Zophatikizananso erythropoietin. Zophatikizananso erythropoietin anthu

Erythropoietin (EPO) - glycoprotein timadzi kuti akulamulira mlingo wa erythropoiesis anthu. Pawiri Pakalipano apanga makamaka impso, pang'ono (pafupifupi 10 peresenti) ndi kutulutsa mu chiwindi. The timadzi erythropoietin imayendetsa magawano ndi zosiyanasiyana za makolo erythroid. Kuchuluka kwa amkati timadzi mu madzi a m'magazi a anthu athanzi zimasiyanasiyana mkati osiyanasiyana ndipo inversely njila kwa hemoglobin ndende ndi digiri ya oxygenation wa zimakhala. Ntchito pa payekha kupanga timadzi izi kuti mankhwala ndi zothandiza kwambiri.

Kapangidwe ndi phindu timadzi

Molekyulu tichipeza kwa amino zidulo timadzi. Pa akusowa wa amkati erythropoietin wakhala kuchepa lakuthwa mu mlingo wa hemoglobin ndi maselo ofiira, ndi osauka otchedwa eritropoetindefitsitnaya magazi m'thupi. anakhalabe zosatheka chifukwa chosowa mankhwala oyenerera M'mbuyo monsemu mankhwala ngati awongolera magazi m'thupi. Lero, ndi kuchepekedwa pamwamba pa timadzi mu thupi la munthu, madokotala mankhwala zophatikizananso erythropoietin. Kukonza kuwapeza maselo nyama imene anayambitsa jini kachidindo kwa EPO anthu. Zophatikizananso Human Erythropoietin mu kwa amino acid ndi zimam'patsa zikuchokera ndi zofanana kwa mahomoni zachilengedwe, kumawonjezera chiwerengero cha maselo ofiira, reticulocytes, akuziyambitsa ndi biosynthesis wa hemoglobin mu maselo. Ntchito zamoyo nkhani chifukwa palibe osiyana timadzi amkati. Zophatikizananso erythropoietin si kuonetsa zotsatira cytotoxic ndipo alibe bwanji leucopoiesis. Asayansi amati EPO interacts ndi maselo yeniyeni eritropoetinchuvstvitelnymi, zomwe zili padziko selo.

A ndondomeko mayeretsedwe zophatikizananso erythropoietin anthu

Zophatikizananso anthu EPO - ndi imodzi mwa mapuloteni kwambiri wochuluka opangidwa ndi makampani kwachilengedwenso ndi mankhwala kuzungulira dziko kwa mankhwala. Pawiri Pakalipano apanga maselo n'kuwasanganiza Chinese hamster (Cho) mwa njira zophatikizananso DNA. Mmodzi polypeptide unyolo zophatikizananso EPO lili 165 kwa amino zidulo, ndi masamu maselo kulemera kwa 24,000 Eya, ndipo anaona maselo kulemera kwa glycosylated mapuloteni - 30 400 Da. Nthambi erythropoietin ku zodetsa ikuchitika ndi ion-kuwombola ndi kuyandikana koromatogarafe. Anthu zophatikizananso EPO ali ndi chiyero cha 98%.

Zophatikizananso erythropoietin ndi analogs zace

Yotithandiza erythropoiesis ndondomeko madokotala amagwiritsa ntchito mankhwala osiyanasiyana:

• "Aranesp";
• "Aeprin";
• "Epobiokrin";
• "Bioein";
• "Vepoks";
• "Binokrit";
• "Epokrin";
• "Gemax";
• "Epogen";
• "Eprex";
• "Epovitan";
• "Epomaks";
• "Giperkrit";
• "Eralfon";
• "Eritrea";
• "Recormon";
• "Epostim";
• "Epozino";
• "Epoetin Yoyeserera".

Musanayambe m'malo ndi zophatikizananso erythropoietin analogues, ayenera kufunsa dokotala.

zikuonetsa

kutsatilidwa Medical zambiri timalimbana ndi eritropoetindefitsitnymi magazi m'thupi (EDA). gulu izi zikuphatikiza pathologies zotsatirazi:

• magazi a neoplasms zilonda;
• oyambirira magazi a ana aang'ono prematurity (pamaso masabata 34 gestation) ndi thupi la 750 ndi 1500 ga;
• nephrogenic magazi m'thupi;
• Magazi m'thupi ku matenda aakulu (chiwindi C, nyamakazi, HIV, matenda alimentary ngalande).

Chinthu chapadera pamwambapa-akusowa magazi m'thupi n'chakuti iwo ankachitira kukonzekera chitsulo. Mpaka posachedwapa yekha mankhwala ogwira ndi magazi. Chifukwa chakuti mtundu uwu wa mankhwala ali ndi chiwerengero chachikulu mavuto ndi chiopsezo kutenga matenda odzera m'magazi a matenda oopsa opatsirana (HIV, matenda a chiwindi mavairasi, etc.), njira imeneyi mankhwala amakono pafupifupi konse ntchito. Zophatikizananso erythropoietin anthu amathandiza kusintha khalidwe la moyo odwala ndi matenda a "eritropoetindefitsitnaya magazi m'thupi." Biosynthesis ndi oyamba zophatikizananso EPO anthu anatsegula nyengo yatsopano pa matenda a magazi m'thupi eritropoetinzavisimyh.

contraindications

Madokotala sali kulengeza ntchito zophatikizananso erythropoietin (Buku akuchenjeza za izo) mu kukhalapo kwa pathologies zotsatirazi:

• thromboembolism;
• hypersensitivity kuti mankhwala;
• ndikosatheka anticoagulant mankhwala ogwira;
• anasamutsa oziziritsa sitiroko kapena m'mnyewa wamtima infarction;
• wosakhazikika angina;
• kusalankhula oopsa;
• nthawi wobereka ndi yoyamwitsa;
• refractory oopsa.

dosing kamwedwe

Mlingo ndi nthawi ya mankhwala chiwembu unakhazikitsidwa mu maziko mosamalitsa munthu, malingana ndi kuopsa kwa magazi m'thupi, mmene ambiri a wodwalayo komanso chikhalidwe cha kudwala lapansi. mankhwala cholinga ntchito parenteral. Mlingo koyamba zosiyanasiyana osiyanasiyana 50 150 IU / kg. mlingo ayenera kusintha malingana ndi zaka wodwalayo. Zophatikizananso erythropoietin nthawi kutumikiridwa 3 pa sabata. Ngati ambiri osokoneza wakhala kuwonjezeka mavuto. Zotsatira zake zimakhala zambiri kapena zochepa kuonekera pambuyo masabata 2-3 ntchito.

mbali zotsatira

Inu yoikidwiratu zophatikizananso erythropoietin anthu? Malangizo Ntchito si amapatula chitukuko mavuto. Ali:

• myalgia;
• chizungulire;
• hyperthermia;
• kusinza;
• kusanza;
• mutu;
• m'mimba;
• arthralgia;
• oopsa;
• ululu pachifuwa;
• thrombocytosis;
• tachycardia;
• hypertensive mavuto;
• kupweteka;
• steatosis;
• kulera mlingo wa Ast, alt m'mwazi;
• erythrocyte nyongolosi selo aplasia;
• chikanga;
• angioedema;
• zotupa pa khungu ndi oyabwa;
• asthenia;
• ming'oma, redness ndi moto malo utsogoleli;
• hyperkalemia;
• kuchepetsa mapuloteni ndende mu plasma ferritin;
• hyperphosphatemia.

Erythropoiesis ogalamutsa masewera

Posachedwapa, kambirimbiri mankhwala "Epovitan" (zophatikizananso anthu erythropoietin). The chida pano kawirikawiri amagwiritsidwa ntchito masewera (zamijaha, ojambula, kusambira, Masewerera a Biathlon). Anati kukonzekera imayendetsa ndi biosynthesis maselo a magazi, womwe amatsogolera ndi kuwonjezeka zili mpweya pa wagawo buku la magazi ndi, chotero, akuchuluka mu mphamvu magazi mpweya ndi O ₂ yobereka ziwalo ndipo zimakhala. limagwirira Izi kanthu kumawonjezera kupirira aerobic wa maseŵero. A kuchita chimodzimodzi zimawonedwa pophunzitsa woseŵera mu Midlands, kumene kupanda O ₂ mpweya amachititsa chitukuko cha hypoxia, womwe imayendetsa ndi biosynthesis wa amkati erythropoietin. EPO kukonzekera ntchito limodzi ndi insulin, kukula timadzi (GH, somatotropin) ndi stanazolol.

Kugwiritsa, kusalankhula ntchito "Erythropoietin" mankhwala masewera zimachititsa magazi kuundana kuti zambiri limadzetsa imfa. Azindikire zophatikizananso EPO ndi kovuta, chifukwa kupanga mankhwala kapangidwe ndi ofanana ndi analogi ake thupi, kotero biosoedinenie ichi mozemba ntchito masewera mkulu-ntchito monga doping.