"Nimesulide": ndemanga, ntchito analogues

Nonsteroidal antiinflammatory wothandizila ndi gulu lopatulika la mankhwala ndi chidwi mavuto atatu: antiinflammatory, antipyretic ndi analgesic. Chifukwa makhalidwe amenewa pharmacodynamic wa gulu la mankhwala chimagwiritsidwa ntchito yochizira matenda. Tiyeni tione mbali ya ntchito "Nimesulide" mankhwala, mtima umboni za mankhwala mankhwala, komanso zotheka chokhwima zotsatira ndi mbali ya dosing.

makhalidwe pharmacodynamic

"Nimesulide" ndi nthumwi za gulu la anthu omwe sanali steroidal mankhwala odana ndi yotupa. Mu gulu mankhwala osokoneza bongo amatanthauza kusankha zoletsa wa enzyme cyclooxygenase-2, kuti othandiza kukwaniritsa chopinga wa yopanga prostaglandins mu kutupa.

Wina chizindikiro cha limagwirira kanthu "nimesulide" chiphunzitso ndi mphamvu yake ziletsa kumasula puloteni ina yotchedwa myeloperoxidase, amene kwambiri kumabwezera mmbuyo yopanga ankafuna kusintha zinthu mopitirira popanda zokhudza njira chemo- ndi tigmotaksisa ndi phagocytosis. Komanso, "nimesulide" kumathandiza kuti yimitsira la mapangidwe chotupa necrosis Chinthu ndi owayimira zina zopezeka mu zochita yotupa wa chamoyo.

Makhalidwe pharmacokinetic wa

Njira yaikulu ya utsogoleli wa medicament ndi m'kamwa, chifukwa bioavailability mkulu wa mankhwala, mlingo wa ndende pazipita mu plasma odwala. Motero, anthu ambiri pazipita zimatheka pambuyo Mphindi 120-180 pambuyo boma ndi digiri ya kumanga mankhwala ndi mapuloteni plasma ali pafupi ndi 98% wa pachiyambi anayambitsa kuchuluka "nimesulide" kukonzekera (mavoti odwala ndi madokotala kutsimikizira izo).

Thupi yayikulu kwambiri mu kagayidwe mankhwala ndi chiwindi. Mu ndondomeko ya biotransformation ku metabolite yogwira otchedwa hydroxynimesulide. Njira yaikulu ya excretion wa mankhwala ndi excretion ake mu mkodzo (kotero amasonyeza pafupifupi 65% mankhwala), pafupifupi 35% ya mankhwala ndi excreted mu ndowe za.

Pafupifupi odwala onse pamaso masuku pamutu mfundo zoonjezera za mankhwala "Nimesulide". Malangizo ntchito, analogs, zizindikiro ndi contraindications, mavuto - anthu amakonda kufunsa.

zikuonetsa

Zikuonetsa kuti mankhwala "Nimesulide" osati kwambiri. Mwa iwo Dziwani ululu waukulu akuwuka, ndi chachikulu nyamakazi ululu ndi dysmenorrhea chachikulu amapezeka. Zochita Dokotala monga kugwiritsa ntchito mankhwala. Izi zikuonekera bwino ndi kuvomereza anasiya "Nimesulide" amatanthauza ndemanga. si analimbikitsa kugula kwa ana osaposa zaka 12 - ayenera kudziwa izi.

Contraindications mankhwala

Ngati zonse nonsteroidal odana ndi yotupa mankhwala "nimesulide" ali contraindicated pamaso pa chilonda chapamimba kapena duodenum chilema (12 mmatumbo chilonda) mu gawo pachimake, kutsitsa detoxifying ntchito chiwindi, pamene kusankha mankhwala ndi mankhwala hepatotoxic. Mankhwala ali contraindicated odwala ndi kuchepa kwambiri mu excretory aimpso ntchito (creatinine chilolezo zosakwana 30 mL / mphindi), matenda hematological ndi mavuto clotting, odwala ndi ntchito mkhutu mtima.

"Nimesulide" ali contraindicated mu kukhalapo kwa odwala opaleshoni kudwala, amayi apakati ndi unamwino, ndi ana osaposa zaka 12 chifukwa cha Mwina mkulu wa zosiyanasiyana chokhwima. Sikuti Ndinapereka "Nimesulide" zochizira fuluwenza ndi zinthu fuluwenza-ngati hyperthermia.

zotsatira zoyipazi

Izi zikutanthauza yekha yodziwika ndi mkulu odana ndi yotupa ntchito komanso kufala kwa zochita chowawa. Zidzachitika zambiri mu sabata loyamba la mankhwala ndi "Nimesulide". Reviews a pakutchulidwa mavuto kusiya kwambiri wolakalakika.

Khungu ndi mbali khungu zotsatira imakhudzana ndi maonekedwe a thupi lawo siligwirizana mankhwala ndi amene amaoneka ngati pakutchulidwa wa khungu kuyabwa ndi totupa, dermatitis, redness, urticaria. Zotsatira kuli mbali zimachitika monga poizoni epidermal necrolysis, Stevens-Johnson syndrome.

Pa mbali pa mundawo m'mimba kawirikawiri zikhoza magazi, perforation zilonda. Nthawi zambiri uka kupweteka kwa epigastric dera, nseru, kusanza, kutsekula m'mimba kapena kudzimbidwa.

Pa mbali ya chapakati mantha dongosolo zikhoza ulesi, kugona kwambiri, mutu khama ndipo chizungulire asamakhale ndi matenda vestibular.

Ku mbali ya dongosolo hematopoiesis ndi dongosolo mtima angathe eosinophilia, thrombocytopenia, ndi pancytopenia, syndrome magazi m'thupi, tachycardia, kuthamanga okwera magazi, chitukuko cha hyperkalemia.

Ntchito "Nimesulide" ndi ndemanga

Ntchito "Nimesulide" mwamphamvu chinachitika ake matenda matenda rheumatologic a dongosolo minofu ndi mafupa. Ngakhale zofooka kwambiri umboni mankhwala "nimesulide" maganizo abwino pa izo chifukwa imachita mkulu mankhwala a matenda enaake ophwanya. Izi ndi chifukwa kulunjika wa mmene cyclooxygenase-2 ndi digiri yapamwamba ya selectivity kwa enzyme izi.

Kusamala

Kodi muyenera kukhala osamala pamene mukumwa mankhwala monga "Nimesulide"? Malangizo ntchito, ndemanga mtima kudziwitsa za ena machenjezo. Zikusonyezanso mu kopita "nimesulide" yokonza ndi kugwiritsa ntchito osachepera achire mlingo wa mankhwala. Popeza efficacy ndi dosing kochepa kulandira mankhwala ayenera anasiya.

Pankhani ya hepatotoxicity wa mankhwala (amene kuunikira sayansi magazi) kulandira mankhwala ayenera kuleka yomweyo. Gulu la odwala (amene amayamba chiwindi selo choipa) Ntchito zina zoletsedwa "Nimesulide." Tikumbukenso kuti ngakhale sitili mavuto chiwindi mankhwala sayenera pamodzi ndi mankhwala hepatotoxic, NSAIDs zina, analgesics. Komanso, sayenera kumwa mowa.

"Nimesulide" ayenera kukhala digiri yapamwamba chenjezo kuperekedwa kwa odwala ndi kwa chiwindi kapena insufficiency aimpso kupewa ngozi ya Kukula kwa otsiriza.

chidwi ziperekedwe kwa woika mankhwala odwala ndi zizindikiro fuluwenza ngati. Ichi ndi chifukwa chakuti "nimesulide" ali zotsatira antipyretic ndipo amatha amabisa zizindikiro za matenda omwe amayamba ndi mabakiteriya.

Mwanjira mankhwala

Chifukwa cha luso la mkulu wa mankhwala amachititsa kuti m'mimba magazi "Nimesulide" sayenera pamodzi anticoagulants monga "Warfarin" ngati pali chiopsezo mavuto.

Luso la mankhwala kusokoneza ntchito ya cytochrome P450. Polingalira za ntchito zinchito za chopinga wa enzyme mlingo wa mankhwala zimapukusidwa mwa cytochrome ayenera zingakonzedwenso kunsi.

"Nimesulide": analogues, ndemanga

The analogs chachikulu (monga woukitsa) ndi "Nimid", "Nimesil", "Remesulid", "Ng'ombe-sanovel". Mankhwala akupezeka piritsi mawonekedwe 100 mg sachets kapena mawonekedwe a gel osakaniza 10 mg (pa 1 g wa gel osakaniza). Ntchito achire wa analogues mankhwala ndi abwino, odwala za ndemanga zawo kumanzere zabwino. Odwala kusiya "Nimesulide" amatanthauza ndemanga, miyala kukhala kakang'ono kuposa mankhwala mu mawonekedwe a sachet a.

Pomaliza

"Nimesulide" ndi amphamvu odana ndi yotupa wothandizila zochizira matenda yotupa, makamaka minofu ndi mafupa dongosolo. onetsetsani kukaonana ndi dokotala wanu za kutenga "Nimesulide" mankhwala chifukwa cha chiopsezo mavuto n'kofunika. Reviews madokotala kupereka mankhwala ndi odwala kutenga HIV ake, chifukwa amalimbikitsa kuchepetsa mofulumira zizindikiro matenda.