Mkwiyo wa pharynx ndi m'mphuno, amene amalimbikira kwa nthawi yaitali kwambiri kwa nthawi, tinganene kuti kumasonyeza kulephera mankhwala. Mukhoza kuona kuti sanaulule yimitsira a dongosolo hypothalamic-pituitary-adrenal pambuyo ntchito yaitali mankhwala. Izi zikuonekera bwino ndi ndemanga kukonzekera "Dezrinit".

mwapadera yokha amafuna odwala kulandira chithandizo yaitali ndi corticosteroids kudutsa mankhwala ndi mometasone. Ngati inu adzafafaniza GCS dongosolo kanthu, ndiye mwayi tikhoza kunena kuti adzachititsa kusowa kwa ntchito adrenal, mankhwalawa umene amafuna miyezo yoyenera.

Odwala ena, tinganene kuti mankhwala mometasone pambuyo corticosteroids kumachitika achire zizindikiro zokhudza zonse ntchito glucocorticosteroids. Zikuphatikizapo maganizo, kutopa, kupweteka kwa minofu ndi / kapena mafupa. Odwala ayenera wapadera kutsimikizira kuti mankhwala ndi "Dezrinit" n'koyenera, ngakhale kuchepetsa zovuta zizindikiro za zotupa amphuno mucosa. Masked (koma kale mu mtima) zochizira matenda glucocorticoid zokhudza zonse matupi awo sagwirizana monga chikanga ndi conjunctivitis, tingaone ndi kusintha kwa corticosteroids m'deralo.

Mankhwalawa tizilombo ting'onoting'ono unilateral; tizilombo ting'onoting'ono, amene kugwirizana ndi enaake fibrosis, ndi tizilombo ting'onoting'ono, kwathunthu kuphimba m'mphuno, chitetezo ndi efficacy a "Dezrinita" sichinayambe kuphunzira. Magazi ndi tizilombo ting'onoting'ono unilateral kukhala ndi mawonekedwe osasamba, m'pofunika kufufuza zina.

Odwala kulandira mankhwala ndi corticosteroids, kupeza yafupika reactivity m'thupi choncho tiyenera kuchenjeza iwo kuonjezera kusatetezeka kupyolera mukulumikizana ndi chikuku odwala, nthomba ndi ena opatsirana chikhalidwe cha matenda, ndi bwino kufunsa katswiri, ngati kukhudzana ndi mtima akadali ine ndinatenga malo.

ntchito yaitali corticosteroids m'mphuno pa mlingo waukulu kungakhale chothandizira pa chitukuko mavuto. Komabe, zotsatira zimenezi zingakhale lithe kusiyana corticosteroids zokhudza zonse ntchito, mosiyana ndi odwala payekha. Angathe zotsatira zokhudza zonse zingaphatikizepo matenda Cushing, amene amakhala ndi yimitsira adrenal, khungu, maso, kukula retardation ana ndi achinyamata, ndipo nthawizina angapo zotsatira khalidwe ndi maganizo, kuphatikizapo nkhawa, kugona chisokonezo, kukhumudwa kapena waukali, psychomotor ofuntha.

Koma mogwirizana mankhwala pakati mankhwala osiyana ndi mometasone, za kafukufuku anali imachitika.

M'mphuno kutsitsi «Teva Dezrinit": ndemanga kasitomala ndi madokotala

Reviews kukonzekera makamaka positive. Good thandizo ndi matupi awo sagwirizana rhinitis. Bwinobwino analekerera kawirikawiri kupereka mavuto. Ana amathandiza mu adenoids, kumachepetsa kutupa. Chinthu chachikulu kulemekeza malangizo ntchito.