Zochita Leukemoid ana: zoimira (mitundu), zimayambitsa, matenda aligorivimu chithandizo. zochita Leukemoid ndi khansa ya m'magazi: kusiyana

Leukemoid anachita - amasintha hematopoiesis, ofanana ndi chithunzi magazi m'magazi ndi zotupa ena a dongosolo hematopoietic. Tikumbukenso kuti kulunjika kwa zotsatira ndi kuonetsa yogwira komanso kusowa kusintha khansa. motero akhoza zidzayambike ndi mitundu intoxications zosiyanasiyana, zotupa, matenda, metastatic khansa ya mu ubongo.

Limagwirira chitukuko zimasiyanasiyana ndi osiyanasiyana zosiyanasiyana: zina ndi linanena bungwe mu zinthu mwana maselo a magazi, ena - kuchuluka yopanga maselo magazi kapena kuletsa maselo linanena bungwe mu minofu, kapena pamaso pa njira zingapo nthawi imodzi.

Kodi zikhoza kukhala gwero la matenda?

Pali zifukwa zambiri zomwe zingachitike chifukwa leukemoid anachita. Zifukwa chitukuko ndi:

• chikoka cha ionizing cheza;
• chifuwa chachikulu;
• sepsis;
• purulent njira;
• kamwazi;
• matenda Hodgkin ndi;
• mwakayakaya cranial;
• mantha;
• lobar chibayo;
• erysipelas;
• diphtheria;
• chofiira malungo;
• pachimake chiwindi dystrophy;
• corticoid mankhwala;
• mpweya monoxide poizoni.

matenda mitundu

Mitundu zotsatirazi mosiyanasiyana leukemoid:

• Myeloid anachita.
• Lymphocytic.
• Psevdoblastnye.

Tiyeni tione aliyense wa iwo mwatsatanetsatane.

myeloid

Ndi mtundu wa anachita monga ngati neutrophil, eosinophil ndi promyelocytic. Zotsatira Leukemoid ofanana ndi a aakulu myeloid khansa, limodzi ndi kuledzera ndi matenda akulu. Yogwira leukocytosis kwenikweni nthawi zonse ali ndi ndondomeko zovuta limodzi ndi kukhalapo kwa sepsis, yotupa foci ndi kuchuluka kutentha thupi.

Ndinakumana owonjezera eosinophils mu magazi amakhala zimachitika pamene zina kuti tizilombo mankhwala, matupi awo sagwirizana diathesis, kawirikawiri - pa matenda oncological (matenda Hodgkin ndi lymphosarcoma). motero leukemoid muyenera kwa kafukufuku mabuku matenda adiresi ya m'thupi, ndi mphutsi.

maselo Kuthandiza ngati eritremii. polycythemia zinthu - zambiri kuchepa m'mapapo matenda oxygenation (oxygenation) mwazi, impso zotupa, ndi matenda obadwa nawo a mtima. Zimenezi zimafunika kompyuta ndi ultrasound.

Mielemiya ofanana erythroleukemia pachimake, amene losiyana yekha popanda kuphulika erythrocytes mu mafupa ndi magazi. Nthawi zambiri n'zotheka kudziwa metastases ku matenda a mafupa.

lymphocytic

motero yodziwika ndi kuwonjezeka kwambiri chiwerengero cha lymphocytes mu magazi zotumphukira, chomwe nthawi zambiri udindo kuwonjezeka mu chiwindi, lymph mfundo ndi ndulu.

Kwa mtundu uli mononucleosis, matenda lymphocytosis, monocyte-macrophage zochita leukemoid ana ndi matenda bakiteriya ndi tizilombo ndi matenda parasitic ndi magazi eosinophilia (mwachitsanzo, helminthiasis).

zochita Lymphocytic zimachitika:

• matenda tizilombo (nthomba, chikuku, mumps, adenovirus matenda, chikuku, matenda mononucleosis);
• matenda parasitic (rikketsiozah, toxoplasmosis, chlamydia);
• matenda bakiteriya (chindoko, pertussis, TB);
• mycoses osiyanasiyana;
• matenda autoimmune (seramu matenda, zokhudza zonse lupus erythematosus).

mtundu Lymphocytic ambiri mu macroglobulinemia Waldenstrom, kutupa, sarcoidosis. Onse a matenda pamwamba asonyezedwa lofunika kwambiri ndipo zikhoza kukhala zozunguza wodwalayo kuposa chaka.

Psevdoblastnye

Zimenezi ndi leukemoid ngati wodwala wayamba okha kutuluka kuchokera agranulocytosis m'thupi, chifukwa amene akhoza zidzayambike ndi phwando sulfonamides, "aminopyrine," "butadiene" ndi mankhwala ena.

Zotsatira kagulu yodziwika ndi kukhalapo mu zotumphukira magazi ndi mafupa ndithu chiwerengero cha zigawo ma ndi pakati kwenikweni ndi buluu umodzi nucleoli, woonda, wopanda cytoplasm granular.

Mosiyana ndi mmene kuphulika erythrocytes mu Intaneti izi ndi zenizeni zofewa ndi anayeza chromatin ulusi. Osasamba blastosis anazimiririka popanda mankhwala amphamvu ndi ofanana makhalidwe leukemoid zimapezeka makanda ndi matenda majini chromosomal (mwachitsanzo, ozerezeka).

Mitundu anachita Leukemoid omwe anapereka pamwamba, amene anapanga pa maziko a kudwala aliyense, samasankha chifukwa mavuto oopsa. Nthawi zina kwambiri anaonekera thrombocytopenia ayenera kuti anaganiza ukhala ngati mmodzi mwa zizindikiro khansa pachimake. Kudziwika immunoblastic lymphadenites chapadera kwambiri ndi chitetezo cha dongosolo achilengedwe a mfundo lymph, komanso molondola kudziwa mzere wa follicles ndi.

zochita Leukemoid ndi khansa ya m'magazi: kusiyana

Pali kusiyana pakati pa zotsatira amenewa ndi khansa ya m'magazi, akuti:

1. Pamene leukemoid rejuvenation zochita olumikizidwa ku makina mofulumira mafupa, ndi metamielotsitarnym ndipo wapezeka kuwonjezeka mitundu khansa kuphulika. Pamene zotsatira leukemoid opulumutsidwa erythroid nyongolosi, pali yachibadwa leykoeritroblasticheskoe chiŵerengero - 3: 1 ndi 4: 1.
2. Osati ndikuoneka kuwonekera kwa anaplasia ndi zochitika leukemoid monga izo zimachitika mu khansa pamene pali oumbidwa wa protoplasm ndi phata anomaly.
3. Mu chimake choyamba, mu magazi zotumphukira wakhala kuwonjezeka mu chiwerengero mtheradi ndi kuchuluka kuwonjezeka neutrophils okhwima mu zili khansa amachepetsa neutrophils okhwima amapezeka kuchuluka kwambiri achinyamata, mitundu mwana.
4. Pamene zochita leukemoid pafupipafupi anati granularity poizoni wa neutrophils.
5. Pamene leukocytes cytochemical kuphunzira mu khansa kuchepa kapena kusapezeka kwa munthu phosphatase zamchere, pa zochita leukemoid - chodziwa ntchito.
6. Pa exacerbation cha matenda myeloid khansa kuphulika mavuto wotsogolera ndi eosinophilic kucheza basophilic ndi zochita leukemoid izo olumikizidwa ku makina.
7. Pamene myeloid khansa limakhudza thrombocytosis mkulu, ndi zochita leukemoid kupatsidwa zinthu za m'mwazi kuwerenga mkati osiyanasiyana yachibadwa.
8. Mu masiteji koyamba aakulu myeloid khansa kupeza lalikulu wandiweyani ndulu pa zochita leukemoid zina zimachitika splenomegaly, koma thupi ndi yofewa ndipo konse kufika chachikulu kwambiri.
9. Pamene zochita leukemoid kwa ndondomeko neoplastic wapezeka mu maselo a khansa mafupa.

zochita Leukemoid ana: matenda aligorivimu

yofunika kwambiri matenda a matenda amaperekedwa histopathology kuti ikufotokoza biopsy zakuthupi. Koma kuti asalakwitse mpaka kalekale, ndi dokotala wodziwa za vutoli ayenera deta yolondola za wodwalayo, kumupatsa malangizo a mayesero osiyanasiyana ndi kusankha mankhwala cytostatic, amene amachotsa mavuto a lymphadenitis. Ngati zonse izi sanachite, matenda wapangidwa molondola, choncho kupirira matenda kudzakhala kovuta kwambiri. Ndipotu, matenda ndi choopsa kwambiri. Nthawi zina, chifukwa mapeto a mfundo zofunika kuti kubwereza biopsy.

chapadera kwambiri mu Kupeza Vuto chopaka maonekedwe a biopsies mfundo lymph ndi amaonekera. Pamene ambiri erythrocyte lymphosarcoma (osachepera 30 peresenti) zopanda maselo zonse kuphulika. Ndi erythrocytes ngati immunoblastic lymphadenitis, kawirikawiri peresenti zosakwana 10, ali osiyana mu mawu a basophilia wa cytoplasm ndi phata kukhwima.

Histopathological matenda pa kusanthula lymph mfundo ayenera kukhala mwatsatanetsatane ndi osaphatikiza zolakwika mapeto. Chifukwa histopathology a maphunziro osiyanasiyana a magazi ayenera amaonetsera bwino ndi matenda, ndipo izi zimaonekera m'mawu omaliza. Mwachitsanzo, kwa matenda koyamba chosaopsa lymphoma, zina, nthawi yaitali kusunga mtima ndipo tione lymph mfundo kachiwiri.

Matendawa leukemoid zochita amaganiziridwa pamene kupeza monoclonal immunoglobulin zina tiyeneranso mobwerezabwereza ndi kuyang'anila yaitali la mafupa puncture. Isanafike chiyanjo cha matenda a khansa mankhwala amphamvu ndi contraindicated.

nampsopsonetsa matenda

matenda china chotchedwa Filatov - Pfeyferra, glandular malungo ndi monocytic angina. Ndi matenda tizilombo yodziwika ndi lymphocyte kuphulika kusintha, anaonjezera lymph mfundo ndi ndulu, zotakasika lymphadenitis zimenezi, maselo ofiira enieni mu magazi zotumphukira. Nthumwi causative amati Epstein-Barr HIV. Maziko a matenda - kuphulika wasinthika lymphocytes chifukwa cha matenda wapadera tizilombo.

The vuto matenda ndi osiyana. M'njira bata wa rhinitis chifukwa kukusweka. Chionetsero mbali:

• angina ( "moto pakhosi");
• kukulitsa a ndulu ndi lymph mfundo komanso kupweteka;
• m'mphuno kupuma kukhala kovuta mu masiku oyambirira a matenda chifukwa kutupa kwa mucosa ndi.

Udindo wa magazi: kuwonjezeka mu kuchuluka eosinophils, lymphocytes ndi monocytes.

zosokonezeka

Koyenera ndipo chokwanira pa mapeto a chizindikiro cha matenda ndi kukhalapo mu magazi mononuclear pachiyambi (pa 10-20%) - maselo amasiyana lymphocyte phata lalikulu ndi lonse basophilic cytoplasm ndi mtundu Lilac ndi kutchulidwa perinuclear choonadi. Last zochita leukemoid ana ndi akulu kwa masabata angapo, koma miyezi apitirira mu zinthu zina, ndi normalization chikhalidwe magazi.

Ndipo musabise ali anaona ndi wofatsa, nthawizina intervals wa zaka zingapo pambuyo woyamba nthawi pachimake. Zovuta ingakhale monga iyi:

• pachimake chiwindi;
• encephalitis;
• agranulocytosis;
• splenic anawononga chifukwa cha kuchuluka kwake mofulumira;
• autoimmune hemolysis.

Therapy zochita leukemoid

Monga ulamuliro, odwala popanda mankhwala wapadera, chifukwa kwa masiku angapo zizindikiro zazikulu za matenda zikawoneka ndi boma la magazi mwakale. Pamene yaitali matenda ndi mtima amaona akudwala ntchito mankhwala pathogenetic - tisonyezeni "prednisolone" pa mlingo wa 20-30 mg ndi tsiku kapena mankhwala ena glucocorticoid kuti kuthetsa leukemoid anachita. Chithandizo Mulimonsemo, kokha chimaika katswiri.

kaonedwe

Kawirikawiri HIV: contagiousness si mkulu, kotero wodwala safunikira kwaokha. Komabe, choopsa kwambiri chotupa cha ndulu ya. Akukonza kuchepetsa voliyumu anatsimikiza ndi mbali maonekedwe a thupi ndi kutha kwa angina ndi normalization wa thupi kutentha. Ngati matenda mononucleosis akuwonetseredwa mu mawonekedwe a chiwindi, wodwalayo chofunika m'chipatala.