Sequestrants ya ndulu asidi, mankhwala: mndandanda

mafuta mankhwala asidi sequestrant akutchedwa, amatha kuchepetsa magazi mafuta. Izi mankhwala othandiza ntchito mankhwala. Pali gulu kotsimikizika mankhwala zamadzimadzi-kutsitsa, amene kupewa mafuta apanga m'mwazi. Sequestering wothandizira m'gulu gulu ili. Ndi pokhapo titachitapo lili zosiyanasiyana zipangizo, omwe ndi ofanana ndi limagwirira ntchito mwakhama. Ambiri amadziwika sequestrants asidi ya ndulu - mankhwala "Colestipol", "Cholestyramine", "colesevelam."

Matenda a mtima yafupika ndi sequestering katundu, kuphatikizapo ischemia. zinachitikira chipatala akutsimikiza mphamvu ya SCF mu mfundo zotsatirazi:

• mavuto a khalidwe inatsekeratu ndi liwiro;
• imfa yafupika ku infarction m'mnyewa wamtima.

Mipweya ya mankhwala zimawathandiza kuphatikizapo magulu a resins ion kuwombola. Izi mkulu maselo kulemera kupanga mankhwala amene ali kwenikweni insoluble ma polima olimba nawo sing'anga amadzimadzi mu ion kuwombola ndondomeko. Ndicho chimene sequestering ya ndulu zidulo.

Limagwirira cha zochita za mankhwala

Mawu "sequestrant" amatanthauza "insulator", kuti zikuchitika mu thupi kudzipatula zidulo ya ndulu. Mafuta chimango ndi zidulo ya ndulu, amene kunyamula mafuta kuchokera chiwindi akulowera kuti kutheke kaphatikizidwe wa. Ya ndulu asidi kufalitsidwa dongosolo m'mimba akamafika wa intestine kumene si atamezedwa. Chifukwa cha thupi kwambiri zinthu zamtengo wapatali kwa moyo.

Zotsatira wogwira mtima lipoproteins kuti ndi otsika kachulukidwe. Izi otchedwa mafuta zoipa.

Popeza sequestrants ntchito ya ndulu asidi (kukonzekera kufotokoza mwatsatanetsatane m'munsimu).

Sequestrants si odzipereka mu m'magazi, zotsatira kotero mbali ngati, ndi pa mlingo osachepera, ndipo iwo amaoneka kwambiri kawirikawiri.

Oyembekezera ndi lactating akazi kugwiritsidwa ntchito pa zifukwa izi. Komanso, ana ndi achinyamata ndi hypercholesterolemia banja akutenga mankhwala m'mbuyo ndondomekoyi. Ndi tinatengera kwa thupi, imene kutchulidwa mkulu mafuta ndi mavuto chifukwa.

Ngati portability FFA zachilendo, mukhoza kupiphatisa ndithu nthawi yaitali. Noobyazatelno amafunika kulamulira mafuta, michere chiwindi ndi minofu minofu.

Statins osakaniza FFA ndi aluso ndi yaitali Inde mankhwala. A mafuta zoipa yafupika ndi theka. Ngati pali hyperlipidemia ophatikizana (pamene zambiri mafuta m'magazi), ndiye zotsatira kudzakhala bwino ndi 70-75%. Monga thupi kuchita pa sequestrants ya ndulu asidi? formulations kawirikawiri bwino analekerera.

ndi mavuto otani?

Zotsatira zake zoyipa zimachitika kawirikawiri. Ngati iwo ali, ndiye palibe kwambiri thupi si kutembenuka. Komabe, anthu ena kukhala kusonyeza zizindikiro zotsatirazi sachedwa kutha:

• kudzimbidwa;
• kudzimbidwa (dyspepsia);
• nseru;
• mpweya kwambiri mapangidwe mu intestine (flatulence);
• bloating;
• kutentha, ndipo ambiri mbali zotsatira za sequestrants ya ndulu acid.

Pofuna kupewa kukwiya pa mbali ya thupi, muyenera kumamwa kowirikiza madzi ndi kudya pa chiyambi cha mankhwala pa mlingo yaing'ono.

Pamene ntchito FFA ana ayenera kuti mankhwala chitsulo ndi folic acid. Munthawi yomweyo ndi mankhwala ena angachititse mayamwidwe osauka a zigawo yogwira. Apa m'pofunika kusunga lamulo zotsatirazi: sequestering kumwa ola pambuyo ntchito njira zina, ndipo kwa maola anayi patsogolo.

kawirikawiri zotheka minofu ululu (myalgia), kutupa kwa pharynx (pakhosi). Kwambiri kawirikawiri zosayembekezereka ya chifuwa, kupweteka kumbuyo, ozizira.

contraindications

Kodi contraindications sequestering ya ndulu zidulo? Mankhwala si zinafotokozedwa milandu zotsatirazi.

Pamene hyperlipidemia mtundu 3 ndi 4 (zomwe zingasokoneze pathologies a dongosolo mtima) ali osavomerezeka sequestrants. Angalere triglycerides m'magazi. Pamene chidwi ndi ya ndulu ritsa (biliary matenda enaake ndi wathunthu kutsekeka biliary) sangathe perekani deta medicaments. Ngati munthu amadwala kudzimbidwa pafupipafupi, mankhwala zitha kukulitsa nkhaniyo. matenda a impso, zilonda zam'mimba, zotupa, magazi matenda - onse contraindications kuti SLC.

Mosamala mankhwala kwa anthu a m'mimba, malabsorption syndrome (kulemala matumbo mayamwidwe, ndi zakudya wapatali kovuta kuti ndikhale mu thupi).

Zotheka monga mbali yapadera.

Maonekedwe otsatirawa pa wotchuka sequestrants ya ndulu acid. Mankhwala (mndandanda akhoza funsani dokotala) adzakhala anakonza kuti ku otchuka kwambiri osachepera otchuka.

Mankhwala "Cholestyramine"

Limatchedwanso "Cholestyramine". Pawiri ndi insoluble ion kuwombola resins. Zimadzetsa kuonongeka kwa kuchepetsa milingo magazi mafuta ndi kotala. Ndi yogwira kumangako ya ndulu zidulo, inatuluka iwo amakhala ku thupi. Ngati mankhwala n'kofunika kumwa kwa nthawi yaitali, ndiye muyenera kugwiritsa ntchito madzi ambiri. Statins patsogolo zotsatira, koma maganizo awo yafupika magazi. Pa zaka 60 zotchulidwa mosamala.

Medicament "Colestipol"

Ndi mkulu insoluble copolymer. Katundu kumumanga ya ndulu zidulo ndi pang'ono poipa pa izo kuposa "Kolestiramin".

Zizindikiro, mavuto ndi contraindications ndi amodzi gulu lonse la mankhwala. Kuphatikiza "Kolestepola" ndi statins kupereka zotsatira zabwino.

Mankhwala "colesevelam"

No zosasangalatsa kukoma katundu wa mankhwala kumathandiza chakuti izo ochuluka ntchito poyerekeza ndi mankhwala ena.

Kodi deta sequestering ya ndulu zidulo ndi mavuto?

mavuto obwera pa mundawo m'mimba anali kudziŵika. Zochita ndi mankhwala ena satero. "Colesevelam" angagwiritsidwe ntchito zochizira amayi apakati ndi lactating.