Prothrombin index, mlingo komanso kufunika

Prothrombin index, mlingo wa omwe ali ofanana ndi 95-105% - ndi chimodzi mwa zizindikiro amakhala magazi clotting. Magazi clotting - ndondomeko zovuta yomwe ikuchitika ndi nawo ndi kugwa mapulotini wakupambulika dzinache zinthu coagulation. Kutsegula njira zimenezi m'njira ziwiri - mkati ndi kunja.

Iwo prothrombin index amadziwika kutsegula ya coagulation kudzera njira extrinsic. Icho chiri motere: kuphwanya umphumphu wa zimakhala (bala) ndi allocated otchedwa minofu thromboplastin, puloteni yapadera opezeka zimakhala thupi. Iwo akapsa ndi kugwa anachita akulowamo clotting zinthu zina (V, VII, ndi X, II, I), successively mphamvu wina ndi mnzake. Potsilizira pake, nthinthi magazi likakhazikitsidwa komanso magazi mabasi.

Kodi prothrombin index

zinthu clotting anapanga mu chiwindi. Awa, II, V, X ndi vitamini K-yozungulira. Ndi losowa vitamini kaphatikizidwe awo akusokoneza. Choncho, pali kuyan'anila za hemostasis. Kudziwa prothrombin index, amene ali kudziwika mlingo, dokotala anu mulole:

1. Ntchito Voterani tentatively II, V, VII ndi X komanso clotting zinthu
2. Ukulu wa chizindikiro ichi kuweruza ntchito ya chiwindi
3. Pa machulukitsidwe wa vitamini K
4. Boma ambiri a dongosolo magazi coagulation
5. Malinga ndi chizindikiro ichi, mungathe kuzisonkhanitsa mphamvu ya mankhwala anticoagulant.

Monga anatsimikiza ndi prothrombin index

Prothrombin index anatsimikiza mu capillary kapena magazi venous. Ngati yachiwiri kudya magazi akutengedwa mu mayeso chubu ndi anticoagulant mu chiŵerengero cha 9: 1. Monga citrate ntchito anticoagulant ndi sodium. Zasayansi, magazi ndi centrifuged. The plasma chifukwa ntchito mtima wa prothrombin nthawi (PT). Wakudziko MF ndi mu osiyanasiyana kuchokera masekondi 12 mpaka 20, malinga ndi ntchito za thromboplastin ntchito mu njira ya anachita zasayansi.

Kudziwa PT wodwalayo, mukhoza kuwerengera PI, ie, prothrombin index, umene uli ponseponse mu Laboratories osiyana ungakhalenso pang'ono osiyana. Akhoza chiŵerengero px wathanzi munthu kuti wodwala PV, kuchulukitsa ndi 100:

PI = PV wathanzi. / SA odwala. X 100 (yachibadwa 95-105%)

Tanthauzo matenda a PI

Pa apamwamba PT coagulation kapena prothrombin amene ponseponse masekondi 12 mpaka 20 ali adzafupikitsidwa, ndipo ukuwonjezeka PI. Zimenezi zingakhale woyembekezera, ndi choipa chachikulu pamene magazi abwera kwambiri minofu thromboplastin.

Tikawonetsetsa MF umachuluka ndi amachepetsa ndi kuchepa PI clotting, monga zinachitikira akusowa kobadwa nako zinthu clotting, ndi matenda aakulu chiwindi, ndi akusowa vitamini K (zomwe zingachitike mu cholestasis, dysbacteriosis, kusokoneza m'matumbo ntchito). PI amachepetsa ndi fibrinogen otsika kapena kulumala zinchito, ndi matenda DIC, pamaso pa zinthu ziletsa clotting.

INR Kodi

Chithandizo cha anticoagulants mozungulira mwachibadwa kumachepetsa prothrombin index. wakudziko wake ndi yake iliyonse zasayansi. Choncho, pofuna kuti athe kuyerekeza zotsatira mayeso zopezera Laboratories osiyana, izo anayambitsa mayeso yovomerezeka monga INR. Izi mawerengedwe index. Amaonekera zochokera chiŵerengero cha prothrombin nthawi ya mtima, ubwino yachibadwa MF ndi digiri thromboplastin tilinazo index (Isi).

INR = (b TH PT / MF mlingo) mu mlingo wa Isi

Munthu akakhala wathanzi ndi INR mu zosiyanasiyana 0, 8-1,2.

chizindikiro ichi ntchito kuyan'anila mphamvu ya anticoagulants kanthu. Mankhwalawa anticoagulant pamene coagulation yafupika (mwachitsanzo pambuyo opaleshoni ya mtima) INR ayenera ziwonjezeke kwa 2-3. Ndi kukula INR clotting yafupika. Chiŵerengero pakati pa PI ndi INR ndi chotero kuti kuchepa mu PI index kuchuluka INR.