Antimicrobial TSifran. Kagwiritsidwe mankhwala

Medicine "TSifran" ndi wothandizila antimicrobial ndi sipekitiramu yotakata kanthu ndipo ali gulu pharmacological wa fluoroquinolones. zigawo yogwira mankhwala ndi ciprofloxacin ndi tinidazole. Chifukwa yimitsira ya DNA gyrase ndi bakiteriya DNA kaphatikizidwe chopinga, zinthu izi yogwira mwakhama kwambiri chifukwa ambiri tizilombo galamu-negative.

Makamaka ntchito za kanthu bactericidal lokonzekera "TSifran" zolemba malangizo Buku za mabakiteriya awa: Neisseriagonorrhoeae, Neisseriameningitidis, Haemophilusinfluenzae, Pseudomonasaeruginosa, Salmonellaspp, Escherichiacoli ndi tizilombo ta zina popanga ndi wosapatsa penicillinase, komanso tizilombo ta methicillin zosagwira ndipo Enterococcusspp, Chlamydiaspp, Mycobacteriumspp, Legionellaspp ... ta.

kanthu pharmacological wa bactericidal medicament yotakata sipekitiramu "TSifran" malangizo ntchito chiri motere: ". Chida cholinga zochizira pathologies opatsirana bwino pa matenda a njira yotupa - matenda wosanganiza chikwiyire mu ntchito ya tizilombo aerobic ndi anaerobic mogwirizana".

Pharmacokinetics

The yogwira zosakaniza wa mankhwala "TSifran" malangizo ntchito amatanthauza oyenerana kwambiri. Ndipo ciprofloxacin ndi tinidazole ndi mayamwidwe wabwino kapepala kakuti m'mimba.

Poganizira aliyense wa yogwira zosakaniza mankhwala, tisaiwale kuti ciprofloxacin ali pafupifupi 70% bioavailability. mayamwidwe ake mochedwa penapake, pamene ntchito chakudya. Izi mankhwala ali permeability wabwino zimakhala ndi madzi a m'thupi, kuphatikizapo mafupa, minofu, mafuta, ndi chichereŵechereŵe minofu. Iye likulowerera mu ziwalo za dongosolo mkodzo, kuphatikizapo mu thupi monga prostate. Icho chinali chinsinsi limatifotokozera mkulu ndende zili kiprofloksatsina, monga, ndithudi, ndi umuna, malovu, ya ndulu, lymph madzimadzi, ntchofu.

Tinidazole osiyana bioavailability mtheradi. chigawo ichinso akugwa mofulumira pa woipa mkulu minofu ya thupi madzi Chifalikira sing'anga, makamaka mu madzimadzi cerebrospinal, amene anaikira mu mofanana mu mlingo plasma. Kota kuchuluka kwa zinthu ingested excreted mu mkodzo zikutsatiridwa, pafupifupi 10% adzamasulidwa mu mawonekedwe a metabolites, gawo laling'ono ndithu chigawo m'thupi mu ndowe za.

Zikuonetsa mankhwala "TSifran" malangizo ntchito amatanthauza mankhwala a mitundu yosiyanasiyana njira opatsirana. Pakati pa pathologies mwatsatanetsatane zochizira mankhwala pansi kulingalira zomwe ntchito, matenda awa:

• aakulu osteomyelitis ;

• kwapakati pa-opatsirana yotupa njira;

• amoebic kamwazi ndi kamwazi wosanganiza mtundu (amoebic ndi bakiteriya);

• periodontitis, periostitis ndi matenda ena opatsirana wa M'mimbamo m'kamwa;

• matenda yotupa kudwala;

• aakulu sinusitis;

• Matenda a khungu ndipo zimakhala zofewa;

• postoperative nthenda;

• m'mapapo abscess.

Mmodzi wa iwo, ndipo matenda ena oyambitsidwa ndi thupi ndi anaerobic mabakiteriya tcheru zochita za zigawo mankhwala.

Anavomera kukonzekera "TSifran" postprandial. Mapiritsi ayenera kumwedwa ndi madzi zedi okwanira. odwala wamkulu kutenga mankhwala kawiri pa tsiku kwa piritsi la 500 / 600mg kapena awiri 250 / 300mg. Odwala pansi zaka khumi ndi zisanu ndi zitatu zakubadwa, mankhwala si kutumikiridwa. Iwo ali osavomerezeka ntchito pakati.

Contraindications ntchito mankhwala anafotokoza mu mankhwala ndi bwino kudziwa zigawo zikuluzikulu kupanga gawo la tsifran ndi kudwala magazi, porphyria.