HCG ndi ntchito zawo

Mahomoni ndi raznostrukturnyh organic zinthu angathe zokhudza kugwira ntchito kwa thupi la munthu. mahomoni Gonadotropic bwanji ntchito ziwalo zoberekera. Iwo apanga mu zapambuyo pituitary England ndi ku pali tochoka mu magazi.

The mahomoni wa pituitary zapambuyo

The pituitary England lagawidwa pawiri: kutsogolo ndi kumbuyo. Mwachindunji ku mahomoni kutsogolo apanga ndi tochoka mu m'magazi. The zapambuyo Lobe wa pituitary England, iwo achokera ubongo imene imalamulira kutentha ndi tochoka mu mwazi okha pa zochitika zina.

Gonadotropic pituitary mahomoni Zimachititsa zopangitsa kugonana. Njirazi ndi monga:

• FSH - follicle-zolimbikitsa timadzi. Imalimbikitsa oogenesis ndi spermatogenesis. Ndi zovuta mapuloteni (glycoprotein) amene wapangidwa ndi amino zidulo nadzadziphatika kwa chakudya.
• LH - luteinizing timadzi. Imalimbikitsa kutulutsidwa kwa dzira kuchokera n'kuwasanganiza amakhudza katulutsidwe mahomoni kugonana (esitirojeni, progesterone) anthu amachititsa katulutsidwe wa androgens. Kuchuluka kwa timadzi imasiyana pa mkombero wina kusamba, pali njila ndi synchronous katulutsidwe wa wina kuchuluka kwa FSH ndi LH.

timadzi kupanga ikuchitika gonadotropah (basophilic maselo) adenohypophysis. Iwo amapanga pafupifupi 15% ya maselo onse a Lobe zapambuyo.

Mimba timadzi - HCG

Ngati umuna ndi implantation wa linagwira mu uterine khoma m'thupi la mayi ayamba kutulutsa mahomoni yeniyeni pituitary gonadotropic anapereka chorionic gonadotropin.

Ntchito timadzi ndi kukhala corpus luteum ntchito (Kusankha timafunika ndi progesterone) kwa kusasitsa wodzala latuluka. Imakhala mkulu luteinizing zimakhudzanso thupi, amene kwakukulukulu kuposa FSH ndi LH.

mbali kandalama mahomoni

Ntchito kwachilengedwenso mahomoni amapereka dongosolo lapadera womwenso subunits awiri. Choyamba, a-kagawo kakang'ono, lili ndi dongosolo pafupifupi ofanana mu gonadotropins onse, pamene B-kagawo kakang'ono imapereka kukhudzana wapadera timadzi lapansi.

Payekha, subunits izi suli asatengere pa chamoyo, koma pamene n'zokhudza, anapereka ntchito yawo kwachilengedwenso ndi chikoka pa njira yofunika chamoyo, makamaka cha ziwalo zoberekera. Choncho, mahomoni gonadotropic zimakhudza zofunika osati pa dera kugonana, komanso mu njira endocrine ndi lamulo bwino m'thupi.

Monga mahomoni bwanji thupi

Kuyambira Kale, asayansi anayesapo kuphunzira ntchito kwachilengedwenso mahomoni ndi mmene pa thupi la munthu. Gonadotropic mahomoni ndi chikoka chachikulu pa njira ya thupi la munthu. Choncho, kuphunzira limagwirira zochita ndi funso lofunika kwambiri ndi chidwi. Mu akafufuza ndi timadzi zaikidwa anapezeka kuti maselo amatha kuzindikira mahomoni ena ndi kumumanga yekha maselo yeniyeni.

The ndondomeko ya kumanga ku selo imagwiridwa ndi zimene Kakhungu kapena maselo mwa mapuloteni molekyulu - cholandilira. Okhudza maselo ambiri phwando chikukhudza mahomoni steroid, monga iwo amakhala kudutsa mu maselo ndi chikoka pa ntchito yake. Kakhungu phwando khalidwe mahomoni mapuloteni kuti kumumanga kwa ❖ kuyanika khungu nembanemba.

KUMANGA ya mapuloteni timadzi cholandilira amalimbikitsa mapangidwe zovuta lapansi. siteji izi zimachitika popanda nkhani ya michere, ndipo kusintha. mahomoni steroid kulowa selo, anamanga kuti cholandilira lapansi. Pambuyo kusintha anapanga zovuta akulowa selo phata ndi kulimbikitsa mapangidwe RNA achindunji cytoplasm amene kaphatikizidwe enzymatic wa particles kuchititsa zotsatira za mahomoni pa foni.

Gonadotropic mahomoni: Ntchito ndi Zotsatira pa njira dongosolo ubereki

FSH ntchito ukufika apamwamba akazi. Zimathandiza kukula kwa maselo follicular amene mchikakamizo cha GSIK kuwasandutsa thovu ndi zipse pamaso siteji ovulation.

Mothandizidwa ndi kuwonjezeka mu unyinji wa SFS thumba losunga mazira ndi testes. Komabe, ngakhale ndi kumayambiriro kupanga timadzi yokumba n'zosatheka chifukwa chitukuko cha minofu interstitial, izi zimakhudza katulutsidwe wa androgens zachilengedwe testicular.

GSIK udindo ovulation ndi mapangidwe yamchiberekero corpus luteum. Komanso molumikizana ndi follicle popatsana timadzi izo zimakhudza katulutsidwe timafunika. Mothandizidwa ndi timadzi kumene kumapangitsa maselo interstitial, pali kukula kwa ziwalo udindo makhalidwe sekondale kugonana.

Zotsatira zamoyo LTG

LTG ndi zofanana kwambiri ndi kukula timadzi. Pambuyo mayesero zasayansi anasonyeza kuti ali molekyulu chomwecho, kotero munthu sangakhoze anasankha payekha, aliyense wa mahomoni izi. Ntchito LTG monga katulutsidwe mkaka ndi progesterone. Nkofunika kuzindikira kuti njira izi chifukwa cha mogwirizana kwa ambiri mahomoni, kuyambira padzuwa kwa thupi kokha LTG zizindikiro zimenezi siziwoneka.

Kotero, kuti Kugawilidwa kwanthaka wa mkaka zimafuna mahomoni zotsatirazi:

• FSH ndi GSIK - chifukwa katulutsidwe timafunika ambiri m'mimba ya;
• mchikakamizo cha kukula timadzi ndi esitirojeni ndi kukula kwa ducts mkaka;
• LTG amachititsa katulutsidwe wa progesterone mu corpus luteum;
• Progesterone kumapangitsa munthu akule bwino kwa England mammary mu mlingo alveolar-lobed.

mahomoni Gonadotropic amafuna mogwirizana zonse kuonetsetsa kuti ntchito zonse za thupi ndi machitidwe ake onse. N'chifukwa chake chikoka osiyana aliyense wa iwo (mu nkhani ya utsogoleli wa mahomoni kupanga) sayambitsa zochita kuyembekezera.

hypothalamic timadzi

The ubongo imene imalamulira kutentha zimatulutsa gonadotropin kumasuka mu magazi timadzi. Iwo ali dongosolo polypeptide ndipo zidzakhudza katulutsidwe mahomoni pituitary. Mbali yaikulu izo zimakhudza luteinizing timadzi, ndi follicle ndiye. GnRH kamapangikira intervals ndi zodziwika nthawi, akazi, iwo osiyanasiyana monga mphindi 15 45 (malingana ndi kuzungulira), ndi amuna ndi timadzi tochoka ndi aliyense mphindi 90.

Mu yokumba kupanga timadzi kutumikiridwa ndi dropper linaphwanya ntchito katulutsidwe mahomoni omwe yaifupi utithandize katulutsidwe, ndiyeno - mu kutha wathunthu wa yopanga gonadotropins ndi pituitary zapambuyo.

GnRH kukhudzana ndondomeko pa chamoyo

GnRH kukondoweza amapereka zapambuyo pituitary Lobe, zomwe maselo (gonadotropins) ndi GnRH cholandilira lenileni la katulutsidwe wa FSH ndi LH mahomoni, amene nawonso, bwanji ntchito gonads lapansi.

PG kumapangitsa kusasitsa la umuna ndi dzira maselo, LH kumakhudzanso katulutsidwe mahomoni kugonana (esitirojeni, progesterone, testosterone). Mchikakamizo cha kugonana mahomoni maselo a ziwalo zoberekera zipse ndi okonzeka kuti umuna.

Pa otaya kwambiri mofulumira njira ya spermatogenesis ndi oogenesis allocated inhibin kumamukopa mahomoni gonadotropic wa zapambuyo pituitary England zimene zimalimbikitsa m'mbuyo njira kusasitsa wa gametes kudzera kanthu follicle zolimbikitsa timadzi.

Chifukwa ntchito yokonzekera gonadotropic

Ochuluka amakonda mu zachipatala mchitidwe chithandizo mwa kuyambitsa mahomoni yokumba. Matenda ena endocrine kapena matenda a ziwalo zoberekera za munthu ntchito mankhwala gonadotropins. Dongosolo awo pamlingo winawake kulimbikitsa ulimi wa mahomoni kugonana ndi njira zikuchitika mu thupi.

Ngati kaphatikizidwe gonadotrophins angathe zina endocrine matenda (mimba mu trimester, chosakhwima kugonana, infantilism kugonana, panhypopituitarism ndi matenda Sheehan a).

Kuti tithane pathologies awa, magazi wochititsidwa kafukufuku ndi kusanthula kapangidwe kake m'thupi. Ndiye prescribers ofunika kubwezeretsa mosanyanyira mahomoni, choncho lamulo njira yofunika m'thupi.