Makandulo "Flex": zimatsogolera ndemanga, mitengo, analogs

"Idzakungana" Makandulo ndi gulu mankhwala a NSAIDs (sanali steroidal odana ndi yotupa wothandizila). Iwo ali wotsutsa-yotupa, antipyretic, analgesic ndi kanthu antiagregatsionnoe. Anapereka midadada mankhwala enzyme ntchito (cyclooxygenases 1 ndi 2) ndipo prostaglandin kaphatikizidwe. Zimenezi zimathandiza mapangidwe owayimira yotupa ndi kumabwezera mmbuyo maonekedwe a leukotrienes.

Makandulo "idzakungana" antibradikininovuyu ntchito chionetsero, ziziyenda lysosomal biomembrane, chifukwa chopinga wa ntchito neutrophil odwala ndi matenda a "nyamakazi". Ziletsa kupatsidwa zinthu za m'mwazi loitanirana. Zotsatira analgesic ndi chifukwa zimagwirira onse chapakati ndi zotumphukira. madokotala ambiri mpumulo ululu ndi mankhwala nyamakazi Kwalamulidwa "Flex" (makandulo). Mtengo wa mankhwala limachititsa kuti tikhale nacho kwa osiyana- siyana odwala. Reviews a medicament umboni Mwachangu ake okwezeka ndi chitetezo cha umoyo mogwirizana ndi malangizo.

Malangizo ntchito mankhwala ndi mwachilungamo wophweka, ndi ndemanga kutsimikizira akuoneka achire zotsatira. Gawo la mankhwala? Kodi katundu nyamayi? Kodi pali zovuta zilizonse oopsa mbali? Mayankho a mafunso amenewa akufunafuna odwala ambiri.

Mipweya ya mankhwala

lokonzekera ndi zovuta zinthu bioactive ndi excipients:

• Ketoprofen (zikuluzikulu bioactive pawiri);
• phula;
• hydrogenated masamba mafuta;
• colloidal pakachitsulo woipa;
• ndi sodium ethyl parahydroxybenzoate;
• sorbitol;
• gelatin;
• masamba mafuta;
• glycerol;
• soya lecithin;
• titaniyamu woipa;
• ndi sodium propyl parahydroxybenzoate.

"Idzakungana" makandulo analogues

Mu achire mchitidwe madokotala m'malo mwakhama ntchito analogues wa chiphunzitso zatchulidwazi:

• "Artrozilen".
• "Ketonal awiriwa".
• "Artrum".
• "Bystrumgel".
• "Valusal".
• "Bystrumkaps".
• "Ketonal".
• "Oruvel".
• "Febrofit".
• "Flamaks".
• "Profenid".
• "Ketonal uno".

ubwino mankhwala

Ubwino waukulu wa mankhwala muyenera kukhala akalozera zotsatirazi:

• pazipita achire zotsatira;
• mkulu bioavailability wa mankhwala poyerekeza ndi anzanu ake.

kuipa mankhwala

The zovuta waukulu "Flex" pazikhalanso mfundo zotsatirazi:

• mtengo wa mankhwala poyerekeza ndi anzanu;
• palibe tsiku (yaitali) kumasulidwa mitundu.

Pharmacokinetics

Bondability bioactive zinthu mankhwala ndi mapuloteni mu madzi a m'magazi peresenti 99. Makandulo "idzakungana" yodziwika ndi bioavailability mkulu (90%). ndende achire "Flex" m'magazi anakhalabe kwa maola 6. Main kagayidwe kachakudya pogawanikana pamawere mankhwala akupezeka hepatocytes ndi glyukorirovaniya. Hafu ya moyo wa maola awiri. Mankhwala si cumulated, linachokera makamaka impso ndi kudzera matumbo.

"Flex" (kandulo): malangizo ntchito, mtengo

The medicament pamwamba akusonyeza ndi sipekitiramu lonse kanthu achire. "Idzakungana" makandulo nthawi zambiri zotchulidwa mu mchitidwe matenda zochizira ululu ndi zochita yotupa ya chiyambi zosiyanasiyana. Kugwiritsa ntchito mankhwala ovomerezeka pathologies zotsatirazi:

• migraine;
• psoriatic nyamakazi;
• tenosynovitis;
• aimpso colic;
• gouty nyamakazi;
• bursitis;
• dorsalgia;
• myalgia;
• nyamakazi;
• otitis TV;
• nyamakazi osiyana kutanthauzira;
• polymyalgia rheumatica;
• ululu fupa;
• sciatica;
• phlebitis;
• ankylosing spondylitis;
• neuralgia;
• thrombophlebitis;
• sciatica;
• adnexitis;
• Kudwala mu plexus lumbosacral;
• sciatica;
• algodismenorei;
• postoperative ndi post- syndrome kusokonezeka maganizo ;
• lymphangitis;
• ululu pathologies khansa.

Kugula mankhwala "Flex", mtengo umene zimasiyanasiyana mu osiyanasiyana 200-300 rubles, ngati muli ndi mankhwala pa mankhwala aliwonse. Komanso Dziwani kuti makandulo "Flex" mu matenda achikazi ndi mwachilungamo zambiri ntchito yawo analamula kuti chotupa yamchiberekero. Malinga ndi umboni wa anthu ambiri odwala, mankhwala ntchito bwino. madokotala ambiri amanena kuti mankhwala "Fleksenom" masiku 10 ndipo mulandire mankhwala owonjezera chotupa kusiyiratu.

contraindications

Ngati mwaganiza ntchito "Flex" (makandulo), malangizo Buku akusonyeza kuti mankhwala ayenera kugwiritsidwa ntchito pa milandu zotsatirazi:

• magazi kapepala kakuti m'mimba;
• m'kukoma impso ndi chiwindi kukanika;
• mimba ndi mkaka wa m'mawere nthawi;
• hypersensitivity osakhala steroidal mankhwala odana ndi yotupa;
• zotupa;
• "Aspirin" mphumu;
• matenda a clotting magazi ;
• proctitis;
• zaka pansi zaka 15;
• kukanika kwa dongosolo hematopoietic (leukopenia, matenda coagulation, thrombocytopenia, amapatsira mwana wake);
• matenda matumbo exacerbation.

malangizo Special

"Idzakungana" (makandulo) Chiongoko kusonyezedwa ntchito mosamala odwala ndi kukanika aimpso, chiwindi, kapepala m'mimba, bronchial mphumu, uchidakwa, rhinitis, pa tizilombo ting'onoting'ono mu amphuno mucosa, kuchepa madzi m'thupi, urticaria, kusuta, matenda enaake, hyperbilirubinemia, matenda magazi sepsis, shuga, msana pathologies, anthu okalamba. Pa thandizo anati medicament amafuna polojekiti mwadongosolo ntchito aimpso ndi chiwindi. Ngati "Flex" makandulo yoikidwiratu ichitikire ndi anticoagulants (heparin), ndi chiopsezo cha magazi kuchuluka. Long achire Inde n'chotheka mu zikhalidwe za kuchipatala. Pa mankhwala, pewani kudya mowa.

mbali zotsatira

Anatumizidwa kwa inu "Flex" (makandulo)? Malangizo Ntchito si amapatula chitukuko mavuto. Ali:

• mutu chaukali;
• nseru;
• kutentha;
• chizungulire;
• kusanza;
• kusafuna kudya;
• tulo;
• m'mimba kukha mwazi;
• asthenia;
• kusinza;
• conjunctivitis;
• xerophthalmia;
• mantha;
• kudzimbidwa;
• tinnitus;
• kuyiwala;
• amaona masomphenya;
• chiwindi;
• kumva imfa;
• vertigo;
• neuropathy zotumphukira;
• gastralgia;
• tachycardia;
• chosakhalitsa dysuria;
• ankatenthetsa;
• chikanga;
• cystitis;
• nephrotic syndrome;
• urethritis;
• fotodermatit;
• laryngeal edema;
• hematuria;
• erythema;
• aimpso kukanika;
• edema syndrome ;
• khungu kuyabwa;
• chifuwa khungu;
• kuwonjezera transaminases (alanine aminotransferase ndi aspartate aminotransferase) mu seramu magazi;
• kufupika kwa mpweya;
• rhinitis;
• nosebleeds;
• bronchospasm;
• anaphylactic mantha.

Ntchito suppositories akhoza kuyambitsa kutsekula m'mimba, tenesmus ndi kuwotchedwa zotengeka.

Zizindikiro mu ambiri osokoneza

Makandulo "idzakungana" anafuna kuti ntchito thumbo - 1 suppository (100 mg) katatu 1-2 tsiku. The pazipita kololeka tsiku mlingo wa ketoprofen - 300 mg. Zizindikiro zotsatirazi anati mu nkhani cha mankhwala osokoneza bongo:

• kukanika kwa chiwindi ndi impso;
• kusinza;
• nseru;
• magazi;
• kupweteka kwambiri m'dera epigastric;
• kusanza.

Pamene kupeza mbali pamwamba anatumizidwa mankhwala symptomatic. Palibe adakalibe yeniyeni. Monga adsorbent adamulowetsa makala, "Sorbeks", "Medetopek" kapena "Neointestopan". Dialysis, anakakamizika diuresis - mankhwala operewera. Perekani wothandizila alkalizing kuti atsogolere mbali ya zizindikiro alimentary ngalande. glucocorticoids angagwiritsidwe ntchito ngati kuli kofunika. Mu insufficiency aimpso, hemodialysis. Mu zopweteka adzaika "ntchito diazepam" benzodiazepanovye kapena mankhwala ena anticonvulsant; mu aakulu mmalo hypotension plasma kutumikiridwa ( "Reopoligljukin", "Poliglyukin", "Enterodez", "Polidez", "Hemodez"). Wodwala amafuna Ataona zonse kwa masiku angapo, monga pali ngozi kumasonyeza kenako matenda ena m'mimba (magazi, ulceration).

Mogwirizana ndi mankhwala ena

Imeneyi timapitiriza zimene anticoagulants, fibrinolytics, Mowa, wothandizila antiplatelet, amachepetsa zotsatira za vasodilators zotumphukira, spironolactone, dzuwa mankhwala uricosuric, asatayike ndi okodzetsa hypotensive. Pamwamba anapereka mankhwala atakwatirana ndi "tramadol." The ntchito ophatikizana a "Flex" omwe si steroidal wothandizila ena odana ndi yotupa, ethyl mowa, corticosteroids, corticotropin amakwiya mapangidwe zilonda ndi chitukuko cha magazi m'mimba. Mankhwalawa ayenera kumwedwa kuchepetsa dzuwa la mayamwidwe mankhwala. masiku awiri pamaso yobereka za kufufuza pa nkhani za 17 ketosteroids mankhwala linathetsedwa.

"Idzakungana" kumawonjezera zotsatira hypoglycemic wa insulin ndi mankhwala m'kamwa hypoglycemic. mankhwala Myelotoxic kuwonjezera mawu gematotoksichnosti mankhwala. Inductors microsomal biooxidation mu chiwindi ( "phenylbutazone", Mowa, tricyclic antidepressants, "Phenytoin", "Rifampicin" barbiturates) mphamvu ya biosynthesis wa yogwira metabolites hydroxylated. Munthawi yomweyo ntchito "idzakungana" ndi "valproate ndi sodium" amachititsa zikusokoneza wa kupatsidwa zinthu za m'mwazi loitanirana.

Reviews kukonzekera

odwala ambiri amachita chidwi ndi funso zimene kwenikweni ndi makandulo "idzakungana". Malangizo ntchito, mtengo wa mankhwala, zizindikiro ndi contraindications - ndi, kumene, mfundo zikuluzikulu. Komabe, ayenera dziŵani okha ndi maganizo a akatswiri ndi odwala pankhaniyi. madokotala ambiri amakhulupirira kuti analgesic bwino ndi odana ndi yotupa wothandizila - "idzakungana" (makandulo). Mayankho odwala Nthawi zambiri (80 90%) ndi zabwino, chifukwa dzuwa mkulu wa mankhwala, thandizo ululu odalirika etiology osiyana ndi kutanthauzira, zotsatira ndipo chomasuka ntchito mpaka kalekale. A ubwino Tingaone pa masiku oyamba omwe chikuonetseratu. ndemanga zoipa zokhudza kukonzekera makamaka zokhudzana ndi maonekedwe mavuto ndi mtengo wake, koma kuipa awa mankhwala sangathe kuposa dzuwa ake okwezeka.

Zinthu kotunga pharmacies

The mankhwala ndi mu mawonekedwe a suppositories ndi makapisozi anamasulidwa mosamalitsa pa mankhwala. A medicament mu mawonekedwe a gel osakaniza akhoza zidzaperekedwa popanda dotolo.

zinthu yosungirako

Muyenera kuwasunga patali ndi ana pa kutentha pamwamba kuposa 25-30 ° C. Mwachindunji kutentha osiyanasiyana amanena mitundu yonse ya kumasuka. Tsiku lothera pa phukusi. Mankhwala ayenera kumwedwa pambuyo pa tsiku lotha!